FI120145B - Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi - Google Patents

Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi Download PDF

Info

Publication number
FI120145B
FI120145B FI960722A FI960722A FI120145B FI 120145 B FI120145 B FI 120145B FI 960722 A FI960722 A FI 960722A FI 960722 A FI960722 A FI 960722A FI 120145 B FI120145 B FI 120145B
Authority
FI
Finland
Prior art keywords
formula
group
hydrogen
pyrimidinyl
ethyl
Prior art date
Application number
FI960722A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960722A0 (fi
FI960722A (fi
Inventor
Bruyn Marcel Frans Leopold De
Lommen Guy Rosalia Eugene Van
Piet Tom Bert Paul Wigerinck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI960722A0 publication Critical patent/FI960722A0/fi
Publication of FI960722A publication Critical patent/FI960722A/fi
Application granted granted Critical
Publication of FI120145B publication Critical patent/FI120145B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12Nitrogen atoms not forming part of a nitro radical
    • C07D239/14Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D411/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI960722A 1993-08-19 1996-02-16 Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi FI120145B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP93202444 1993-08-19
EP93202445 1993-08-19
EP93202444 1993-08-19
EP93202445 1993-08-19
EP9402702 1994-08-12
PCT/EP1994/002702 WO1995005366A1 (en) 1993-08-19 1994-08-12 Vasoconstrictive substituted aryloxyalkyl diamines

Publications (3)

Publication Number Publication Date
FI960722A0 FI960722A0 (fi) 1996-02-16
FI960722A FI960722A (fi) 1996-02-16
FI120145B true FI120145B (fi) 2009-07-15

Family

ID=26133971

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960722A FI120145B (fi) 1993-08-19 1996-02-16 Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi

Country Status (21)

Country Link
US (2) US5677310A (zh)
EP (1) EP0714388B1 (zh)
JP (1) JP3659969B2 (zh)
KR (1) KR100345046B1 (zh)
CN (1) CN1066718C (zh)
AT (1) ATE165091T1 (zh)
AU (1) AU682396B2 (zh)
BR (1) BR9407313A (zh)
CA (1) CA2168023C (zh)
CZ (1) CZ39396A3 (zh)
DE (1) DE69409652T2 (zh)
FI (1) FI120145B (zh)
HU (1) HU222275B1 (zh)
IL (1) IL110689A (zh)
NO (1) NO305283B1 (zh)
NZ (1) NZ271994A (zh)
PL (1) PL179008B1 (zh)
RU (1) RU2158126C2 (zh)
SK (1) SK21596A3 (zh)
WO (1) WO1995005366A1 (zh)
ZA (1) ZA946270B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9507288D0 (en) * 1995-04-07 1995-05-31 Sod Conseils Rech Applic Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors
FR2753967B1 (fr) * 1996-09-27 1998-11-27 Sod Conseils Rech Applic Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
RU2007110731A (ru) * 2004-09-23 2008-10-27 Редди Юс Терапевтикс Новые соединения пиримидина, способ их получения и содержащие их композиции
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
AU2008297877C1 (en) * 2007-09-14 2013-11-07 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
CA2704436C (en) * 2007-11-14 2016-01-05 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ, インコーポレイテッド. 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
PT2430022E (pt) 2009-05-12 2013-12-26 Janssen Pharmaceuticals Inc Derivados de 1,2,3-triazolo[4,3-a]piridina e a sua utilização para o tratamento ou prevenção de doenças neurológicas e psiquiátricas
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
EP3071203B1 (en) 2013-11-18 2020-12-23 Forma Therapeutics, Inc. Tetrahydroquinoline compositions as bet bromodomain inhibitors
WO2015074081A1 (en) 2013-11-18 2015-05-21 Bair Kenneth W Benzopiperazine compositions as bet bromodomain inhibitors
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3023369A1 (de) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4593039A (en) * 1984-04-02 1986-06-03 Merck & Co., Inc. 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US5231166A (en) * 1988-10-25 1993-07-27 Takeda Chemical Industries, Ltd. Endothelin
US5399581A (en) * 1990-12-26 1995-03-21 Laragh; John H. Method and compositions for treatment of sexual impotence
FR2675799B1 (fr) * 1991-04-24 1993-12-24 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2697253B1 (fr) * 1992-10-22 1994-12-02 Synthelabo Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
KR100345046B1 (ko) 2002-12-05
CZ39396A3 (en) 1996-05-15
NO960648D0 (no) 1996-02-19
PL313081A1 (en) 1996-05-27
CN1129935A (zh) 1996-08-28
ATE165091T1 (de) 1998-05-15
CN1066718C (zh) 2001-06-06
IL110689A0 (en) 1994-11-11
PL179008B1 (pl) 2000-07-31
AU682396B2 (en) 1997-10-02
HU222275B1 (hu) 2003-05-28
ZA946270B (en) 1996-02-19
IL110689A (en) 1998-12-27
HUT73977A (en) 1996-10-28
RU2158126C2 (ru) 2000-10-27
US5677310A (en) 1997-10-14
BR9407313A (pt) 1996-10-08
JP3659969B2 (ja) 2005-06-15
FI960722A0 (fi) 1996-02-16
CA2168023A1 (en) 1995-02-23
NO960648L (no) 1996-02-19
AU7613094A (en) 1995-03-14
EP0714388B1 (en) 1998-04-15
JPH09502962A (ja) 1997-03-25
EP0714388A1 (en) 1996-06-05
DE69409652T2 (de) 1998-10-15
DE69409652D1 (de) 1998-05-20
HU9600349D0 (en) 1996-04-29
WO1995005366A1 (en) 1995-02-23
SK21596A3 (en) 1997-03-05
US5801179A (en) 1998-09-01
NO305283B1 (no) 1999-05-03
NZ271994A (en) 1997-06-24
FI960722A (fi) 1996-02-16
CA2168023C (en) 2006-10-24

