FI72317B - Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-etyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid-3-(n-2-pyrid yl-karboxamid och i foerfarandet anvaendbar mellanprodukt - Google Patents

Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-etyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid-3-(n-2-pyrid yl-karboxamid och i foerfarandet anvaendbar mellanprodukt Download PDF

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Publication number
FI72317B
FI72317B FI833628A FI833628A FI72317B FI 72317 B FI72317 B FI 72317B FI 833628 A FI833628 A FI 833628A FI 833628 A FI833628 A FI 833628A FI 72317 B FI72317 B FI 72317B
Authority
FI
Finland
Prior art keywords
benzothiazine
pyridyl
hydroxy
carboxamide
dioxide
Prior art date
Application number
FI833628A
Other languages
English (en)
Finnish (fi)
Other versions
FI833628A (fi
FI833628A0 (fi
FI72317C (sv
Inventor
Pekka Juhani Kairisalo
Erkki Juhani Honkanen
Magnus Edvard Valdem Johansson
Matti Karhu
Pentti Tapio Nore
Aino Kyllikki Pippuri
Irma Ritva Helena Kurimo
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI833628A0 publication Critical patent/FI833628A0/fi
Priority to FI833628A priority Critical patent/FI72317C/sv
Priority to NO843949A priority patent/NO159275C/no
Priority to DK471284A priority patent/DK154504C/da
Priority to HU844649A priority patent/HU195493B/hu
Priority to HU843746A priority patent/HU194559B/hu
Priority to CS847493A priority patent/CS253593B2/cs
Priority to IT22981/84A priority patent/IT1218850B/it
Priority to YU1708/84A priority patent/YU43381B/xx
Priority to PT79326A priority patent/PT79326B/pt
Priority to SE8405002A priority patent/SE460789B/sv
Priority to BE0/213782A priority patent/BE900758A/fr
Priority to PL1984249918A priority patent/PL143957B1/pl
Priority to CA000464861A priority patent/CA1246066A/en
Priority to DD84268074A priority patent/DD224594A5/de
Priority to AT0316384A priority patent/AT387775B/de
Priority to ES536544A priority patent/ES536544A0/es
Priority to SU843805901A priority patent/SU1405703A3/ru
Publication of FI833628A publication Critical patent/FI833628A/fi
Priority to ES549709A priority patent/ES549709A0/es
Priority to YU1496/86A priority patent/YU43603B/xx
Application granted granted Critical
Publication of FI72317B publication Critical patent/FI72317B/fi
Publication of FI72317C publication Critical patent/FI72317C/sv
Priority to NO875130A priority patent/NO159088C/no
Priority to SE8900248A priority patent/SE464411B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Claims (6)

