FI66614C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 9-ydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidinderi va - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 9-ydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidinderi va Download PDF

Info

Publication number
FI66614C
FI66614C FI794013A FI784013A FI66614C FI 66614 C FI66614 C FI 66614C FI 794013 A FI794013 A FI 794013A FI 784013 A FI784013 A FI 784013A FI 66614 C FI66614 C FI 66614C
Authority
FI
Finland
Prior art keywords
formula
pyrido
tetrahydro
alkyl
methyl
Prior art date
Application number
FI794013A
Other languages
English (en)
Finnish (fi)
Other versions
FI784013A (fi
FI66614B (fi
Inventor
Istvan Hermecz
Zoltan Meszaros
Tibor Breining
Sandor Virag
Nee Debreczy Lelle Vasvari
Agnes Horvath
Gabor Nagy
Attila Mandi
Tamas Szuecs
Istvan Bitter
Gyula Sebestyen
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of FI784013A publication Critical patent/FI784013A/fi
Application granted granted Critical
Publication of FI66614B publication Critical patent/FI66614B/fi
Publication of FI66614C publication Critical patent/FI66614C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI794013A 1977-12-29 1978-12-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara 9-ydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidinderi va FI66614C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU77CI1794A HU178496B (en) 1977-12-29 1977-12-29 Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
HUCI001794 1977-12-29

Publications (3)

Publication Number Publication Date
FI784013A FI784013A (fi) 1979-06-30
FI66614B FI66614B (fi) 1984-07-31
FI66614C true FI66614C (fi) 1984-11-12

Family

ID=10994683

Family Applications (1)

Application Number Title Priority Date Filing Date
FI794013A FI66614C (fi) 1977-12-29 1978-12-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara 9-ydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidinderi va

Country Status (29)

Country Link
US (2) US4234586A (it)
JP (1) JPS5495598A (it)
AR (3) AR222985A1 (it)
AT (1) AT375936B (it)
AU (1) AU520428B2 (it)
BE (1) BE873194A (it)
CA (1) CA1130284A (it)
CH (1) CH642078A5 (it)
CS (1) CS244654B2 (it)
DD (1) DD139854A5 (it)
DE (1) DE2854115A1 (it)
DK (1) DK157022C (it)
ES (7) ES476442A1 (it)
FI (1) FI66614C (it)
FR (1) FR2413389A1 (it)
GB (1) GB2011898B (it)
GR (1) GR68357B (it)
HU (1) HU178496B (it)
IL (1) IL56078A (it)
IT (1) IT1203210B (it)
LU (1) LU80601A1 (it)
NL (1) NL7812547A (it)
NO (1) NO151287C (it)
PL (5) PL119641B1 (it)
PT (1) PT68935A (it)
SE (1) SE438675B (it)
SU (2) SU999972A3 (it)
YU (3) YU42093B (it)
ZA (1) ZA787385B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
HU178453B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4482557A (en) * 1979-05-11 1984-11-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity
HU179443B (en) * 1979-05-11 1982-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines
HU176942B (hu) * 1979-05-11 1981-06-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija 2,3- i 3,4-dvuzamehhjonnykh tetragidro-pirrolo!1,2-a!-pirimidinov
HU178452B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives
HU183173B (en) * 1980-06-24 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 6-hydrazono-pyrido-aracket-2,1-b-bracket closed-quinazolin-11-ones
AT381093B (de) * 1980-06-24 1986-08-25 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung neuer 6-hydrazono-pyrido(2,1-b)chinazolin-11-on-deriv te, von deren salzen sowie von deren stereomeren
HU183408B (en) 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
US4395549A (en) * 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
US5344933A (en) * 1991-09-11 1994-09-06 Fuji Photo Film Co., Ltd. Pyrrole ring-or condensed pyrrole ring-containing azomethine dye
EP1790649A1 (en) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
EP2138498A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138488A1 (en) 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138493A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786056A (en) * 1954-05-03 1957-03-19 Merck & Co Inc Acylamido-hydroxy pteridines and preparation thereof
US2894031A (en) * 1958-09-16 1959-07-07 Grace W R & Co Process for cyclohexanone hydrazone hydrate
US3140315A (en) * 1959-02-18 1964-07-07 Bayer Ag Alkyl-substituted hydrazines and hydrazones and process for preparation thereof
FR1255365A (fr) * 1959-12-22 1961-03-10 Cfmc Nouveaux colorants basiques, leur procédé de préparation et leurs applications
US3141043A (en) * 1961-03-24 1964-07-14 Purdue Research Foundation Cyclopentadienylimines, process for their production and condensation products thereof
CH441366A (de) * 1961-06-09 1967-08-15 Hoffmann La Roche Verfahren zur Herstellung von substituierten Hydrazinverbindungen
US3417082A (en) * 1965-08-16 1968-12-17 Polaroid Corp Novel chemical compounds and syntheses
AT294107B (de) * 1966-11-02 1971-11-10 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen
HU168014B (it) * 1973-03-30 1976-02-28
US4024132A (en) * 1973-09-07 1977-05-17 Ciba-Geigy Corporation Azomethine pigments
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Also Published As

