FI91877C - Menetelmä osseiini-hydroksiapatiittiyhdisteen valmistamiseksi - Google Patents
Menetelmä osseiini-hydroksiapatiittiyhdisteen valmistamiseksi Download PDFInfo
- Publication number
- FI91877C FI91877C FI871670A FI871670A FI91877C FI 91877 C FI91877 C FI 91877C FI 871670 A FI871670 A FI 871670A FI 871670 A FI871670 A FI 871670A FI 91877 C FI91877 C FI 91877C
- Authority
- FI
- Finland
- Prior art keywords
- ohc
- bone
- chondrocytes
- collagen
- maximum
- Prior art date
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- -1 hydroxyapatite compound Chemical class 0.000 title claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 76
- 210000004027 cell Anatomy 0.000 claims description 66
- 210000001612 chondrocyte Anatomy 0.000 claims description 36
- 210000002950 fibroblast Anatomy 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 28
- 230000000694 effects Effects 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 21
- 239000011575 calcium Substances 0.000 claims description 21
- 229910052791 calcium Inorganic materials 0.000 claims description 21
- 229920001436 collagen Polymers 0.000 claims description 21
- 210000000963 osteoblast Anatomy 0.000 claims description 20
- 238000012360 testing method Methods 0.000 claims description 20
- 102000008186 Collagen Human genes 0.000 claims description 19
- 108010035532 Collagen Proteins 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- 230000004936 stimulating effect Effects 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 14
- 230000004071 biological effect Effects 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 230000000638 stimulation Effects 0.000 claims description 11
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 10
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 238000001243 protein synthesis Methods 0.000 claims description 10
- 230000014616 translation Effects 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 238000003786 synthesis reaction Methods 0.000 claims description 7
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 229910052742 iron Inorganic materials 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 230000006820 DNA synthesis Effects 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052802 copper Inorganic materials 0.000 claims description 5
- 230000004069 differentiation Effects 0.000 claims description 5
- 230000000813 microbial effect Effects 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 229910052759 nickel Inorganic materials 0.000 claims description 5
- 239000011574 phosphorus Substances 0.000 claims description 5
- 229910052698 phosphorus Inorganic materials 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000011573 trace mineral Substances 0.000 claims description 5
- 235000013619 trace mineral Nutrition 0.000 claims description 5
- 241000305071 Enterobacterales Species 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 230000001953 sensory effect Effects 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 231100000419 toxicity Toxicity 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims description 2
- 239000012254 powdered material Substances 0.000 claims 2
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 238000004448 titration Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 38
- 229940104230 thymidine Drugs 0.000 description 26
- 241001465754 Metazoa Species 0.000 description 19
- 239000002609 medium Substances 0.000 description 19
- 229960005069 calcium Drugs 0.000 description 17
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 16
- 239000012091 fetal bovine serum Substances 0.000 description 16
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 15
- 239000002953 phosphate buffered saline Substances 0.000 description 15
- 208000001132 Osteoporosis Diseases 0.000 description 11
- 210000002449 bone cell Anatomy 0.000 description 11
- 210000000845 cartilage Anatomy 0.000 description 11
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 10
- 230000007423 decrease Effects 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 230000007935 neutral effect Effects 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 230000007547 defect Effects 0.000 description 9
- 239000000284 extract Substances 0.000 description 9
- 230000035876 healing Effects 0.000 description 9
- 206010017076 Fracture Diseases 0.000 description 8
- 229960003957 dexamethasone Drugs 0.000 description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 206010065687 Bone loss Diseases 0.000 description 7
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 7
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 229960002061 ergocalciferol Drugs 0.000 description 7
