FI56524C - Nya komogena substrat foer serinproteaser - Google Patents

Nya komogena substrat foer serinproteaser Download PDF

Info

Publication number
FI56524C
FI56524C FI762009A FI762009A FI56524C FI 56524 C FI56524 C FI 56524C FI 762009 A FI762009 A FI 762009A FI 762009 A FI762009 A FI 762009A FI 56524 C FI56524 C FI 56524C
Authority
FI
Finland
Prior art keywords
substrates
group
pna
reaction
enzyme
Prior art date
Application number
FI762009A
Other languages
English (en)
Finnish (fi)
Other versions
FI762009A (ru
FI56524B (fi
Inventor
Bo Thoresson Af Ekenstam
Leif Erik Aurell
Karl Goeran Claeson
Birgitta Gunilla Karlsson
Stig Ingemar Gustavsson
Gun Anita Olausson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of FI762009A publication Critical patent/FI762009A/fi
Publication of FI56524B publication Critical patent/FI56524B/fi
Application granted granted Critical
Publication of FI56524C publication Critical patent/FI56524C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI762009A 1975-07-11 1976-07-09 Nya komogena substrat foer serinproteaser FI56524C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7507974 1975-07-11
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser

Publications (3)

Publication Number Publication Date
FI762009A FI762009A (ru) 1977-01-12
FI56524B FI56524B (fi) 1979-10-31
FI56524C true FI56524C (fi) 1980-02-11

Family

ID=20325115

Family Applications (1)

Application Number Title Priority Date Filing Date
FI762009A FI56524C (fi) 1975-07-11 1976-07-09 Nya komogena substrat foer serinproteaser

Country Status (23)

Country Link
US (1) US4214049A (ru)
JP (1) JPS5224581A (ru)
AT (1) AT349648B (ru)
AU (1) AU497546B2 (ru)
BE (1) BE843969A (ru)
CA (1) CA1081212A (ru)
CH (1) CH622285A5 (ru)
CS (1) CS199631B2 (ru)
DD (1) DD127320A5 (ru)
DE (1) DE2629067A1 (ru)
DK (1) DK146937C (ru)
ES (1) ES449738A1 (ru)
FI (1) FI56524C (ru)
FR (1) FR2317278A1 (ru)
GB (1) GB1510925A (ru)
IL (1) IL49830A (ru)
IT (1) IT1062604B (ru)
NL (1) NL187693C (ru)
NO (1) NO142812C (ru)
PL (1) PL103098B1 (ru)
SE (1) SE407571B (ru)
SU (1) SU700060A3 (ru)
ZA (1) ZA763585B (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
DE2964956D1 (en) * 1978-07-18 1983-04-07 Kabi Ab Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS5537120A (en) * 1978-09-06 1980-03-15 Kanji Tsuchiya Method and device for preparation of food from oilseed
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4327178A (en) 1979-05-01 1982-04-27 University Of Miami Urinary kallikrein assay: specific substrates and assay method
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
JPS57177985U (ru) * 1981-04-30 1982-11-11
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP0182929A1 (de) * 1984-11-26 1986-06-04 American Hospital Supply Corporation Koaktivator zur Aktivierung von Protein C
DE3536903A1 (de) * 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα1−アンチトリプシン測定用化合物
DE3710937A1 (de) * 1987-04-01 1988-10-13 Boehringer Mannheim Gmbh Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) * 1987-07-10 1989-04-28 Yamanouchi Pharmaceut Co Ltd 組織プラスミノーゲンアクチベーター活性の測定法,測定具及び測定用キット
JPH0383093U (ru) * 1989-12-09 1991-08-23
WO1996021740A1 (en) * 1995-01-10 1996-07-18 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
JPWO2021045182A1 (ru) * 2019-09-05 2021-03-11

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (ru) * 1975-06-23 1981-03-31 Pentapharm Ag

Also Published As

Publication number Publication date
NL7607433A (nl) 1977-01-13
NO762406L (ru) 1977-01-12
GB1510925A (en) 1978-05-17
SE407571B (sv) 1979-04-02
DK146937B (da) 1984-02-20
DK146937C (da) 1984-07-30
DD127320A5 (ru) 1977-09-14
US4214049A (en) 1980-07-22
CS199631B2 (en) 1980-07-31
NL187693C (nl) 1991-12-16
SE7507974L (sv) 1977-01-12
JPS5224581A (en) 1977-02-24
FI762009A (ru) 1977-01-12
AU1530476A (en) 1978-01-05
NL187693B (nl) 1991-07-16
DK312776A (da) 1977-01-12
NO142812C (no) 1980-10-22
DE2629067A1 (de) 1977-01-13
SU700060A3 (ru) 1979-11-25
ES449738A1 (es) 1977-12-16
AU497546B2 (en) 1978-12-14
ATA464076A (de) 1978-09-15
AT349648B (de) 1979-04-10
FR2317278B1 (ru) 1981-01-30
JPS5615238B2 (ru) 1981-04-09
BE843969A (fr) 1976-11-03
IL49830A0 (en) 1976-08-31
NO142812B (no) 1980-07-14
PL103098B1 (pl) 1979-05-31
CA1081212A (en) 1980-07-08
IL49830A (en) 1978-12-17
ZA763585B (en) 1977-05-25
IT1062604B (it) 1984-10-20
CH622285A5 (ru) 1981-03-31
FR2317278A1 (fr) 1977-02-04
DE2629067C2 (ru) 1989-08-03
FI56524B (fi) 1979-10-31

Similar Documents

Publication Publication Date Title
FI56524C (fi) Nya komogena substrat foer serinproteaser
US4137225A (en) Novel chromogenic enzyme substrates
US4279810A (en) Easily split substrates for the quantification of proteases
US4061625A (en) Novel chromogenic thrombin substrates
US4457866A (en) Chromogenic compounds and their use as enzyme substrates
US4508644A (en) Chromogenic compounds, a process for their preparation and their use
US4703107A (en) Water-soluble acylated derivatives of peptides or amino acids, their preparation and their use
US4016042A (en) Substrate for the quantitative determination of enzymes
NO142074B (no) Nye kromogene enzymsubstrater for serinproteaser
US4428874A (en) Tripeptide derivatives
US4247454A (en) Novel chromogenic thrombin substrates
FI56525C (fi) Nya kromogena trombinsubstrat
US4568636A (en) Tripeptide derivatives
Filippova et al. Fluorogenic peptide substrates for assay of aspartyl proteinases
US4244865A (en) α hydroxy tripeptide substrates
US4169015A (en) Novel chromogenic thrombin substrates
US5097014A (en) Chromogenic tripeptides
Harnois-Pontoni et al. Hydrosoluble fluorogenic substrates for plasmin
US4434096A (en) Substrates for the quantitative determination of proteolytic enzymes
KR840001485B1 (ko) 펩타이드의 제조방법
Kasafírek et al. N-Acylated phenylalanine p-nitroanilides: New substrates for chymotrypsin
EP0513863B1 (en) Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
JPH0244839B2 (ru)

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: AKTIEBOLAGET KABI