Publication number Publication date
AR228949A1 (es) 1983-05-13
YU296478A (en) 1983-10-31
ES481748A1 (es) 1980-07-01
FR2413389A1 (fr) 1979-07-27
YU279582A (en) 1983-10-31
PL119501B1 (en) 1982-01-30
PL125321B1 (en) 1983-04-30
IL56078A (en) 1982-11-30
DD139854A5 (de) 1980-01-23
GR68357B (it) 1981-12-23
AU520428B2 (en) 1982-01-28
SE438675B (sv) 1985-04-29
SU999972A3 (ru) 1983-02-23
DK157022B (da) 1989-10-30
JPH0146514B2 (it) 1989-10-09
GB2011898A (en) 1979-07-18
ES481747A1 (es) 1980-07-01
CS909178A2 (en) 1985-08-15
US4234586A (en) 1980-11-18
SE7813226L (sv) 1979-06-30
LU80601A1 (de) 1979-03-22
GB2011898B (en) 1982-04-28
FI784013A (fi) 1979-06-30
YU41538B (en) 1987-08-31
IT7869933A0 (it) 1978-12-22
CS244654B2 (en) 1986-08-14
FR2413389B1 (it) 1982-03-26
FI66614B (fi) 1984-07-31
ES481749A1 (es) 1980-07-01
PL122965B1 (en) 1982-09-30
AT375936B (de) 1984-09-25
AR222985A1 (es) 1981-07-15
DK157022C (da) 1990-04-02
ES476442A1 (es) 1979-11-16
PT68935A (en) 1979-01-01
CH642078A5 (de) 1984-03-30
IL56078A0 (en) 1979-01-31
YU279682A (en) 1983-10-31
HU178496B (en) 1982-05-28
NO151287C (no) 1985-03-13
DE2854115A1 (de) 1979-07-12
ES481745A1 (es) 1980-07-01
NL7812547A (nl) 1979-07-03
IT1203210B (it) 1989-02-15
SU978730A3 (ru) 1982-11-30
US4461769A (en) 1984-07-24
DK585578A (da) 1979-06-30
AR227882A1 (es) 1982-12-30
CA1130284A (en) 1982-08-24
YU42093B (en) 1988-04-30
PL119641B1 (en) 1982-01-30
JPS5495598A (en) 1979-07-28
NO151287B (no) 1984-12-03
PL119520B1 (en) 1982-01-30
ES481746A1 (es) 1980-07-01
ES481744A1 (es) 1980-06-16
DE2854115C2 (it) 1988-07-28
BE873194A (fr) 1979-04-17
YU42062B (en) 1988-04-30
PL212212A1 (it) 1980-02-25
AU4262778A (en) 1979-07-05
NO784393L (no) 1979-07-02
ZA787385B (en) 1980-02-27
ATA873678A (de) 1984-02-15

Similar Documents

Publication Publication Date Title
FI66614C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 9-ydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidinderi va
KR100597505B1 (ko) 4-아미노-6-페닐-피롤로[2,3-ｄ]피리미딘 유도체
US3709898A (en) Process for the production of triazolobenzodiazepines and intermediates
AU2002324029A1 (en) 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
JP2002518500A (ja) ７−アルキル−及びシクロアルキル−置換イミダゾトリアジノン
EA004373B1 (ru) 1-АМИНОТРИАЗОЛО[4,3-a]ХИНАЗОЛИН-5-ОНЫ И/ИЛИ -5-ТИОНЫ, ИНГИБИРУЮЩИЕ ФОСФОДИЭСТЕРАЗУ IV
CH682151A5 (it)
US3489755A (en) Imidazo (1,2-b) pyridazines
US6262045B1 (en) 4-Oxo-3,5-dihydro-4H-pyridazino[4,5-b]-indole-1-acetamide derivatives, their preparation and their application in therapy
EP0655451A1 (en) Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia
US4463007A (en) Triazoloquinazolinones, and compositions and methods for treating allergic disorders with them
US3966736A (en) 2,9-Dihydro-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-ones
FI68824C (fi) Foerfarande foer framstaellning av terapeutiskt effektiva substituerade 2-etenyl-4-oxo-4h-pyrido(1,2-a)pyrimidiner
IE49795B1 (en) Improvements in or relating to pyrazinobenzodiazepines
CZ660487A3 (en) PYRIDO£3,2,1-ij|/1,3,4-BENZOXADIAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS BASED THEREON
US3859289A (en) Tricyclic pyrimidinones
EP0888356B1 (de) Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer
US4053600A (en) Tricyclic 1,2,4-triazolo-quinazolines
US3853872A (en) 2,3,4,5-substituted thiazoles
CA1131226A (en) Heterocyclic compounds
EP1150983A1 (en) Triazolo-pyridazine derivatives as ligands for gaba receptors
US6201129B1 (en) Tricyclic derivatives and their use as anti-cancer agents
Chunchatprasert et al. Anti-tumour heterocycles. Part xiv. A new route to pyrrolo-[3, 2-f] indoles and the novel pyrrolo [3, 2-f; 4, 5-f′] diindole system
US4547501A (en) Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents
GUEIFFIER et al. Synthesis of 1H-imidazo [1, 2-a] pyrazolo [3, 4-c] pyridines

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: CHINOIN GYOGUSZER ES VEGYESZETI TERMEKEK