ES469473A1 - N-phenyl-n-(4-piperidinyl)-amides - Google Patents

N-phenyl-n-(4-piperidinyl)-amides

Info

Publication number
ES469473A1
ES469473A1 ES469473A ES469473A ES469473A1 ES 469473 A1 ES469473 A1 ES 469473A1 ES 469473 A ES469473 A ES 469473A ES 469473 A ES469473 A ES 469473A ES 469473 A1 ES469473 A1 ES 469473A1
Authority
ES
Spain
Prior art keywords
compounds
formula
piperidinyl
phenyl
amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469473A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES469473A1 publication Critical patent/ES469473A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

N-Phenyl-N-(4-piperidinyl)amides have the following formula < IMAGE > in which the substituents are defined in Claim 1 the compounds can also be present as acid addition salts. The compounds of the formula I, in which Z is oxygen, are prepared by reacting a corresponding 4,5-dihydro-1H-tetrazol-5-one with a corresponding N-phenyl-N-(4-piperidinyl)amide. Compounds of the formula I, in which Z = O, are likewise obtained by N-acylating a corresponding 4-piperidinamine. Compounds in which Z = S are prepared from compounds of the formula I, in which Z = O, by reaction with a sulphurating agent. Pharmaceutical compositions having an analgesic effect contain, as the active compound component, at least one novel compound of the formula I or a pharmaceutically acceptable acid addition salt thereof.
ES469473A 1977-05-05 1978-05-04 N-phenyl-n-(4-piperidinyl)-amides Expired ES469473A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79381477A 1977-05-05 1977-05-05
US88618878A 1978-03-13 1978-03-13

Publications (1)

Publication Number Publication Date
ES469473A1 true ES469473A1 (en) 1979-09-16

Family

ID=27121432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469473A Expired ES469473A1 (en) 1977-05-05 1978-05-04 N-phenyl-n-(4-piperidinyl)-amides

Country Status (26)

Country Link
JP (1) JPS53149980A (en)
AT (1) AT368994B (en)
AU (1) AU514360B2 (en)
CA (1) CA1105464A (en)
CH (1) CH635585A5 (en)
CY (1) CY1253A (en)
DE (1) DE2819873A1 (en)
DK (1) DK152211C (en)
ES (1) ES469473A1 (en)
FI (1) FI64364C (en)
FR (1) FR2389622B1 (en)
GB (1) GB1598872A (en)
HK (1) HK72585A (en)
HU (1) HU179204B (en)
IE (1) IE46836B1 (en)
IL (1) IL54639A (en)
IT (1) IT1105288B (en)
KE (1) KE3429A (en)
LU (1) LU79575A1 (en)
NL (1) NL186861C (en)
NO (1) NO148747C (en)
NZ (1) NZ187164A (en)
PH (1) PH12831A (en)
SE (1) SE437516B (en)
SU (1) SU867304A3 (en)
YU (1) YU40703B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6144294A (en) * 1984-08-07 1986-03-03 Nippon Denso Co Ltd Heat exchanger
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
JPH08193074A (en) * 1994-11-18 1996-07-30 Nippon Bayeragrochem Kk Herbicidal 1-cyclopropyltetrazolinones
JP2000327668A (en) 1999-05-21 2000-11-28 Nippon Bayer Agrochem Co Ltd Tetrazolinone derivative
JP2003515588A (en) * 1999-12-06 2003-05-07 マリンクロッド・インコーポレイテッド New synthetic route to alfentanil, sufentanil and remifentanil
EP1795526A4 (en) * 2004-09-14 2010-10-13 Nippon Chemiphar Co N-substituted n-(4-piperidinyl)amide derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates

Also Published As

Publication number Publication date
NL186861C (en) 1991-03-18
AU3552278A (en) 1979-11-01
CH635585A5 (en) 1983-04-15
HK72585A (en) 1985-10-04
HU179204B (en) 1982-09-28
IT1105288B (en) 1985-10-28
DK193778A (en) 1978-11-06
NO781559L (en) 1978-11-07
DK152211C (en) 1988-08-08
FI781398A (en) 1978-11-06
IT7849203A0 (en) 1978-05-04
KE3429A (en) 1984-08-10
CY1253A (en) 1984-08-31
DE2819873C2 (en) 1989-05-03
SE437516B (en) 1985-03-04
FR2389622A1 (en) 1978-12-01
GB1598872A (en) 1981-09-23
CA1105464A (en) 1981-07-21
YU108578A (en) 1983-01-21
SU867304A3 (en) 1981-09-23
LU79575A1 (en) 1978-11-03
NO148747C (en) 1983-12-07
SE7805110L (en) 1978-11-06
FI64364B (en) 1983-07-29
FI64364C (en) 1983-11-10
IL54639A (en) 1982-02-28
NL186861B (en) 1990-10-16
YU40703B (en) 1986-04-30
JPS6324995B2 (en) 1988-05-23
PH12831A (en) 1979-09-05
AU514360B2 (en) 1981-02-05
ATA322078A (en) 1982-04-15
IE46836B1 (en) 1983-10-05
IE780901L (en) 1978-11-05
JPS53149980A (en) 1978-12-27
NO148747B (en) 1983-08-29
DK152211B (en) 1988-02-08
AT368994B (en) 1982-11-25
IL54639A0 (en) 1978-07-31
NL7804844A (en) 1978-11-07
DE2819873A1 (en) 1978-11-09
NZ187164A (en) 1981-03-16
FR2389622B1 (en) 1982-05-21

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