ES459866A1 - Indole derivatives and process for preparing the same - Google Patents

Indole derivatives and process for preparing the same

Info

Publication number
ES459866A1
ES459866A1 ES459866A ES459866A ES459866A1 ES 459866 A1 ES459866 A1 ES 459866A1 ES 459866 A ES459866 A ES 459866A ES 459866 A ES459866 A ES 459866A ES 459866 A1 ES459866 A1 ES 459866A1
Authority
ES
Spain
Prior art keywords
preparing
same
compounds
formula
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459866A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Publication of ES459866A1 publication Critical patent/ES459866A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds of formula VI - the meaning of the symbols is defined in Claim 1 - are prepared by reaction of a corresponding indole either with an omega -haloamine or first with ethyl chloroacetate or acrylonitrile and then, after saponification to the carboxylic acid, with an amine NHR4R5, and the amide formed is reduced. The starting indoles can be obtained by well-known Fischer or Bichler methods. The compounds of formula VI as well as their acid addition salts are useful in medicine as anti-depressant agents for the central nervous system.
ES459866A 1976-06-17 1977-06-17 Indole derivatives and process for preparing the same Expired ES459866A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7618365A FR2355006A1 (en) 1976-06-17 1976-06-17 NEW INDOLE DERIVATIVES AND METHODS FOR PREPARING THEM

Publications (1)

Publication Number Publication Date
ES459866A1 true ES459866A1 (en) 1978-04-01

Family

ID=9174513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459866A Expired ES459866A1 (en) 1976-06-17 1977-06-17 Indole derivatives and process for preparing the same

Country Status (9)

Country Link
JP (1) JPS5340764A (en)
BE (1) BE855762A (en)
CH (1) CH627163A5 (en)
DE (1) DE2727046A1 (en)
ES (1) ES459866A1 (en)
FR (1) FR2355006A1 (en)
GB (1) GB1562967A (en)
IT (1) IT1114800B (en)
NL (1) NL7706384A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012786A1 (en) * 1986-07-10 1993-07-08 Howard Harry R Jr Indolinone derivatives
TW270114B (en) * 1993-10-22 1996-02-11 Hoffmann La Roche

Also Published As

Publication number Publication date
JPS5340764A (en) 1978-04-13
DE2727046A1 (en) 1977-12-29
BE855762A (en) 1977-12-16
IT1114800B (en) 1986-01-27
GB1562967A (en) 1980-03-19
FR2355006B1 (en) 1979-06-01
CH627163A5 (en) 1981-12-31
FR2355006A1 (en) 1978-01-13
NL7706384A (en) 1977-12-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990601