FI71156C - Foerfarande foer framstaellning av nya 6-hydroxialkylpenicillansyraderivat med beta-laktamasinhibitoraktivitet - Google Patents

Foerfarande foer framstaellning av nya 6-hydroxialkylpenicillansyraderivat med beta-laktamasinhibitoraktivitet Download PDF

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Publication number
FI71156C
FI71156C FI803311A FI803311A FI71156C FI 71156 C FI71156 C FI 71156C FI 803311 A FI803311 A FI 803311A FI 803311 A FI803311 A FI 803311A FI 71156 C FI71156 C FI 71156C
Authority
FI
Finland
Prior art keywords
benzyl
penicillanate
added
acid
sulfone
Prior art date
Application number
FI803311A
Other languages
English (en)
Finnish (fi)
Other versions
FI803311L (fi
FI71156B (fi
Inventor
Michael Stephen Kellogg
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI803311L publication Critical patent/FI803311L/fi
Application granted granted Critical
Publication of FI71156B publication Critical patent/FI71156B/fi
Publication of FI71156C publication Critical patent/FI71156C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/74—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with carbocyclic rings directly attached to the carboxamido radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI803311A 1979-10-22 1980-10-21 Foerfarande foer framstaellning av nya 6-hydroxialkylpenicillansyraderivat med beta-laktamasinhibitoraktivitet FI71156C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8686479 1979-10-22
US06/086,864 US4287181A (en) 1979-10-22 1979-10-22 Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Publications (3)

Publication Number Publication Date
FI803311L FI803311L (fi) 1981-04-23
FI71156B FI71156B (fi) 1986-08-14
FI71156C true FI71156C (fi) 1986-11-24

Family

ID=22201393

Family Applications (1)

Application Number Title Priority Date Filing Date
FI803311A FI71156C (fi) 1979-10-22 1980-10-21 Foerfarande foer framstaellning av nya 6-hydroxialkylpenicillansyraderivat med beta-laktamasinhibitoraktivitet

Country Status (38)

Country Link
US (1) US4287181A (el)
JP (2) JPS5665892A (el)
KR (1) KR840000797B1 (el)
AR (1) AR227164A1 (el)
AT (2) AT369372B (el)
AU (1) AU519578B2 (el)
BE (1) BE885812A (el)
BG (2) BG38639A3 (el)
CA (2) CA1144159A (el)
CH (2) CH646175A5 (el)
CS (2) CS219291B2 (el)
DD (1) DD154542A5 (el)
DE (1) DE3039504C2 (el)
DK (1) DK389480A (el)
ES (1) ES496166A0 (el)
FI (1) FI71156C (el)
FR (1) FR2467852A1 (el)
GB (3) GB2061930B (el)
GR (1) GR70714B (el)
GT (1) GT198065892A (el)
HU (1) HU183236B (el)
IE (3) IE51027B1 (el)
IL (1) IL61307A (el)
IN (1) IN154918B (el)
IT (1) IT1149259B (el)
LU (1) LU82880A1 (el)
MX (1) MX6094E (el)
NL (1) NL183358C (el)
NO (1) NO159019C (el)
NZ (1) NZ195307A (el)
PH (5) PH16219A (el)
PL (2) PL129638B1 (el)
PT (1) PT71946B (el)
RO (2) RO86176B (el)
SE (1) SE451455B (el)
SU (2) SU1122227A3 (el)
YU (2) YU41743B (el)
ZA (1) ZA806452B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49770B1 (en) * 1979-05-21 1985-12-11 Leo Pharm Prod Ltd 6beta-halopenicillanic acid derivatives
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
JPS58109490A (ja) * 1981-12-21 1983-06-29 Sankyo Co Ltd ペニシリン誘導体
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
RO87705A (ro) * 1982-01-11 1985-10-31 Pfizer Inc,Us Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
US4588527A (en) * 1983-06-06 1986-05-13 Pfizer Inc. Process for preparing penicillanic acid 1,1-dioxide derivatives
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
DD247677A5 (de) * 1984-01-30 1987-07-15 ������@���Kk�� Verfahren zur herstellung von 6-(subst.)-methylenpenicillan- und 6-(subst.)-hydroxymehtylpenicillansaeure und deren derivaten
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DE3584015D1 (de) * 1984-01-30 1991-10-17 Pfizer 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
US4503040A (en) * 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4847247A (en) * 1984-07-30 1989-07-11 Merck & Co., Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
US4590073A (en) * 1984-10-22 1986-05-20 Pfizer Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
US4591459A (en) * 1984-12-03 1986-05-27 Pfizer Inc. Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides
US4762921A (en) * 1985-04-18 1988-08-09 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4675186A (en) 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4613462A (en) * 1985-07-02 1986-09-23 Pfizer, Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
EP0276942B1 (en) * 1987-01-27 1992-04-01 Pfizer Inc. 6-beta(substituted)-(s)-hydroxymethylpenicillanic acids and derivatives thereof
US4782050A (en) * 1987-01-27 1988-11-01 Pfizer Inc. 6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
US6395726B1 (en) 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
EP1636240A1 (en) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
US8293893B2 (en) * 2007-03-09 2012-10-23 Otsuka Chemical Co., Ltd. Method for producing 6-hydroxyethylpenam compound
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5749555B2 (el) * 1973-04-04 1982-10-22
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
US4093625A (en) * 1976-08-09 1978-06-06 Massachusetts Institute Of Technology 6-Sulfur analogs of penicillins and cephalosporins
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
JPS5598186A (en) * 1979-01-10 1980-07-25 Beecham Group Ltd Manufacture of penicillin derivative
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use