- 235000001892 vitamin D2 Nutrition 0.000 description 7
- 239000011653 vitamin D2 Substances 0.000 description 7
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 230000001133 acceleration Effects 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 102000004142 Trypsin Human genes 0.000 description 5
- 108090000631 Trypsin Proteins 0.000 description 5
- 239000003246 corticosteroid Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000012588 trypsin Substances 0.000 description 5
- 208000010392 Bone Fractures Diseases 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000004227 calcium gluconate Substances 0.000 description 4
- 229960004494 calcium gluconate Drugs 0.000 description 4
- 235000013927 calcium gluconate Nutrition 0.000 description 4
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 4
- 244000309466 calf Species 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 229960001334 corticosteroids Drugs 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000012737 fresh medium Substances 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- 239000011701 zinc Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 3
- 230000008468 bone growth Effects 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 210000003953 foreskin Anatomy 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 210000001626 skin fibroblast Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 206010041569 spinal fracture Diseases 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000002303 tibia Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000000623 ulna Anatomy 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102400001368 Epidermal growth factor Human genes 0.000 description 2
- 101800003838 Epidermal growth factor Proteins 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 101150012619 FCS1 gene Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 206010054949 Metaplasia Diseases 0.000 description 2
- 229920001410 Microfiber Polymers 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 2
- 239000003470 adrenal cortex hormone Substances 0.000 description 2
- 230000004097 bone metabolism Effects 0.000 description 2
- 210000003321 cartilage cell Anatomy 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 2
- 210000004748 cultured cell Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 229940116977 epidermal growth factor Drugs 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 239000007941 film coated tablet Substances 0.000 description 2
- 210000002288 golgi apparatus Anatomy 0.000 description 2
- 210000002758 humerus Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000015689 metaplastic ossification Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 239000003658 microfiber Substances 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 230000002297 mitogenic effect Effects 0.000 description 2
- 230000003562 morphometric effect Effects 0.000 description 2
- 238000013425 morphometry Methods 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 210000002320 radius Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
- ONIBWKKTOPOVIA-NBFSVELBSA-N (2S)-5-tritiopyrrolidine-2-carboxylic acid Chemical compound N1[C@@H](CCC1[3H])C(=O)O ONIBWKKTOPOVIA-NBFSVELBSA-N 0.000 description 1
- JCVDICFLPGDHAT-DJLDLDEBSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethylpyrimidine-2,4-dione Chemical compound O=C1N(C)C(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 JCVDICFLPGDHAT-DJLDLDEBSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 229940078581 Bone resorption inhibitor Drugs 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 241000252206 Cypriniformes Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical group N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000007470 bone biopsy Methods 0.000 description 1
- 239000002617 bone density conservation agent Substances 0.000 description 1
- 229940036811 bone meal Drugs 0.000 description 1
- 239000002374 bone meal Substances 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008414 cartilage metabolism Effects 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 208000021863 corticosteroid-induced osteoporosis Diseases 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 210000004513 dentition Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000004821 effect on bone Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002745 epiphysis Anatomy 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000011990 functional testing Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000004349 growth plate Anatomy 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000002411 hand bone Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 210000004663 osteoprogenitor cell Anatomy 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3626414A DE3626414C2 (de) | 1986-08-05 | 1986-08-05 | Präparat zur Stimulierung von Chondrocyten und Osteoblasten (Ossein-Hydroxyapatit-Komplex), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel |
