FI63220C - Foerfarande foer framstaellning av nya benshydrylsulfinyler me terapeutisk verkan pao det centrala nervsystemet - Google Patents

Foerfarande foer framstaellning av nya benshydrylsulfinyler me terapeutisk verkan pao det centrala nervsystemet Download PDF

Info

Publication number
FI63220C
FI63220C FI762810A FI762810A FI63220C FI 63220 C FI63220 C FI 63220C FI 762810 A FI762810 A FI 762810A FI 762810 A FI762810 A FI 762810A FI 63220 C FI63220 C FI 63220C
Authority
FI
Finland
Prior art keywords
crl
acid
water
solution
nhoh
Prior art date
Application number
FI762810A
Other languages
English (en)
Finnish (fi)
Other versions
FI762810A (ja
FI63220B (fi
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of FI762810A publication Critical patent/FI762810A/fi
Application granted granted Critical
Publication of FI63220B publication Critical patent/FI63220B/fi
Publication of FI63220C publication Critical patent/FI63220C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
FI762810A 1975-10-02 1976-10-01 Foerfarande foer framstaellning av nya benshydrylsulfinyler me terapeutisk verkan pao det centrala nervsystemet FI63220C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB40419/75A GB1520812A (en) 1975-10-02 1975-10-02 Benzhydrylsulphinyl derivatives
GB4041975 1975-10-02

Publications (3)

Publication Number Publication Date
FI762810A FI762810A (ja) 1977-04-03
FI63220B FI63220B (fi) 1983-01-31
FI63220C true FI63220C (fi) 1983-05-10

Family

ID=10414819

Family Applications (1)

Application Number Title Priority Date Filing Date
FI762810A FI63220C (fi) 1975-10-02 1976-10-01 Foerfarande foer framstaellning av nya benshydrylsulfinyler me terapeutisk verkan pao det centrala nervsystemet

Country Status (29)

Country Link
US (1) US4066686A (ja)
JP (1) JPS6045186B2 (ja)
AT (1) AT347426B (ja)
AU (1) AU511619B2 (ja)
BE (1) BE846880A (ja)
CH (1) CH614934A5 (ja)
CS (1) CS200195B2 (ja)
DE (1) DE2642511C2 (ja)
DK (1) DK151009C (ja)
ES (1) ES452063A1 (ja)
FI (1) FI63220C (ja)
FR (1) FR2326181A1 (ja)
GB (1) GB1520812A (ja)
GE (1) GEP19960242B (ja)
HU (1) HU175109B (ja)
IE (1) IE43553B1 (ja)
IL (1) IL50599A (ja)
LU (1) LU75909A1 (ja)
NL (1) NL187629C (ja)
NO (1) NO143219C (ja)
NZ (1) NZ182207A (ja)
OA (1) OA05444A (ja)
PH (1) PH12533A (ja)
PL (1) PL105506B1 (ja)
PT (1) PT65648B (ja)
SE (1) SE431088B (ja)
SU (1) SU651693A3 (ja)
YU (1) YU40464B (ja)
ZA (1) ZA765830B (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1106403A (en) * 1977-04-29 1981-08-04 Victor Lafon Process for preparing (3,4-dichlorophenyl-sulphinyl)- acetamidoxime and its addition salts
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
FR2528040A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Benzhydrylsulfinylethylamines, procede de preparation et utilisation en therapeutique
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
FR2561646B1 (fr) * 1984-03-23 1987-10-09 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
FR2569186B1 (fr) * 1984-08-20 1986-09-05 Lafon Labor Derives de 1-(n-(a-amino-a-methylacetyl)-aminophenyl)-2-amino-propanone, procede de preparation et utilisation en therapeutique
DE3604050A1 (de) * 1986-02-08 1987-08-13 Boehringer Mannheim Gmbh Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
FR2606015B1 (fr) * 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
JPH02162176A (ja) * 1988-12-14 1990-06-21 Sanyo Electric Co Ltd ライトの取付装置
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2708201B1 (fr) * 1993-06-30 1995-10-20 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
US5571825A (en) * 1995-03-31 1996-11-05 Warner-Lambert Company Method of selectively inhibiting prostaglandin G/H synthase-2
YU40999A (sh) * 1997-02-27 2002-06-19 American Cyanamid Company N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
EP1437345A1 (en) * 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
CA2514900A1 (en) 2003-01-31 2004-09-10 Alembic Limited Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
MXPA05008088A (es) * 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
WO2005046854A2 (en) * 2003-09-12 2005-05-26 Sun Pharmaceutical Industries Limited A process for the preparation of diphenylmethylsulfinyl derivatives
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
EP1586560A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US7297817B2 (en) * 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
AU2007272501A1 (en) * 2006-07-12 2008-01-17 Elan Pharma International Limited Nanoparticulate formulations of modafinil
WO2008077127A2 (en) * 2006-12-19 2008-06-26 Lavin Thomas N Use of modafinil to treat restless leg syndrome
USD681056S1 (en) * 2012-09-09 2013-04-30 Apple Inc. Electronic device
WO2014138518A2 (en) 2013-03-08 2014-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
CN104610108B (zh) * 2015-01-27 2016-03-30 潍坊医学院 一种中枢神经系统药物阿屈非尼中间体化合物的合成方法
WO2019094856A1 (en) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof
KR102126389B1 (ko) 2018-09-14 2020-06-25 셀라이온바이오메드 주식회사 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물
KR102277739B1 (ko) 2019-12-11 2021-07-15 셀라이온바이오메드 주식회사 벤즈히드릴 티오 아세트아미드 화합물을 유효성분으로 포함하는 섬유화 질환의 치료용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2394597A (en) * 1942-07-09 1946-02-12 Eastman Kodak Co Preparation of organic dhsocyanates
NL6406688A (ja) * 1964-06-05 1965-12-06