Similar Documents

Publication Publication Date Title
FI120145B (fi) Menetelmä verisuonia supistavien substituoitujen aryylioksialkyylidiamiinien valmistamiseksi
US6642224B1 (en) Diazepan derivatives or salts thereof
JP3834098B2 (ja) ベンゾニトリル類およびベンゾフルオリド類
JP5540087B2 (ja) P2x3および/またはp2x2/3アンタゴニストとしての、新規なインドール、インダゾールおよびベンゾイミダゾールアリールアミド
WO2018084321A1 (ja) Egfr阻害及び腫瘍治療に有用な新規化合物
JP2014040426A (ja) [5−(4,6−ジメチル−1h−ベンゾイミダゾール−2−イル)−4−メチル−ピリミジン−2−イル]−[3−(1−メチル−ピペリジン−4−イル)−プロピル]−アミンの結晶性ヘミタートレート
ZA200603472B (en) Bicyclo[3.1.1]heptane substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
JP4740114B2 (ja) クロメノンインドール
JP2007529553A (ja) N−アリール−ピペラジン誘導体を調製する方法
US20120157482A1 (en) Compounds and methods
FI113774B (fi) Verisuonia supistavat substituoidut 2,3-dihydro-1,4-dioksinopyridiinit
TWI697496B (zh) 咪唑二氮呯化合物
FI113773B (fi) Menetelmä verisuonia supistavien substituoitujen dihydropyranopyridiinien valmistamiseksi
WO2013064029A1 (zh) 具有抗癌活性的苯甲酰脲衍生物及其制备方法和用途
US6486164B2 (en) 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
AU2022326885A1 (en) Small molecule urea derivatives as sting antagonists
JP2000007671A (ja) 2,3−ジヒドロベンゾフラン誘導体
US7834032B2 (en) Piperidine derivatives
CN116710463A (zh) 用于抑制nav1.8电压门控钠通道和治疗nav1.8介导的疾病的化学化合物
MXPA06010720A (en) Process for preparing n-aryl-piperazine derivatives cross-reference to related applications

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120145

Country of ref document: FI

MA Patent expired