| DE3626414 | 1986-08-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI871670A0 FI871670A0 (fi) | 1987-04-15 |
| FI871670L FI871670L (fi) | 1988-02-06 |
| FI91877B FI91877B (fi) | 1994-05-13 |
| FI91877C true FI91877C (fi) | 1994-08-25 |
Family
ID=6306689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI871670A FI91877C (fi) | 1986-08-05 | 1987-04-15 | Menetelmä osseiini-hydroksiapatiittiyhdisteen valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4919931A (en, 2012) |
| EP (1) | EP0255565B1 (en, 2012) |
| JP (1) | JPS6344527A (en, 2012) |
| KR (2) | KR880002897A (en, 2012) |
| CN (1) | CN1028237C (en, 2012) |
| AR (1) | AR242589A1 (en, 2012) |
| AT (1) | ATE77239T1 (en, 2012) |
| AU (1) | AU604014B2 (en, 2012) |
| CA (1) | CA1289878C (en, 2012) |
| DE (2) | DE3626414C2 (en, 2012) |
| DK (1) | DK175488B1 (en, 2012) |
| ES (1) | ES2041647T3 (en, 2012) |
| FI (1) | FI91877C (en, 2012) |
| GR (1) | GR3005579T3 (en, 2012) |
| HU (1) | HU205373B (en, 2012) |
| IE (1) | IE59916B1 (en, 2012) |
| IL (1) | IL82213A (en, 2012) |
| NO (1) | NO173786C (en, 2012) |
| PT (1) | PT84693B (en, 2012) |
| ZA (1) | ZA872701B (en, 2012) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861590A (en) * | 1986-09-25 | 1989-08-29 | Colgate-Palmolive Company | Sustained release fluoride and calcium composition |
| US4859467A (en) * | 1986-09-25 | 1989-08-22 | Colgate-Palmotive Company | Sustained release fluoride composition |
| JPH02149618A (ja) * | 1988-11-30 | 1990-06-08 | Kobe Steel Ltd | 加工性に優れた高強度熱延鋼板の製造方法 |
| CN1045719C (zh) * | 1993-04-10 | 1999-10-20 | 北京市西城区华新生化技术研究所 | 口服接骨和治骨质疏松液 |
| EP0635518B1 (en) * | 1993-07-23 | 2003-10-08 | Kato, Yukio, Prof. | New chondrocyte protein |
| JPH10504555A (ja) * | 1994-08-23 | 1998-05-06 | デーゲーエフ ストーエス アクチェンゲゼルシャフト | 無味の加水分解コラーゲンの使用及びそれを含む薬剤 |
| US5788941A (en) * | 1996-01-31 | 1998-08-04 | Steris Corporation | Method of sterilization of bone tussue |
| JPH09238291A (ja) * | 1996-02-29 | 1997-09-09 | Sony Corp | メニュー操作方法及び電子機器及びテレビジョン受像機 |
| RU2168998C1 (ru) * | 2000-02-14 | 2001-06-20 | Волова Лариса Теодоровна | Способ получения аллогенного гидроксилапатита |
| NL1020729C2 (nl) * | 2002-05-31 | 2003-12-02 | Gelatine Smits Beheer B V | Calciumbevattende samenstelling, werkwijze voor het bereiden daarvan, en farmaceutisch preparaat op basis van de samenstelling. |
| CN1212126C (zh) * | 2002-07-09 | 2005-07-27 | 中国科学院长春应用化学研究所 | 纳米羟基磷灰石补钙剂 |
| RU2233177C1 (ru) * | 2002-11-22 | 2004-07-27 | Общество с ограниченной ответственностью Клиническое научно-производственное объединение "Биотехника" | Способ получения кальцийфосфатных порошков |
| JP4369969B2 (ja) * | 2007-10-26 | 2009-11-25 | 株式会社アールビーエス | 生体適合性材料並びにその製造方法 |
| US9347081B2 (en) | 2011-04-19 | 2016-05-24 | Bioiberica, S.A. | Cartilage product |
| RU2478394C1 (ru) * | 2011-11-23 | 2013-04-10 | Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения и социального развития Российской Федерации | Биоматериал для возмещения дефектов костей и способ его получения |
| WO2015033211A1 (en) | 2013-09-05 | 2015-03-12 | Waitaki Biosciences | High osteocalcin microcrystalline hydroxyapatite for calcium supplement |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE894895C (de) * | 1950-03-06 | 1953-10-29 | Albert Dr Reissner | Verfahren zur Herstellung eines Praeparates zur Anregung der Zahnerhaltung |
| BE650626A (en, 2012) * | 1962-02-28 | 1900-01-01 | ||
| US3400199A (en) * | 1965-02-26 | 1968-09-03 | Leslie L. Balassa | Wound-healing cartilage powder |
| USRE28093E (en) * | 1962-02-28 | 1974-07-30 | Wound-healing cartilage powder | |
| DE2425266A1 (de) * | 1974-05-24 | 1975-11-27 | Lothar Tischmann | Zum einnehmen bestimmtes naehr- und heilmittel aus tierischer knochen-substanz und verfahren zu seiner herstellung |
| DE2840064C2 (de) * | 1978-09-14 | 1989-09-21 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Verfahren zur Herstellung von Knochenkontaktschichten |
| US4232425A (en) * | 1980-01-15 | 1980-11-11 | Darling & Company | Method of producing stabilized bone |
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
| NZ198510A (en) * | 1980-10-07 | 1984-09-28 | Lensfield Prod Ltd | Protein from animal bones by demineralisation with acid;process and apparatus |
| US4444752A (en) * | 1982-09-13 | 1984-04-24 | Lescarden Ltd. | Method for treating progressive systemic sclerosis |
| US4436720A (en) * | 1983-03-04 | 1984-03-13 | Pakhomov Gennady N | Granulated treatment-and-prophylactic dental preparation possessing anticarious effect |