Also Published As

Publication number Publication date
PL235907A1 (el) 1982-09-13
RO81225A (ro) 1983-02-15
DE3039504A1 (de) 1981-04-30
KR830004309A (ko) 1983-07-09
GB2061930B (en) 1984-06-13
AT374479B (de) 1984-04-25
CA1163924A (en) 1984-03-20
DD154542A5 (de) 1982-03-31
ATA10882A (de) 1983-09-15
NL183358B (nl) 1988-05-02
CS219292B2 (en) 1983-03-25
YU42075B (en) 1988-04-30
PH18316A (en) 1985-05-29
AR227164A1 (es) 1982-09-30
LU82880A1 (fr) 1981-06-04
YU41743B (en) 1987-12-31
PT71946B (en) 1981-08-31
PH17458A (en) 1984-08-29
RO86176B (ro) 1985-03-31
AU519578B2 (en) 1981-12-10
GB2129421B (en) 1984-11-14
FI803311L (fi) 1981-04-23
NZ195307A (en) 1984-08-24
SU1026654A3 (ru) 1983-06-30
AU6354880A (en) 1981-04-30
IE802174L (en) 1981-04-22
IT8025488A0 (it) 1980-10-21
DK389480A (da) 1981-04-23
NL8005810A (nl) 1981-04-24
GB2128986A (en) 1984-05-10
BG35189A3 (en) 1984-02-15
PT71946A (en) 1980-11-01
IT1149259B (it) 1986-12-03
FR2467852A1 (fr) 1981-04-30
AT369372B (de) 1982-12-27
BG38639A3 (en) 1986-01-15
FI71156B (fi) 1986-08-14
JPS61178988A (ja) 1986-08-11
SE451455B (sv) 1987-10-12
GB8316830D0 (en) 1983-07-27
GB2128986B (en) 1985-06-19
RO86176A (ro) 1985-03-15
FR2467852B1 (el) 1983-10-07
YU267680A (en) 1983-09-30
KR840000797B1 (ko) 1984-06-12
JPS5665892A (en) 1981-06-03
IE51026B1 (en) 1986-09-17
ZA806452B (en) 1981-10-28
PL129638B1 (en) 1984-05-31
IN154918B (el) 1984-12-22
GB2129421A (en) 1984-05-16
HU183236B (en) 1984-04-28
BE885812A (fr) 1981-04-21
CA1144159A (en) 1983-04-05
NO159019C (no) 1988-11-23
IE850293L (en) 1981-04-22
GT198065892A (es) 1982-04-10
NL183358C (nl) 1988-10-03
IE51028B1 (en) 1986-09-17
PL129534B1 (en) 1984-05-31
PH17315A (en) 1984-07-20
IE852229L (en) 1981-04-22
SU1122227A3 (ru) 1984-10-30
IL61307A (en) 1984-03-30
SE8007354L (sv) 1981-04-23
NO159019B (no) 1988-08-15
CH646175A5 (fr) 1984-11-15
CS219291B2 (en) 1983-03-25
GR70714B (el) 1983-01-18
IE51027B1 (en) 1986-09-17
RO81225B (ro) 1983-02-28
US4287181A (en) 1981-09-01
CH647242A5 (fr) 1985-01-15
PL227420A1 (el) 1982-08-30
MX6094E (es) 1984-11-12
IL61307A0 (en) 1980-12-31
GB2061930A (en) 1981-05-20
YU67183A (en) 1984-02-29
DE3039504C2 (de) 1984-10-11
GB8316829D0 (en) 1983-07-27
ATA518580A (de) 1982-05-15
PH17317A (en) 1984-07-20
JPS6135197B2 (el) 1986-08-12
ES8204437A1 (es) 1982-05-01
PH16219A (en) 1983-08-09
ES496166A0 (es) 1982-05-01
NO803136L (no) 1981-04-23

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Owner name: PFIZER INC.