FI69627C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-(3,4,5-trimetoxifenoxi)-2-hydroxipropyl)-4-aryl-piperazin-derivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-(3,4,5-trimetoxifenoxi)-2-hydroxipropyl)-4-aryl-piperazin-derivat Download PDF

Info

Publication number
FI69627C
FI69627C FI781009A FI781009A FI69627C FI 69627 C FI69627 C FI 69627C FI 781009 A FI781009 A FI 781009A FI 781009 A FI781009 A FI 781009A FI 69627 C FI69627 C FI 69627C
Authority
FI
Finland
Prior art keywords
acid
piperazine
residue
compound
group
Prior art date
Application number
FI781009A
Other languages
English (en)
Finnish (fi)
Other versions
FI69627B (fi
FI781009A (fi
Inventor
Axel Kleemann
Vladimir Jakovlev
Klaus Thiemer
Juergen Engel
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of FI781009A publication Critical patent/FI781009A/fi
Publication of FI69627B publication Critical patent/FI69627B/fi
Application granted granted Critical
Publication of FI69627C publication Critical patent/FI69627C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI781009A 1977-04-04 1978-04-03 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-(3,4,5-trimetoxifenoxi)-2-hydroxipropyl)-4-aryl-piperazin-derivat FI69627C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1410077 1977-04-04
GB14100/77A GB1583372A (en) 1977-04-04 1977-04-04 1-(3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl)-4-aryl piperazine derivatives

Publications (3)

Publication Number Publication Date
FI781009A FI781009A (fi) 1978-10-05
FI69627B FI69627B (fi) 1985-11-29
FI69627C true FI69627C (fi) 1986-03-10

Family

ID=10034980

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781009A FI69627C (fi) 1977-04-04 1978-04-03 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-(3,4,5-trimetoxifenoxi)-2-hydroxipropyl)-4-aryl-piperazin-derivat

Country Status (23)

Country Link
JP (1) JPS6038383B2 (sv)
AR (1) AR222149A1 (sv)
AT (1) AT360997B (sv)
AU (1) AU516315B2 (sv)
BE (1) BE865642A (sv)
CA (1) CA1124718A (sv)
CH (1) CH638795A5 (sv)
CS (1) CS249503B2 (sv)
DE (1) DE2814168A1 (sv)
DK (1) DK145225C (sv)
ES (1) ES468486A1 (sv)
FI (1) FI69627C (sv)
FR (1) FR2395264A1 (sv)
GB (1) GB1583372A (sv)
HU (1) HU179952B (sv)
MX (1) MX6120E (sv)
NL (1) NL7803540A (sv)
NO (1) NO149209C (sv)
PL (1) PL112249B1 (sv)
SE (1) SE435507B (sv)
SU (1) SU893133A3 (sv)
YU (1) YU40513B (sv)
ZA (1) ZA781889B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335126A (en) * 1977-03-10 1982-06-15 Degussa Aktiengesellschaft 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
FR2488892A2 (fr) * 1977-04-04 1982-02-26 Degussa Nouveaux derives 1-(3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl)-4-aryl-piperaziniques, procede pour leur preparation et leur application en tant que medicament
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
DE3023369A1 (de) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2568878B1 (fr) * 1984-08-07 1986-11-21 Cortial Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
FR2068051A5 (sv) * 1969-11-26 1971-08-20 Robert Jean
SE397088B (sv) * 1972-06-17 1977-10-17 Sumitomo Chemical Co Forfarande for framstellning av nya 2-propanolderivat
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES468486A1 (es) 1979-01-16
FR2395264A1 (fr) 1979-01-19
NL7803540A (nl) 1978-10-06
JPS53130682A (en) 1978-11-14
HU179952B (en) 1983-01-28
FI69627B (fi) 1985-11-29
SU893133A3 (ru) 1981-12-23
YU40513B (en) 1986-02-28
DK145225B (da) 1982-10-11
ZA781889B (en) 1979-03-28
YU76778A (en) 1982-10-31
DE2814168C2 (sv) 1989-02-16
CA1124718A (en) 1982-06-01
PL112249B1 (en) 1980-10-31
BE865642A (fr) 1978-10-03
JPS6038383B2 (ja) 1985-08-31
NO781159L (no) 1978-10-05
DK145225C (da) 1983-04-11
CS249503B2 (en) 1987-03-12
MX6120E (es) 1984-11-19
FI781009A (fi) 1978-10-05
AU516315B2 (en) 1981-05-28
GB1583372A (en) 1981-01-28
CH638795A5 (en) 1983-10-14
DE2814168A1 (de) 1978-10-05
SE7803742L (sv) 1978-10-05
SE435507B (sv) 1984-10-01
FR2395264B1 (sv) 1980-03-07
PL205745A1 (pl) 1979-05-07
ATA233078A (de) 1980-07-15
DK146678A (da) 1978-10-05
NO149209C (no) 1984-03-07
AT360997B (de) 1981-02-10
NO149209B (no) 1983-11-28
AR222149A1 (es) 1981-04-30
AU3470378A (en) 1979-10-11

