GB735438A - Improvements in or relating to phenanthridinium salts - Google Patents

Improvements in or relating to phenanthridinium salts

Info

Publication number
GB735438A
GB735438A GB1882452A GB1882452A GB735438A GB 735438 A GB735438 A GB 735438A GB 1882452 A GB1882452 A GB 1882452A GB 1882452 A GB1882452 A GB 1882452A GB 735438 A GB735438 A GB 735438A
Authority
GB
United Kingdom
Prior art keywords
chloride
ethyl
compound
phenanthridinium
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1882452A
Inventor
William Robert Wragg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB1882452A priority Critical patent/GB735438A/en
Publication of GB735438A publication Critical patent/GB735438A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises the chemotherapeutic compound, 2,7-diamino-9-phenyl-10-ethyl-phenanthridinium chloride. It may be prepared by treating a compound <FORM:0735438/IV (b)/1> wherein X is a group convertible to a primary amino group, e.g., a nitro, acylamino or carbalkoxyamino group, with an ethyl ester of a strong acid to produce the 10-ethyl quaternary salt and the radicals X are then converted into amino groups and the anion, if not a chloride, is converted into a chloride. The compound may also be prepared from other 2,7-diamino-9-phenyl - 10 - ethyl - phenanthridinium salts by metathesis or from the quaternary hydroxide or pseudo-base by treatment with HCl or with a chloride of a volatile base. Specifications 587,673, 697,296 and 724,114 are referred to.
GB1882452A 1952-07-24 1952-07-24 Improvements in or relating to phenanthridinium salts Expired GB735438A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1882452A GB735438A (en) 1952-07-24 1952-07-24 Improvements in or relating to phenanthridinium salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1882452A GB735438A (en) 1952-07-24 1952-07-24 Improvements in or relating to phenanthridinium salts

Publications (1)

Publication Number Publication Date
GB735438A true GB735438A (en) 1955-08-24

Family

ID=10119035

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1882452A Expired GB735438A (en) 1952-07-24 1952-07-24 Improvements in or relating to phenanthridinium salts

Country Status (1)

Country Link
GB (1) GB735438A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1203781B (en) * 1958-07-02 1965-10-28 May & Baker Ltd Process for the preparation of trypanocidally active phenanthridinium derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1203781B (en) * 1958-07-02 1965-10-28 May & Baker Ltd Process for the preparation of trypanocidally active phenanthridinium derivatives

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