FI62838C - Foerfarande foer framstaellning av den nya farmaceutiskt anvaendbara hoegerroterande isomeren av en asymmetriskt spiro-hydantoinfoerening - Google Patents
Foerfarande foer framstaellning av den nya farmaceutiskt anvaendbara hoegerroterande isomeren av en asymmetriskt spiro-hydantoinfoerening Download PDFInfo
- Publication number
- FI62838C FI62838C FI781613A FI781613A FI62838C FI 62838 C FI62838 C FI 62838C FI 781613 A FI781613 A FI 781613A FI 781613 A FI781613 A FI 781613A FI 62838 C FI62838 C FI 62838C
- Authority
- FI
- Finland
- Prior art keywords
- spiro
- dione
- fluoro
- isomer
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/799,586 US4130714A (en) | 1977-05-23 | 1977-05-23 | Hydantoin therapeutic agents |
US79958677 | 1977-05-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI781613A FI781613A (fi) | 1978-11-24 |
FI62838B FI62838B (fi) | 1982-11-30 |
FI62838C true FI62838C (fi) | 1983-03-10 |
Family
ID=25176274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781613A FI62838C (fi) | 1977-05-23 | 1978-05-22 | Foerfarande foer framstaellning av den nya farmaceutiskt anvaendbara hoegerroterande isomeren av en asymmetriskt spiro-hydantoinfoerening |
Country Status (37)
Country | Link |
---|---|
US (1) | US4130714A (de) |
JP (1) | JPS6035350B2 (de) |
AR (1) | AR219531A1 (de) |
AT (1) | AT357170B (de) |
AU (1) | AU499518B1 (de) |
BE (1) | BE867248A (de) |
CA (1) | CA1088073A (de) |
CH (1) | CH631455A5 (de) |
CS (1) | CS200550B2 (de) |
DD (1) | DD137107A5 (de) |
DE (2) | DE2858042C2 (de) |
DK (1) | DK147941C (de) |
EG (1) | EG13691A (de) |
ES (1) | ES470070A1 (de) |
FI (1) | FI62838C (de) |
FR (1) | FR2392024A1 (de) |
GB (1) | GB1572688A (de) |
GR (1) | GR68694B (de) |
HK (1) | HK53981A (de) |
HU (1) | HU177718B (de) |
IE (1) | IE47273B1 (de) |
IL (1) | IL54754A (de) |
IN (1) | IN147854B (de) |
IT (1) | IT1096306B (de) |
KE (1) | KE3168A (de) |
LU (1) | LU79685A1 (de) |
MY (1) | MY8200156A (de) |
NL (1) | NL7804158A (de) |
NO (1) | NO150206C (de) |
NZ (1) | NZ187334A (de) |
PH (1) | PH13828A (de) |
PL (1) | PL110460B1 (de) |
PT (1) | PT68071B (de) |
SE (1) | SE437375B (de) |
SU (1) | SU873885A3 (de) |
YU (1) | YU40829B (de) |
ZA (1) | ZA782919B (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11608323B2 (en) * | 2013-10-07 | 2023-03-21 | Syngenta Participations Ag | Herbicidal compounds |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1088945A (en) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
US4181728A (en) * | 1978-11-16 | 1980-01-01 | Pfizer Inc. | Spiro-polycyclicimidazolidinedione derivatives |
US4181729A (en) * | 1979-03-21 | 1980-01-01 | Pfizer Inc. | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives |
US4210667A (en) * | 1979-04-19 | 1980-07-01 | Pfizer Inc. | Pharmaceutical preparations containing coumarin carboxylic acid derivatives |
IE50332B1 (en) * | 1979-11-13 | 1986-04-02 | Ici Ltd | 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof |
US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
US4419521A (en) * | 1981-11-12 | 1983-12-06 | Pfizer Inc. | 6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins |
JPS58124788A (ja) * | 1982-01-20 | 1983-07-25 | Eisai Co Ltd | 光学活性ヒダントイン誘導体,その製造方法ならびにそれを含有する治療用薬剤 |
US4464385A (en) * | 1982-04-15 | 1984-08-07 | Alcon Laboratories, Inc. | Treatment of diabetic complications with hydantoins |
US4540700A (en) * | 1982-04-15 | 1985-09-10 | Alcon Laboratories, Inc. | Treatment of diabetic complications with certain spiro-imidazolidine-diones |
US4438272A (en) | 1982-04-15 | 1984-03-20 | Alcon Laboratories, Inc. | Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones |
US4436745A (en) | 1982-04-15 | 1984-03-13 | Alcon Laboratories, Inc. | Method of inhibiting aldose reductase activity |
US4431828A (en) * | 1982-11-10 | 1984-02-14 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil |
US4528387A (en) * | 1982-11-10 | 1985-07-09 | Pfizer Inc. | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid |
US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
US4474967A (en) * | 1983-04-27 | 1984-10-02 | Pfizer Inc. | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
US5153211A (en) * | 1983-09-14 | 1992-10-06 | Alcon Laboratories, Inc. | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase |
US4537892A (en) * | 1983-09-14 | 1985-08-27 | Alcon Laboratories, Inc. | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase |
EP0159143B1 (de) * | 1984-03-23 | 1987-12-16 | Pfizer Inc. | Spiro-Indene und Spiro-1,2-Dihydro-Naphthalene für die Behandlung von diabetischen Komplikationen |
US4717725A (en) * | 1984-04-11 | 1988-01-05 | Alcon Laboratories, Inc. | Ophthalmic wound healing with aldose reductase inhibitors |
US4600717A (en) * | 1984-04-11 | 1986-07-15 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in ophthalmic wound healing |
JPH06772B2 (ja) * | 1984-07-09 | 1994-01-05 | 鐘淵化学工業株式会社 | 3―(4―フルオロフエノキシ)プロピオニトリルを用いる6―フルオロ―4―クロマノンの製造法 |
WO1986000807A1 (en) * | 1984-07-20 | 1986-02-13 | Pfizer Inc. | Spiro-imidazolones for treatment of diabetes complications |
US4656169A (en) * | 1984-08-14 | 1987-04-07 | Pfizer Inc. | Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions |
ATE37371T1 (de) * | 1984-08-20 | 1988-10-15 | Pfizer | Verfahren zur herstellung asymmetrischer hydantoine. |
US4620019A (en) * | 1984-08-23 | 1986-10-28 | Pfizer Inc. | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil |
US4609663A (en) * | 1984-09-11 | 1986-09-02 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in glaucoma therapy |
US4551542A (en) * | 1984-09-26 | 1985-11-05 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid |
US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
JPS61200991A (ja) * | 1985-03-04 | 1986-09-05 | Sanwa Kagaku Kenkyusho:Kk | スピロ―3―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 |
WO1986007353A1 (en) | 1985-06-14 | 1986-12-18 | Pfizer Inc. | Intermediate in the production of an asymmetric hydantoin |
JPS627654U (de) * | 1985-06-26 | 1987-01-17 | ||
WO1987004344A1 (en) * | 1986-01-17 | 1987-07-30 | Pfizer Inc. | Hydroxyacetic acid derivatives for the treatment of diabetic complications |
JPS6357588A (ja) * | 1986-08-28 | 1988-03-12 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
CA1310269C (en) * | 1987-03-20 | 1992-11-17 | Billie M. York, Jr. | Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus |
US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
US4952694A (en) * | 1988-07-27 | 1990-08-28 | Pfizer Inc. | Novel resolution process for racemic spiro-hydantoins |
US5006657A (en) * | 1988-07-27 | 1991-04-09 | Pfizer Inc. | Intermediates in a resolution process for racemic spiro hydantoins |
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
JPH05508386A (ja) * | 1989-02-10 | 1993-11-25 | ワシントン リサーチ ファンデション | 免疫調整剤 |
US4980357A (en) * | 1990-03-01 | 1990-12-25 | Pfizer Inc. | Azolidinedione derivatives |
US5039672A (en) * | 1990-04-05 | 1991-08-13 | Pfizer Inc. | Heterocyclic compounds as aldose reductase inhibitors |
US5236945A (en) * | 1990-06-11 | 1993-08-17 | Pfizer Inc. | 1H-indazole-3-acetic acids as aldose reductase inhibitors |
US5206367A (en) * | 1992-02-18 | 1993-04-27 | Pfizer Inc. | Preparation of optically active spiro-hydantoins |
WO1994007867A1 (en) * | 1992-09-28 | 1994-04-14 | Pfizer Inc. | Substituted pyrimidines for control of diabetic complications |
US5521208A (en) * | 1993-07-29 | 1996-05-28 | Alcon Laboratories, Inc. | Compositions and methods for the treatment of the metabolically impaired and for improved compliance |
KR100891756B1 (ko) * | 1997-04-15 | 2009-04-07 | 씨에스아이알 | 식욕 억제 활성을 갖는 약학 조성물 |
GB2396815B (en) * | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
IL155710A0 (en) | 2000-11-30 | 2003-11-23 | Pfizer Prod Inc | Combination of gaba agonists and aldose reductase inhibitors |
