FI63571C - Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter Download PDF

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Publication number
FI63571C
FI63571C FI750652A FI750652A FI63571C FI 63571 C FI63571 C FI 63571C FI 750652 A FI750652 A FI 750652A FI 750652 A FI750652 A FI 750652A FI 63571 C FI63571 C FI 63571C
Authority
FI
Finland
Prior art keywords
formula
dimethyl
tetrahydrofurfuryl
compounds
hydroxy
Prior art date
Application number
FI750652A
Other languages
English (en)
Finnish (fi)
Other versions
FI63571B (fi
FI750652A (fr
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI750652A publication Critical patent/FI750652A/fi
Publication of FI63571B publication Critical patent/FI63571B/fi
Application granted granted Critical
Publication of FI63571C publication Critical patent/FI63571C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI750652A 1974-03-09 1975-03-06 Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter FI63571C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2411382A DE2411382C3 (de) 1974-03-09 1974-03-09 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2411382 1974-03-09

Publications (3)

Publication Number Publication Date
FI750652A FI750652A (fr) 1975-09-10
FI63571B FI63571B (fi) 1983-03-31
FI63571C true FI63571C (fi) 1983-07-11

Family

ID=5909593

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750652A FI63571C (fi) 1974-03-09 1975-03-06 Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter

Country Status (25)

Country Link
JP (1) JPS5827275B2 (fr)
AT (1) AT344332B (fr)
BE (1) BE826440A (fr)
BG (3) BG24814A4 (fr)
CA (1) CA1049511A (fr)
CH (8) CH612425A5 (fr)
CS (1) CS188221B2 (fr)
DD (1) DD119236A5 (fr)
DE (1) DE2411382C3 (fr)
DK (1) DK137188C (fr)
ES (6) ES440345A1 (fr)
FI (1) FI63571C (fr)
FR (1) FR2262984B1 (fr)
GB (1) GB1496418A (fr)
HU (1) HU177408B (fr)
IE (1) IE40945B1 (fr)
IL (1) IL46760A (fr)
NL (1) NL7502724A (fr)
NO (1) NO141800C (fr)
PH (1) PH14127A (fr)
PL (3) PL93699B1 (fr)
RO (2) RO70051A (fr)
SE (1) SE421919B (fr)
SU (3) SU577982A3 (fr)
ZA (1) ZA751394B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JP3955093B2 (ja) * 1995-03-10 2007-08-08 フォトキュア エイエスエイ 光化学治療における光増感剤としての５−アミノレブリン酸のエステル
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
ATE554078T1 (de) 2007-07-26 2012-05-15 Vitae Pharmaceuticals Inc Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
WO2009075835A1 (fr) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc Inhibiteurs cycliques d'urée de la 11-hydroxystéroïde déhydrogénase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
AR071609A1 (es) 2008-05-01 2010-06-30 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
CL2009001151A1 (es) 2008-05-13 2010-08-13 Boehringer Ingelheim Int Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
WO2010010157A2 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 bêta-hydroxystéroïde déshydrogénase 1
CA2730499A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11 beta-hydroxysteroide deshydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (fr) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (fr) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (fr) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Dérivés d'indénopyridine

Also Published As

Publication number Publication date
IE40945L (en) 1975-09-09
ES440346A1 (es) 1977-03-01
IE40945B1 (en) 1979-09-12
RO69617A (fr) 1980-08-15
FI63571B (fi) 1983-03-31
ES440348A1 (es) 1977-06-01
CH622016A5 (en) 1981-03-13
CH622015A5 (en) 1981-03-13
DD119236A5 (fr) 1976-04-12
AU7894275A (en) 1976-09-16
SU588916A3 (ru) 1978-01-15
IL46760A (en) 1978-12-17
ES440350A1 (es) 1977-03-16
BG24813A4 (en) 1978-05-12
NO750773L (fr) 1975-09-10
HU177408B (en) 1981-10-28
DK92975A (fr) 1975-09-10
DK137188B (da) 1978-01-30
CA1049511A (fr) 1979-02-27
PL93699B1 (fr) 1977-06-30
CS188221B2 (en) 1979-02-28
CH622014A5 (en) 1981-03-13
FR2262984A1 (fr) 1975-10-03
SU577983A3 (ru) 1977-10-25
IL46760A0 (en) 1975-05-22
CH612425A5 (en) 1979-07-31
PL93499B1 (fr) 1977-05-30
BG25087A3 (en) 1978-07-12
RO70051A (fr) 1980-12-30
DE2411382B2 (de) 1979-01-18
ES440347A1 (es) 1977-06-01
DK137188C (da) 1978-07-03
NO141800C (no) 1980-06-04
BG24814A4 (en) 1978-05-12
CH620681A5 (en) 1980-12-15
JPS5827275B2 (ja) 1983-06-08
AT344332B (de) 1978-07-10
CH620440A5 (en) 1980-11-28
NO141800B (no) 1980-02-04
DE2411382C3 (de) 1979-09-06
ATA153875A (de) 1977-11-15
CH622017A5 (en) 1981-03-13
ZA751394B (en) 1976-11-24
BE826440A (fr) 1975-09-08
FR2262984B1 (fr) 1978-07-28
NL7502724A (nl) 1975-09-11
PL93700B1 (fr) 1977-06-30
SE7502592L (fr) 1975-09-10
ES440349A1 (es) 1977-03-01
SU577982A3 (ru) 1977-10-25
FI750652A (fr) 1975-09-10
JPS50123675A (fr) 1975-09-29
PH14127A (en) 1981-02-26
CH620439A5 (en) 1980-11-28
ES440345A1 (es) 1977-03-01
GB1496418A (en) 1977-12-30
SE421919B (sv) 1982-02-08
DE2411382A1 (de) 1975-09-18

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Owner name: C.H. BOEHRINGER SOHN