FI67844C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat Download PDFInfo
- Publication number
- FI67844C FI67844C FI801758A FI801758A FI67844C FI 67844 C FI67844 C FI 67844C FI 801758 A FI801758 A FI 801758A FI 801758 A FI801758 A FI 801758A FI 67844 C FI67844 C FI 67844C
- Authority
- FI
- Finland
- Prior art keywords
- diamino
- hydrogen
- triazine
- compound
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI840888A FI73203C (fi) | 1979-06-01 | 1984-03-06 | Mellanprodukt foer anvaendning vid framstaellning av terapeutiskt anvaendbara 3,5-diamino-6-fenyl-1,2,4- triazinderivat och foerfarande foer dess framstaellning. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7919257 | 1979-06-01 | ||
GB7919257 | 1979-06-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI801758A FI801758A (fi) | 1980-12-02 |
FI67844B FI67844B (fi) | 1985-02-28 |
FI67844C true FI67844C (fi) | 1985-06-10 |
Family
ID=10505597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI801758A FI67844C (fi) | 1979-06-01 | 1980-05-30 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3,5-diamino-6-(substituerad fenyl)-1,2,4-triazinderivat |
Country Status (30)
Country | Link |
---|---|
US (2) | US4486354A (pl) |
EP (2) | EP0059987B1 (pl) |
JP (2) | JPS5625169A (pl) |
AR (1) | AR227521A1 (pl) |
AT (1) | AT370097B (pl) |
AU (2) | AU530999B2 (pl) |
BG (1) | BG60427B2 (pl) |
CA (1) | CA1112643A (pl) |
CS (1) | CS234018B2 (pl) |
CZ (1) | CZ384891A3 (pl) |
DD (1) | DD151309A5 (pl) |
DK (1) | DK153787C (pl) |
ES (1) | ES8104993A1 (pl) |
FI (1) | FI67844C (pl) |
GE (1) | GEP19960470B (pl) |
GR (1) | GR68380B (pl) |
HU (1) | HU182086B (pl) |
IE (1) | IE49823B1 (pl) |
IL (1) | IL60201A (pl) |
IT (1) | IT1147087B (pl) |
MX (1) | MX9202962A (pl) |
MY (1) | MY8500062A (pl) |
NL (1) | NL950007I2 (pl) |
NZ (1) | NZ193890A (pl) |
PL (1) | PL124029B1 (pl) |
SU (1) | SU1055331A3 (pl) |
UA (1) | UA5576A1 (pl) |
YU (1) | YU145680A (pl) |
ZA (1) | ZA803250B (pl) |
ZW (1) | ZW12980A1 (pl) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0086502B1 (en) * | 1979-08-16 | 1987-03-25 | The Wellcome Foundation Limited | Substituted aromatic triazines |
GB8328757D0 (en) * | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
DE3600891A1 (de) * | 1986-01-15 | 1987-07-16 | Bayer Ag | 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel |
GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
US4972496A (en) * | 1986-07-25 | 1990-11-20 | Grid Systems Corporation | Handwritten keyboardless entry computer system |
FI895821A0 (fi) | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
US5136080A (en) * | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
GB9012312D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
GB9124807D0 (en) * | 1991-11-22 | 1992-01-15 | Wellcome Found | Pharmaceutical formulations |
US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
NL9220009A (nl) * | 1991-01-30 | 1993-11-01 | Wellcome Found | In water-dispergeerbare tabletten. |
GB9203483D0 (en) * | 1992-02-19 | 1992-04-08 | Wellcome Found | Anti-inflammatory compounds |
WO1993025207A1 (en) * | 1992-06-12 | 1993-12-23 | The Wellcome Foundation Limited | Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate for the treatment and prevention of dependence, tolerance and sensitization of drugs |
GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
US6133299A (en) * | 1993-02-25 | 2000-10-17 | Warner-Lambert Company | Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds |
