GB739944A - New derivatives of colchicoside and process for their preparation - Google Patents
New derivatives of colchicoside and process for their preparationInfo
- Publication number
- GB739944A GB739944A GB5304/54A GB530454A GB739944A GB 739944 A GB739944 A GB 739944A GB 5304/54 A GB5304/54 A GB 5304/54A GB 530454 A GB530454 A GB 530454A GB 739944 A GB739944 A GB 739944A
- Authority
- GB
- United Kingdom
- Prior art keywords
- colchicosamide
- colchicoside
- hydroxyalkyl
- aralkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G33/00—Religious or ritual equipment in dwelling or for general use
Landscapes
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The invention comprises colchicoside amides of the formula <FORM:0739944/IV (b)/1> where R is hydrogen, alkyl, hydroxyalkyl or aralkyl and R1 is hydrogen, alkyl, hydroxyalkyl, aralkyl, amino or arylamino, or R and R1 together form a saturated ring with the nitrogen atom. These are made by treating colchicoside with HNRR1, preferably in a solvent such as water, anhydrous or aqueous alcohol, or an excess of the amine reactant. In the examples the following are prepared: colchicosamide (R = R1 = H in above formula), N - methylcolchicosamide, N - ethyl - colchicosamide, N-propyl - colchicosamide, N - n - butyl - colchicosamide, N - n - amyl - colchicosamide, N - n - hexyl - colchicosamide, N : N - dimethylcolchicosamide, N : N - diethyl - colchicosamide, N - (b - hydroxyethyl) - colchicosamide, N : N - di - (b - hydroxyethyl) - colchicosamide, colchicoside hydrazide, colchicoside b - phenylhydrazide, N - benzyl - colchicosamide, N-benzhydryl - colchicosamide, N - (b - phenylisopropyl) - colchicosamide and colchicoside piperidide. Specification 732,265 is referred to. p ALSO:Compositions for the modification of mitosis and the creation of polyploids comprise colchicoside amides of the formula <FORM:0739944/I/1> in a solvent or on a carrier; R is hydrogen, alkyl, hydroxyalkyl or aralkyl and R1 is hydrogen, alkyl, hydroxyalkyl, aralkyl, amino or arylamino, or R and R1 together form a saturated ring with the nitrogen atom.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR739944X | 1953-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB739944A true GB739944A (en) | 1955-11-02 |
Family
ID=9132996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5304/54A Expired GB739944A (en) | 1953-02-25 | 1954-02-23 | New derivatives of colchicoside and process for their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB739944A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1209122B (en) * | 1963-05-07 | 1966-01-20 | Roussel Uclaf | Process for the preparation of 1-cyano-colchiceinamides |
-
1954
- 1954-02-23 GB GB5304/54A patent/GB739944A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1209122B (en) * | 1963-05-07 | 1966-01-20 | Roussel Uclaf | Process for the preparation of 1-cyano-colchiceinamides |
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