1. Förfarande för framställning av farmaceutiskt användbar 2-metyl-4-hydroxi-2H-l,2-benzotiazin-l,l-dioxid-3-(N-2-05 pyridyl)-karboxamid med formeln I OH rrV*ö ίο °2 kännetecknat av att 2-metyl-4-mesyloxi-2H-l, 2-benzotiazin-1,l-dioxid-3-karboxylsyra med formeln II 15 o-so2-ch3 a^v^COOH S^-CH | Ln3 20 0 2 omsättes med 2-aminopyridin i närvaro av tionylklorid i ett inert lösningsmedel, varefter mesyloxiskyddsgruppen avspjälkas. 25
2. Förfarande enligt patentkravet 1, kännneteck- n a t av att i reaktionen ocksä används en tertiär amin, säsom 2,6-dimetylpyridin.
3. Mellanprodukt för att användas vid framställningen av 30 farmaceutiskt användbar 2-metyl-4-hydroxi-2H-l,2-benzotiazin- 1,l-dioxid-3-(N-2-pyridyl)-karboxamid med formeln OH -- 35 °2 tl
FI833628A 1983-10-06 1983-10-06 Förfarande för framställning av farmaceutiskt användbar 2-metyl-4-hydr oxi-2H-1,2-benzotiazin-1,1-dioxid-3-(N-2-pyridyl)-karboxamid och i för farandet användbar mellanprodukt. FI72317C (sv)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FI833628A FI72317C (sv) 1983-10-06 1983-10-06 Förfarande för framställning av farmaceutiskt användbar 2-metyl-4-hydr oxi-2H-1,2-benzotiazin-1,1-dioxid-3-(N-2-pyridyl)-karboxamid och i för farandet användbar mellanprodukt.
NO843949A NO159275C (no) 1983-10-06 1984-10-01 Fremgangsmaate for fremstilling av 2-metyl-4-hydroksy-2h-1,2-benzotiazin-1,1-dioksyd-3-(n-2-pyridyl)-karboksamid (piroksikam).
DK471284A DK154504C (da) 1983-10-06 1984-10-02 Fremgangsmaade til fremstilling af benzotiazindioxyd samt mellemprodukt til anvendelse ved udoevelse af fremgangsmaaden
HU844649A HU195493B (en) 1983-10-06 1984-10-03 Process for producing new benzothiazine-dioxide-carboxylic acid derivative
HU843746A HU194559B (en) 1983-10-06 1984-10-03 New process for the production of curative benzothiazine-dioxide-derivatives
CS847493A CS253593B2 (en) 1983-10-06 1984-10-03 Method of pharmaceutically applicable 2-methyl-4-hydrox!-2h-1,2-benzothiazine-1,1-dioxide-3-(n-2-pyridyl)carboxamide production
IT22981/84A IT1218850B (it) 1983-10-06 1984-10-04 Procedimento per la preaparazione di biossido di benzotiazina farmaceuticamente utilizzabile e intermedio da usare nel procedimento
YU1708/84A YU43381B (en) 1983-10-06 1984-10-04 Process for making pharmaceutically useful 2-methyl-4-hydroxy-2h-1,2-benzothiazine-1,1-dioxide-3-(n-2-pyridil)-carboxamide
PT79326A PT79326B (en) 1983-10-06 1984-10-04 Process for preparing a pharmaceutically usable benzothiazine dioxide and an intermediate for said process
SU843805901A SU1405703A3 (ru) 1983-10-06 1984-10-05 Способ получени 2-метил-4-гидрокси-2Н-1,2-бензотиазин-1,1-диоксид-3-N-(2-пиридил)-карбоксамида
SE8405002A SE460789B (sv) 1983-10-06 1984-10-05 Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-metyl-4-hydroxi-2h-1,2-bensotiazin-1,1-dioxid-3-(n-2-pyridyl)-karboxamid
PL1984249918A PL143957B1 (en) 1983-10-06 1984-10-05 Method of obtaining pharmaceutically useful benzothiasine dioxide
CA000464861A CA1246066A (en) 1983-10-06 1984-10-05 Method for the preparation of a pharmaceutically usable benzothiazine dioxide, and an intermediate for use in the method
DD84268074A DD224594A5 (de) 1983-10-06 1984-10-05 Verfahren zur herstellung eines pharmazeutisch verwendbaren benzothiazindioxids
AT0316384A AT387775B (de) 1983-10-06 1984-10-05 Verfahren zur herstellung von piroxicam
ES536544A ES536544A0 (es) 1983-10-06 1984-10-05 Un metodo para la preparacion de una 2-metil-4-hidroxi-2h-1, 2-benzotiacin-1, 1-dioxido-3-(n-2-piridil)-carboxamida
BE0/213782A BE900758A (fr) 1983-10-06 1984-10-05 Procede de preparation d'un benzothiadiazine dioxyde et intermediaire convenant a sa preparation.
ES549709A ES549709A0 (es) 1983-10-06 1985-12-09 Procedimiento de preparacion de 2-metil-4-hidroxi-2h-1, 2-benzotiazina-1,1-dioxido-3-(n-2-piridil)-carboxamida.
YU1496/86A YU43603B (en) 1983-10-06 1986-08-27 Process for making pharmaceutically usable 2-methyl-4-carboxy-4-mezyloxy-2h-1,2-benzothiazine-1,1-dioxide-3-n,n-dimethylacetamid solvates
NO875130A NO159088C (no) 1983-10-06 1987-12-09 Nytt benzotiazindioksyd-derivat.
SE8900248A SE464411B (sv) 1983-10-06 1989-01-24 Mellanprodukten 2-metyl-4-mesyloxi-2h-1,2-bensotiazin-1,1-dioxid-3-karboxylsyra eller ett solvat daerav med dimetylacetamid foer anvaendning vid framstaellning av en farmaceutiskt anvaendbar bensotiazin-dioxid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI833628 1983-10-06
FI833628A FI72317C (sv) 1983-10-06 1983-10-06 Förfarande för framställning av farmaceutiskt användbar 2-metyl-4-hydr oxi-2H-1,2-benzotiazin-1,1-dioxid-3-(N-2-pyridyl)-karboxamid och i för farandet användbar mellanprodukt.

