FI62077C - Foerfarande foer framstaellning av farmaceutiskt anvaendbara fenoximetylpiperidinopropanolderivat - Google Patents
Foerfarande foer framstaellning av farmaceutiskt anvaendbara fenoximetylpiperidinopropanolderivat Download PDFInfo
- Publication number
- FI62077C FI62077C FI773346A FI773346A FI62077C FI 62077 C FI62077 C FI 62077C FI 773346 A FI773346 A FI 773346A FI 773346 A FI773346 A FI 773346A FI 62077 C FI62077 C FI 62077C
- Authority
- FI
- Finland
- Prior art keywords
- group
- propoxy
- phenoxymethyl
- hydroxy
- piperidino
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- -1 acetyl- Chemical group 0.000 claims description 69
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 11
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
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- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
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- 239000013558 reference substance Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000005624 silicic acid group Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000002316 solid fats Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762651574 DE2651574A1 (de) | 1976-11-12 | 1976-11-12 | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
| DE2651574 | 1976-11-12 | ||
| DE2737630 | 1977-08-20 | ||
| DE19772737630 DE2737630A1 (de) | 1977-08-20 | 1977-08-20 | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI773346A7 FI773346A7 (fi) | 1978-05-13 |
| FI62077B FI62077B (fi) | 1982-07-30 |
| FI62077C true FI62077C (fi) | 1982-11-10 |
Family
ID=25771134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI773346A FI62077C (fi) | 1976-11-12 | 1977-11-08 | Foerfarande foer framstaellning av farmaceutiskt anvaendbara fenoximetylpiperidinopropanolderivat |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4146630A (en, 2012) |
| JP (1) | JPS5363385A (en, 2012) |
| AR (3) | AR218643A1 (en, 2012) |
| AT (1) | AT361476B (en, 2012) |
| AU (1) | AU510284B2 (en, 2012) |
| CA (1) | CA1086740A (en, 2012) |
| CH (3) | CH636099A5 (en, 2012) |
| CS (1) | CS228106B2 (en, 2012) |
| DD (1) | DD133801A5 (en, 2012) |
| DK (1) | DK500677A (en, 2012) |
| ES (2) | ES472746A1 (en, 2012) |
| FI (1) | FI62077C (en, 2012) |
| FR (1) | FR2370744A1 (en, 2012) |
| GB (1) | GB1541547A (en, 2012) |
| HU (1) | HU177410B (en, 2012) |
| IL (1) | IL53323A (en, 2012) |
| IT (1) | IT1087490B (en, 2012) |
| LU (1) | LU78498A1 (en, 2012) |
| NL (1) | NL7712220A (en, 2012) |
| PL (2) | PL110782B1 (en, 2012) |
| SE (1) | SE7712720L (en, 2012) |
| SU (2) | SU890975A3 (en, 2012) |
| YU (3) | YU266477A (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314943A (en) * | 1977-07-13 | 1982-02-09 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
| US4495352A (en) * | 1979-02-13 | 1985-01-22 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
| DE2905876A1 (de) * | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | Neue piperidinopropylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2922084A1 (de) * | 1979-05-31 | 1980-12-11 | Boehringer Mannheim Gmbh | Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3584560D1 (de) * | 1984-04-09 | 1991-12-05 | Du Pont | Arzneimittelzusammensetzung geeignet zur behandlung oder prophylaxe von herzstoerungen. |
| FR2574795B1 (fr) * | 1984-12-18 | 1987-11-20 | Ile De France | Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide |
| US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB925429A (en) * | 1960-04-01 | 1963-05-08 | Irwin Neisler & Co | Indole derivatives |
| US3699123A (en) * | 1970-03-24 | 1972-10-17 | Sandoz Ltd | 4-(3-amino-2-hydroxy-propoxy) indole derivatives |
| BE794333A (fr) * | 1972-01-20 | 1973-07-19 | Wyeth John & Brother Ltd | Composes heterocycliques azotes therapeutiques |
| JPS48103590A (en, 2012) * | 1972-04-13 | 1973-12-25 | ||
| JPS6024100B2 (ja) * | 1975-02-11 | 1985-06-11 | ベーリンガー・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | アミノプロパノ−ル−誘導体の製法 |
| DE2549568C3 (de) * | 1975-11-05 | 1981-10-29 | Bayer Ag, 5090 Leverkusen | 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
-
1977
- 1977-10-27 US US05/846,057 patent/US4146630A/en not_active Expired - Lifetime
- 1977-11-07 YU YU02664/77A patent/YU266477A/xx unknown
- 1977-11-07 AR AR269873A patent/AR218643A1/es active
- 1977-11-07 NL NL7712220A patent/NL7712220A/xx not_active Application Discontinuation
- 1977-11-07 IL IL53323A patent/IL53323A/xx unknown
- 1977-11-08 IT IT29456/77A patent/IT1087490B/it active
- 1977-11-08 AU AU30466/77A patent/AU510284B2/en not_active Expired
- 1977-11-08 GB GB46415/77A patent/GB1541547A/en not_active Expired
- 1977-11-08 FI FI773346A patent/FI62077C/fi not_active IP Right Cessation
- 1977-11-08 DD DD7700201951A patent/DD133801A5/xx unknown
- 1977-11-08 CS CS777291A patent/CS228106B2/cs unknown
- 1977-11-09 CH CH1367177A patent/CH636099A5/de not_active IP Right Cessation
- 1977-11-09 PL PL1977201997A patent/PL110782B1/pl not_active IP Right Cessation
- 1977-11-09 PL PL1977213346A patent/PL112683B1/pl unknown
- 1977-11-09 CA CA290,495A patent/CA1086740A/en not_active Expired
- 1977-11-10 HU HU77BO1689A patent/HU177410B/hu unknown
- 1977-11-10 FR FR7733907A patent/FR2370744A1/fr active Granted
- 1977-11-10 SE SE7712720A patent/SE7712720L/xx not_active Application Discontinuation
- 1977-11-11 LU LU7778498A patent/LU78498A1/xx unknown
- 1977-11-11 AT AT808277A patent/AT361476B/de active
- 1977-11-11 DK DK500677A patent/DK500677A/da not_active Application Discontinuation
- 1977-11-11 JP JP13559177A patent/JPS5363385A/ja active Granted
-
1978
- 1978-08-22 ES ES472746A patent/ES472746A1/es not_active Expired
- 1978-08-22 ES ES472747A patent/ES472747A1/es not_active Expired
- 1978-10-20 SU SU782675553A patent/SU890975A3/ru active
- 1978-10-20 SU SU782674802A patent/SU826955A3/ru active
-
1979
- 1979-02-28 AR AR275655A patent/AR221868A1/es active
- 1979-02-28 AR AR275657A patent/AR221081A1/es active
-
1982
- 1982-06-14 CH CH367682A patent/CH639086A5/de not_active IP Right Cessation
-
1983
- 1983-05-02 CH CH233783A patent/CH643554A5/de not_active IP Right Cessation
- 1983-06-09 YU YU01289/83A patent/YU128983A/xx unknown
- 1983-06-09 YU YU01288/83A patent/YU128883A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |