IE40945B1 - Benzomorphanes derivatives - Google Patents

Benzomorphanes derivatives

Info

Publication number
IE40945B1
IE40945B1 IE505/75A IE50575A IE40945B1 IE 40945 B1 IE40945 B1 IE 40945B1 IE 505/75 A IE505/75 A IE 505/75A IE 50575 A IE50575 A IE 50575A IE 40945 B1 IE40945 B1 IE 40945B1
Authority
IE
Ireland
Prior art keywords
methyl
formula
action
denotes hydrogen
morphine
Prior art date
Application number
IE505/75A
Other versions
IE40945L (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IE40945L publication Critical patent/IE40945L/en
Publication of IE40945B1 publication Critical patent/IE40945B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R<1> denotes methyl, ethyl or propyl; R<2> denotes hydrogen, methyl or ethyl; R<3> denotes hydrogen or methyl; and R<4> denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action. <IMAGE> [GB1496418A]
IE505/75A 1974-03-09 1975-03-07 Benzomorphanes derivatives IE40945B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2411382A DE2411382C3 (en) 1974-03-09 1974-03-09 2-Tetrahydrofurfuryl-6,7-benzomorphane, process for the preparation and their use

Publications (2)

Publication Number Publication Date
IE40945L IE40945L (en) 1975-09-09
IE40945B1 true IE40945B1 (en) 1979-09-12

Family

ID=5909593

Family Applications (1)

Application Number Title Priority Date Filing Date
IE505/75A IE40945B1 (en) 1974-03-09 1975-03-07 Benzomorphanes derivatives

Country Status (25)

Country Link
JP (1) JPS5827275B2 (en)
AT (1) AT344332B (en)
BE (1) BE826440A (en)
BG (3) BG24814A4 (en)
CA (1) CA1049511A (en)
CH (8) CH612425A5 (en)
CS (1) CS188221B2 (en)
DD (1) DD119236A5 (en)
DE (1) DE2411382C3 (en)
DK (1) DK137188C (en)
ES (6) ES440346A1 (en)
FI (1) FI63571C (en)
FR (1) FR2262984B1 (en)
GB (1) GB1496418A (en)
HU (1) HU177408B (en)
IE (1) IE40945B1 (en)
IL (1) IL46760A (en)
NL (1) NL7502724A (en)
NO (1) NO141800C (en)
PH (1) PH14127A (en)
PL (3) PL93499B1 (en)
RO (2) RO69617A (en)
SE (1) SE421919B (en)
SU (3) SU577982A3 (en)
ZA (1) ZA751394B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716687A1 (en) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-HYDROXY-2- (5-ISOXAZOLYLMETHYL) -6.7BENZOMORPHANES, THEIR ACID ADDITIONAL SALTS AND MEDICINAL PRODUCTS CONTAINING THEM
DE2828039A1 (en) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
HU225148B1 (en) * 1995-03-10 2006-07-28 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
ES2395081T3 (en) 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Synthesis of 11 beta-hydroxysteroid dehydrogenase inhibitors type 1
US8859580B2 (en) 2007-11-16 2014-10-14 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5730021B2 (en) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cycloalkyllactam derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5538365B2 (en) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1
RU2531272C2 (en) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Cyclic inhibitors of 11beta-hydroxysteroid-dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5711115B2 (en) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Benzomorphan and related skeleton alicyclic carboxylic acid derivatives, medicaments containing such compounds and uses thereof
ES2432150T3 (en) 2008-07-25 2013-12-02 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
JP5777030B2 (en) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Inhibitor of 11β-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5656986B2 (en) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 based on 1,3-oxazinan-2-one structure
AR078887A1 (en) 2009-11-06 2011-12-07 Boehringer Ingelheim Int ARILO AND HETEROARILCARBONILO DERIVATIVES OF HEXAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
JP5860042B2 (en) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use
TWI537258B (en) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives

Also Published As

Publication number Publication date
DK92975A (en) 1975-09-10
ES440350A1 (en) 1977-03-16
NO750773L (en) 1975-09-10
ES440345A1 (en) 1977-03-01
AU7894275A (en) 1976-09-16
BG25087A3 (en) 1978-07-12
GB1496418A (en) 1977-12-30
BE826440A (en) 1975-09-08
DE2411382B2 (en) 1979-01-18
CH622014A5 (en) 1981-03-13
CH622015A5 (en) 1981-03-13
CH620681A5 (en) 1980-12-15
RO69617A (en) 1980-08-15
ES440349A1 (en) 1977-03-01
FI63571B (en) 1983-03-31
SU577982A3 (en) 1977-10-25
JPS50123675A (en) 1975-09-29
SE421919B (en) 1982-02-08
NO141800B (en) 1980-02-04
AT344332B (en) 1978-07-10
NO141800C (en) 1980-06-04
CA1049511A (en) 1979-02-27
BG24814A4 (en) 1978-05-12
PL93699B1 (en) 1977-06-30
NL7502724A (en) 1975-09-11
PL93700B1 (en) 1977-06-30
DE2411382A1 (en) 1975-09-18
ES440348A1 (en) 1977-06-01
DK137188C (en) 1978-07-03
HU177408B (en) 1981-10-28
PH14127A (en) 1981-02-26
ATA153875A (en) 1977-11-15
ES440347A1 (en) 1977-06-01
CH612425A5 (en) 1979-07-31
FI63571C (en) 1983-07-11
SU588916A3 (en) 1978-01-15
DK137188B (en) 1978-01-30
CS188221B2 (en) 1979-02-28
SU577983A3 (en) 1977-10-25
DD119236A5 (en) 1976-04-12
BG24813A4 (en) 1978-05-12
ZA751394B (en) 1976-11-24
CH620440A5 (en) 1980-11-28
CH622016A5 (en) 1981-03-13
IE40945L (en) 1975-09-09
FR2262984B1 (en) 1978-07-28
FI750652A (en) 1975-09-10
CH622017A5 (en) 1981-03-13
SE7502592L (en) 1975-09-10
JPS5827275B2 (en) 1983-06-08
PL93499B1 (en) 1977-05-30
DE2411382C3 (en) 1979-09-06
ES440346A1 (en) 1977-03-01
RO70051A (en) 1980-12-30
CH620439A5 (en) 1980-11-28
IL46760A0 (en) 1975-05-22
FR2262984A1 (en) 1975-10-03
IL46760A (en) 1978-12-17

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