FI74457C - Förfarande för framställning av 2-amino-3-(alkyltiobenzoyl)-fenylättik syror. - Google Patents
Förfarande för framställning av 2-amino-3-(alkyltiobenzoyl)-fenylättik syror. Download PDFInfo
- Publication number
- FI74457C FI74457C FI802282A FI802282A FI74457C FI 74457 C FI74457 C FI 74457C FI 802282 A FI802282 A FI 802282A FI 802282 A FI802282 A FI 802282A FI 74457 C FI74457 C FI 74457C
- Authority
- FI
- Finland
- Prior art keywords
- amino
- methylthiobenzoyl
- fluorobenzoyl
- lower alkyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
Claims (6)
1. Förfarande för framstäl1ning av en farmakologiskt an- vändbar 2-amino-3-(ai ky1tiobensoy1)-feny1ättiksyra med for-mel n
2 CH^COOR «h I c=o Λ J -jj--S-l ägre ai kyl där R betecknar väte, lägre alkyl eller en farmakologiskt ac-ceptabel metallkatjon och R betecknar väte, halogen eller lägre alkyl kännetecknat av att en förening med formeln C = 0 H __S-l ägre alkyl 2 där R betecknar detsamma som ovan, hydrolyseras med en ai kaiimetal 1bas, och det erhallna ai kaiimetal1 saitet en-ligt formel I omvandlas vld behov tili fri syra, alkalime-tallsaltet enligt formel I alkyleras vid behov tili en förening enligt formel I, där R är lägre alkyl. 25 7 4 4 5 7
2. Förfarande enligt patentkravet 1, kännetecknat av att 2-amino-3-(4-metyltiobensoyl)-fenyl ättiksyra framställs.
3. Förfarande enligt patentkravet 1, kännetecknat av att natrium-2-amino-3-(4-metyltiobensoyl)-fenylättiksyramono-hydrat framställs.
4. Mel 1anprodukt för framstäl1ning av 2-amino-3-(ai ky 1 -tiobensoyl )-feny1ättiksyra med formeln ^ CH COOR 2 2 r-U \J M I T 2 C=0 ,A) I --S-lägre alkyl där R betecknar väte, lägre alkyl eller en farmakologiskt ac-ceptabel metallkatjon och R betecknar väte, halogen eller lägre alkyl kännetecknad av att mel1anprodukten är en förening med for-mel n 2 R . H
1. II C=0 H 11 --S-lägre ai ky 1 2 dar R betecknar detsamma som ovan.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6302979A | 1979-08-01 | 1979-08-01 | |
| US6302979 | 1979-08-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI802282A FI802282A (fi) | 1981-02-02 |
| FI74457B FI74457B (fi) | 1987-10-30 |
| FI74457C true FI74457C (sv) | 1988-02-08 |
Family
ID=22046443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI802282A FI74457C (sv) | 1979-08-01 | 1980-07-18 | Förfarande för framställning av 2-amino-3-(alkyltiobenzoyl)-fenylättik syror. |
Country Status (37)
| Country | Link |
|---|---|
| JP (1) | JPS5629568A (sv) |
| KR (1) | KR840000605B1 (sv) |
| AR (1) | AR226855A1 (sv) |
| AT (1) | AT369648B (sv) |
| AU (1) | AU532247B2 (sv) |
| BE (1) | BE884556A (sv) |
| BR (1) | BR8004546A (sv) |
| CA (1) | CA1147746A (sv) |
| CH (1) | CH648295A5 (sv) |
| CS (1) | CS214716B2 (sv) |
| DE (1) | DE3026964A1 (sv) |
| DK (1) | DK330380A (sv) |
| EG (1) | EG14771A (sv) |
| ES (1) | ES493880A0 (sv) |
| FI (1) | FI74457C (sv) |
| FR (1) | FR2463124A1 (sv) |
| GB (2) | GB2055820B (sv) |
| GR (1) | GR69714B (sv) |
| HK (2) | HK37584A (sv) |
| HU (1) | HU181728B (sv) |
| IE (1) | IE50293B1 (sv) |
| IL (1) | IL60444A (sv) |
| IN (1) | IN151542B (sv) |
| IT (1) | IT1132273B (sv) |
| KE (2) | KE3368A (sv) |
| LU (1) | LU82672A1 (sv) |
| MX (1) | MX6175E (sv) |
