IL64501A - 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use - Google Patents
9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral useInfo
- Publication number
- IL64501A IL64501A IL64501A IL6450181A IL64501A IL 64501 A IL64501 A IL 64501A IL 64501 A IL64501 A IL 64501A IL 6450181 A IL6450181 A IL 6450181A IL 64501 A IL64501 A IL 64501A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- hydroxybutyl
- substituted
- guanine derivatives
- antiviral use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8009040 | 1980-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL64501A0 IL64501A0 (en) | 1982-03-31 |
IL64501A true IL64501A (en) | 1985-07-31 |
Family
ID=20342543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL64501A IL64501A (en) | 1980-12-22 | 1981-12-10 | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
Country Status (17)
Country | Link |
---|---|
US (1) | US4495190A (da) |
EP (1) | EP0055239B1 (da) |
JP (1) | JPS57501963A (da) |
AT (1) | ATE20748T1 (da) |
AU (1) | AU542373B2 (da) |
CA (1) | CA1172633A (da) |
DE (1) | DE3174948D1 (da) |
DK (1) | DK148279C (da) |
FI (1) | FI68054C (da) |
GR (1) | GR76971B (da) |
IL (1) | IL64501A (da) |
NO (1) | NO822712L (da) |
NZ (1) | NZ199334A (da) |
RO (1) | RO85288B (da) |
SU (2) | SU1272991A3 (da) |
WO (1) | WO1982002202A1 (da) |
ZA (1) | ZA818781B (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8203855D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine i |
SE8203856D0 (sv) * | 1982-06-21 | 1982-06-21 | Astra Laekemedel Ab | Novel derivatives of guanine ii |
HUT36464A (en) * | 1983-05-24 | 1985-09-30 | Newport Pharmaceuticals | Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide |
US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
GB8320308D0 (en) * | 1983-07-28 | 1983-09-01 | Wellcome Found | Antiviral combinations |
US5684153A (en) | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
US4801710A (en) * | 1984-10-26 | 1989-01-31 | Merck & Co., Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
YU45690B (sh) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina |
EP0193454A1 (en) * | 1985-02-25 | 1986-09-03 | Merck & Co. Inc. | 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them |
EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
US5578468A (en) * | 1987-08-10 | 1996-11-26 | Duke University | Site-specific RNA cleavage |
US5443964A (en) * | 1987-08-10 | 1995-08-22 | Duke University | Poxvirus insertion/expression vector |
US4935427A (en) * | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
US4966895A (en) * | 1989-02-02 | 1990-10-30 | Merck & Co. Inc. | Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents |
US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
CZ285420B6 (cs) * | 1990-04-24 | 1999-08-11 | Ústav Organické Chemie A Biochemie Avčr | N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití |
US5368853A (en) * | 1990-05-11 | 1994-11-29 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Leukoregulin anti-viral therapy |
JP2939646B2 (ja) * | 1990-07-17 | 1999-08-25 | チッソ株式会社 | 4―置換―2―ヒドロキシブタン酸エステルおよび製造法 |
US5874578A (en) * | 1992-07-13 | 1999-02-23 | Bristol-Myers Squibb | Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process |
US5525606A (en) * | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
US6359114B1 (en) | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
US6060458A (en) * | 1998-02-13 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use |
US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
EP2336133A1 (en) * | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
US7138401B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | 2-aminopurine analogs having HSP90-inhibiting activity |
NZ561939A (en) * | 2005-03-30 | 2011-03-31 | Conforma Therapeutics Corp | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
