FI88577C - Kontinuerligt förfarande för tabletering av extruderbara farmaceutiska blandningar - Google Patents

Kontinuerligt förfarande för tabletering av extruderbara farmaceutiska blandningar

Info

Publication number
FI88577C
FI88577C FI871538A FI871538A FI88577C FI 88577 C FI88577 C FI 88577C FI 871538 A FI871538 A FI 871538A FI 871538 A FI871538 A FI 871538A FI 88577 C FI88577 C FI 88577C
Authority
FI
Finland
Prior art keywords
tabletting
continuous process
pharmaceutical mixtures
extrudable pharmaceutical
extrudable
Prior art date
Application number
FI871538A
Other languages
English (en)
Finnish (fi)
Other versions
FI88577B (fi
FI871538A (fi
FI871538A0 (fi
Inventor
Roger Guenther Klimesch
Gerhard Bleckmann
Karl-Peter Farwerck
Hans-Helmut Goertz
Lothar Schlemmer
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of FI871538A0 publication Critical patent/FI871538A0/fi
Publication of FI871538A publication Critical patent/FI871538A/fi
Publication of FI88577B publication Critical patent/FI88577B/fi
Application granted granted Critical
Publication of FI88577C publication Critical patent/FI88577C/sv

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00Making granules
    • B29B9/02Making granules by dividing preformed material
    • B29B9/06Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B11/00Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/16Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using pocketed rollers, e.g. two co-operating pocketed rollers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B30PRESSES
    • B30BPRESSES IN GENERAL
    • B30B15/00Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30Feeding material to presses
    • B30B15/302Feeding material in particulate or plastic state to moulding presses
    • B30B15/308Feeding material in particulate or plastic state to moulding presses in a continuous manner, e.g. for roller presses, screw extrusion presses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00General characteristics or adaptations
    • A61J2200/20Extrusion means, e.g. for producing pharmaceutical forms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2503/00Use of resin-bonded materials as filler

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
FI871538A 1986-04-11 1987-04-08 Kontinuerligt förfarande för tabletering av extruderbara farmaceutiska blandningar FI88577C (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863612211 DE3612211A1 (de) 1986-04-11 1986-04-11 Kontinuierliches verfahren zum tablettieren

Publications (4)

Publication Number Publication Date
FI871538A0 FI871538A0 (fi) 1987-04-08
FI871538A FI871538A (fi) 1987-10-12
FI88577B FI88577B (fi) 1993-02-26
FI88577C true FI88577C (sv) 1993-06-10

Family

ID=6298472

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871538A FI88577C (sv) 1986-04-11 1987-04-08 Kontinuerligt förfarande för tabletering av extruderbara farmaceutiska blandningar

Country Status (18)