Also Published As

Publication number Publication date
BE846880A (fr) 1977-04-01
FI762810A (ja) 1977-04-03
IL50599A0 (en) 1976-12-31
DE2642511C2 (de) 1986-07-31
ES452063A1 (es) 1977-10-01
PT65648A (pt) 1976-10-01
AT347426B (de) 1978-12-27
DK437576A (da) 1977-04-03
PL105506B1 (pl) 1979-10-31
CH614934A5 (ja) 1979-12-28
GEP19960242B (en) 1996-06-01
NL187629C (nl) 1991-12-02
IE43553B1 (en) 1981-03-25
AU1818876A (en) 1978-04-06
NZ182207A (en) 1978-03-06
IL50599A (en) 1980-09-16
NL7610929A (nl) 1977-04-05
DK151009C (da) 1988-02-29
ZA765830B (en) 1977-09-28
JPS5246058A (en) 1977-04-12
AU511619B2 (en) 1980-08-28
NO763372L (ja) 1977-04-05
FR2326181A1 (fr) 1977-04-29
PT65648B (fr) 1978-04-07
LU75909A1 (ja) 1977-05-11
CS200195B2 (cs) 1980-08-29
DE2642511A1 (de) 1977-04-14
HU175109B (hu) 1980-05-28
ATA720876A (de) 1978-05-15
SE431088B (sv) 1984-01-16
IE43553L (en) 1977-04-02
DK151009B (da) 1987-10-12
NL187629B (nl) 1991-07-01
PH12533A (en) 1979-05-17
NO143219B (no) 1980-09-22
FR2326181B1 (ja) 1980-08-08
JPS6045186B2 (ja) 1985-10-08
US4066686A (en) 1978-01-03
NO143219C (no) 1981-01-07
SU651693A3 (ru) 1979-03-05
YU241476A (en) 1982-02-28
OA05444A (fr) 1981-03-31
FI63220B (fi) 1983-01-31
SE7610940L (sv) 1977-04-03
GB1520812A (en) 1978-08-09
YU40464B (en) 1986-02-28

Similar Documents

Publication Publication Date Title
FI63220C (fi) Foerfarande foer framstaellning av nya benshydrylsulfinyler me terapeutisk verkan pao det centrala nervsystemet
IE42447B1 (en) New sulphur-containing arylamine derivatives
CH628026A5 (fr) Derives d'acetamide et composition therapeutique contenant ces derives.
FR2528038A2 (fr) Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
JPS6049192B2 (ja) 新規置換ベンズアミド、その製造方法及びこれを有効成分とする向精神薬
IE44416B1 (en) Substituted phenyl amidines
PT820438E (pt) O-carbamoil-fenilalaninol possuindo um substituinte no anel benzeno, seus sais farmaceuticamente uteis e processo para preparacao do mesmo
US4098824A (en) Benzhydrylsulphinyl derivatives
KR20030038868A (ko) 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및용도
JP2005508987A6 (ja) ３−アミド−１，２−ベンゾイソオキサゾール誘導体、その塩の製造方法及び使用
JPS61280473A (ja) ３−フエニル−テトラヒドロピリジン誘導体及びその製造方法
CH630606A5 (en) Phenylamidine derivatives useful especially in therapeutics
FR2460294A1 (fr) Nouveaux oxime-ethers, leur procede de preparation et compositions pharmaceutiques les contenant
FR2467203A1 (fr) Derives de 1,2,4-oxadiazolin-5-one, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2534915A1 (fr) Nouveaux derives de 2-(phenoxymethyl)-morpholine, utilisation en therapeutique et procede de preparation
FI61182C (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva butylaminderivat
EP0669322B1 (fr) Sulfonamides substituées, leur procédé de préparation et les compositions pharmaceutiques les renfermant
JPH0522704B2 (ja)
LU84473A1 (fr) Derives benzylideniques,leur preparation et leur application en therapeutique
FI60863C (fi) Foerfarande foer framstaellning av nya bentshydryloxialkylaminderivat med foerlaengd antihistamineffekt
IE54987B1 (en) Benzhydrylsulfinylethylamine derivatives
KR800000144B1 (ko) 벤즈 히드릴 술피닐 유도체의 제조방법
US3883548A (en) 3-Arylthioalkyl-4-optionally substituted sydnones
US3377245A (en) Methods and compositions for treating hypertension
CH667873A5 (fr) Derive de n-imidazolidinylmethyl benzamide.

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: LABORATOIRE L. LAFON