RO85288B - Procedeu de preparare a unor derivati ai guaninei - Google Patents
Procedeu de preparare a unor derivati ai guanineiInfo
- Publication number
- RO85288B RO85288B RO108498A RO10849882A RO85288B RO 85288 B RO85288 B RO 85288B RO 108498 A RO108498 A RO 108498A RO 10849882 A RO10849882 A RO 10849882A RO 85288 B RO85288 B RO 85288B
- Authority
- RO
- Romania
- Prior art keywords
- fluoro
- hydroxy
- guanine derivatives
- hydrogen
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de guanina, cu formula generala I: 8vezi formula) în care fiecare dintre R1 si R2 care sînt identici sau diferiti reprezinta hidrogen, hidroxi sau fluor, cu conditia ca unul din R1 sau R2 sa fie hidrogen, cînd R1 si R2 sînt identici, sau o sare fiziologica acceptabila sau un izomer optic. Procedeul consta în aceea ca cuprinde: hidrolizarea cu acid clorhidric la reflux a unui compus cu formula generala II: (vezi formula) în care Y este OH sau o grupa scindabila, cum ar fi, clor, brom, iod, sau o grupa -SH, -OR2, -SR3 sau -SO2R2; B înseamna (vezi formula) în care R3, R4, R5 si R6 sînt identici sau diferiti si înseamna hidrogen, -COR2, -SO2R2, sau în care R3 si R4 sau R3 si r5 sau R4 si R5 formeaza împreunaî un cetal ciclic ca în formula urmatoare (vezi formula) pentru a forma un compus de formula generala I, în care ......
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8009040 | 1980-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO85288A RO85288A (ro) | 1984-11-25 |
RO85288B true RO85288B (ro) | 1984-11-30 |
Family
ID=20342543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO108498A RO85288B (ro) | 1980-12-22 | 1982-08-21 | Procedeu de preparare a unor derivati ai guaninei |
Country Status (17)
Country | Link |
---|---|
US (1) | US4495190A (ro) |
EP (1) | EP0055239B1 (ro) |
JP (1) | JPS57501963A (ro) |
AT (1) | ATE20748T1 (ro) |
AU (1) | AU542373B2 (ro) |
CA (1) | CA1172633A (ro) |
DE (1) | DE3174948D1 (ro) |
DK (1) | DK148279C (ro) |
FI (1) | FI68054C (ro) |
GR (1) | GR76971B (ro) |
IL (1) | IL64501A (ro) |
NO (1) | NO822712L (ro) |
NZ (1) | NZ199334A (ro) |
RO (1) | RO85288B (ro) |
SU (2) | SU1272991A3 (ro) |
WO (1) | WO1982002202A1 (ro) |
ZA (1) | ZA818781B (ro) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8203855D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine i |
SE8203856D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine ii |
HUT36464A (en) * | 1983-05-24 | 1985-09-30 | Newport Pharmaceuticals | Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide |
US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
GB8320308D0 (en) * | 1983-07-28 | 1983-09-01 | Wellcome Found | Antiviral combinations |
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
US5684153A (en) | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
US4801710A (en) * | 1984-10-26 | 1989-01-31 | Merck & Co., Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
YU45690B (sh) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina |
EP0193454A1 (en) * | 1985-02-25 | 1986-09-03 | Merck & Co. Inc. | 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them |
EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
US5443964A (en) * | 1987-08-10 | 1995-08-22 | Duke University | Poxvirus insertion/expression vector |
US5578468A (en) * | 1987-08-10 | 1996-11-26 | Duke University | Site-specific RNA cleavage |
US4935427A (en) * | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
US4966895A (en) * | 1989-02-02 | 1990-10-30 | Merck & Co. Inc. | Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents |
US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
SK280313B6 (sk) * | 1990-04-24 | 1999-11-08 | �Stav Organick� Chemie A Biochemie Av �R | N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov |
US5368853A (en) * | 1990-05-11 | 1994-11-29 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Leukoregulin anti-viral therapy |
JP2939646B2 (ja) * | 1990-07-17 | 1999-08-25 | チッソ株式会社 | 4―置換―2―ヒドロキシブタン酸エステルおよび製造法 |
US5874578A (en) * | 1992-07-13 | 1999-02-23 | Bristol-Myers Squibb | Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process |
US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
US6359114B1 (en) * | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
US6060458A (en) * | 1998-02-13 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use |
US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
EP2336133A1 (en) * | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
BRPI0414533A (pt) * | 2003-09-18 | 2006-11-07 | Conforma Therapeutics Corp | composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90 |
