GB755203A - Improvements in or relating to basically substituted carboxylic acid amides - Google Patents

Improvements in or relating to basically substituted carboxylic acid amides

Info

Publication number
GB755203A
GB755203A GB35306/54A GB3530654A GB755203A GB 755203 A GB755203 A GB 755203A GB 35306/54 A GB35306/54 A GB 35306/54A GB 3530654 A GB3530654 A GB 3530654A GB 755203 A GB755203 A GB 755203A
Authority
GB
United Kingdom
Prior art keywords
piperidyl
compounds
relating
carboxylic acid
acid amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35306/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ed Geistlich Soehne AG fuer Chemische Industrie
Original Assignee
Ed Geistlich Soehne AG fuer Chemische Industrie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ed Geistlich Soehne AG fuer Chemische Industrie filed Critical Ed Geistlich Soehne AG fuer Chemische Industrie
Publication of GB755203A publication Critical patent/GB755203A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

The invention comprises compounds of the general formula <FORM:0755203/IV(a)/1> wherein R1 is hydrogen or an alkyl group of from one to five carbon atoms, R2 is an alkyl group of from one to five carbon atoms, and R3 is an N-piperidyl or monoalkyl-N-piperidyl group, and their non-toxic salts. The invention also includes the preparation of the above compounds, in which a compound of the general formula <FORM:0755203/IV(a)/2> is heated at a temperature between 90 DEG and 200 DEG C. with piperidine or a mono alkyl piperidine. The reaction may be conducted at atmospheric or increased pressure and a large excess of the secondary amine is preferably used. The reaction product may be purified by dissolution in acid, filtration and reprecipitation with alkali, followed by repeated crystallization from a solvent such as alcohol, or of a soluble salt from water. Examples describe the preparation of b - (N - piperidyl) - butyric, - valeric, - hexanoic and -isovaleric acid anilides and of b -(2-methyl-N-piperidyl)-butyric acid anilide. Hydrochlorides of some of these compounds are described.
GB35306/54A 1953-12-22 1954-12-06 Improvements in or relating to basically substituted carboxylic acid amides Expired GB755203A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH755203X 1953-12-22

Publications (1)

Publication Number Publication Date
GB755203A true GB755203A (en) 1956-08-15

Family

ID=4534216

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35306/54A Expired GB755203A (en) 1953-12-22 1954-12-06 Improvements in or relating to basically substituted carboxylic acid amides

Country Status (1)

Country Link
GB (1) GB755203A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124586A (en) * 1964-03-10 Conhz

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124586A (en) * 1964-03-10 Conhz

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