ES452063A1 - Procedimiento de preparacion de un nuevo compuesto benzhi- drisulfinilo. - Google Patents

Procedimiento de preparacion de un nuevo compuesto benzhi- drisulfinilo.

Info

Publication number
ES452063A1
ES452063A1 ES452063A ES452063A ES452063A1 ES 452063 A1 ES452063 A1 ES 452063A1 ES 452063 A ES452063 A ES 452063A ES 452063 A ES452063 A ES 452063A ES 452063 A1 ES452063 A1 ES 452063A1
Authority
ES
Spain
Prior art keywords
formula
new
nhoh
alkyl
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452063A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of ES452063A1 publication Critical patent/ES452063A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electronic Switches (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES452063A 1975-10-02 1976-10-01 Procedimiento de preparacion de un nuevo compuesto benzhi- drisulfinilo. Expired ES452063A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB40419/75A GB1520812A (en) 1975-10-02 1975-10-02 Benzhydrylsulphinyl derivatives

Publications (1)

Publication Number Publication Date
ES452063A1 true ES452063A1 (es) 1977-10-01

Family

ID=10414819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES452063A Expired ES452063A1 (es) 1975-10-02 1976-10-01 Procedimiento de preparacion de un nuevo compuesto benzhi- drisulfinilo.

Country Status (29)

Country Link
US (1) US4066686A (es)
JP (1) JPS6045186B2 (es)
AT (1) AT347426B (es)
AU (1) AU511619B2 (es)
BE (1) BE846880A (es)
CH (1) CH614934A5 (es)
CS (1) CS200195B2 (es)
DE (1) DE2642511C2 (es)
DK (1) DK151009C (es)
ES (1) ES452063A1 (es)
FI (1) FI63220C (es)
FR (1) FR2326181A1 (es)
GB (1) GB1520812A (es)
GE (1) GEP19960242B (es)
HU (1) HU175109B (es)
IE (1) IE43553B1 (es)
IL (1) IL50599A (es)
LU (1) LU75909A1 (es)
NL (1) NL187629C (es)
NO (1) NO143219C (es)
NZ (1) NZ182207A (es)
OA (1) OA05444A (es)
PH (1) PH12533A (es)
PL (1) PL105506B1 (es)
PT (1) PT65648B (es)
SE (1) SE431088B (es)
SU (1) SU651693A3 (es)
YU (1) YU40464B (es)
ZA (1) ZA765830B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1574003A (en) * 1977-04-29 1980-09-03 Lafon Labor (3,4-dichlorophenylsulphinyl) - acet-amidoxime and its addition salts
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
FR2528040A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Benzhydrylsulfinylethylamines, procede de preparation et utilisation en therapeutique
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
FR2561646B1 (fr) * 1984-03-23 1987-10-09 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
FR2569186B1 (fr) * 1984-08-20 1986-09-05 Lafon Labor Derives de 1-(n-(a-amino-a-methylacetyl)-aminophenyl)-2-amino-propanone, procede de preparation et utilisation en therapeutique
DE3604050A1 (de) * 1986-02-08 1987-08-13 Boehringer Mannheim Gmbh Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
FR2606015B1 (fr) * 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
JPH02162176A (ja) * 1988-12-14 1990-06-21 Sanyo Electric Co Ltd ライトの取付装置
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2708201B1 (fr) * 1993-06-30 1995-10-20 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
US5571825A (en) * 1995-03-31 1996-11-05 Warner-Lambert Company Method of selectively inhibiting prostaglandin G/H synthase-2
DK0970046T3 (da) * 1997-02-27 2004-04-13 Wyeth Corp N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
EP1437345A1 (en) * 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
CA2514900A1 (en) * 2003-01-31 2004-09-10 Alembic Limited Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
EP1603867A2 (en) * 2003-02-24 2005-12-14 Mallinckrodt Inc. Process for preparing benzhydrylthioacetamide
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
WO2005046854A2 (en) * 2003-09-12 2005-05-26 Sun Pharmaceutical Industries Limited A process for the preparation of diphenylmethylsulfinyl derivatives
US7297817B2 (en) * 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
CA2657409A1 (en) * 2006-07-12 2008-01-17 Elan Corporation, Plc Nanoparticulate formulations of modafinil
US20100010092A1 (en) * 2006-12-19 2010-01-14 Arless Ltd. Use of modafinil to treat restless leg syndrome
USD681056S1 (en) * 2012-09-09 2013-04-30 Apple Inc. Electronic device
EP2964611B1 (en) 2013-03-08 2022-10-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
CN104610108B (zh) * 2015-01-27 2016-03-30 潍坊医学院 一种中枢神经系统药物阿屈非尼中间体化合物的合成方法
US11365195B2 (en) 2017-11-13 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof
KR102126389B1 (ko) 2018-09-14 2020-06-25 셀라이온바이오메드 주식회사 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물
KR102277739B1 (ko) 2019-12-11 2021-07-15 셀라이온바이오메드 주식회사 벤즈히드릴 티오 아세트아미드 화합물을 유효성분으로 포함하는 섬유화 질환의 치료용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2394597A (en) * 1942-07-09 1946-02-12 Eastman Kodak Co Preparation of organic dhsocyanates
NL6406688A (es) * 1964-06-05 1965-12-06

Also Published As

Publication number Publication date
NO763372L (es) 1977-04-05
BE846880A (fr) 1977-04-01
FI63220C (fi) 1983-05-10
CH614934A5 (es) 1979-12-28
ZA765830B (en) 1977-09-28
FR2326181B1 (es) 1980-08-08
SE431088B (sv) 1984-01-16
DE2642511C2 (de) 1986-07-31
GEP19960242B (en) 1996-06-01
PL105506B1 (pl) 1979-10-31
FI762810A (es) 1977-04-03
DK151009C (da) 1988-02-29
FR2326181A1 (fr) 1977-04-29
NO143219B (no) 1980-09-22
NL187629B (nl) 1991-07-01
PT65648A (pt) 1976-10-01
JPS5246058A (en) 1977-04-12
AU511619B2 (en) 1980-08-28
AT347426B (de) 1978-12-27
YU241476A (en) 1982-02-28
DK151009B (da) 1987-10-12
NL7610929A (nl) 1977-04-05
GB1520812A (en) 1978-08-09
FI63220B (fi) 1983-01-31
IL50599A0 (en) 1976-12-31
IE43553B1 (en) 1981-03-25
HU175109B (hu) 1980-05-28
IE43553L (en) 1977-04-02
AU1818876A (en) 1978-04-06
NO143219C (no) 1981-01-07
YU40464B (en) 1986-02-28
NZ182207A (en) 1978-03-06
US4066686A (en) 1978-01-03
DE2642511A1 (de) 1977-04-14
IL50599A (en) 1980-09-16
JPS6045186B2 (ja) 1985-10-08
PH12533A (en) 1979-05-17
PT65648B (fr) 1978-04-07
ATA720876A (de) 1978-05-15
OA05444A (fr) 1981-03-31
LU75909A1 (es) 1977-05-11
DK437576A (da) 1977-04-03
CS200195B2 (cs) 1980-08-29
SU651693A3 (ru) 1979-03-05
SE7610940L (sv) 1977-04-03
NL187629C (nl) 1991-12-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970623