GB9305693D0 (en) * | 1993-03-19 | 1993-05-05 | Wellcome Found | Therapeutic triazine compounds and use |
US5866597A (en) * | 1993-03-19 | 1999-02-02 | Glaxo Wellcome Inc. | Use of triazine compounds for the treatment of memory and learning disorders |
GB9305692D0 (en) * | 1993-03-19 | 1993-05-05 | Wellcome Found | Therapeutic triazine compounds and use |
US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
GB9317146D0 (en) * | 1993-08-18 | 1993-10-06 | Wellcome Found | Therapeutic combinations |
GB9424766D0 (en) * | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
WO1996020934A1 (en) * | 1994-12-30 | 1996-07-11 | The Wellcome Foundation Limited | Process for the preparation of lamotrigine |
GB9426448D0 (en) * | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
GB9518027D0 (en) * | 1995-09-05 | 1995-11-08 | Wellcome Found | Pharmacologically active compound |
FR2741879A1 (fr) * | 1995-12-05 | 1997-06-06 | Esteve Labor Dr | Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament |
US6202491B1 (en) | 1997-07-22 | 2001-03-20 | Skf Condition Monitoring, Inc. | Digital vibration coupling stud |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
US6124500A (en) * | 1998-03-09 | 2000-09-26 | Rohm And Haas Company | Process for synthesizing benzoic acids |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
CA2334937C (en) * | 1998-12-14 | 2004-09-21 | Torrent Pharmaceuticals Ltd. | An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
US20020055177A1 (en) * | 1999-03-10 | 2002-05-09 | Glaxo Wellcome Inc. | Compound and its use |
GB9907965D0 (en) | 1999-04-09 | 1999-06-02 | Glaxo Group Ltd | Medical use |
EP1169060B1 (en) * | 1999-04-09 | 2005-08-31 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
US6639072B1 (en) | 2000-01-03 | 2003-10-28 | Rpg Life Sciences Limited | Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
IL134730A (en) * | 2000-02-25 | 2003-10-31 | Chemagis Ltd | Process for preparing substituted benzoyl cyanide amidinohydrazones |
AP2001002360A0 (en) | 2000-11-30 | 2001-12-31 | Pfizer Prod Inc | Combination of gaba agonists and sorbitol dehydrogenase inhibitors. |
AU2002215160A1 (en) | 2000-11-30 | 2002-06-11 | Pfizer Products Inc. | Combination of gaba agonists and aldose reductase inhibitors |
CA2439468A1 (en) * | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | New crystal forms of lamotrigine and processes for their preparations |
JP4350508B2 (ja) * | 2001-09-03 | 2009-10-21 | ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー | ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途 |
CA2366521C (en) | 2001-12-24 | 2007-03-06 | Brantford Chemicals Inc. | A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines |
AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
EP1496864B1 (en) * | 2002-04-23 | 2007-03-21 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
HU225667B1 (en) | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
ES2209639B1 (es) | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
US7521553B2 (en) * | 2003-03-17 | 2009-04-21 | Hetero Drugs Limited | Crystalline forms of lamotrigine |
AU2003230193A1 (en) | 2003-03-27 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of candesartan cilexetil |
JP2006528676A (ja) | 2003-05-16 | 2006-12-21 | ファイザー・プロダクツ・インク | 非定形型抗精神病薬と、gaba調節薬及び/又は抗痙攣薬の治療上の組合せ |
WO2004103340A1 (en) * | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Water dispersible tablets of lamotrigine |
