GB1190054A - Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides - Google Patents
Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester AmidesInfo
- Publication number
- GB1190054A GB1190054A GB3184867A GB3184867A GB1190054A GB 1190054 A GB1190054 A GB 1190054A GB 3184867 A GB3184867 A GB 3184867A GB 3184867 A GB3184867 A GB 3184867A GB 1190054 A GB1190054 A GB 1190054A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- phosphoric
- halogenoalkyl
- production
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/564—Three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Abstract
1,190,054. Preparing N,N<SP>1</SP>-bis(halogenoalkyl) phosphorus ester amides. ASTA-WERKE A.G. CHEMISCHE FABRIK. 11 July, 1967 [11 July, 1966], No. 31848/67. Heading C2C. N,N<SP>1</SP>-bishalogenoalkyl phosphoric and thiophosphoric acid esters amides of the formula wherein X is halogen, X 1 is an O or S atom, and R 1 is C 1 -C 4 alkyl substituted by one or more halogen atoms are obtained by reacting a hydrohalic acid with a compound of the formula wherein R 1 and X 1 are as defined above and recovering the compound of Formula I. The hydrohalic acid may be HF, HCl, HBr or HI and is preferably HCl. The reaction may be carried out in the presence of an inert solvent, e.g. a hydrocarbon or halogenated hydrocarbon. Traces of water may be present but water is preferably absent. An example is given for the production of N,N<SP>1</SP>-bis-(2- chloroethyl)-N<SP>1</SP>,O-propylene phosphoric acid ester diamide. The products are cytostatically active.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEA0052990 | 1966-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1190054A true GB1190054A (en) | 1970-04-29 |
Family
ID=6938756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3184867A Expired GB1190054A (en) | 1966-07-11 | 1967-07-11 | Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides |
Country Status (9)
Country | Link |
---|---|
AT (1) | AT265313B (en) |
BE (1) | BE700713A (en) |
CH (1) | CH484200A (en) |
DE (1) | DE1645922A1 (en) |
DK (1) | DK121232B (en) |
GB (1) | GB1190054A (en) |
IL (1) | IL28262A (en) |
NL (1) | NL158182B (en) |
SE (1) | SE327203B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4684742A (en) * | 1984-07-31 | 1987-08-04 | Polska Akademia Nauk-Centrum Baden Molekularnych i Makromolekularnych | Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorinanes |
-
1966
- 1966-07-11 DE DE19661645922 patent/DE1645922A1/en active Pending
-
1967
- 1967-06-27 AT AT597867A patent/AT265313B/en active
- 1967-06-30 SE SE997167A patent/SE327203B/xx unknown
- 1967-06-30 BE BE700713D patent/BE700713A/xx not_active IP Right Cessation
- 1967-07-05 IL IL2826267A patent/IL28262A/en unknown
- 1967-07-07 CH CH967467A patent/CH484200A/en not_active IP Right Cessation
- 1967-07-10 DK DK353567A patent/DK121232B/en not_active IP Right Cessation
- 1967-07-11 NL NL6709607A patent/NL158182B/en not_active IP Right Cessation
- 1967-07-11 GB GB3184867A patent/GB1190054A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4684742A (en) * | 1984-07-31 | 1987-08-04 | Polska Akademia Nauk-Centrum Baden Molekularnych i Makromolekularnych | Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorinanes |
Also Published As
Publication number | Publication date |
---|---|
CH484200A (en) | 1970-01-15 |
DE1645922A1 (en) | 1971-01-28 |
AT265313B (en) | 1968-10-10 |
NL158182B (en) | 1978-10-16 |
SE327203B (en) | 1970-08-17 |
NL6709607A (en) | 1968-01-12 |
BE700713A (en) | 1967-12-01 |
DK121232B (en) | 1971-09-27 |
IL28262A (en) | 1971-05-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |