FI120391B - Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä - Google Patents

Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä Download PDF

Info

Publication number
FI120391B
FI120391B FI960688A FI960688A FI120391B FI 120391 B FI120391 B FI 120391B FI 960688 A FI960688 A FI 960688A FI 960688 A FI960688 A FI 960688A FI 120391 B FI120391 B FI 120391B
Authority
FI
Finland
Prior art keywords
atoms
sulfonylamino
acid
formula
methylaminothiocarbonyl
Prior art date
Application number
FI960688A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960688A0 (fi
FI960688A (fi
Inventor
Joachim Kaiser
Dieter Mania
Heinrich Englert
Heinz Goegelein
Uwe Gerlach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19505398A external-priority patent/DE19505398A1/de
Priority claimed from DE19522920A external-priority patent/DE19522920A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI960688A0 publication Critical patent/FI960688A0/fi
Publication of FI960688A publication Critical patent/FI960688A/fi
Application granted granted Critical
Publication of FI120391B publication Critical patent/FI120391B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42Sulfonylthioureas; Sulfonylisothioureas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52Y being a hetero atom
    • C07C311/54Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI960688A 1995-02-17 1996-02-15 Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä FI120391B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19505398 1995-02-17
DE19505398A DE19505398A1 (de) 1995-02-17 1995-02-17 Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und Verwendung pharmazeutischer Präparate auf Basis dieser Verbindungen sowie sie enthaltende Heilmittel
DE19522920 1995-06-23
DE19522920A DE19522920A1 (de) 1995-06-23 1995-06-23 Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und Verwendung pharmazeutischer Präparate auf Basis dieser Verbindungen sowie sie enthaltende Heilmittel

Publications (3)

Publication Number Publication Date
FI960688A0 FI960688A0 (fi) 1996-02-15
FI960688A FI960688A (fi) 1996-08-18
FI120391B true FI120391B (fi) 2009-10-15

Family

ID=26012537

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960688A FI120391B (fi) 1995-02-17 1996-02-15 Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä

Country Status (29)

Country Link
US (2) US5880155A (pl)
EP (1) EP0727417B1 (pl)
JP (1) JP3905573B2 (pl)
KR (1) KR100432259B1 (pl)
CN (1) CN1060162C (pl)
AR (1) AR002708A1 (pl)
AT (1) ATE199541T1 (pl)
AU (1) AU700254B2 (pl)
BR (1) BR9600779A (pl)
CA (1) CA2169696C (pl)
CZ (1) CZ291793B6 (pl)
DE (1) DE59606531D1 (pl)
DK (1) DK0727417T3 (pl)
ES (1) ES2155546T3 (pl)
FI (1) FI120391B (pl)
GR (1) GR3035710T3 (pl)
HR (1) HRP960076B1 (pl)
HU (1) HU226462B1 (pl)
IL (1) IL117152A (pl)
MY (1) MY115795A (pl)
NO (1) NO305795B1 (pl)
NZ (1) NZ280992A (pl)
PL (1) PL181792B1 (pl)
PT (1) PT727417E (pl)
RU (1) RU2198872C2 (pl)
SI (1) SI9600050B (pl)
SK (1) SK282131B6 (pl)
TR (1) TR199600117A2 (pl)
TW (1) TW357141B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
PL335052A1 (en) * 1997-01-29 2000-03-27 Pfizer Derivatives of sulphonylurea and their application in regulating activity of interleukin-1
DE19832009A1 (de) 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
DE10129704A1 (de) * 2001-06-22 2003-01-02 Aventis Pharma Gmbh Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
KR20090006237A (ko) 2004-11-22 2009-01-14 일라이 릴리 앤드 캄파니 글루타메이트 수용체의 증강제
CN104649945B (zh) * 2015-02-05 2017-02-22 中国农业大学 一种磺酰脲类、磺酰胺基甲酸酯类化合物的制备方法
WO2023020412A1 (zh) * 2021-08-16 2023-02-23 中国科学院上海药物研究所 磺酰脲化合物、制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1198354B (de) * 1963-09-25 1965-08-12 Hoechst Ag Verfahren zur Herstellung von Benzol-sulfonylharnstoffen
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
BE754454A (fr) * 1969-08-06 1971-02-05 Bayer Ag Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
ES2098069T3 (es) * 1993-02-23 1997-04-16 Hoechst Ag Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.

Also Published As

Publication number Publication date
HRP960076B1 (en) 2001-12-31
AR002708A1 (es) 1998-04-29
CN1134415A (zh) 1996-10-30
SI9600050B (en) 2001-12-31
EP0727417A1 (de) 1996-08-21
HUT73982A (en) 1996-10-28
AU4555996A (en) 1996-08-29
IL117152A0 (en) 1996-06-18
CN1060162C (zh) 2001-01-03
TW357141B (en) 1999-05-01
KR960031432A (ko) 1996-09-17
ATE199541T1 (de) 2001-03-15
DE59606531D1 (de) 2001-04-12
NO305795B1 (no) 1999-07-26
GR3035710T3 (en) 2001-07-31
TR199600117A2 (tr) 1996-10-21
SK282131B6 (sk) 2001-11-06
PL181792B1 (pl) 2001-09-28
CA2169696C (en) 2008-09-02
PL312530A1 (en) 1996-08-19
NO960628D0 (no) 1996-02-16
AU700254B2 (en) 1998-12-24
BR9600779A (pt) 1997-12-23
EP0727417B1 (de) 2001-03-07
KR100432259B1 (ko) 2004-09-18
CZ291793B6 (cs) 2003-05-14
FI960688A0 (fi) 1996-02-15
NZ280992A (en) 1996-10-28
CA2169696A1 (en) 1996-08-18
MY115795A (en) 2003-09-30
JPH08245556A (ja) 1996-09-24
JP3905573B2 (ja) 2007-04-18
DK0727417T3 (da) 2001-07-09
PT727417E (pt) 2001-08-30
IL117152A (en) 2002-07-25
HU226462B1 (en) 2008-12-29
RU2198872C2 (ru) 2003-02-20
ES2155546T3 (es) 2001-05-16
US5977177A (en) 1999-11-02
HRP960076A2 (en) 1997-12-31
NO960628L (no) 1996-08-19
US5880155A (en) 1999-03-09
HU9503877D0 (en) 1996-02-28
CZ43596A3 (en) 1996-09-11
SI9600050A (en) 1996-10-31
FI960688A (fi) 1996-08-18
SK21296A3 (en) 1996-10-02

Similar Documents

Publication Publication Date Title
FI114152B (fi) Menetelmä terapeuttisesti käyttökelpoisten substituoitujen bentseenisulfonyylivirtsa-aineiden ja -tiovirtsa-aineiden valmistamiseksi
FI120391B (fi) Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä
FI120393B (fi) Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke
FI120392B (fi) Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö farmaseuttisten valmisteiden valmistukseen ja niitä sisältäviä lääkkeitä
FI107917B (fi) Menetelmä terapeuttisesti käyttökelpoisten 2-okso-3-pyrrolinyylikarboksiamidoetyylibentseenisulfonyylivirtsa-aine- ja tiovirtsa-ainejohdannaisten valmistamiseksi
JP4132115B2 (ja) 置換されたクロマニルスルホニル(チオ)尿素、それらの製法、医薬製剤におけるそれらの使用およびそれらを含有する医薬製剤

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120391

Country of ref document: FI

MM Patent lapsed