Country Link
US (1) US4880585A (sv)
EP (1) EP0240906B1 (sv)
JP (1) JPH078293B2 (sv)
KR (1) KR940005302B1 (sv)
CN (1) CN1056508C (sv)
AR (1) AR241630A1 (sv)
AT (1) ATE63056T1 (sv)
AU (1) AU590697B2 (sv)
CA (1) CA1303501C (sv)
CS (1) CS270222B2 (sv)
DE (2) DE3612211A1 (sv)
ES (1) ES2022188B3 (sv)
FI (1) FI88577C (sv)
GR (1) GR3002559T3 (sv)
HU (1) HUT55218A (sv)
NO (1) NO173588C (sv)
PT (1) PT84660B (sv)
YU (1) YU45412B (sv)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051261A (en) * 1987-11-24 1991-09-24 Fmc Corporation Method for preparing a solid sustained release form of a functionally active composition
DE3812567A1 (de) * 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
DE3830353A1 (de) * 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
US5073323A (en) * 1990-05-30 1991-12-17 Washington Mills Ceramics Corporation Method and apparatus for producing compacted particulate articles
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
AU1537292A (en) * 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
DE4138513A1 (de) * 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US6312726B1 (en) * 1993-08-20 2001-11-06 Nippon Shinyaku Co., Ltd. Gastric remaining preparation, swollen molding, and production process
AU694490B2 (en) * 1994-03-09 1998-07-23 Wm. Wrigley Jr. Company Method and apparatus for forming miniature size confectionery products
DE4413350A1 (de) 1994-04-18 1995-10-19 Basf Ag Retard-Matrixpellets und Verfahren zu ihrer Herstellung
DE19509807A1 (de) * 1995-03-21 1996-09-26 Basf Ag Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE4446467A1 (de) * 1994-12-23 1996-06-27 Basf Ag Verfahren zur Herstellung von linsenförmigen Tabletten durch Schmelzkalandrierung
DE4446470A1 (de) * 1994-12-23 1996-06-27 Basf Ag Verfahren zur Herstellung von teilbaren Tabletten
DE4446468A1 (de) * 1994-12-23 1996-06-27 Basf Ag Verfahren zur Herstellung von umhüllten Tabletten
DE19504832A1 (de) * 1995-02-14 1996-08-22 Basf Ag Feste Wirkstoff-Zubereitungen
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
DE19536394A1 (de) 1995-09-29 1997-04-03 Basf Ag Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
DE19539359A1 (de) * 1995-10-23 1997-04-24 Knoll Ag Formbandkalander
DE19629040A1 (de) * 1996-07-19 1998-01-22 Basf Ag Pflanzenextrakthaltige Arzneiformen
DE19629753A1 (de) 1996-07-23 1998-01-29 Basf Ag Verfahren zur Herstellung von festen Arzneiformen
DE19635676A1 (de) * 1996-09-03 1998-03-05 Basf Ag Feste geschäumte Wirkstoffzubereitungen
TW474824B (en) 1996-09-13 2002-02-01 Basf Ag The production of solid pharmaceutical forms
DE19710213A1 (de) * 1997-03-12 1998-09-17 Basf Ag Verfahren zur Herstellung von festen Kombinationsarzneiformen
DE19733504A1 (de) * 1997-08-01 1999-02-04 Basf Ag Langsam sinkende Pellets oder Granulate für die Fischzucht
DE19753298A1 (de) 1997-12-01 1999-06-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
WO1999034780A1 (de) * 1998-01-12 1999-07-15 Bühler AG Verfahren und vorrichtung zum verkapseln von wirkstoffen
US6787157B1 (en) * 1998-03-10 2004-09-07 Abbott Laboratories Multiphase active ingredient-containing formulations
DE19812688A1 (de) 1998-03-23 1999-09-30 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
ATE265138T1 (de) 1998-04-30 2004-05-15 Basf Ag Retardformulierungen von pflanzenschutzwirkstoffen
DE19839276A1 (de) 1998-08-28 2000-03-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19840256A1 (de) 1998-09-03 2000-03-09 Basf Ag Verfahren zur Herstellung von beschichteten festen Dosierungsformen
DE19841244A1 (de) 1998-09-09 2000-03-16 Knoll Ag Verfahren und Vorrichtung zum Herstellen von Tabletten
DE19842753A1 (de) 1998-09-18 2000-03-23 Bayer Ag Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung
DE19843904A1 (de) 1998-09-24 2000-03-30 Basf Ag Feste Dosierungsform mit polymerem Bindemittel
DE19847618A1 (de) 1998-10-15 2000-04-20 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19853985A1 (de) 1998-11-23 2000-05-25 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE19901383A1 (de) 1999-01-15 2000-07-20 Knoll Ag Verfahren zur Herstellung unterschiedlicher fester Dosierungsformen
DE19913692A1 (de) 1999-03-25 2000-09-28 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
ES2252030T3 (es) 1999-09-06 2006-05-16 Firmenich S.A. Procedimiento relacionado con la elaboracion de granulos para la liberacion controlada de compuestos volatiles.
DE19943501A1 (de) 1999-09-10 2001-03-15 Basf Ag Unterwassergranulation wirkstoffhaltiger Schmelzen
DE60010919T2 (de) * 1999-10-13 2005-06-09 Novo Nordisk A/S Verfahren zum herstellung von medizinische formkörpern
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
