DK369982A - Nye derivater af guanin - Google Patents

Nye derivater af guanin Download PDF

Info

Publication number
DK369982A
DK369982A DK369982A DK369982A DK369982A DK 369982 A DK369982 A DK 369982A DK 369982 A DK369982 A DK 369982A DK 369982 A DK369982 A DK 369982A DK 369982 A DK369982 A DK 369982A
Authority
DK
Denmark
Prior art keywords
guanine
fluoro
hydroxy
hydrogen
new derivatives
Prior art date
Application number
DK369982A
Other languages
English (en)
Other versions
DK148279C (da
DK148279B (da
Inventor
C-E Hagberg
K N G Johansson
Z M I Kovacs
G B Stening
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of DK369982A publication Critical patent/DK369982A/da
Publication of DK148279B publication Critical patent/DK148279B/da
Application granted granted Critical
Publication of DK148279C publication Critical patent/DK148279C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK369982A 1980-12-22 1982-08-18 Analogifremgangsmaade til fremstilling af 9-substituerede guaninderivater eller fysiologisk acceptable salte eller optiske isomerer deraf DK148279C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8009040 1980-12-22
SE8009040 1980-12-22
PCT/SE1981/000389 WO1982002202A1 (en) 1980-12-22 1981-12-22 Novel derivatives of guanine
SE8100389 1981-12-22

Publications (3)

Publication Number Publication Date
DK369982A true DK369982A (da) 1982-08-18
DK148279B DK148279B (da) 1985-05-28
DK148279C DK148279C (da) 1986-02-17

Family

ID=20342543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK369982A DK148279C (da) 1980-12-22 1982-08-18 Analogifremgangsmaade til fremstilling af 9-substituerede guaninderivater eller fysiologisk acceptable salte eller optiske isomerer deraf

Country Status (17)

Country Link
US (1) US4495190A (da)
EP (1) EP0055239B1 (da)
JP (1) JPS57501963A (da)
AT (1) ATE20748T1 (da)
AU (1) AU542373B2 (da)
CA (1) CA1172633A (da)
DE (1) DE3174948D1 (da)
DK (1) DK148279C (da)
FI (1) FI68054C (da)
GR (1) GR76971B (da)
IL (1) IL64501A (da)
NO (1) NO822712L (da)
NZ (1) NZ199334A (da)
RO (1) RO85288B (da)
SU (2) SU1272991A3 (da)
WO (1) WO1982002202A1 (da)
ZA (1) ZA818781B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
HUT36464A (en) * 1983-05-24 1985-09-30 Newport Pharmaceuticals Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
EP0141927B1 (en) * 1983-08-18 1991-10-30 Beecham Group Plc Antiviral guanine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4801710A (en) * 1984-10-26 1989-01-31 Merck & Co., Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
YU45690B (sh) * 1984-12-22 1992-07-20 Krka Tovarna Zdraviln.Sol.O. Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina
EP0193454A1 (en) * 1985-02-25 1986-09-03 Merck & Co. Inc. 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them
EP0219838A3 (en) * 1985-10-22 1988-04-06 Takeda Chemical Industries, Ltd. Carbocyclic purine nucleosides, their production and use
US5578468A (en) * 1987-08-10 1996-11-26 Duke University Site-specific RNA cleavage
US5443964A (en) * 1987-08-10 1995-08-22 Duke University Poxvirus insertion/expression vector
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
US5368853A (en) * 1990-05-11 1994-11-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Leukoregulin anti-viral therapy
JP2939646B2 (ja) * 1990-07-17 1999-08-25 チッソ株式会社 ４―置換―２―ヒドロキシブタン酸エステルおよび製造法
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US6359114B1 (en) * 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
EP2336133A1 (en) * 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
BRPI0414533A (pt) * 2003-09-18 2006-11-07 Conforma Therapeutics Corp composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
CA2602257A1 (en) * 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
AU2006259431B2 (en) * 2005-06-14 2011-09-29 Brigham Young University Methods for selective N-9 glycosylation of purines
US20070105874A1 (en) * 2005-09-23 2007-05-10 Conforma Therapeutics Corporation Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
CN108912055B (zh) * 2018-08-20 2020-06-30 河南师范大学 一种合成抗病毒药物西多福韦中间体和布昔洛韦中间体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL34188A (en) * 1969-04-09 1972-12-29 Seiyaku T Co 4-(9-adenyl)-2,3-dihydroxy butyric acid and the preparation thereof
US3836656A (en) * 1972-02-07 1974-09-17 Sandoz Ag Substituted purines as hypolipidemics
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4230708A (en) * 1977-10-20 1980-10-28 Stichting Rega V.Z.W. Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
CS199093B1 (en) * 1977-10-20 1980-07-31 Antonin Holy Antiviral agent
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds

