FI68054C - Foerfarande foer framstaellning av nya guaninderivat - Google Patents
Foerfarande foer framstaellning av nya guaninderivat Download PDFInfo
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- FI68054C FI68054C FI822891A FI822891A FI68054C FI 68054 C FI68054 C FI 68054C FI 822891 A FI822891 A FI 822891A FI 822891 A FI822891 A FI 822891A FI 68054 C FI68054 C FI 68054C
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- Finland
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- formula
- group
- compound
- vis
- guanine
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- 150000001875 compounds Chemical class 0.000 claims abstract description 99
- 238000000034 method Methods 0.000 claims abstract description 85
- 238000002360 preparation method Methods 0.000 claims abstract description 62
- 150000003839 salts Chemical class 0.000 claims abstract description 45
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
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- 230000008569 process Effects 0.000 claims description 13
- QOVUZUCXPAZXDZ-UHFFFAOYSA-N 2-amino-9-(3,4-dihydroxybutyl)-3h-purin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(O)CO)C=N2 QOVUZUCXPAZXDZ-UHFFFAOYSA-N 0.000 claims description 12
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- 239000004479 aerosol dispenser Substances 0.000 description 1
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- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 125000001743 benzylic group Chemical group 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000006491 bone marrow cancer Diseases 0.000 description 1
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- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 231100000300 cellular toxicity test Toxicity 0.000 description 1
- 230000036232 cellulite Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 101150054130 chfr gene Proteins 0.000 description 1
- 229910001902 chlorine oxide Inorganic materials 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
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- 239000012043 crude product Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000033420 disorder of pharynx Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- ZISXOMFOPIDLBP-UHFFFAOYSA-N ethyl 4-bromo-2-fluorobutanoate hydrobromide Chemical compound Br.C(C)OC(C(CCBr)F)=O ZISXOMFOPIDLBP-UHFFFAOYSA-N 0.000 description 1
- OOFYYUYDYBKRGY-UHFFFAOYSA-N ethyl 4-bromo-2-hydroxybutanoate Chemical compound CCOC(=O)C(O)CCBr OOFYYUYDYBKRGY-UHFFFAOYSA-N 0.000 description 1
- 230000006203 ethylation Effects 0.000 description 1
- 238000006200 ethylation reaction Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 150000002221 fluorine Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 150000004675 formic acid derivatives Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229910052717 sulfur Chemical group 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000009489 vacuum treatment Methods 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Detection And Prevention Of Errors In Transmission (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8009040 | 1980-12-22 | ||
| SE8009040 | 1980-12-22 | ||
| PCT/SE1981/000389 WO1982002202A1 (en) | 1980-12-22 | 1981-12-22 | Novel derivatives of guanine |
| SE8100389 | 1981-12-22 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI822891L FI822891L (fi) | 1982-08-19 |
| FI822891A0 FI822891A0 (fi) | 1982-08-19 |
| FI68054B FI68054B (fi) | 1985-03-29 |
| FI68054C true FI68054C (fi) | 1985-07-10 |
Family
ID=20342543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI822891A FI68054C (fi) | 1980-12-22 | 1982-08-19 | Foerfarande foer framstaellning av nya guaninderivat |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4495190A (cs) |
| EP (1) | EP0055239B1 (cs) |
| JP (1) | JPS57501963A (cs) |
| AT (1) | ATE20748T1 (cs) |
| AU (1) | AU542373B2 (cs) |
| CA (1) | CA1172633A (cs) |
| DE (1) | DE3174948D1 (cs) |
| DK (1) | DK148279C (cs) |
| FI (1) | FI68054C (cs) |
| GR (1) | GR76971B (cs) |
| IL (1) | IL64501A (cs) |
| NO (1) | NO822712L (cs) |
| NZ (1) | NZ199334A (cs) |
| RO (1) | RO85288B (cs) |
| SU (2) | SU1272991A3 (cs) |
| WO (1) | WO1982002202A1 (cs) |
| ZA (1) | ZA818781B (cs) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8203856D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine ii |
| SE8203855D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine i |
| HUT36464A (en) * | 1983-05-24 | 1985-09-30 | Newport Pharmaceuticals | Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide |
| US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
| GB8320308D0 (en) * | 1983-07-28 | 1983-09-01 | Wellcome Found | Antiviral combinations |
| DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
| US5684153A (en) | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
| US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
| US4801710A (en) * | 1984-10-26 | 1989-01-31 | Merck & Co., Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
| YU45690B (sh) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina |
| EP0193454A1 (en) * | 1985-02-25 | 1986-09-03 | Merck & Co. Inc. | 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them |
| EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
| US5443964A (en) * | 1987-08-10 | 1995-08-22 | Duke University | Poxvirus insertion/expression vector |
| US5578468A (en) * | 1987-08-10 | 1996-11-26 | Duke University | Site-specific RNA cleavage |
| US4935427A (en) * | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
| US4966895A (en) * | 1989-02-02 | 1990-10-30 | Merck & Co. Inc. | Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents |
| US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
| US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
| CZ285420B6 (cs) * | 1990-04-24 | 1999-08-11 | Ústav Organické Chemie A Biochemie Avčr | N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití |
| US5368853A (en) * | 1990-05-11 | 1994-11-29 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Leukoregulin anti-viral therapy |
| JP2939646B2 (ja) * | 1990-07-17 | 1999-08-25 | チッソ株式会社 | ４―置換―２―ヒドロキシブタン酸エステルおよび製造法 |
| US5874578A (en) * | 1992-07-13 | 1999-02-23 | Bristol-Myers Squibb | Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process |
| US5525606A (en) * | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
| US6359114B1 (en) * | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
| US6060458A (en) * | 1998-02-13 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use |
| US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
| EP2336133A1 (en) * | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| AU2004274507B2 (en) | 2003-09-18 | 2010-08-19 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as HSP90-inhibitors |
| EA013522B1 (ru) | 2005-03-30 | 2010-06-30 | Конформа Терапьютикс Корпорейшн | Алкинилпирролопиримидины и их применение в качестве ингибиторов hsp90 |
| CA2653247C (en) * | 2005-06-14 | 2012-12-18 | Brigham Young University | Methods for selective n-9 glycosylation of purines |
| EP1937258A2 (en) * | 2005-09-23 | 2008-07-02 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
| CN108912055B (zh) * | 2018-08-20 | 2020-06-30 | 河南师范大学 | 一种合成抗病毒药物西多福韦中间体和布昔洛韦中间体的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL34188A (en) * | 1969-04-09 | 1972-12-29 | Seiyaku T Co | 4-(9-adenyl)-2,3-dihydroxy butyric acid and the preparation thereof |
| US3836656A (en) * | 1972-02-07 | 1974-09-17 | Sandoz Ag | Substituted purines as hypolipidemics |
| US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
| US4230708A (en) * | 1977-10-20 | 1980-10-28 | Stichting Rega V.Z.W. | Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents |
| CS199093B1 (en) * | 1977-10-20 | 1980-07-31 | Antonin Holy | Antiviral agent |
| US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
| US4423050A (en) * | 1981-05-21 | 1983-12-27 | Syntex (U.S.A.) Inc. | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent |
| US4451478A (en) * | 1982-03-12 | 1984-05-29 | Newport Pharmaceuticals International, Inc. | Imidazole compounds |
-
1981
- 1981-12-10 IL IL64501A patent/IL64501A/xx unknown
- 1981-12-18 ZA ZA818781A patent/ZA818781B/xx unknown
- 1981-12-21 GR GR66864A patent/GR76971B/el unknown
- 1981-12-21 CA CA000392782A patent/CA1172633A/en not_active Expired
- 1981-12-21 AU AU78721/81A patent/AU542373B2/en not_active Ceased
- 1981-12-21 NZ NZ199334A patent/NZ199334A/xx unknown
- 1981-12-22 EP EP81850250A patent/EP0055239B1/en not_active Expired
- 1981-12-22 AT AT81850250T patent/ATE20748T1/de not_active IP Right Cessation
- 1981-12-22 WO PCT/SE1981/000389 patent/WO1982002202A1/en not_active Ceased
- 1981-12-22 JP JP57500239A patent/JPS57501963A/ja active Pending
- 1981-12-22 DE DE8181850250T patent/DE3174948D1/de not_active Expired
-
1982
- 1982-08-09 NO NO822712A patent/NO822712L/no unknown
- 1982-08-18 DK DK369982A patent/DK148279C/da not_active IP Right Cessation
- 1982-08-19 FI FI822891A patent/FI68054C/fi not_active IP Right Cessation
- 1982-08-20 SU SU823480213A patent/SU1272991A3/ru active
- 1982-08-21 RO RO108498A patent/RO85288B/ro unknown
- 1982-10-25 US US06/436,522 patent/US4495190A/en not_active Expired - Fee Related
-
1983
- 1983-10-31 SU SU833657074A patent/SU1272992A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1172633A (en) | 1984-08-14 |
| RO85288A (ro) | 1984-11-25 |
| FI822891L (fi) | 1982-08-19 |
| DK148279B (da) | 1985-05-28 |
| DK369982A (da) | 1982-08-18 |
| DK148279C (da) | 1986-02-17 |
| FI68054B (fi) | 1985-03-29 |
| NZ199334A (en) | 1985-09-13 |
| AU542373B2 (en) | 1985-02-21 |
| FI822891A0 (fi) | 1982-08-19 |
| SU1272991A3 (ru) | 1986-11-23 |
| WO1982002202A1 (en) | 1982-07-08 |
| ATE20748T1 (de) | 1986-08-15 |
| EP0055239B1 (en) | 1986-07-16 |
| NO822712L (no) | 1982-08-09 |
| ZA818781B (en) | 1982-11-24 |
| DE3174948D1 (en) | 1986-08-21 |
| US4495190A (en) | 1985-01-22 |
| IL64501A0 (en) | 1982-03-31 |
| EP0055239A1 (en) | 1982-06-30 |
| GR76971B (cs) | 1984-09-04 |
| AU7872181A (en) | 1982-07-01 |
| RO85288B (ro) | 1984-11-30 |
| JPS57501963A (cs) | 1982-11-04 |
| SU1272992A3 (ru) | 1986-11-23 |
| IL64501A (en) | 1985-07-31 |
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Owner name: ASTRA LAEKEMEDEL AKTIEBOLAG |