JP5767429B2 (ja) 1999-11-12 2015-08-19 アッヴィ・インコーポレイテッド 固体分散剤中の結晶化阻害剤
GB9927682D0 (en) * 1999-11-23 2000-01-19 Unilever Plc Process for the manufacture of shaped articles
DE10017102A1 (de) 2000-04-06 2001-10-11 Basf Ag Verfahren zur Herstellung von festen Kreatin-Dosierungsformen und dadurch erhältliche Dosierungsformen
GB0008553D0 (en) * 2000-04-06 2000-05-24 Unilever Plc Process and apparatus for the production of a detergent bar
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
DE10038571A1 (de) * 2000-08-03 2002-02-14 Knoll Ag Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen
DE10046541A1 (de) * 2000-09-19 2002-03-28 Knoll Ag Mechanisch stabile darreichungsformen, enthaltend Ubichinone
US6767619B2 (en) * 2001-05-17 2004-07-27 Charles R. Owens Preform for manufacturing a material having a plurality of voids and method of making the same
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
US20030203027A1 (en) * 2002-04-26 2003-10-30 Ethicon, Inc. Coating technique for deposition of drug substance on a substrate
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10247037A1 (de) * 2002-10-09 2004-04-22 Abbott Gmbh & Co. Kg Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers
US6797213B2 (en) * 2002-10-15 2004-09-28 Frito-Lay North America, Inc Method and apparatus for producing a curly puff extrudate
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
EP1572190B1 (en) * 2002-12-17 2007-04-18 Abbott GmbH & Co. KG Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof
JP2006518380A (ja) * 2003-01-31 2006-08-10 スミスクライン・ビーチャム・コーポレイション 固体分散体組成物
WO2004093819A2 (en) 2003-04-21 2004-11-04 Euro-Celtique, S.A. Tamper resistant dosage form comprising co-extruded, adverse agent particles and process of making same
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
ES2281851T3 (es) * 2003-12-09 2007-10-01 Euro-Celtique S.A. Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo.
US8883204B2 (en) 2003-12-09 2014-11-11 Purdue Pharma L.P. Tamper resistant co-extruded dosage form containing an active agent and an adverse agent and process of making same
GB2409204A (en) * 2003-12-19 2005-06-22 Reckitt Benckiser Nv Plasticized thermoplastic polymer
WO2005115343A2 (de) 2004-05-28 2005-12-08 Abbott Gmbh & Co. Kg Dosierungsform, erhältlich aus einer ein anorganisches pigment umfassenden pulvermischung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
ATE476997T1 (de) * 2005-07-05 2010-08-15 Abbott Gmbh & Co Kg Zusammensetzung und dosierform mit einer festen oder halbfesten matrix
EP1912625B1 (en) 2005-08-08 2016-04-13 AbbVie Deutschland GmbH & Co KG Itraconazole compositions with improved bioavailability
US20090028938A1 (en) 2005-08-08 2009-01-29 Abbott Gmbh & Co. Kg Dosage forms with improved bioavailability
EP1832281A1 (en) * 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
US7850894B2 (en) * 2006-05-04 2010-12-14 Ethicon, Inc. Tissue holding devices and methods for making the same
EP1925441A1 (de) 2006-11-24 2008-05-28 Abbott GmbH & Co. KG Vorrichtung und Verfahren zum Bilden von Formlingen aus einer formbaren Masse
EP1925442A1 (de) 2006-11-24 2008-05-28 Abbott GmbH & Co. KG Hochleistungs-Rotationsumlauf-Form-Verfahren und -Vorrichtung
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US8562644B2 (en) * 2007-08-06 2013-10-22 Ethicon, Inc. Barbed suture with non-symmetric barbs
WO2009040818A1 (en) 2007-09-25 2009-04-02 Solubest Ltd Compositions comprising lipophilic active compounds and method for their preparation
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
US8727754B2 (en) 2009-03-26 2014-05-20 Swiss Caps Rechte Und Lizenzen Ag Method and device for producing soft capsules
WO2011009604A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Oxidation-stabilized tamper-resistant dosage form
PE20121067A1 (es) 2009-07-22 2012-09-05 Gruenenthal Chemie Forma de dosificacion de liberacion controlada extruida por fusion en caliente
ES2606227T3 (es) 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
CN103179956A (zh) 2010-09-02 2013-06-26 格吕伦塔尔有限公司 包含阴离子聚合物的抗破碎剂型
CA2808541C (en) 2010-09-02 2019-01-08 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
WO2012028319A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
EP2463327A3 (de) 2010-12-10 2015-06-03 Basf Se Verfahren zur herstellung von granulaten, enthaltend mindestens eine wasserlösliche komponente
ES2598235T3 (es) 2010-12-23 2017-01-26 AbbVie Deutschland GmbH & Co. KG Formulaciones de retardo sólidas basadas en dispersiones sólidas
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
KR101274387B1 (ko) * 2011-09-03 2013-06-17 김경란 구형물 성형장치
KR101437423B1 (ko) * 2011-12-21 2014-09-11 권오익 다공판이 구비된 환 제조장치