| NZ210699A (en) * | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| DE3409372A1 (de) * | 1984-03-14 | 1985-09-19 | Dr. Ruhland Nachf. GmbH, 8425 Neustadt | Material zum vitalisieren von implantatoberflaechen |
| DE3422466C1 (de) * | 1984-06-16 | 1986-03-20 | Lothar 6750 Kaiserslautern Tischmann | Verfahren zum Herstellen eines eßbaren, proteinhaltigen Knochenmehlpräparates aus frischen Tierknochen |
| US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
-
1986
- 1986-08-05 DE DE3626414A patent/DE3626414C2/de not_active Expired - Lifetime
-
1987
- 1987-01-28 AT AT87101136T patent/ATE77239T1/de not_active IP Right Cessation
- 1987-01-28 DE DE8787101136T patent/DE3779829T2/de not_active Expired - Lifetime
- 1987-01-28 ES ES198787101136T patent/ES2041647T3/es not_active Expired - Lifetime
- 1987-01-28 EP EP87101136A patent/EP0255565B1/en not_active Expired - Lifetime
- 1987-02-05 US US07/011,504 patent/US4919931A/en not_active Expired - Lifetime
- 1987-04-14 CN CN87102744A patent/CN1028237C/zh not_active Expired - Lifetime
- 1987-04-15 NO NO871599A patent/NO173786C/no unknown
- 1987-04-15 JP JP62092963A patent/JPS6344527A/ja active Granted
- 1987-04-15 AU AU71577/87A patent/AU604014B2/en not_active Expired
- 1987-04-15 DK DK198701963A patent/DK175488B1/da not_active IP Right Cessation
- 1987-04-15 ZA ZA872701A patent/ZA872701B/xx unknown
- 1987-04-15 CA CA000534786A patent/CA1289878C/en not_active Expired - Lifetime
- 1987-04-15 HU HU871671A patent/HU205373B/hu unknown
- 1987-04-15 AR AR87307298A patent/AR242589A1/es active
- 1987-04-15 PT PT84693A patent/PT84693B/pt unknown
- 1987-04-15 FI FI871670A patent/FI91877C/fi not_active IP Right Cessation
- 1987-04-15 KR KR870003615A patent/KR880002897A/ko not_active Withdrawn
- 1987-04-15 IL IL82213A patent/IL82213A/xx not_active IP Right Cessation
- 1987-04-15 IE IE98387A patent/IE59916B1/en not_active IP Right Cessation
- 1987-07-29 KR KR87008237A patent/KR960009651B1/ko not_active Expired - Lifetime
-
1992
- 1992-09-01 GR GR920401915T patent/GR3005579T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI91877C (fi) | Menetelmä osseiini-hydroksiapatiittiyhdisteen valmistamiseksi | |
| Rüegsegger et al. | Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females | |
| KR100399374B1 (ko) | 오가피 추출물 및 이를 포함하는 성장기 뼈 형성 촉진 및 골다공증 예방 또는 치료용 약학적 조성물 | |
| Harris et al. | Stimulation of bone formation in vivo by phosphate supplementation | |
| US6344217B1 (en) | Putamen OVI | |
| Lang et al. | Case report: fibrogenesis imperfecta ossium with early onset: Observations after 20 years of illness | |
| KR101790031B1 (ko) | 인삼 추출물, 작약 추출물, 감초 추출물 및 키토산을 유효성분으로 포함하는 폐경 또는 난소절제로 인한 여성 골다공증 예방 또는 치료용 약학적 조성물 | |
| JP2003502377A (ja) | キマメ（ＣａｊａｎｕｓＣａｊａｎ（Ｌ．）Ｍｉｌｌｓｐ）の葉及びその抽出物、製剤とそれらの効用 | |
| KR20240005368A (ko) | 나리루틴을 유효성분으로 함유하는 뼈 건강 개선용 조성물 | |
| WO2008084283A2 (en) | Andrographis paniculata plant extracts for treating osteoporosis and the extraction process thereof | |
| Abdullah et al. | Aloin Extract on Histopathological Features of Osteogenesis in Fractures of Rattus Norvegicus Wistar Strains | |
| WO2009007774A1 (en) | Asparagus racemosa extracts for treating osteoporosis and the extraction process thereof | |
| Vujasinović-Stupar et al. | Supplementation with bio-calcium from shells Pinctada maxima in postmenopausal women with decreased mineral bone density: Pilot study | |
| CN100509023C (zh) | 一种细胞生长营养素、制备方法，及其成品的用途 | |
| KR20050051595A (ko) | 괴각 추출물을 유효성분으로 함유하는 골 대사성 질환의예방 및 개선용 식품 조성물 | |
| WO2008004026A1 (en) | Citrus reticulata plant extracts for treating osteoporosis and the extraction process thereof | |
| AU2020200192B2 (en) | High osteocalcin microcrystalline hydroxyapatite for calcium supplement | |
| WO2008004119A2 (en) | Eugenia jambolana plant extracts for treating osteoporosis and the extraction process thereof | |
| WO2008004121A2 (en) | Allium sativum plant extracts for treating osteoporosis and the extraction process thereof | |
| CN100367952C (zh) | 一种含有l-苏糖酸钙和大豆异黄酮的组合物 | |
| WO2008007214A2 (en) | Glycyrrhiza glabra plant extracts for treating osteoporosis and the extraction process thereof | |
| WO2008084282A2 (en) | Punica granatum plant extracts for treating osteoporosis and the extraction process thereof | |
| WO2008007216A2 (en) | Psoralea corylifolia plant extracts for treating osteoporosis and the extraction process thereof | |
| CN113826899A (zh) | 一种增强人体免疫力的营养片及其制备方法 | |
| WO2008081233A2 (en) | Cissus quadrangularis plant extracts for treating osteoporosis and the extraction process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: ROBAPHARM AG |
|
| MA | Patent expired |