FI86254C - Foerfarande foer framstaellning av insulinpreparat. - Google Patents

Foerfarande foer framstaellning av insulinpreparat. Download PDF

Info

Publication number
FI86254C
FI86254C FI874596A FI874596A FI86254C FI 86254 C FI86254 C FI 86254C FI 874596 A FI874596 A FI 874596A FI 874596 A FI874596 A FI 874596A FI 86254 C FI86254 C FI 86254C
Authority
FI
Finland
Prior art keywords
insulin
protamine
solution
zinc
magnesium
Prior art date
Application number
FI874596A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI86254B (fi
FI874596A0 (fi
FI874596L (fi
Inventor
Klavs Holger Joergensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK503386A external-priority patent/DK503386D0/da
Priority claimed from DK356987A external-priority patent/DK356987D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI874596A0 publication Critical patent/FI874596A0/fi
Publication of FI874596L publication Critical patent/FI874596L/fi
Application granted granted Critical
Publication of FI86254B publication Critical patent/FI86254B/fi
Publication of FI86254C publication Critical patent/FI86254C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
FI874596A 1986-10-20 1987-10-19 Foerfarande foer framstaellning av insulinpreparat. FI86254C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK503386A DK503386D0 (da) 1986-10-20 1986-10-20 Peptidpraeparater
DK503386 1986-10-20
DK356987A DK356987D0 (enEXAMPLES) 1987-07-10 1987-07-10
DK356987 1987-07-10

Publications (4)

Publication Number Publication Date
FI874596A0 FI874596A0 (fi) 1987-10-19
FI874596L FI874596L (fi) 1988-04-21
FI86254B FI86254B (fi) 1992-04-30
FI86254C true FI86254C (fi) 1992-08-10

Family

ID=26067111

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874596A FI86254C (fi) 1986-10-20 1987-10-19 Foerfarande foer framstaellning av insulinpreparat.

Country Status (18)

Country Link
US (1) US5070186A (enEXAMPLES)
EP (1) EP0265213B1 (enEXAMPLES)
KR (1) KR880004819A (enEXAMPLES)
CN (1) CN87107049A (enEXAMPLES)
AU (1) AU616381B2 (enEXAMPLES)
CA (1) CA1316819C (enEXAMPLES)
DE (1) DE3778287D1 (enEXAMPLES)
ES (1) ES2033871T3 (enEXAMPLES)
FI (1) FI86254C (enEXAMPLES)
GR (1) GR3004912T3 (enEXAMPLES)
HU (1) HU201475B (enEXAMPLES)
IE (1) IE60264B1 (enEXAMPLES)
IL (1) IL84203A (enEXAMPLES)
NO (1) NO170754C (enEXAMPLES)
NZ (1) NZ222214A (enEXAMPLES)
PH (1) PH23446A (enEXAMPLES)
PT (1) PT85949B (enEXAMPLES)
YU (1) YU46665B (enEXAMPLES)

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US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
JP2002500196A (ja) * 1998-01-09 2002-01-08 ノヴォ ノルディスク アクティーゼルスカブ 安定化させたインスリン組成物
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
DE10114178A1 (de) * 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
JP4224702B2 (ja) * 2001-08-27 2009-02-18 ノボ・ノルデイスク・エー／エス カートリッジおよび該カートリッジを収容した薬剤投与システム
CA2512052C (en) * 2002-12-31 2016-06-21 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
ZA200505306B (en) * 2002-12-31 2006-09-27 Altus Pharmaceuticals Inc Complexes of protein crystals and ionic polymers
AU2006330833A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
PT2074141T (pt) 2006-09-22 2016-11-10 Novo Nordisk As Análogos de insulina resistentes a proteases
US20100120660A1 (en) * 2007-04-30 2010-05-13 Per Balschmidt Highly concentrated insulin solutions and compositions
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
JP5749155B2 (ja) 2008-03-18 2015-07-15 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化アシル化インスリンアナログ
CN105396126A (zh) 2008-10-17 2016-03-16 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
KR101337322B1 (ko) 2009-11-13 2013-12-06 사노피-아벤티스 도이칠란트 게엠베하 Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
US8637458B2 (en) * 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
RS55378B1 (sr) 2010-08-30 2017-03-31 Sanofi Aventis Deutschland Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
US9381247B2 (en) * 2012-04-16 2016-07-05 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9399065B2 (en) 2012-04-16 2016-07-26 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
BR112015024659A8 (pt) 2013-04-03 2019-12-17 Sanofi Sa formulação farmacêutica aquosa, seu uso, método de tratamento de diabetes mellitus e artigo de fabricação
BR112016007166A2 (pt) 2013-10-07 2017-09-12 Novo Nordisk As derivado de um análogo de insulina
HRP20230470T1 (hr) 2014-12-12 2023-07-21 Sanofi-Aventis Deutschland Gmbh Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CA3046583A1 (en) 2016-12-16 2018-06-21 Novo Nordisk A/S Insulin containing pharmaceutical compositions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2076082A (en) * 1935-04-08 1937-04-06 Nordisk Insulinlab Therapeutic product and process
US2179384A (en) * 1937-04-05 1939-11-07 Univ Alberta Therapeutic composition and process of making it
US2190134A (en) * 1939-06-09 1940-02-13 Norton Co Grinding machine
US2538018A (en) * 1944-04-04 1951-01-16 Nordisk Insulinlab Crystalline product of insulin and alkaline protein and process of making it
US2474729A (en) * 1945-01-03 1949-06-28 Rhone Poulenc Sa Insulin preparations
US2801953A (en) * 1952-02-28 1957-08-06 Hoechst Ag Process of preparing crystallized insulin preparations
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
DK98342C (da) * 1959-06-16 1964-03-31 Henry Marinus Dr Christensen Fremgangsmåde til fremstilling af et insulinpræparat til peroral applikation.
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
GB1426061A (en) * 1972-12-28 1976-02-25 Ici Ltd Polypeptides
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
US4196196A (en) * 1978-06-19 1980-04-01 Tiholiz Ivan C Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states
AU550068B2 (en) * 1981-03-10 1986-02-27 Novo Nordisk A/S Zinc insulin stabilized with calcium or magnesium salts
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production

Also Published As

Publication number Publication date
CA1316819C (en) 1993-04-27
HUT46232A (en) 1988-10-28
EP0265213A3 (en) 1988-11-09
FI86254B (fi) 1992-04-30
NO170754B (no) 1992-08-24
KR880004819A (ko) 1988-06-27
NO874347D0 (no) 1987-10-19
AU616381B2 (en) 1991-10-31
FI874596A0 (fi) 1987-10-19
PT85949B (pt) 1990-07-31
EP0265213B1 (en) 1992-04-15
NO170754C (no) 1992-12-02
YU46665B (sh) 1994-01-20
PT85949A (en) 1987-11-01
US5070186A (en) 1991-12-03
AU7990787A (en) 1988-04-21
CN87107049A (zh) 1988-07-06
EP0265213A2 (en) 1988-04-27
FI874596L (fi) 1988-04-21
DE3778287D1 (de) 1992-05-21
YU191887A (en) 1989-04-30
IE60264B1 (en) 1994-06-29
GR3004912T3 (enEXAMPLES) 1993-04-28
NO874347L (no) 1988-04-21
PH23446A (en) 1989-08-07
NZ222214A (en) 1989-11-28
IE872799L (en) 1988-04-20
ES2033871T3 (es) 1993-04-01
HU201475B (en) 1990-11-28
IL84203A (en) 1993-04-04

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Owner name: NOVO NORDISK A/S