ES440348A1 - Benzomorphanes derivatives - Google Patents
Benzomorphanes derivativesInfo
- Publication number
- ES440348A1 ES440348A1 ES440348A ES440348A ES440348A1 ES 440348 A1 ES440348 A1 ES 440348A1 ES 440348 A ES440348 A ES 440348A ES 440348 A ES440348 A ES 440348A ES 440348 A1 ES440348 A1 ES 440348A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- formula
- action
- denotes hydrogen
- morphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R<1> denotes methyl, ethyl or propyl R<2> denotes hydrogen, methyl or ethyl R<3> denotes hydrogen or methyl and R<4> denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2411382A DE2411382C3 (en) | 1974-03-09 | 1974-03-09 | 2-Tetrahydrofurfuryl-6,7-benzomorphane, process for the preparation and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440348A1 true ES440348A1 (en) | 1977-06-01 |
Family
ID=5909593
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440348A Expired ES440348A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440350A Expired ES440350A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440349A Expired ES440349A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440345A Expired ES440345A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440347A Expired ES440347A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440346A Expired ES440346A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440350A Expired ES440350A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440349A Expired ES440349A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440345A Expired ES440345A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440347A Expired ES440347A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
| ES440346A Expired ES440346A1 (en) | 1974-03-09 | 1975-08-20 | Benzomorphanes derivatives |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5827275B2 (en) |
| AT (1) | AT344332B (en) |
| BE (1) | BE826440A (en) |
| BG (3) | BG25087A3 (en) |
| CA (1) | CA1049511A (en) |
| CH (8) | CH612425A5 (en) |
| CS (1) | CS188221B2 (en) |
| DD (1) | DD119236A5 (en) |
| DE (1) | DE2411382C3 (en) |
| DK (1) | DK137188C (en) |
| ES (6) | ES440348A1 (en) |
| FI (1) | FI63571C (en) |
| FR (1) | FR2262984B1 (en) |
| GB (1) | GB1496418A (en) |
| HU (1) | HU177408B (en) |
| IE (1) | IE40945B1 (en) |
| IL (1) | IL46760A (en) |
| NL (1) | NL7502724A (en) |
| NO (1) | NO141800C (en) |
| PH (1) | PH14127A (en) |
| PL (3) | PL93700B1 (en) |
| RO (2) | RO69617A (en) |
| SE (1) | SE421919B (en) |
| SU (3) | SU577982A3 (en) |
| ZA (1) | ZA751394B (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2716687A1 (en) * | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-HYDROXY-2- (5-ISOXAZOLYLMETHYL) -6.7BENZOMORPHANES, THEIR ACID ADDITIONAL SALTS AND MEDICINAL PRODUCTS CONTAINING THEM |
| DE2828039A1 (en) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| CA2215069C (en) * | 1995-03-10 | 2006-09-12 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
| JP5470557B2 (en) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
| CL2008003407A1 (en) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1. |
| JP5490014B2 (en) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 11β-hydroxysteroid dehydrogenase type 1 cyclic urea inhibitor |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CA2715290A1 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8138178B2 (en) | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR071719A1 (en) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | ALICICLIC DERIVATIVES OF CARBOXILIC ACID OF BENZOMORPHANS AND RELATED STRUCTURES, MEDICINES CONTAINING THESE COMPOUNDS AND THEIR USE. OBTAINING PROCESSES |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| UY33001A (en) | 2009-11-06 | 2011-05-31 | Boehringer Ingelheim Int | ARYL AND HETEROARILCARBONYL HIVAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE DERIVATIVES |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| TWI537258B (en) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
| WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
-
1974
- 1974-03-09 DE DE2411382A patent/DE2411382C3/en not_active Expired
-
1975
- 1975-02-28 AT AT153875A patent/AT344332B/en not_active IP Right Cessation
- 1975-03-05 CH CH280275A patent/CH612425A5/en not_active IP Right Cessation
- 1975-03-05 SU SU7502110984A patent/SU577982A3/en active
- 1975-03-06 FI FI750652A patent/FI63571C/en not_active IP Right Cessation
- 1975-03-07 HU HU75BO1536A patent/HU177408B/en unknown
- 1975-03-07 BG BG029183A patent/BG25087A3/en unknown
- 1975-03-07 DD DD184642A patent/DD119236A5/xx unknown
- 1975-03-07 RO RO7589653A patent/RO69617A/en unknown
- 1975-03-07 FR FR7507239A patent/FR2262984B1/fr not_active Expired
- 1975-03-07 BE BE154138A patent/BE826440A/en not_active IP Right Cessation
- 1975-03-07 NL NL7502724A patent/NL7502724A/en not_active Application Discontinuation
- 1975-03-07 CA CA221,554A patent/CA1049511A/en not_active Expired
- 1975-03-07 RO RO7589654A patent/RO70051A/en unknown
- 1975-03-07 BG BG030537A patent/BG24813A4/en unknown
- 1975-03-07 BG BG030538A patent/BG24814A4/en unknown
- 1975-03-07 IL IL46760A patent/IL46760A/en unknown
- 1975-03-07 IE IE505/75A patent/IE40945B1/en unknown
- 1975-03-07 JP JP50027915A patent/JPS5827275B2/en not_active Expired
- 1975-03-07 ZA ZA751394A patent/ZA751394B/en unknown
- 1975-03-07 DK DK92975A patent/DK137188C/en active
- 1975-03-07 GB GB9633/75A patent/GB1496418A/en not_active Expired
- 1975-03-07 NO NO750773A patent/NO141800C/en unknown
- 1975-03-07 SE SE7502592A patent/SE421919B/en not_active IP Right Cessation
- 1975-03-08 PL PL1975191319A patent/PL93700B1/pl unknown
- 1975-03-08 PL PL1975178582A patent/PL93499B1/pl unknown
- 1975-03-08 PL PL1975191318A patent/PL93699B1/pl unknown
- 1975-03-10 PH PH16895A patent/PH14127A/en unknown
- 1975-03-10 CS CS751583A patent/CS188221B2/en unknown
- 1975-08-20 ES ES440348A patent/ES440348A1/en not_active Expired
- 1975-08-20 ES ES440350A patent/ES440350A1/en not_active Expired
- 1975-08-20 ES ES440349A patent/ES440349A1/en not_active Expired
- 1975-08-20 ES ES440345A patent/ES440345A1/en not_active Expired
- 1975-08-20 ES ES440347A patent/ES440347A1/en not_active Expired
- 1975-08-20 ES ES440346A patent/ES440346A1/en not_active Expired
- 1975-12-19 SU SU752199295A patent/SU588916A3/en active
- 1975-12-19 SU SU7502199294A patent/SU577983A3/en active
-
1979
- 1979-04-24 CH CH384579A patent/CH622015A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384379A patent/CH620439A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384679A patent/CH620440A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384979A patent/CH622017A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384879A patent/CH620681A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384479A patent/CH622014A5/en not_active IP Right Cessation
- 1979-04-24 CH CH384779A patent/CH622016A5/en not_active IP Right Cessation
Also Published As
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