Also Published As

Publication number Publication date
RO85288A (ro) 1984-11-25
US4495190A (en) 1985-01-22
NZ199334A (en) 1985-09-13
EP0055239A1 (en) 1982-06-30
FI68054C (fi) 1985-07-10
DK148279C (da) 1986-02-17
IL64501A0 (en) 1982-03-31
CA1172633A (en) 1984-08-14
EP0055239B1 (en) 1986-07-16
FI68054B (fi) 1985-03-29
DK148279B (da) 1985-05-28
ATE20748T1 (de) 1986-08-15
AU7872181A (en) 1982-07-01
SU1272992A3 (ru) 1986-11-23
IL64501A (en) 1985-07-31
FI822891L (fi) 1982-08-19
DE3174948D1 (en) 1986-08-21
SU1272991A3 (ru) 1986-11-23
ZA818781B (en) 1982-11-24
AU542373B2 (en) 1985-02-21
RO85288B (ro) 1984-11-30
GR76971B (da) 1984-09-04
NO822712L (no) 1982-08-09
JPS57501963A (da) 1982-11-04
FI822891A0 (fi) 1982-08-19
WO1982002202A1 (en) 1982-07-08

Similar Documents

Publication Publication Date Title
DK369982A (da) Nye derivater af guanin
SE8204347L (sv) N-fenylpyrazolderivat anvendbara som herbicider
DK148183A (da) Fremgangsmaade til fremstilling af imidazolylphenyl-tetrahydropyridaziner
ATE18225T1 (de) Guanin-derivate.
FI863565A0 (fi) Foerfarande foer framstaellning av nya pyrrobenzimidazoler, pyrrolbenzoxazoler och pyrrolbenztiazoler.
ATE19632T1 (de) Guanin-derivate.
IT1201963B (it) Derivati delle rifamicine e procedimento per la loro preparazione
NO861923L (no) Nye isoksazolderivater, fremgangsmaate til deres fremstilling, og farmasoeytiske preparater inneholdende dem.
FR2385672A1 (fr) Procede de preparation d'halogeno-cyclobutanones
SE8206128L (sv) Farmaceutisk komposition for behandling av njurstenar framkallade genom infektion
ZA817646B (en) 5-phenyltetrazoles containing basic substituents,a process for their preparation and their use as drugs
FR2384742A1 (fr) Nouvelles diphenyl cycloalkylamines, procede d'obtention et application a titre de medicament
DK0437645T3 (da) Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse
SE8202433L (sv) Linkomycin-3-(5'-ribonukleotider)lempade for behandling av protosoriska sjukdomar
FR2390956A1 (fr) Derives substitues de la quinolizidine et de l'indolizidine, leur procede de preparation et agents therapeutiques contenant lesdits derives
NO159277C (no) 2,6-bis-halogenacylamino-benzo(1,2-d:5,4-d[)-bistiazol-derivater egnet som mellomprodukter for fremstilling av terapeutisk aktive 2,6-bisaminobinzo-(1,2-d:5,4-d[)bistiazol-derivater.

Legal Events

Date Code Title Description
PBP Patent lapsed