EP1869027A4 (en) | 2005-03-30 | 2010-06-23 | Conforma Therapeutics Corp | ALKYNYL-PYRROLOPYRIMIDINES AND CORRESPONDING ANALOGS AS HSP90 INHIBITORS |
JP4966969B2 (ja) * | 2005-06-14 | 2012-07-04 | ブリガム ヤング ユニバーシティ | プリンの選択的n−9グリコシル化のための方法 |
WO2007035963A2 (en) * | 2005-09-23 | 2007-03-29 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
CN108912055B (zh) * | 2018-08-20 | 2020-06-30 | 河南师范大学 | 一种合成抗病毒药物西多福韦中间体和布昔洛韦中间体的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL34188A (en) * | 1969-04-09 | 1972-12-29 | Seiyaku T Co | 4-(9-adenyl)-2,3-dihydroxy butyric acid and the preparation thereof |
US3836656A (en) * | 1972-02-07 | 1974-09-17 | Sandoz Ag | Substituted purines as hypolipidemics |
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
US4230708A (en) * | 1977-10-20 | 1980-10-28 | Stichting Rega V.Z.W. | Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents |
CS199093B1 (en) * | 1977-10-20 | 1980-07-31 | Antonin Holy | Antiviral agent |
US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
US4423050A (en) * | 1981-05-21 | 1983-12-27 | Syntex (U.S.A.) Inc. | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent |
US4451478A (en) * | 1982-03-12 | 1984-05-29 | Newport Pharmaceuticals International, Inc. | Imidazole compounds |
-
1981
- 1981-12-10 IL IL64501A patent/IL64501A/xx unknown
- 1981-12-18 ZA ZA818781A patent/ZA818781B/xx unknown
- 1981-12-21 GR GR66864A patent/GR76971B/el unknown
- 1981-12-21 CA CA000392782A patent/CA1172633A/en not_active Expired
- 1981-12-21 NZ NZ199334A patent/NZ199334A/xx unknown
- 1981-12-21 AU AU78721/81A patent/AU542373B2/en not_active Ceased
- 1981-12-22 AT AT81850250T patent/ATE20748T1/de not_active IP Right Cessation
- 1981-12-22 JP JP57500239A patent/JPS57501963A/ja active Pending
- 1981-12-22 EP EP81850250A patent/EP0055239B1/en not_active Expired
- 1981-12-22 WO PCT/SE1981/000389 patent/WO1982002202A1/en active IP Right Grant
- 1981-12-22 DE DE8181850250T patent/DE3174948D1/de not_active Expired
-
1982
- 1982-08-09 NO NO822712A patent/NO822712L/no unknown
- 1982-08-18 DK DK369982A patent/DK148279C/da not_active IP Right Cessation
- 1982-08-19 FI FI822891A patent/FI68054C/fi not_active IP Right Cessation
- 1982-08-20 SU SU823480213A patent/SU1272991A3/ru active
- 1982-08-21 RO RO108498A patent/RO85288B/ro unknown
- 1982-10-25 US US06/436,522 patent/US4495190A/en not_active Expired - Fee Related
-
1983
- 1983-10-31 SU SU833657074A patent/SU1272992A3/ru active
Also Published As
Publication number | Publication date |
---|---|
NO822712L (no) | 1982-08-09 |
US4495190A (en) | 1985-01-22 |
FI822891L (fi) | 1982-08-19 |
FI68054B (fi) | 1985-03-29 |
SU1272992A3 (ru) | 1986-11-23 |
DK369982A (da) | 1982-08-18 |
EP0055239A1 (en) | 1982-06-30 |
GR76971B (ro) | 1984-09-04 |
DK148279C (da) | 1986-02-17 |
NZ199334A (en) | 1985-09-13 |
IL64501A0 (en) | 1982-03-31 |
RO85288A (ro) | 1984-11-25 |
IL64501A (en) | 1985-07-31 |
JPS57501963A (ro) | 1982-11-04 |
ZA818781B (en) | 1982-11-24 |
DE3174948D1 (en) | 1986-08-21 |
DK148279B (da) | 1985-05-28 |
AU542373B2 (en) | 1985-02-21 |
EP0055239B1 (en) | 1986-07-16 |
WO1982002202A1 (en) | 1982-07-08 |
ATE20748T1 (de) | 1986-08-15 |
SU1272991A3 (ru) | 1986-11-23 |
AU7872181A (en) | 1982-07-01 |
FI822891A0 (fi) | 1982-08-19 |
CA1172633A (en) | 1984-08-14 |
FI68054C (fi) | 1985-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RO85288B (ro) | Procedeu de preparare a unor derivati ai guaninei | |
PT76495B (en) | Process for preparing new imidazolphenyl-tetrahydropyridazines | |
AU582235B2 (en) | Quinolylglycinamide derivatives,the process for preparation thereof and their therapeutic application as psychotropic drugs | |
AU584235B2 (en) | New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them | |
PT76902A (en) | Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same | |
PT76903B (en) | Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same | |
ES516158A0 (es) | Procedimiento de preparacion de nuevos derivados del adamantano. | |
ZA817646B (en) | 5-phenyltetrazoles containing basic substituents,a process for their preparation and their use as drugs | |
FI925051A (fi) | Ett nytt foerfarande foer framstaellning av en lakton av 1R,cis-2,2-dimetyl-3-formylcyklopropan-1-karboxylsyra och halogenerade mellanprodukter | |
SE8202433L (sv) | Linkomycin-3-(5'-ribonukleotider)lempade for behandling av protosoriska sjukdomar | |
FR2401923A1 (fr) | Nouvelles octahydropyrazinopyrimidinones 2,3,4,7,8,9-substituees, procede de preparation de ces derives et leur application en tant que medicaments |