Similar Documents

Publication Publication Date Title
EP3459925B1 (en) Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
DK171990B1 (da) 1-Heteroaryl-4-((2,5-pyrrolidindion-1-yl)-alkyl)piperazin-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske midler omfattende disse derivater
AU2008255733B8 (en) Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
JP5284291B2 (ja) 潜在的制癌剤としての新規アントラニル酸誘導体及びその調製方法
EA003924B1 (ru) Арилсульфонанилидмочевины
EP0385663B1 (en) Heterocyclic cycloalkanes as inhibitors of 5-lipoxygenase
EP4163281A1 (en) Process for preparing heterocyclic compounds for the treatment of disease and intermediate compounds used therein
MX2012005189A (es) Inhibidores de ire-1-alfa.
JPS60255760A (ja) 新規置換ビス‐（４‐アミノフエニル）‐スルホン
EP0145010B1 (en) Carbostyril derivatives
FI69627C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-(3,4,5-trimetoxifenoxi)-2-hydroxipropyl)-4-aryl-piperazin-derivat
WO2018211324A1 (en) Prodrugs for the treatment of disease
Keshari et al. Novel Mannich-bases as potential anticonvulsants: syntheses, characterization and biological evaluation
US4971985A (en) Pyridylketoxime ether compound and pharmaceutical composition containing it
DK166022B (da) Bis-(piperazinyl- eller homopiperazinyl)-alkaner og syreadditionssalte deraf, fremgangsmaade til deres fremstilling, farmaceutiske praeparater indeholdende forbindelserne, fremgangsmaade til fremstilling af saadanne praeparater og anvendelse af forbindelserne til fremstilling af et farmaceutisk praeparat med antiallergisk og antiinflammatorisk virkning
FI73674B (fi) Foerfarande och mellanprodukt foer framstaellning av farmakologiskt vaerdefulla 1-fenylindazol-3-on-foereningar.
IE55377B1 (en) 1,5-diphenylpyrazolin-3-one compounds,method for preparing them,and pharmaceutical compositions containing these compounds
CA2787860C (en) Substituted 2-imidazolidones and analogs and their use against cancer
WO2018211323A1 (en) Hetercyclic compounds for the treatment of disease
CN111617085B (zh) 靶向hdac抑制剂及其在抗肿瘤治疗药物中的应用
FI96417C (sv) Förfarande för framställning av nya terapeutiskt användbara isokinolinderivat
NZ247787A (en) Di-substituted phenyl piperazine and piperidine derivatives, medicaments, and precursors
JPS6229558A (ja) ベンゾフエノン誘導体
PL94559B1 (pl) Sposob wytwarzania nowych pochodnych pirydyny
JPS6121463B2 (sv)

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DEGUSSA AG