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Sandoz AG
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Sandoz AG
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Publication of ES305716A1publicationCriticalpatent/ES305716A1/en
C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
C07D519/02—Ergot alkaloids of the cyclic peptide type
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Chemical & Material Sciences
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Organic Chemistry
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Nitrogen Condensed Heterocyclic Rings
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Process for the production of alkaloids of general formula I, ** (See formula) ** wherein R1 signifies a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms inclusive, R2 means an alkyl radical containing from 1 to 4 carbon atoms inclusive, R3 means an alkyl radical containing from 1 to 4 carbon atoms inclusive or a benzyl radical that can be substituted in the position p by an oxygen function andxy means the radical (see formula) or (see formula), and its salts with organic or inorganic acids, characterized in that a salt of a compound of general formula II is condensed, ** (See formula) ** wherein R1, R2 and R3 have the meanings indicated above, together with d-lysergic acid chloride hydrochloride or with 9,10-dihydro-d-lysergic acid hydrochloride in an inert solvent and in the presence of an agent acidic fixative and the resulting compound I is purified in a known manner, isolated. (Machine-translation by Google Translate, not legally binding)
ES0305716A1963-11-081964-11-06Procedure for the production of alcaloids. (Machine-translation by Google Translate, not legally binding)
ExpiredES305716A1
(en)