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
MX357783B (es) 2012-05-11 2018-07-25 Gruenenthal Gmbh Forma de dosificacion farmaceutica termoconformada, resistente al uso indebido, que contiene zinc.
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CN103478878A (zh) * 2012-06-12 2014-01-01 昆山市张浦镇合通网络科技服务部 简易快捷制块机
DE102013003032A1 (de) * 2013-02-22 2014-09-25 Automatik Plastics Machinery Gmbh Quetschwalzengranulator und Verwendung desselben
WO2014139803A1 (en) * 2013-03-15 2014-09-18 AbbVie Deutschland GmbH & Co. KG Process and apparatus for metering a plasticized formulation
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
WO2015091352A1 (en) 2013-12-16 2015-06-25 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion
CA2947786A1 (en) 2014-05-12 2015-11-19 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising tapentadol
WO2015181059A1 (en) 2014-05-26 2015-12-03 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
DE202014008800U1 (de) * 2014-11-05 2014-11-17 Automatik Plastics Machinery Gmbh Quetschwalzengranulator mit Quetschwalzenpaar und Verwendung desselben
JP2018503693A (ja) 2015-02-03 2018-02-08 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ポリエチレングリコールグラフトコポリマーを含む改変防止剤形
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
JP2017137279A (ja) * 2016-02-04 2017-08-10 秀介 大友 連結状態で一個ずつ又は複数個ずつ自由に分割できる錠剤
WO2018024709A1 (en) 2016-08-01 2018-02-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polysaccharide
CN107714654A (zh) * 2016-08-11 2018-02-23 董玲 一种冻干制剂及其制备方法
US20180042868A1 (en) 2016-08-12 2018-02-15 Grünenthal GmbH Tamper resistant formulation of ephedrine and its derivatives
BE1024283B1 (fr) * 2016-10-10 2018-01-12 Universite De Liege Appareillage pour la production en continu de formes orales solides
CN106827289A (zh) * 2017-03-28 2017-06-13 洛阳欧祺精密零件制造有限公司 一种造粒机
TW202002957A (zh) 2018-02-09 2020-01-16 德商歌林達有限公司 包含轉化抑制劑之麻黃素及其衍生物之抗損壞調配物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US99083A (en) * 1870-01-25 Improvement in moulding and glazing forms made of plastic material
FR537444A (fr) * 1920-11-24 1922-05-23 Machine pour la fabrication des cachets pharmaceutiques
US2988774A (en) * 1957-07-22 1961-06-20 Lever Brothers Ltd Method and apparatus for the production of soap tablets
DE1766546C3 (de) * 1968-06-11 1974-11-28 Karl Gunnar Lidingoe Eriksson Verfahren zum Herstellen von festen dragee- oder tablettenförmigen Arzneimittelzubereitungen
US3755527A (en) * 1969-10-09 1973-08-28 Exxon Research Engineering Co Process for producing melt blown nonwoven synthetic polymer mat having high tear resistance
BE795766A (fr) * 1972-02-22 1973-08-22 Lilly Co Eli Particules de napsylate de propoxyphene retard et procede de fabrication de ces particules
US3859407A (en) * 1972-05-15 1975-01-07 Corning Glass Works Method of manufacturing particles of uniform size and shape
DE2241616C3 (de) * 1972-08-24 1978-07-13 Buss Ag, Basel (Schweiz) Verfahren und Vorrichtung zur Aufbereitung von Polyadditionsharzzwischenprodukten
US3843299A (en) * 1972-09-01 1974-10-22 V Minchenko Device for shaping spherical pellets
US4028024A (en) * 1974-10-31 1977-06-07 Moreland Stephen T Manufacture of filled capsules or the like
IT1065137B (it) * 1976-08-05 1985-02-25 Sir Soc Italiana Resine Spa Composizioni da stampaggio comprendenti una resina fenolica novolacca e procedimento per la loro preparazione
US4130521A (en) * 1977-04-25 1978-12-19 Chevron Research Company Densification of polypyrrolidone
US4256448A (en) * 1978-03-09 1981-03-17 Usm Corporation Roller die
AU525847B2 (en) * 1978-03-09 1982-12-02 Usm Corp. Roller die 0
US4165978A (en) * 1978-07-14 1979-08-28 Midrex Corporation Briquet sheet breaking by cooling and bending
JPS56160900A (en) * 1980-05-16 1981-12-10 Mitsubishi Heavy Ind Ltd Briquette machine
US4340557A (en) * 1980-12-16 1982-07-20 Ball Corporation Method of making unfestooned plastic containers from polygonal blanks
US4411161A (en) * 1981-08-10 1983-10-25 International Telephone & Telegraph Corporation Mass flowmeter or the like
US4451260A (en) * 1982-03-26 1984-05-29 Minnesota Mining And Manufacturing Company Sustained release oral medicinal delivery device
US4520179A (en) * 1982-09-20 1985-05-28 Gaf Corporation Preparation of vinylpyrrolidone/vinyl acetate copolymers of various molecular weights using a single initiator system consisting essentially of t-Butylperoxypivalate
US4520180A (en) * 1982-09-20 1985-05-28 Gaf Corporation Polymerization of vinylpyrrolidone to various molecular weights using a single initiator system consisting essentially of t-Butylperoxypivalate
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen

Also Published As

Publication number Publication date
CN1056508C (zh) 2000-09-20
FI88577B (fi) 1993-02-26
FI871538A (fi) 1987-10-12
NO871512D0 (no) 1987-04-10
US4880585A (en) 1989-11-14
JPH078293B2 (ja) 1995-02-01
CS253187A2 (en) 1989-10-13
HUT55218A (en) 1991-05-28
DE3769687D1 (de) 1991-06-06
AU7140087A (en) 1987-10-15
CA1303501C (en) 1992-06-16
CS270222B2 (en) 1990-06-13
EP0240906A2 (de) 1987-10-14
PT84660A (en) 1987-05-01
GR3002559T3 (en) 1993-01-25
AR241630A1 (es) 1992-10-30
AU590697B2 (en) 1989-11-09
PT84660B (pt) 1989-11-30
KR870009705A (ko) 1987-11-30
FI871538A0 (fi) 1987-04-08
ATE63056T1 (de) 1991-05-15
YU45412B (en) 1992-05-28
DE3612211A1 (de) 1987-10-15
JPS62240061A (ja) 1987-10-20
NO871512L (no) 1987-10-12
CN87102755A (zh) 1987-10-28
ES2022188B3 (es) 1991-12-01
NO173588C (no) 1994-01-05
KR940005302B1 (ko) 1994-06-16
EP0240906B1 (de) 1991-05-02
YU59087A (en) 1989-12-31
NO173588B (no) 1993-09-27
EP0240906A3 (en) 1988-08-03

Similar Documents

Publication Publication Date Title
FI88577C (sv) Kontinuerligt förfarande för tabletering av extruderbara farmaceutiska blandningar
NO177038C (no) Fremgangsmåte for fremstilling av et farmasöytisk doseringssystem
DE3780223D1 (de) Arzneimittel mit gesteuerter freisetzung.
DK153787A (da) Laegemidler med langsom frigivelse
DE3774468D1 (de) Arzneimittel fuer periodontale erkrankungen.
FI892640A0 (sv) Förfarande för framställning av en piperidinoalkanol-ibuprofenkomposition innehållande farmaceutisk komposition
FI873630A0 (fi) Stabilt farmaceutiskt preparat.
PT86986A (pt) Substituted 9-amino-tetrahydroacridines and related compounds a process for their preparation and their use as medicaments
FI94752C (sv) Förfarande för framställning av terapeutiskt användbara propenonoximetrar
GB8619432D0 (en) Pharmaceutical compounds
FI881303A (sv) Förfarande för framställning av ibuprofen
FI935065A (fi) Farmaceutiska foereningar
FI92065C (sv) Förfarande för framställning av farmaceutiska piperidinderivat
DK548689D0 (da) Farmaceutisk oploesning
FI902316A0 (sv) Förfarande för framställning av terapeutiskt verkande substituerade dihydropyrrolizinföreningar
FI913554A0 (sv) Förfarande för framställning av en stabiliserad farmaceutisk komposition
DE3763519D1 (de) Heilnahrungsmittel.
FI892144A (sv) Förfarande för framställning av 5-C-hydroximetylaldohexosbaserade föreningar
DE3781045D1 (de) Antirheumatisches arzneimittel.
FI88294C (sv) Förfarande för framställning av azetidinoner
FI874643A0 (fi) Terapeutiska medel och deras anvaendning.
DK524587D0 (da) Laegemiddel
DK611887A (da) Farmaceutiske materialer
RO91711A2 (ro) Produs medicamentos reconfortant
DK654389D0 (da) Laegemiddel

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: BASF AKTIENGESELLSCHAFT