FI62071C - Foerfarande foer framstaellning av antitumoeraktiva 1-asyloximetyl-5-fluoruracilderivat - Google Patents

Foerfarande foer framstaellning av antitumoeraktiva 1-asyloximetyl-5-fluoruracilderivat Download PDF

Info

Publication number
FI62071C
FI62071C FI772594A FI772594A FI62071C FI 62071 C FI62071 C FI 62071C FI 772594 A FI772594 A FI 772594A FI 772594 A FI772594 A FI 772594A FI 62071 C FI62071 C FI 62071C
Authority
FI
Finland
Prior art keywords
group
fluorouracil
alkyl group
hydrogen atom
carbon atoms
Prior art date
Application number
FI772594A
Other languages
English (en)
Finnish (fi)
Other versions
FI772594A (fi
FI62071B (fi
Inventor
Shoichiro Ozaki
Yoshimasa Ike
Katsutoshi Ishikawa
Haruki Tamura
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of FI772594A publication Critical patent/FI772594A/fi
Application granted granted Critical
Publication of FI62071B publication Critical patent/FI62071B/fi
Publication of FI62071C publication Critical patent/FI62071C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI772594A 1976-09-06 1977-09-01 Foerfarande foer framstaellning av antitumoeraktiva 1-asyloximetyl-5-fluoruracilderivat FI62071C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10571476A JPS5331676A (en) 1976-09-06 1976-09-06 Uracil derivatives and their preparation
JP10571476 1976-09-06

Publications (3)

Publication Number Publication Date
FI772594A FI772594A (fi) 1978-03-07
FI62071B FI62071B (fi) 1982-07-30
FI62071C true FI62071C (fi) 1982-11-10

Family

ID=14414993

Family Applications (1)

Application Number Title Priority Date Filing Date
FI772594A FI62071C (fi) 1976-09-06 1977-09-01 Foerfarande foer framstaellning av antitumoeraktiva 1-asyloximetyl-5-fluoruracilderivat

Country Status (16)

Country Link
US (1) US4267326A (zh)
JP (1) JPS5331676A (zh)
AU (1) AU513153B2 (zh)
CH (1) CH634567A5 (zh)
DE (1) DE2739912A1 (zh)
DK (1) DK142413B (zh)
FI (1) FI62071C (zh)
FR (1) FR2363563A1 (zh)
GB (1) GB1543467A (zh)
HU (1) HU177482B (zh)
NL (1) NL7709808A (zh)
PH (1) PH14000A (zh)
PL (1) PL108914B1 (zh)
SE (1) SE438856B (zh)
SU (1) SU795468A3 (zh)
ZA (1) ZA775361B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
JPS54122281A (en) * 1978-03-13 1979-09-21 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation
JPS5668674A (en) * 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
JPS5724369A (en) * 1980-07-19 1982-02-08 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative and its preparation
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
WO1985001729A1 (en) * 1983-10-20 1985-04-25 Terumo Kabushiki Kaisha 5-fluorouracil derivatives and medicinal preparation containing same
DK197486A (da) * 1986-04-30 1987-10-31 Ferring Farma Lab 5-fluoruracilprodug
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
EP2445343B1 (en) 2009-06-25 2021-08-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
ES2639065T5 (es) 2009-06-25 2023-01-30 Alkermes Pharma Ireland Ltd Compuestos heterocíclicos para el tratamiento de trastornos neurológicos y psicológicos
EP3718536A1 (en) 2012-09-19 2020-10-07 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
CN112423754A (zh) 2018-03-05 2021-02-26 奥克梅斯制药爱尔兰有限公司 阿立哌唑的给药策略
CN109761915B (zh) * 2019-03-05 2021-12-21 沈阳药科大学 靶向mct1转运体的5-氟尿嘧啶成酯前药

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5324951B2 (zh) * 1973-11-28 1978-07-24
JPS603071B2 (ja) * 1975-02-17 1985-01-25 三井製薬工業株式会社 １−（α−アシロキシアルキル）−５−フルオロウラシル類の製造方法

Also Published As

Publication number Publication date
US4267326A (en) 1981-05-12
FR2363563B1 (zh) 1980-06-20
CH634567A5 (de) 1983-02-15
PH14000A (en) 1980-11-28
DE2739912A1 (de) 1978-03-09
JPS5331676A (en) 1978-03-25
DK142413B (da) 1980-10-27
PL108914B1 (en) 1980-05-31
DK142413C (zh) 1981-03-23
AU513153B2 (en) 1980-11-20
DK394477A (zh) 1978-03-07
AU2857177A (en) 1979-03-15
GB1543467A (en) 1979-04-04
FI772594A (fi) 1978-03-07
FI62071B (fi) 1982-07-30
FR2363563A1 (fr) 1978-03-31
SE7709942L (sv) 1978-03-07
SU795468A3 (ru) 1981-01-07
PL200685A1 (pl) 1978-10-09
JPS6114148B2 (zh) 1986-04-17
HU177482B (en) 1981-10-28
SE438856B (sv) 1985-05-13
ZA775361B (en) 1978-07-26
NL7709808A (nl) 1978-03-08

Similar Documents

Publication Publication Date Title
FI62071C (fi) Foerfarande foer framstaellning av antitumoeraktiva 1-asyloximetyl-5-fluoruracilderivat
RU2718058C2 (ru) Способ синтеза производных рапамицина
FI64372B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 1-substitueradaminometyl-1-etyl-indolo-(2,3-a)-kinolizidiner
FI61886C (fi) Foerfarande foer framstaellning av i tumoerterapi anvaendbara 1-alkylkarbamoyl-5-fluoruraciler
US6794526B2 (en) Process for the preparation of manganese complexes of salen compounds
US4293700A (en) 2,6-Dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid esters and method for preparing same
ES2716748T3 (es) Procedimientos de preparación de compuestos, tales como 3-arilbutanales, útiles en la síntesis de medetomidina
US4287348A (en) Preparation of sulphoalkyl quaternary salts
FI82239B (fi) Framstaellning av aminderivat.
IL30637A (en) Process for the preparation of N-tritilimidazoles
US3906042A (en) Multifunctional hydroxy compounds
EP4249468A1 (en) A method for synthesis of halide salts
FI65991B (fi) Foerfarande foer framstaellning av terapeutiskt vaerdefull 5-((3,4,5-trimetoxifenyl)metyl)-2,4-pyrimidindiamin
CA1122983A (en) Method of producing 5-fluorouracil derivatives
Fisher et al. Some Anionic Cleavage Reactions of Alloxan
JPH0528708B2 (zh)
US4002620A (en) 2-Anilino-4H-3,1-benzothiazines
US3378556A (en) 3, 4, 5, 6-tetrahydro-2-keto-6-phenyl-4, 4, 5-trimethyl-2h-1, 3, 4-oxadiazinium halides
US4189444A (en) Process for the preparation of N,N'-disubstituted 2-naphthaleneethanimidamide and intermediates used therein
USH214H (en) Distillation process for the isolation of 1,1-difluoro(mono- or dihalo)ethoxybenzeneamines
Kiełbasiński et al. Organosulphur compounds: XLVII Alkylation of sulphinic acids by o-alkylisoureas: O-versus s-reactivity and asymmetric synthesis of alkyl sulphinates
EP0005174B1 (de) 2-Methyl-5-(2-hydroxystyryl)-1.3.4-thiadiazol und seine Herstellung
JP3376481B2 (ja) ヘキサヒドロピリダジンの製造法
JPS6159309B2 (zh)
GB2119788A (en) Process for removing 1-sulfonyl groups from benzimidazoles

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: MITSUI TOATSU CHEMICALS INCORPORATED