FI68239C - Kristallina 3-hydroxicefalosporinsolvat som aer mellanprodukter vid framstaellning av 3-hydroxicefalosporiner anvaendbara som mellanprodukter vid framstaellning av cefalosporiner ochfoerfarande foer framstaellning av dessa solvat - Google Patents

Kristallina 3-hydroxicefalosporinsolvat som aer mellanprodukter vid framstaellning av 3-hydroxicefalosporiner anvaendbara som mellanprodukter vid framstaellning av cefalosporiner ochfoerfarande foer framstaellning av dessa solvat Download PDF

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Publication number
FI68239C
FI68239C FI800300A FI800300A FI68239C FI 68239 C FI68239 C FI 68239C FI 800300 A FI800300 A FI 800300A FI 800300 A FI800300 A FI 800300A FI 68239 C FI68239 C FI 68239C
Authority
FI
Finland
Prior art keywords
acetic acid
hydroxy
solvate
som
cephem
Prior art date
Application number
FI800300A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI800300A (fi
FI68239B (fi
Inventor
Jack W Fisher
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI800300A publication Critical patent/FI800300A/fi
Application granted granted Critical
Publication of FI68239B publication Critical patent/FI68239B/fi
Publication of FI68239C publication Critical patent/FI68239C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/30—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino-radical acylated by an araliphatic carboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI800300A 1979-02-01 1980-02-01 Kristallina 3-hydroxicefalosporinsolvat som aer mellanprodukter vid framstaellning av 3-hydroxicefalosporiner anvaendbara som mellanprodukter vid framstaellning av cefalosporiner ochfoerfarande foer framstaellning av dessa solvat FI68239C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US846879A 1979-02-01 1979-02-01
US846879 1979-02-01

Publications (3)

Publication Number Publication Date
FI800300A FI800300A (fi) 1980-08-02
FI68239B FI68239B (fi) 1985-04-30
FI68239C true FI68239C (fi) 1985-08-12

Family

ID=21731772

Family Applications (1)

Application Number Title Priority Date Filing Date
FI800300A FI68239C (fi) 1979-02-01 1980-02-01 Kristallina 3-hydroxicefalosporinsolvat som aer mellanprodukter vid framstaellning av 3-hydroxicefalosporiner anvaendbara som mellanprodukter vid framstaellning av cefalosporiner ochfoerfarande foer framstaellning av dessa solvat

Country Status (32)

Country Link
EP (1) EP0014565B1 (bs)
JP (1) JPS55104288A (bs)
KR (1) KR830001890B1 (bs)
AR (1) AR228342A1 (bs)
AT (1) AT366052B (bs)
AU (1) AU532573B2 (bs)
BE (1) BE881423A (bs)
BG (1) BG32857A3 (bs)
CA (1) CA1142173A (bs)
CH (1) CH647525A5 (bs)
CS (1) CS214694B2 (bs)
DD (1) DD148953A5 (bs)
DE (1) DE3062095D1 (bs)
DK (1) DK159157C (bs)
ES (1) ES488229A0 (bs)
FI (1) FI68239C (bs)
FR (1) FR2447925A1 (bs)
GB (1) GB2041934B (bs)
GR (1) GR72785B (bs)
HU (2) HU181761B (bs)
IE (1) IE49374B1 (bs)
IL (1) IL59265A (bs)
IT (1) IT1130239B (bs)
LU (1) LU82118A1 (bs)
NZ (1) NZ192750A (bs)
PH (1) PH15152A (bs)
PL (1) PL122609B1 (bs)
PT (1) PT70742A (bs)
RO (2) RO83702B (bs)
SU (2) SU897109A3 (bs)
YU (1) YU22480A (bs)
ZA (1) ZA80523B (bs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128949A1 (de) * 1981-07-22 1983-02-10 Basf Ag, 6700 Ludwigshafen Lichtempfindliche aufzeichnungsmaterialien zur herstellung von abriebs- und kratzfesten tiefdruckformen sowie verfahren zur herstellung von tiefdruckformen mittels dieser aufzeichnungsmaterialien
JPS6011491A (ja) * 1983-03-04 1985-01-21 Shionogi & Co Ltd セフアロチンナトリウムの結晶性凍結乾燥粉末の製造法
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4044002A (en) * 1976-06-09 1977-08-23 Eli Lilly And Company Reduction process for cephalosporin sulfoxides

Also Published As

Publication number Publication date
AR228342A1 (es) 1983-02-28
DK159157B (da) 1990-09-10
ES8103098A1 (es) 1981-02-16
JPS55104288A (en) 1980-08-09
HU182095B (en) 1983-12-28
SU897109A3 (ru) 1982-01-07
KR830001951A (ko) 1983-05-21
IT1130239B (it) 1986-06-11
DK159157C (da) 1991-02-11
ATA49980A (de) 1981-07-15
EP0014565B1 (en) 1983-02-23
RO83702B (ro) 1984-03-30
IL59265A0 (en) 1980-05-30
FR2447925A1 (fr) 1980-08-29
SU938740A3 (ru) 1982-06-23
NZ192750A (en) 1982-05-25
ZA80523B (en) 1981-09-30
AT366052B (de) 1982-03-10
AU5502680A (en) 1980-08-07
DD148953A5 (de) 1981-06-17
PT70742A (en) 1980-02-01
CS214694B2 (en) 1982-05-28
IL59265A (en) 1983-05-15
FI800300A (fi) 1980-08-02
IT8019607A0 (it) 1980-01-31
EP0014565A1 (en) 1980-08-20
LU82118A1 (fr) 1980-04-23
DK41180A (da) 1980-08-02
RO79181A (ro) 1982-06-25
FI68239B (fi) 1985-04-30
IE49374B1 (en) 1985-09-18
IE800191L (en) 1980-08-01
ES488229A0 (es) 1981-02-16
GR72785B (bs) 1983-12-05
YU22480A (en) 1983-02-28
BG32857A3 (en) 1982-10-15
GB2041934B (en) 1983-03-23
FR2447925B1 (bs) 1984-02-03
GB2041934A (en) 1980-09-17
HU181761B (en) 1983-11-28
PL221748A1 (bs) 1980-12-15
PH15152A (en) 1982-08-24
PL122609B1 (en) 1982-08-31
AU532573B2 (en) 1983-10-06
BE881423A (fr) 1980-07-30
KR830001890B1 (ko) 1983-09-17
CH647525A5 (fr) 1985-01-31
RO83702A (ro) 1984-03-15
DE3062095D1 (en) 1983-03-31
JPH0128035B2 (bs) 1989-05-31
CA1142173A (en) 1983-03-01

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MA Patent expired

Owner name: ELI LILLY AND COMPANY