FI120145B - Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi - Google Patents
Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi Download PDFInfo
- Publication number
- FI120145B FI120145B FI960722A FI960722A FI120145B FI 120145 B FI120145 B FI 120145B FI 960722 A FI960722 A FI 960722A FI 960722 A FI960722 A FI 960722A FI 120145 B FI120145 B FI 120145B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- group
- hydrogen
- pyrimidinyl
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202445 | 1993-08-19 | ||
| EP93202444 | 1993-08-19 | ||
| EP93202444 | 1993-08-19 | ||
| EP93202445 | 1993-08-19 | ||
| PCT/EP1994/002702 WO1995005366A1 (en) | 1993-08-19 | 1994-08-12 | Vasoconstrictive substituted aryloxyalkyl diamines |
| EP9402702 | 1994-08-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI960722A0 FI960722A0 (fi) | 1996-02-16 |
| FI960722A FI960722A (fi) | 1996-02-16 |
| FI120145B true FI120145B (fi) | 2009-07-15 |
Family
ID=26133971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI960722A FI120145B (fi) | 1993-08-19 | 1996-02-16 | Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5677310A (zh) |
| EP (1) | EP0714388B1 (zh) |
| JP (1) | JP3659969B2 (zh) |
| KR (1) | KR100345046B1 (zh) |
| CN (1) | CN1066718C (zh) |
| AT (1) | ATE165091T1 (zh) |
| AU (1) | AU682396B2 (zh) |
| BR (1) | BR9407313A (zh) |
| CA (1) | CA2168023C (zh) |
| CZ (1) | CZ39396A3 (zh) |
| DE (1) | DE69409652T2 (zh) |
| FI (1) | FI120145B (zh) |
| HU (1) | HU222275B1 (zh) |
| IL (1) | IL110689A (zh) |
| NO (1) | NO305283B1 (zh) |
| NZ (1) | NZ271994A (zh) |
| PL (1) | PL179008B1 (zh) |
| RU (1) | RU2158126C2 (zh) |
| SK (1) | SK21596A3 (zh) |
| WO (1) | WO1995005366A1 (zh) |
| ZA (1) | ZA946270B (zh) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507288D0 (en) * | 1995-04-07 | 1995-05-31 | Sod Conseils Rech Applic | Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors |
| FR2753967B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| WO2006034474A2 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| JP5366269B2 (ja) | 2007-09-14 | 2013-12-11 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １，３−二置換４−（アリル−ｘ−フェニル）−１ｈ−ピリジン−２−オン |
| US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
| CN101801930B (zh) * | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
| US8785486B2 (en) * | 2007-11-14 | 2014-07-22 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
| SG10201402250TA (en) | 2009-05-12 | 2014-07-30 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| WO2012062750A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| RU2720237C2 (ru) | 2013-11-18 | 2020-04-28 | Форма Терапеутикс, Инк. | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет |
| ES2860695T3 (es) | 2013-11-18 | 2021-10-05 | Forma Therapeutics Inc | Composiciones de tetrahidroquinolina como inhibidores de bromodominio BET |
| EA201891617A3 (ru) | 2014-01-21 | 2019-04-30 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
| HUE053734T2 (hu) | 2014-01-21 | 2021-07-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
| US5231166A (en) * | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
| US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
| FR2675799B1 (fr) * | 1991-04-24 | 1993-12-24 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| FR2697253B1 (fr) * | 1992-10-22 | 1994-12-02 | Synthelabo | Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. |
-
1994
- 1994-08-12 CN CN94193180A patent/CN1066718C/zh not_active Expired - Lifetime
- 1994-08-12 CA CA002168023A patent/CA2168023C/en not_active Expired - Lifetime
- 1994-08-12 DE DE69409652T patent/DE69409652T2/de not_active Expired - Lifetime
- 1994-08-12 RU RU96105988/14A patent/RU2158126C2/ru active
- 1994-08-12 BR BR9407313A patent/BR9407313A/pt not_active Application Discontinuation
- 1994-08-12 AT AT94926190T patent/ATE165091T1/de not_active IP Right Cessation
- 1994-08-12 SK SK215-96A patent/SK21596A3/sk unknown
- 1994-08-12 HU HU9600349A patent/HU222275B1/hu active IP Right Grant
- 1994-08-12 PL PL94313081A patent/PL179008B1/pl unknown
- 1994-08-12 AU AU76130/94A patent/AU682396B2/en not_active Expired
- 1994-08-12 JP JP50675195A patent/JP3659969B2/ja not_active Expired - Lifetime
- 1994-08-12 NZ NZ271994A patent/NZ271994A/en not_active IP Right Cessation
- 1994-08-12 EP EP94926190A patent/EP0714388B1/en not_active Expired - Lifetime
- 1994-08-12 WO PCT/EP1994/002702 patent/WO1995005366A1/en not_active Application Discontinuation
- 1994-08-12 CZ CZ96393A patent/CZ39396A3/cs unknown
- 1994-08-12 US US08/612,849 patent/US5677310A/en not_active Expired - Lifetime
- 1994-08-12 KR KR1019960700634A patent/KR100345046B1/ko not_active IP Right Cessation
- 1994-08-17 IL IL11068994A patent/IL110689A/en not_active IP Right Cessation
- 1994-08-18 ZA ZA946270A patent/ZA946270B/xx unknown
-
1996
- 1996-02-16 FI FI960722A patent/FI120145B/fi not_active IP Right Cessation
- 1996-02-19 NO NO960648A patent/NO305283B1/no not_active IP Right Cessation
-
1997
- 1997-06-02 US US08/867,870 patent/US5801179A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ271994A (en) | 1997-06-24 |
| NO960648D0 (no) | 1996-02-19 |
| CA2168023A1 (en) | 1995-02-23 |
| US5801179A (en) | 1998-09-01 |
| PL179008B1 (pl) | 2000-07-31 |
| SK21596A3 (en) | 1997-03-05 |
| WO1995005366A1 (en) | 1995-02-23 |
| US5677310A (en) | 1997-10-14 |
| CN1129935A (zh) | 1996-08-28 |
| FI960722A0 (fi) | 1996-02-16 |
| AU7613094A (en) | 1995-03-14 |
| CN1066718C (zh) | 2001-06-06 |
| CZ39396A3 (en) | 1996-05-15 |
| RU2158126C2 (ru) | 2000-10-27 |
| AU682396B2 (en) | 1997-10-02 |
| ATE165091T1 (de) | 1998-05-15 |
| ZA946270B (en) | 1996-02-19 |
| PL313081A1 (en) | 1996-05-27 |
| HU9600349D0 (en) | 1996-04-29 |
| DE69409652D1 (de) | 1998-05-20 |
| KR100345046B1 (ko) | 2002-12-05 |
| HUT73977A (en) | 1996-10-28 |
| JPH09502962A (ja) | 1997-03-25 |
| IL110689A0 (en) | 1994-11-11 |
| IL110689A (en) | 1998-12-27 |
| NO960648L (no) | 1996-02-19 |
| CA2168023C (en) | 2006-10-24 |
| BR9407313A (pt) | 1996-10-08 |
| DE69409652T2 (de) | 1998-10-15 |
| JP3659969B2 (ja) | 2005-06-15 |
| FI960722A (fi) | 1996-02-16 |
| EP0714388B1 (en) | 1998-04-15 |
| NO305283B1 (no) | 1999-05-03 |
| EP0714388A1 (en) | 1996-06-05 |
| HU222275B1 (hu) | 2003-05-28 |
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| Date | Code | Title | Description |
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| FG | Patent granted |
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| MA | Patent expired |