GB2395483A (en) * | 2003-07-03 | 2004-05-26 | Jubilant Organosys Ltd | Crystalline lamotrigine and its monohydrate |
EP1691811B1 (en) | 2003-12-11 | 2014-07-23 | Sunovion Pharmaceuticals Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
JP2007537151A (ja) * | 2004-01-29 | 2007-12-20 | ファイザー・プロダクツ・インク | γ−アミノ酪酸モジュレータと5−HT1B受容体アンタゴニストとの組合せ |
EP1737473A4 (en) * | 2004-04-19 | 2009-08-26 | Noven Therapeutics Llc | COMBINATIONS OF LITHIUM AND USES THEREOF |
BRPI0515154A (pt) * | 2004-09-10 | 2008-07-08 | Newron Pharm Spa | uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica |
US7851498B2 (en) * | 2005-09-23 | 2010-12-14 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
DK1937259T3 (da) * | 2005-09-23 | 2012-02-13 | Janssen Pharmaceutica Nv | Hexahydro-cycloheptapyrazol-cannabinoid-modulatorer |
KR20080050511A (ko) | 2005-09-23 | 2008-06-05 | 얀센 파마슈티카 엔.브이. | 테트라하이드로-사이클로펜틸 피라졸 카나비노이드모듈레이터 |
US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US20070117858A1 (en) * | 2005-11-23 | 2007-05-24 | Mingde Xia | Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators |
WO2007092456A2 (en) * | 2006-02-03 | 2007-08-16 | Rolls-Royce Corporation | Gas turbine engine fuel system with fuel metering valve |
WO2007095513A1 (en) * | 2006-02-14 | 2007-08-23 | Janssen Pharmaceutica, Nv | Tetrahydr0-2h-indaz0le derivatives for use as cannabinoid modulators |
US8012957B2 (en) * | 2006-03-27 | 2011-09-06 | Janssen Pharmaceutica Nv | Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators |
US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
WO2007122638A2 (en) * | 2006-04-26 | 2007-11-01 | Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. | An improved process for preparation of lamotrigine intermediates |
WO2007138075A1 (en) * | 2006-05-31 | 2007-12-06 | Calaire Chimie Sas | Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride |
GB0613836D0 (en) * | 2006-07-13 | 2006-08-23 | Univ Greenwich | New medical use of triazine derivatives |
US20120142919A1 (en) | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
CN101506178A (zh) * | 2006-08-14 | 2009-08-12 | 隆沙有限公司 | 制备拉莫三嗪的方法 |
EP2129381A1 (en) | 2007-01-24 | 2009-12-09 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
US20090076010A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched lamotrigine |
WO2009061513A1 (en) * | 2007-11-09 | 2009-05-14 | Thar Pharmaceuticals | Crystalline forms of lamotrigine |
GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
US20100190752A1 (en) * | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
KR101799113B1 (ko) | 2009-05-13 | 2017-11-17 | 넥타르 테라퓨틱스 | 올리고머를 함유하는 치환된 방향족 트리아진 화합물 |
EP2263657B1 (en) | 2009-05-20 | 2013-07-17 | Ranbaxy Laboratories Limited | Controlled release lamotrigine formulations |
GB2471729A (en) | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
GB2471713A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
US20110052686A1 (en) | 2009-09-03 | 2011-03-03 | Ranbaxy Laboratories Limited | Modified release lamotrigine tablets |
GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
WO2013183985A1 (en) | 2012-06-05 | 2013-12-12 | Erasmus University Medical Center Rotterdam | Method of treating cognitive impairment and compounds for use therein |
WO2015092819A2 (en) * | 2013-12-21 | 2015-06-25 | Nektar Therapeutics (India) Pvt. Ltd. | Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5- amine |