US20110092566A1 (en) * | 2004-11-19 | 2011-04-21 | Srivastava Satish K | Treatment of cancer with aldose reductase inhibitors |
US8158667B2 (en) | 2006-08-21 | 2012-04-17 | Kador Peter F | Topical treatment of cataracts in dogs |
ATE518544T1 (de) | 2007-03-12 | 2011-08-15 | Zadec Aps | Rotbusch-extrakt gegen diabetes |
WO2008118844A1 (en) | 2007-03-23 | 2008-10-02 | The Board Of Regents Of The University Of Texas System | Methods involving aldose reductase inhibitors |
US20090270490A1 (en) * | 2008-04-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Methods involving aldose reductase inhibition |
CA2822672C (en) | 2010-12-23 | 2018-06-05 | The Board Of Regents Of The University Of Texas System | Methods for treating copd |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2683718A (en) * | 1952-01-11 | 1954-07-13 | Searle & Co | Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione |
DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
CA1088945A (en) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
-
1977
- 1977-05-23 US US05/799,586 patent/US4130714A/en not_active Expired - Lifetime
-
1978
- 1978-03-30 SE SE7803626A patent/SE437375B/sv not_active IP Right Cessation
- 1978-04-15 IN IN272/DEL/78A patent/IN147854B/en unknown
- 1978-04-19 NL NL7804158A patent/NL7804158A/xx active Search and Examination
- 1978-04-19 PH PH21026A patent/PH13828A/en unknown
- 1978-05-11 CS CS783021A patent/CS200550B2/cs unknown
- 1978-05-13 JP JP53057064A patent/JPS6035350B2/ja not_active Expired
- 1978-05-16 PL PL1978206826A patent/PL110460B1/pl unknown
- 1978-05-16 YU YU1169/78A patent/YU40829B/xx unknown
- 1978-05-17 HU HU78PI625A patent/HU177718B/hu not_active IP Right Cessation
- 1978-05-17 SU SU782616255A patent/SU873885A3/ru active
- 1978-05-18 AR AR272227A patent/AR219531A1/es active
- 1978-05-18 GB GB20352/78A patent/GB1572688A/en not_active Expired
- 1978-05-18 DD DD78205450A patent/DD137107A5/de unknown
- 1978-05-19 BE BE187841A patent/BE867248A/xx not_active IP Right Cessation
- 1978-05-19 DE DE2858042A patent/DE2858042C2/de not_active Expired
- 1978-05-19 CA CA303,740A patent/CA1088073A/en not_active Expired
- 1978-05-19 DE DE2821966A patent/DE2821966C2/de not_active Expired
- 1978-05-19 AT AT365378A patent/AT357170B/de not_active IP Right Cessation
- 1978-05-20 GR GR56282A patent/GR68694B/el unknown
- 1978-05-20 EG EG320/78A patent/EG13691A/xx active
- 1978-05-22 FI FI781613A patent/FI62838C/fi not_active IP Right Cessation
- 1978-05-22 NZ NZ187334A patent/NZ187334A/en unknown
- 1978-05-22 NO NO781769A patent/NO150206C/no unknown
- 1978-05-22 IE IE1015/78A patent/IE47273B1/en not_active IP Right Cessation
- 1978-05-22 IL IL54754A patent/IL54754A/xx not_active IP Right Cessation
- 1978-05-22 PT PT68071A patent/PT68071B/pt unknown
- 1978-05-22 FR FR7815032A patent/FR2392024A1/fr active Granted
- 1978-05-22 CH CH552778A patent/CH631455A5/fr not_active IP Right Cessation
- 1978-05-22 ZA ZA00782919A patent/ZA782919B/xx unknown
- 1978-05-22 DK DK226778A patent/DK147941C/da not_active IP Right Cessation
- 1978-05-22 LU LU79685A patent/LU79685A1/xx unknown
- 1978-05-22 AU AU36328/78A patent/AU499518B1/en not_active Expired
- 1978-05-22 ES ES470070A patent/ES470070A1/es not_active Expired
- 1978-05-22 IT IT23672/78A patent/IT1096306B/it active
-
1981
- 1981-10-15 KE KE3168A patent/KE3168A/xx unknown
- 1981-11-05 HK HK539/81A patent/HK53981A/xx unknown
-
1982
- 1982-12-30 MY MY156/82A patent/MY8200156A/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11608323B2 (en) * | 2013-10-07 | 2023-03-21 | Syngenta Participations Ag | Herbicidal compounds |
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Legal Events
Date | Code | Title | Description |
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MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: PFIZER INC. |