| NL (1) | NL8004397A (sv) |
| NO (1) | NO150080C (sv) |
| NZ (1) | NZ194515A (sv) |
| PH (1) | PH18030A (sv) |
| PL (1) | PL127122B1 (sv) |
| PT (1) | PT71632B (sv) |
| SE (1) | SE447247B (sv) |
| SG (1) | SG19884G (sv) |
| YU (1) | YU41725B (sv) |
| ZA (1) | ZA804703B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0723478U (ja) * | 1993-10-08 | 1995-05-02 | 有限会社伊藤商店 | 衿カバー |
| FR2711076B1 (fr) * | 1993-10-13 | 1995-12-08 | Robatel Slpi | Dispositif étanche et déformable élastiquement pour le débatissage de la couche résiduelle. |
| US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE400966B (sv) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
-
1980
- 1980-06-30 IL IL60444A patent/IL60444A/xx unknown
- 1980-07-02 IN IN761/CAL/80A patent/IN151542B/en unknown
- 1980-07-11 AR AR281743A patent/AR226855A1/es active
- 1980-07-14 EG EG420/80A patent/EG14771A/xx active
- 1980-07-14 GB GB8022968A patent/GB2055820B/en not_active Expired
- 1980-07-16 DE DE19803026964 patent/DE3026964A1/de active Granted
- 1980-07-18 FI FI802282A patent/FI74457C/sv not_active IP Right Cessation
- 1980-07-19 GR GR62503A patent/GR69714B/el unknown
- 1980-07-22 BR BR8004546A patent/BR8004546A/pt unknown
- 1980-07-23 YU YU1870/80A patent/YU41725B/xx unknown
- 1980-07-23 PH PH24330A patent/PH18030A/en unknown
- 1980-07-24 IE IE1537/80A patent/IE50293B1/en unknown
- 1980-07-24 CA CA000356926A patent/CA1147746A/en not_active Expired
- 1980-07-28 AU AU60840/80A patent/AU532247B2/en not_active Ceased
- 1980-07-28 SE SE8005425A patent/SE447247B/sv not_active IP Right Cessation
- 1980-07-29 JP JP10423980A patent/JPS5629568A/ja active Granted
- 1980-07-30 CS CS805349A patent/CS214716B2/cs unknown
- 1980-07-30 KR KR1019800003043A patent/KR840000605B1/ko active
- 1980-07-30 LU LU82672A patent/LU82672A1/fr unknown
- 1980-07-30 BE BE0/201593A patent/BE884556A/fr not_active IP Right Cessation
- 1980-07-31 PT PT71632A patent/PT71632B/pt unknown
- 1980-07-31 NL NL8004397A patent/NL8004397A/nl not_active Application Discontinuation
- 1980-07-31 IT IT23840/80A patent/IT1132273B/it active
- 1980-07-31 HU HU801919A patent/HU181728B/hu not_active IP Right Cessation
- 1980-07-31 NZ NZ194515A patent/NZ194515A/en unknown
- 1980-07-31 MX MX808949U patent/MX6175E/es unknown
- 1980-07-31 DK DK330380A patent/DK330380A/da unknown
- 1980-07-31 PL PL1980225990A patent/PL127122B1/pl unknown
- 1980-07-31 NO NO802306A patent/NO150080C/no unknown
- 1980-07-31 FR FR8016939A patent/FR2463124A1/fr active Granted
- 1980-07-31 ES ES493880A patent/ES493880A0/es active Granted
- 1980-07-31 CH CH5844/80A patent/CH648295A5/fr not_active IP Right Cessation
- 1980-08-01 ZA ZA00804703A patent/ZA804703B/xx unknown
- 1980-08-04 AT AT0403580A patent/AT369648B/de not_active IP Right Cessation
-
1982
- 1982-05-21 GB GB08214848A patent/GB2105708B/en not_active Expired
-
1984
- 1984-01-18 KE KE3368A patent/KE3368A/xx unknown
- 1984-03-03 SG SG198/84A patent/SG19884G/en unknown
- 1984-03-30 KE KE3390A patent/KE3390A/xx unknown
- 1984-05-03 HK HK375/84A patent/HK37584A/xx unknown
- 1984-06-14 HK HK490/84A patent/HK49084A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: A.H. ROBINS CO INCORPORATED |