FI882390A - Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita - Google Patents

Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita Download PDF

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Publication number
FI882390A
FI882390A FI882390A FI882390A FI882390A FI 882390 A FI882390 A FI 882390A FI 882390 A FI882390 A FI 882390A FI 882390 A FI882390 A FI 882390A FI 882390 A FI882390 A FI 882390A
Authority
FI
Finland
Prior art keywords
tetrazoles
intermediates
antihypertensive compounds
antihypertensive
compounds
Prior art date
Application number
FI882390A
Other languages
English (en)
Swedish (sv)
Other versions
FI93831B (fi
FI882390A0 (fi
FI93831C (fi
Inventor
Paul Edward Aldrich
John Jonas Vytautas Duncia
Michael Ernest Pierce
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of FI882390A0 publication Critical patent/FI882390A0/fi
Publication of FI882390A publication Critical patent/FI882390A/fi
Publication of FI93831B publication Critical patent/FI93831B/fi
Application granted granted Critical
Publication of FI93831C publication Critical patent/FI93831C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
FI882390A 1987-05-22 1988-05-20 Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita FI93831C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/053,198 US4820843A (en) 1987-05-22 1987-05-22 Tetrazole intermediates to antihypertensive compounds
US5319887 1987-05-22

Publications (4)

Publication Number Publication Date
FI882390A0 FI882390A0 (fi) 1988-05-20
FI882390A true FI882390A (fi) 1988-11-23
FI93831B FI93831B (fi) 1995-02-28
FI93831C FI93831C (fi) 1995-06-12

Family

ID=21982564

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882390A FI93831C (fi) 1987-05-22 1988-05-20 Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita

Country Status (20)