CA3021424C (en) | 2015-06-12 | 2023-03-21 | University Of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
PT3554490T (pt) | 2016-12-16 | 2022-03-17 | Idorsia Pharmaceuticals Ltd | Combinação farmacêutica compreendendo um bloqueador de canais de cálcio de tipo t |
TWI826531B (zh) | 2018-09-21 | 2023-12-21 | 南韓商愛思開生物製藥股份有限公司 | 具有㗁二唑之化合物及包含該化合物之醫藥組合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB759014A (en) * | 1952-02-26 | 1956-10-10 | Wellcome Found | Improvements in triazines and their manufacture |
AT190941B (de) * | 1954-09-22 | 1957-07-25 | Chemie Linz Ag | Verfahren zur Herstellung neuer Guanylhydrazone |
US2952677A (en) * | 1956-10-01 | 1960-09-13 | Ici Ltd | Aminoguanadine compounds |
BE663481A (pl) * | 1964-05-05 | |||
FR7689M (pl) * | 1967-10-12 | 1970-02-16 | ||
GB1223491A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
US3637688A (en) * | 1970-01-09 | 1972-01-25 | American Home Prod | 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines |
EP0086502B1 (en) * | 1979-08-16 | 1987-03-25 | The Wellcome Foundation Limited | Substituted aromatic triazines |
-
1980
- 1980-05-30 EP EP82102293A patent/EP0059987B1/en not_active Expired
- 1980-05-30 NZ NZ193890A patent/NZ193890A/en unknown
- 1980-05-30 DK DK233880A patent/DK153787C/da active
- 1980-05-30 AR AR281263A patent/AR227521A1/es active
- 1980-05-30 DD DD80221474A patent/DD151309A5/de unknown
- 1980-05-30 ZW ZW129/80A patent/ZW12980A1/xx unknown
- 1980-05-30 IL IL60201A patent/IL60201A/xx unknown
- 1980-05-30 HU HU801364A patent/HU182086B/hu unknown
- 1980-05-30 PL PL1980224633A patent/PL124029B1/pl unknown
- 1980-05-30 IE IE1126/80A patent/IE49823B1/en not_active IP Right Cessation
- 1980-05-30 CA CA353,081A patent/CA1112643A/en not_active Expired
- 1980-05-30 JP JP7158080A patent/JPS5625169A/ja active Granted
- 1980-05-30 ES ES491998A patent/ES8104993A1/es not_active Expired
- 1980-05-30 EP EP80103032A patent/EP0021121B1/en not_active Expired
- 1980-05-30 ZA ZA00803250A patent/ZA803250B/xx unknown
- 1980-05-30 FI FI801758A patent/FI67844C/fi not_active IP Right Cessation
- 1980-05-30 IT IT48848/80A patent/IT1147087B/it active Protection Beyond IP Right Term
- 1980-05-30 AU AU58906/80A patent/AU530999B2/en not_active Expired
- 1980-05-30 GR GR62081A patent/GR68380B/el unknown
- 1980-05-30 CS CS803829A patent/CS234018B2/cs unknown
- 1980-05-30 AT AT0289680A patent/AT370097B/de not_active IP Right Cessation
- 1980-05-31 YU YU01456/80A patent/YU145680A/xx unknown
- 1980-06-02 SU SU802932704A patent/SU1055331A3/ru active
- 1980-06-02 UA UA2932704A patent/UA5576A1/uk unknown
-
1981
- 1981-10-05 US US06/308,805 patent/US4486354A/en not_active Expired - Lifetime
-
1983
- 1983-04-28 AU AU14051/83A patent/AU566870B2/en not_active Expired
-
1984
- 1984-02-27 US US06/583,286 patent/US4602017A/en not_active Expired - Lifetime
-
1985
- 1985-06-04 JP JP12137085A patent/JPS6133163A/ja active Granted
- 1985-12-30 MY MY62/85A patent/MY8500062A/xx unknown
-
1991
- 1991-12-17 CZ CS913848A patent/CZ384891A3/cs unknown
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1992
- 1992-06-17 MX MX9202962A patent/MX9202962A/es unknown
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1993
- 1993-07-29 BG BG97992A patent/BG60427B2/bg unknown
-
1994
- 1994-05-16 GE GEAP19941909A patent/GEP19960470B/en unknown
-
1995
- 1995-04-28 NL NL950007C patent/NL950007I2/nl unknown
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Owner name: THE WELLCOME FOUNDATION LIMITED |