ES440346A1 - Benzomorphanes derivatives - Google Patents
Benzomorphanes derivativesInfo
- Publication number
- ES440346A1 ES440346A1 ES440346A ES440346A ES440346A1 ES 440346 A1 ES440346 A1 ES 440346A1 ES 440346 A ES440346 A ES 440346A ES 440346 A ES440346 A ES 440346A ES 440346 A1 ES440346 A1 ES 440346A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- formula
- action
- denotes hydrogen
- morphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R<1> denotes methyl, ethyl or propyl R<2> denotes hydrogen, methyl or ethyl R<3> denotes hydrogen or methyl and R<4> denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2411382A DE2411382C3 (en) | 1974-03-09 | 1974-03-09 | 2-Tetrahydrofurfuryl-6,7-benzomorphane, process for the preparation and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440346A1 true ES440346A1 (en) | 1977-03-01 |
Family
ID=5909593
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440350A Expired ES440350A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440348A Expired ES440348A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440346A Expired ES440346A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440349A Expired ES440349A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440345A Expired ES440345A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440347A Expired ES440347A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440350A Expired ES440350A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440348A Expired ES440348A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440349A Expired ES440349A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440345A Expired ES440345A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440347A Expired ES440347A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5827275B2 (en) |
| AT (1) | AT344332B (en) |
| BE (1) | BE826440A (en) |
| BG (3) | BG24813A4 (en) |
| CA (1) | CA1049511A (en) |
| CH (8) | CH612425A5 (en) |
| CS (1) | CS188221B2 (en) |
| DD (1) | DD119236A5 (en) |
| DE (1) | DE2411382C3 (en) |
| DK (1) | DK137188C (en) |
| ES (6) | ES440350A1 (en) |
| FI (1) | FI63571C (en) |
| FR (1) | FR2262984B1 (en) |
| GB (1) | GB1496418A (en) |
| HU (1) | HU177408B (en) |
| IE (1) | IE40945B1 (en) |
| IL (1) | IL46760A (en) |
| NL (1) | NL7502724A (en) |
| NO (1) | NO141800C (en) |
| PH (1) | PH14127A (en) |
| PL (3) | PL93700B1 (en) |
| RO (2) | RO69617A (en) |
| SE (1) | SE421919B (en) |
| SU (3) | SU577982A3 (en) |
| ZA (1) | ZA751394B (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2716687A1 (en) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-HYDROXY-2- (5-ISOXAZOLYLMETHYL) -6.7BENZOMORPHANES, THEIR ACID ADDITIONAL SALTS AND MEDICINAL PRODUCTS CONTAINING THEM |
| DE2828039A1 (en) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| CZ291132B6 (en) * | 1995-03-10 | 2002-12-11 | Photocure Asa | Esters of 5-aminolevullinic acids and pharmaceutical preparation in which the esters are comprised |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
| ATE554078T1 (en) | 2007-07-26 | 2012-05-15 | Vitae Pharmaceuticals Inc | SYNTHESIS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 INHIBITORS |
| WO2009063061A2 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| JP5490014B2 (en) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 11β-hydroxysteroid dehydrogenase type 1 cyclic urea inhibitor |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (en) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2254872A2 (en) | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2300461B1 (en) | 2008-05-01 | 2013-04-17 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5538365B2 (en) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
| TW201004945A (en) | 2008-05-01 | 2010-02-01 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2724214A1 (en) | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| DK2324018T3 (en) | 2008-07-25 | 2013-10-14 | Boehringer Ingelheim Int | CYCLE INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 |
| UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| TWI531571B (en) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| TWI537258B (en) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
| US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
-
1974
- 1974-03-09 DE DE2411382A patent/DE2411382C3/en not_active Expired
-
1975
- 1975-02-28 AT AT153875A patent/AT344332B/en not_active IP Right Cessation
- 1975-03-05 CH CH280275A patent/CH612425A5/en not_active IP Right Cessation
- 1975-03-05 SU SU7502110984A patent/SU577982A3/en active
- 1975-03-06 FI FI750652A patent/FI63571C/en not_active IP Right Cessation
- 1975-03-07 DD DD184642A patent/DD119236A5/xx unknown
- 1975-03-07 BE BE154138A patent/BE826440A/en not_active IP Right Cessation
- 1975-03-07 JP JP50027915A patent/JPS5827275B2/en not_active Expired
- 1975-03-07 CA CA221,554A patent/CA1049511A/en not_active Expired
- 1975-03-07 GB GB9633/75A patent/GB1496418A/en not_active Expired
- 1975-03-07 NO NO750773A patent/NO141800C/en unknown
- 1975-03-07 ZA ZA751394A patent/ZA751394B/en unknown
- 1975-03-07 BG BG7500030537A patent/BG24813A4/en unknown
- 1975-03-07 IL IL46760A patent/IL46760A/en unknown
- 1975-03-07 RO RO7589653A patent/RO69617A/en unknown
- 1975-03-07 BG BG7500029183A patent/BG25087A3/en unknown
- 1975-03-07 SE SE7502592A patent/SE421919B/en not_active IP Right Cessation
- 1975-03-07 IE IE505/75A patent/IE40945B1/en unknown
- 1975-03-07 RO RO7589654A patent/RO70051A/en unknown
- 1975-03-07 BG BG7500030538A patent/BG24814A4/en unknown
- 1975-03-07 FR FR7507239A patent/FR2262984B1/fr not_active Expired
- 1975-03-07 DK DK92975A patent/DK137188C/en active
- 1975-03-07 HU HU75BO1536A patent/HU177408B/en unknown
- 1975-03-07 NL NL7502724A patent/NL7502724A/en not_active Application Discontinuation
- 1975-03-08 PL PL1975191319A patent/PL93700B1/pl unknown
- 1975-03-08 PL PL1975191318A patent/PL93699B1/pl unknown
- 1975-03-08 PL PL1975178582A patent/PL93499B1/pl unknown
- 1975-03-10 PH PH16895A patent/PH14127A/en unknown
- 1975-03-10 CS CS751583A patent/CS188221B2/en unknown
- 1975-08-20 ES ES440350A patent/ES440350A1/en not_active Expired
- 1975-08-20 ES ES440348A patent/ES440348A1/en not_active Expired
- 1975-08-20 ES ES440346A patent/ES440346A1/en not_active Expired
- 1975-08-20 ES ES440349A patent/ES440349A1/en not_active Expired
- 1975-08-20 ES ES440345A patent/ES440345A1/en not_active Expired
- 1975-08-20 ES ES440347A patent/ES440347A1/en not_active Expired
- 1975-12-19 SU SU7502199294A patent/SU577983A3/en active
- 1975-12-19 SU SU752199295A patent/SU588916A3/en active
-
1979
- 1979-04-24 CH CH384879A patent/CH620681A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384779A patent/CH622016A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384679A patent/CH620440A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384579A patent/CH622015A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384979A patent/CH622017A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384379A patent/CH620439A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384479A patent/CH622014A5/en not_active IP Right Cessation
Also Published As
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