Country Link
US (1) US4820843A (fi)
EP (1) EP0291969B1 (fi)
JP (1) JPH0774207B2 (fi)
KR (1) KR960009571B1 (fi)
AT (1) ATE101603T1 (fi)
AU (1) AU603525B2 (fi)
CA (1) CA1340325C (fi)
DE (1) DE3887772T2 (fi)
DK (1) DK274788A (fi)
ES (1) ES2061552T3 (fi)
FI (1) FI93831C (fi)
HU (1) HU198698B (fi)
IE (1) IE63204B1 (fi)
IL (1) IL86456A (fi)
MY (1) MY101284A (fi)
NO (1) NO178189C (fi)
NZ (1) NZ224741A (fi)
PT (1) PT87552B (fi)
RU (1) RU2091376C1 (fi)
ZA (1) ZA883528B (fi)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0733366B1 (en) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
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AU645022B2 (en) * 1989-06-30 1994-01-06 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
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DE69016125T2 (de) * 1989-08-11 1995-06-01 Zeneca Ltd Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
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IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
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IE903911A1 (en) * 1989-11-20 1991-05-22 Ici Plc Diazine derivatives
EP0442473B1 (en) * 1990-02-15 1998-08-19 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
ATE134624T1 (de) * 1990-02-19 1996-03-15 Ciba Geigy Ag Acylverbindungen
US5284661A (en) * 1990-02-22 1994-02-08 Takeda Chemical Industries, Ltd. Fused thiophene derivatives, their production and use
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
FR2665702B1 (fr) * 1990-08-08 1994-02-25 Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IE910913A1 (en) * 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
FR2659967B1 (fr) * 1990-03-20 1992-07-24 Sanofi Sa Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
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GB2244054B (en) * 1990-04-19 1994-04-06 Ici Plc Pyridine derivatives
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US6004989A (en) 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
ZA912983B (en) 1990-04-27 1992-01-29 Takeda Chemical Industries Ltd Benzimidazole derivatives,their production and use
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
CA2041763A1 (en) 1990-05-11 1991-11-12 Sheih-Shung T. Chen Microbial transformation process for antihypertensive products
FR2663027B1 (fr) * 1990-06-08 1994-12-02 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2673943B1 (fr) * 1991-03-13 1994-02-18 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
AU653524B2 (en) * 1990-06-08 1994-10-06 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
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WO1992004343A1 (en) * 1990-09-04 1992-03-19 Yamanouchi Pharmaceutical Co., Ltd. Novel tetrahydrobenzazole derivative
US5284954A (en) * 1990-09-10 1994-02-08 Abbott Laboratories Process for the preparation of tetrazoles
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
AU9137791A (en) * 1990-12-14 1992-07-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
IE914572A1 (en) * 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5153347A (en) * 1991-01-31 1992-10-06 E. R. Squibb & Sons, Inc. Phosphonate, phosphinate derivatives useful as antihypertensive agents
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US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
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FR2677984B1 (fr) * 1991-06-21 1994-02-25 Elf Sanofi Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
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WO1993004045A1 (en) * 1991-08-19 1993-03-04 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
WO1993004046A1 (en) * 1991-08-19 1993-03-04 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
SG42942A1 (en) * 1991-09-10 1997-10-17 Tanabe Seiyaku Co Imidazopyridine derivatives and process for preparation thereof
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5322950A (en) * 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
US5234923A (en) * 1991-12-16 1993-08-10 E. R. Squibb & Sons, Inc. Substitute indole and benzimidazole derivatives
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US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
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FR2685697B1 (fr) * 1991-12-30 1994-02-04 Synthelabo Nouveaux derives de 2-(tetrazol-5-yl)-(1,1'-biphenyle), leur preparation et leur utilisation comme intermediaires de synthese.
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US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
US5208234A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5484955A (en) * 1992-07-06 1996-01-16 Takeda Chemical Industries, Ltd. Tri-higher alkyl tin azide and its use
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
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US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
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US5438136A (en) * 1993-11-02 1995-08-01 Merck & Co., Inc. Benzo-fused macrocycles promote release of growth hormone
US5606054A (en) * 1993-12-14 1997-02-25 Merck & Co., Inc. Heterocyclic-fused lactams promote release of growth hormone
ATE194603T1 (de) * 1994-01-28 2000-07-15 Takeda Chemical Industries Ltd Ein verfahren zur herstellung von tetrazolyl- verbindungen
HUT74734A (en) * 1994-03-16 1997-02-28 Sankyo Co Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
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WO1995031445A1 (fr) * 1994-05-16 1995-11-23 Sumitomo Chemical Company, Limited Procede pour produire un compose de tetrazole et intermediaire prevu a cet effet
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CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
PT87552A (pt) 1989-05-31
DK274788A (da) 1988-11-23
NO882241L (no) 1988-11-23
NO178189C (no) 1996-02-07
DE3887772T2 (de) 1994-06-23
ATE101603T1 (de) 1994-03-15
IL86456A (en) 1992-12-01
DK274788D0 (da) 1988-05-19
DE3887772D1 (de) 1994-03-24
US4820843A (en) 1989-04-11
ZA883528B (en) 1990-01-31
JPH0774207B2 (ja) 1995-08-09
JPH01117876A (ja) 1989-05-10
MY101284A (en) 1991-08-17
FI93831B (fi) 1995-02-28
IE881515L (en) 1988-11-22
IL86456A0 (en) 1988-11-15
FI882390A0 (fi) 1988-05-20
NO178189B (no) 1995-10-30
HUT47550A (en) 1989-03-28
ES2061552T3 (es) 1994-12-16
KR960009571B1 (ko) 1996-07-20
NZ224741A (en) 1990-12-21
IE63204B1 (en) 1995-04-05
NO882241D0 (no) 1988-05-20
FI93831C (fi) 1995-06-12
AU603525B2 (en) 1990-11-15
PT87552B (pt) 1992-09-30
EP0291969A2 (en) 1988-11-23
EP0291969A3 (en) 1990-10-31
EP0291969B1 (en) 1994-02-16
RU2091376C1 (ru) 1997-09-27
KR880013909A (ko) 1988-12-22
AU1650388A (en) 1988-11-24
HU198698B (en) 1989-11-28
CA1340325C (en) 1999-01-19

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Legal Events

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FD Application lapsed
BB Publication of examined application
FG Patent granted

Owner name: E.I. DU PONT DE NEMOURS AND COMPANY

MA Patent expired