SE407571B - Nya kromogena enzymsubstrat for serinproteaser - Google Patents

Nya kromogena enzymsubstrat for serinproteaser

Info

Publication number
SE407571B
SE407571B SE7507974A SE7507974A SE407571B SE 407571 B SE407571 B SE 407571B SE 7507974 A SE7507974 A SE 7507974A SE 7507974 A SE7507974 A SE 7507974A SE 407571 B SE407571 B SE 407571B
Authority
SE
Sweden
Prior art keywords
substrates
group
omm
reaction
pna
Prior art date
Application number
SE7507974A
Other languages
English (en)
Swedish (sv)
Other versions
SE7507974L (sv
Inventor
L E Aurell
K G Claeson
B G Karlsson
S I Gustavsson
G A Olausson
Af Ekenstam B Thuresson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Priority to SE7507974A priority Critical patent/SE407571B/sv
Priority to ZA763585A priority patent/ZA763585B/xx
Priority to IL49830A priority patent/IL49830A/xx
Priority to GB25411/76A priority patent/GB1510925A/en
Priority to AT464076A priority patent/AT349648B/de
Priority to AU15304/76A priority patent/AU497546B2/en
Priority to DE19762629067 priority patent/DE2629067A1/de
Priority to NLAANVRAGE7607433,A priority patent/NL187693C/xx
Priority to CS764543A priority patent/CS199631B2/cs
Priority to FI762009A priority patent/FI56524C/fi
Priority to FR7621195A priority patent/FR2317278A1/fr
Priority to PL1976191067A priority patent/PL103098B1/pl
Priority to ES449738A priority patent/ES449738A1/es
Priority to DK312776A priority patent/DK146937C/da
Priority to CA256,705A priority patent/CA1081212A/en
Priority to SU762379653A priority patent/SU700060A3/ru
Priority to BE168773A priority patent/BE843969A/xx
Priority to DD193794A priority patent/DD127320A5/xx
Priority to IT50363/76A priority patent/IT1062604B/it
Priority to NO762406A priority patent/NO142812C/no
Priority to CH887176A priority patent/CH622285A5/de
Priority to JP51082441A priority patent/JPS5224581A/ja
Publication of SE7507974L publication Critical patent/SE7507974L/
Priority to US05/888,586 priority patent/US4137225A/en
Priority to US05/955,441 priority patent/US4214049A/en
Publication of SE407571B publication Critical patent/SE407571B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE7507974A 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser SE407571B (sv)

Priority Applications (24)

Application Number Priority Date Filing Date Title
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser
ZA763585A ZA763585B (en) 1975-07-11 1976-06-16 Novel chromogenic enzyme substrates
IL49830A IL49830A (en) 1975-07-11 1976-06-17 Chromogenic enzyme substrates
GB25411/76A GB1510925A (en) 1975-07-11 1976-06-18 Chromogenic enzyme substrates
AT464076A AT349648B (de) 1975-07-11 1976-06-25 Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden
AU15304/76A AU497546B2 (en) 1975-07-11 1976-06-25 Chromogenic enzyme substrate
DE19762629067 DE2629067A1 (de) 1975-07-11 1976-06-29 Chromogene enzymsubstrate
NLAANVRAGE7607433,A NL187693C (nl) 1975-07-11 1976-07-06 Werkwijze ter bereiding van een diagnostisch actief chromogeen substraat.
CS764543A CS199631B2 (en) 1975-07-11 1976-07-08 Method of producing new chromogen enzyme substrate
PL1976191067A PL103098B1 (pl) 1975-07-11 1976-07-09 Sposob wytwarzania nowych chromogennych odczynnikow diagnostycznych do oznaczania enzymow
IT50363/76A IT1062604B (it) 1975-07-11 1976-07-09 Substrato enzimatico cromogeno
FI762009A FI56524C (fi) 1975-07-11 1976-07-09 Nya komogena substrat foer serinproteaser
ES449738A ES449738A1 (es) 1975-07-11 1976-07-09 Procedimiento de obtencion de nuevos sustratos de enzimas cromogenicas.
DK312776A DK146937C (da) 1975-07-11 1976-07-09 Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat for serinproteaser
CA256,705A CA1081212A (en) 1975-07-11 1976-07-09 Chromogenic enzyme substrates
SU762379653A SU700060A3 (ru) 1975-07-11 1976-07-09 Способ получени пептидов или их солей
BE168773A BE843969A (fr) 1975-07-11 1976-07-09 Nouveaux substrats chromogenes d'enzymes
DD193794A DD127320A5 (ru) 1975-07-11 1976-07-09
FR7621195A FR2317278A1 (fr) 1975-07-11 1976-07-09 Nouveaux substrats enzymatiques chromogenes
NO762406A NO142812C (no) 1975-07-11 1976-07-09 Nye diagnostisk aktive kromogene enzymsubstrater
CH887176A CH622285A5 (ru) 1975-07-11 1976-07-09
JP51082441A JPS5224581A (en) 1975-07-11 1976-07-10 Novel colorrproducing enzymatic substrate
US05/888,586 US4137225A (en) 1975-07-11 1978-03-20 Novel chromogenic enzyme substrates
US05/955,441 US4214049A (en) 1975-07-11 1978-10-27 Assay of serine proteases using novel chromogenic enzyme substrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser

Publications (2)

Publication Number Publication Date
SE7507974L SE7507974L (sv) 1977-01-12
SE407571B true SE407571B (sv) 1979-04-02

Family

ID=20325115

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser

Country Status (23)

Country Link
US (1) US4214049A (ru)
JP (1) JPS5224581A (ru)
AT (1) AT349648B (ru)
AU (1) AU497546B2 (ru)
BE (1) BE843969A (ru)
CA (1) CA1081212A (ru)
CH (1) CH622285A5 (ru)
CS (1) CS199631B2 (ru)
DD (1) DD127320A5 (ru)
DE (1) DE2629067A1 (ru)
DK (1) DK146937C (ru)
ES (1) ES449738A1 (ru)
FI (1) FI56524C (ru)
FR (1) FR2317278A1 (ru)
GB (1) GB1510925A (ru)
IL (1) IL49830A (ru)
IT (1) IT1062604B (ru)
NL (1) NL187693C (ru)
NO (1) NO142812C (ru)
PL (1) PL103098B1 (ru)
SE (1) SE407571B (ru)
SU (1) SU700060A3 (ru)
ZA (1) ZA763585B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000252A1 (en) * 1978-07-18 1980-02-21 Kabi Ab Bradykinin-inhibiting tripeptide derivatives

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS5537120A (en) * 1978-09-06 1980-03-15 Kanji Tsuchiya Method and device for preparation of food from oilseed
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4327178A (en) 1979-05-01 1982-04-27 University Of Miami Urinary kallikrein assay: specific substrates and assay method
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
JPS57177985U (ru) * 1981-04-30 1982-11-11
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP0182929A1 (de) * 1984-11-26 1986-06-04 American Hospital Supply Corporation Koaktivator zur Aktivierung von Protein C
DE3536903A1 (de) * 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα１−アンチトリプシン測定用化合物
DE3710937A1 (de) * 1987-04-01 1988-10-13 Boehringer Mannheim Gmbh Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) * 1987-07-10 1989-04-28 Yamanouchi Pharmaceut Co Ltd 組織プラスミノーゲンアクチベーター活性の測定法，測定具及び測定用キット
JPH0383093U (ru) * 1989-12-09 1991-08-23
WO1996021740A1 (en) * 1995-01-10 1996-07-18 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
JPWO2021045182A1 (ru) * 2019-09-05 2021-03-11

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (ru) * 1975-06-23 1981-03-31 Pentapharm Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000252A1 (en) * 1978-07-18 1980-02-21 Kabi Ab Bradykinin-inhibiting tripeptide derivatives

Also Published As

Publication number Publication date
NL7607433A (nl) 1977-01-13
NO762406L (ru) 1977-01-12
GB1510925A (en) 1978-05-17
DK146937B (da) 1984-02-20
DK146937C (da) 1984-07-30
DD127320A5 (ru) 1977-09-14
US4214049A (en) 1980-07-22
CS199631B2 (en) 1980-07-31
NL187693C (nl) 1991-12-16
SE7507974L (sv) 1977-01-12
JPS5224581A (en) 1977-02-24
FI762009A (ru) 1977-01-12
AU1530476A (en) 1978-01-05
NL187693B (nl) 1991-07-16
DK312776A (da) 1977-01-12
NO142812C (no) 1980-10-22
DE2629067A1 (de) 1977-01-13
SU700060A3 (ru) 1979-11-25
ES449738A1 (es) 1977-12-16
AU497546B2 (en) 1978-12-14
ATA464076A (de) 1978-09-15
AT349648B (de) 1979-04-10
FR2317278B1 (ru) 1981-01-30
JPS5615238B2 (ru) 1981-04-09
BE843969A (fr) 1976-11-03
IL49830A0 (en) 1976-08-31
NO142812B (no) 1980-07-14
PL103098B1 (pl) 1979-05-31
CA1081212A (en) 1980-07-08
IL49830A (en) 1978-12-17
ZA763585B (en) 1977-05-25
IT1062604B (it) 1984-10-20
CH622285A5 (ru) 1981-03-31
FR2317278A1 (fr) 1977-02-04
DE2629067C2 (ru) 1989-08-03
FI56524B (fi) 1979-10-31
FI56524C (fi) 1980-02-11

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