CA2653247C (en) * | 2005-06-14 | 2012-12-18 | Brigham Young University | Methods for selective n-9 glycosylation of purines |
WO2007035963A2 (en) * | 2005-09-23 | 2007-03-29 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
CN108912055B (zh) * | 2018-08-20 | 2020-06-30 | 河南师范大学 | 一种合成抗病毒药物西多福韦中间体和布昔洛韦中间体的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL34188A (en) * | 1969-04-09 | 1972-12-29 | Seiyaku T Co | 4-(9-adenyl)-2,3-dihydroxy butyric acid and the preparation thereof |
US3836656A (en) * | 1972-02-07 | 1974-09-17 | Sandoz Ag | Substituted purines as hypolipidemics |
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
US4230708A (en) * | 1977-10-20 | 1980-10-28 | Stichting Rega V.Z.W. | Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents |
CS199093B1 (en) * | 1977-10-20 | 1980-07-31 | Antonin Holy | Antiviral agent |
US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
US4423050A (en) * | 1981-05-21 | 1983-12-27 | Syntex (U.S.A.) Inc. | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent |
US4451478A (en) * | 1982-03-12 | 1984-05-29 | Newport Pharmaceuticals International, Inc. | Imidazole compounds |
-
1981
- 1981-12-10 IL IL64501A patent/IL64501A/xx unknown
- 1981-12-18 ZA ZA818781A patent/ZA818781B/xx unknown
- 1981-12-21 AU AU78721/81A patent/AU542373B2/en not_active Ceased
- 1981-12-21 GR GR66864A patent/GR76971B/el unknown
- 1981-12-21 CA CA000392782A patent/CA1172633A/en not_active Expired
- 1981-12-21 NZ NZ199334A patent/NZ199334A/xx unknown
- 1981-12-22 JP JP57500239A patent/JPS57501963A/ja active Pending
- 1981-12-22 EP EP81850250A patent/EP0055239B1/en not_active Expired
- 1981-12-22 WO PCT/SE1981/000389 patent/WO1982002202A1/en active IP Right Grant
- 1981-12-22 AT AT81850250T patent/ATE20748T1/de not_active IP Right Cessation
- 1981-12-22 DE DE8181850250T patent/DE3174948D1/de not_active Expired
-
1982
- 1982-08-09 NO NO822712A patent/NO822712L/no unknown
- 1982-08-18 DK DK369982A patent/DK148279C/da not_active IP Right Cessation
- 1982-08-19 FI FI822891A patent/FI68054C/fi not_active IP Right Cessation
- 1982-08-20 SU SU823480213A patent/SU1272991A3/ru active
- 1982-08-21 RO RO108498A patent/RO85288B/ro unknown
- 1982-10-25 US US06/436,522 patent/US4495190A/en not_active Expired - Fee Related
-
1983
- 1983-10-31 SU SU833657074A patent/SU1272992A3/ru active
Also Published As
Publication number | Publication date |
---|---|
FI822891A0 (fi) | 1982-08-19 |
ATE20748T1 (de) | 1986-08-15 |
IL64501A0 (en) | 1982-03-31 |
EP0055239B1 (en) | 1986-07-16 |
US4495190A (en) | 1985-01-22 |
FI68054C (fi) | 1985-07-10 |
WO1982002202A1 (en) | 1982-07-08 |
SU1272991A3 (ru) | 1986-11-23 |
JPS57501963A (da) | 1982-11-04 |
DK148279B (da) | 1985-05-28 |
NZ199334A (en) | 1985-09-13 |
AU7872181A (en) | 1982-07-01 |
FI68054B (fi) | 1985-03-29 |
DK369982A (da) | 1982-08-18 |
DE3174948D1 (en) | 1986-08-21 |
RO85288B (ro) | 1984-11-30 |
AU542373B2 (en) | 1985-02-21 |
DK148279C (da) | 1986-02-17 |
SU1272992A3 (ru) | 1986-11-23 |
NO822712L (no) | 1982-08-09 |
EP0055239A1 (en) | 1982-06-30 |
FI822891L (fi) | 1982-08-19 |
CA1172633A (en) | 1984-08-14 |
RO85288A (ro) | 1984-11-25 |
ZA818781B (en) | 1982-11-24 |
GR76971B (da) | 1984-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL64501A (en) | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use | |
ES8800946A1 (es) | Un procedimiento para preparar derivados de guanina | |
ES2001094A6 (es) | Un procedimiento para la preparacion de un derivado de guanina | |
GB2122198B (en) | Antiviral guanine derivatives | |
AU584235B2 (en) | New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them | |
DE3363376D1 (en) | Novel derivatives of guanine | |
ES516158A0 (es) | Procedimiento de preparacion de nuevos derivados del adamantano. | |
SE8202433L (sv) | Linkomycin-3-(5'-ribonukleotider)lempade for behandling av protosoriska sjukdomar |