Publications (4)

Publication Number Publication Date
FI833628A0 FI833628A0 (fi) 1983-10-06
FI833628A FI833628A (fi) 1985-04-07
FI72317B true FI72317B (fi) 1987-01-30
FI72317C FI72317C (sv) 1987-05-11

Family

ID=8517867

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833628A FI72317C (sv) 1983-10-06 1983-10-06 Förfarande för framställning av farmaceutiskt användbar 2-metyl-4-hydr oxi-2H-1,2-benzotiazin-1,1-dioxid-3-(N-2-pyridyl)-karboxamid och i för farandet användbar mellanprodukt.

Country Status (16)

Country Link
AT (1) AT387775B (sv)
BE (1) BE900758A (sv)
CA (1) CA1246066A (sv)
CS (1) CS253593B2 (sv)
DD (1) DD224594A5 (sv)
DK (1) DK154504C (sv)
ES (1) ES536544A0 (sv)
FI (1) FI72317C (sv)
HU (2) HU195493B (sv)
IT (1) IT1218850B (sv)
NO (1) NO159275C (sv)
PL (1) PL143957B1 (sv)
PT (1) PT79326B (sv)
SE (2) SE460789B (sv)
SU (1) SU1405703A3 (sv)
YU (2) YU43381B (sv)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
JPH08270888A (ja) * 1995-03-30 1996-10-15 Nec Eng Ltd 断熱締結機構

Also Published As

Publication number Publication date
FI833628A (fi) 1985-04-07
SE8900248D0 (sv) 1989-01-24
YU149686A (en) 1986-12-31
AT387775B (de) 1989-03-10
HUT37427A (en) 1985-12-28
HU195493B (en) 1988-05-30
FI833628A0 (fi) 1983-10-06
DK471284A (da) 1985-04-07
SE8405002D0 (sv) 1984-10-05
FI72317C (sv) 1987-05-11
DK154504B (da) 1988-11-21
BE900758A (fr) 1985-02-01
PT79326B (en) 1986-09-08
CS253593B2 (en) 1987-11-12
NO843949L (no) 1985-04-09
CA1246066A (en) 1988-12-06
HU194559B (en) 1988-02-29
PT79326A (en) 1984-11-01
NO159275C (no) 1988-12-14
ATA316384A (de) 1988-08-15
NO159275B (no) 1988-09-05
IT8422981A0 (it) 1984-10-04
IT1218850B (it) 1990-04-24
YU170884A (en) 1986-12-31
PL249918A1 (en) 1985-07-30
DD224594A5 (de) 1985-07-10
DK471284D0 (da) 1984-10-02
SE464411B (sv) 1991-04-22
YU43381B (en) 1989-06-30
SE460789B (sv) 1989-11-20
ES8505937A1 (es) 1985-07-01
SU1405703A3 (ru) 1988-06-23
PL143957B1 (en) 1988-03-31
ES536544A0 (es) 1985-07-01
DK154504C (da) 1989-04-10
SE8900248L (sv) 1989-01-24
YU43603B (en) 1989-08-31
SE8405002L (sv) 1985-04-07

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Owner name: PFIZER INC.