GB767679A - Aminoacid amides - Google Patents
Aminoacid amidesInfo
- Publication number
- GB767679A GB767679A GB37092/54A GB3709254A GB767679A GB 767679 A GB767679 A GB 767679A GB 37092/54 A GB37092/54 A GB 37092/54A GB 3709254 A GB3709254 A GB 3709254A GB 767679 A GB767679 A GB 767679A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- chloroethyl
- hydrogen
- compounds
- bisulphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0767679/IV(b)/1> wherein R is hydrogen, a lower alkyl (i.e. of 1 to 5 carbon atoms) or an aryl group and R1 and R2 are hydrogen or a lower alkyl group. Such compounds are obtained by the amidation of compounds of the formula Y-CHR-N(CH2CH2Cl)2 where Y is carboxyl or an ester, halide or nitrile thereof, Where R is other than hydrogen, the products can be resolved into optical isomers. In examples: (1) N-bis-(b -chloroethyl)-glycinenitrile hydrochloride is hydrolysed with concentrated sulphuric acid to N-bis-(b -chlorethyl)-glycineamide bisulphate, which is converted to the free base and then to the hydrochloride; (2) hydrochloric acid is used in a similar hydrolysis, and the product is converted to the picrate; (3) N-bis-(b -chloroethyl)-alanineamide bisulphate is prepared analogously to (1), and in the form of its salt with d-camphor-b -sulphonic acid is resolved into its optical isomers; (4) a - bis(b - chloroethyl) - amino - a - phenylacetamide is prepared by treating a -bis-(b -chloroethyl) -amino-a -phenyl-acetonitrile with cold sulphuric acid. Specification 767,680 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP767679X | 1953-12-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB767679A true GB767679A (en) | 1957-02-06 |
Family
ID=13614747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB37092/54A Expired GB767679A (en) | 1953-12-25 | 1954-12-22 | Aminoacid amides |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB767679A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3387031A (en) * | 1961-06-08 | 1968-06-04 | Union Carbide Corp | Synthesis of alpha-amino acid amide hydrohalides |
-
1954
- 1954-12-22 GB GB37092/54A patent/GB767679A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3387031A (en) * | 1961-06-08 | 1968-06-04 | Union Carbide Corp | Synthesis of alpha-amino acid amide hydrohalides |
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