FI117513B - Förfarande för odling av PRRS-virus och användning därav i vacciner - Google Patents

Förfarande för odling av PRRS-virus och användning därav i vacciner Download PDF

Info

Publication number
FI117513B
FI117513B FI953731A FI953731A FI117513B FI 117513 B FI117513 B FI 117513B FI 953731 A FI953731 A FI 953731A FI 953731 A FI953731 A FI 953731A FI 117513 B FI117513 B FI 117513B
Authority
FI
Finland
Prior art keywords
prrsv
virus
prrs
tissue culture
cell line
Prior art date
Application number
FI953731A
Other languages
English (en)
Finnish (fi)
Other versions
FI953731A (sv
FI953731A0 (sv
Inventor
Thomas Sanderson
Michael J Mcginley
Jeffrey J Zimmerman
Howard T Hill
Michael C Meetz
Eugene C Pirtle
Sabrina L Swenson
George P Shibley
Original Assignee
Univ Iowa State Res Found Inc
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Iowa State Res Found Inc, Bayer Corp filed Critical Univ Iowa State Res Found Inc
Publication of FI953731A publication Critical patent/FI953731A/sv
Publication of FI953731A0 publication Critical patent/FI953731A0/sv
Application granted granted Critical
Publication of FI117513B publication Critical patent/FI117513B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/815—Viral vaccine for porcine species, e.g. swine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (9)

1. Förfarande för tillväxt av PRRSV in en vävnads-odling, som är känslig för infektion, för replikation av 5 viruset i en tillräcklig mängd för att skydda djur mot PRRS eller för att användas vid diagnos av PRRS eller för identifiering av molekylstrukturen hos PRRSV vid utveck-ling av rekombinanta produkter, kännetecknat av att förfarandet innefattar att ett under depositionsnummer 10 ATCC VR 2402 deponerat PRRSV-isolat ympas pä vävnadsod- lingen och replikerade virus tillvaratas.
2. Förfarande enligt patentkrav 1, kännetecknat av att vävnadsodlingen innefattar en cellinje.
3. Förfarande enligt patentkrav 2, känneteck-15 n at av att vävnadsodlingen är en grönapa njurcellinje.
4. Förfarande enligt patentkrav 3, kanne tee k- ’ V nat av att grönapa njurcellinjen är av typ som designeras som MA 104(M).
5. Förfarande enligt patentkrav 4, känneteck-20 nat av att cellinjen är en klon av en grönapa cellinje, som designeras som 9009B.
***** 6. Vävnadsodling, kännetecknad av att den in- • t » • \S nehäller ett PRRSV-isolat som är deponerat under deposi- Γ1.. tionsnummer ATCC VR 2404. • ·*·1· 25
7. Vävnadsodling enligt patentkrav 6 i en kommer- • * ϊ siell skala > 25 1 som FAID50 titer > 105'°/ml. • · · * 1 * 1
8. Förfarande för framställning av ett vaeein, som • * « effektivt skyddar svin mot PRRS kännetecknat av att ett , PRRSV-isolat deponerat under depositionsnummer ATCC VR * i 1 30 2404 tillhandahälls, viruset frän vävnadsodlingsceller :·. • * *·"1 frigörs och den antigena massan justeras genom utspädning, !*:1: koncentration eller extraktion för att producera en immu- « « ·***· nologiskt effektivt mängd av den antigena massan för en ..1 modifierad levande (attenuerad) , inaktiv, underenhets- el- • 1·· * t 35 ler rekombinant formulering. · ; ϊ 21 117513
9. Förfarande för adaptering av PRRSV för produktion av ett modifierat levande eller attenuerat vaccin kännetecknat av att ett PRRSV-isolat deponerat under deposit ionsnuiraner ATCC VR 2404 passeras forcerat genom icke-5 värdceller och cellinjer tills viruset inte längre orsakar symptom av PRRS. • , , , .‘'ΐί ··»«* • · t · · • * · • « M • · • ·· • · · • · · • · • · • * • · · • · · . ···· * · · * · · • · · * ♦ · ··· • · · • · • · ··· • · • · · • * · • · ♦·· • · ··..' • « ··* • ... -• · > • * • ·· **·«· • ·
FI953731A 1993-02-08 1995-08-04 Förfarande för odling av PRRS-virus och användning därav i vacciner FI117513B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1491593A 1993-02-08 1993-02-08
US1491593 1993-02-08
US9400951 1994-01-26
PCT/US1994/000951 WO1994018311A1 (en) 1993-02-08 1994-01-26 Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines

Publications (3)

Publication Number Publication Date
FI953731A FI953731A (sv) 1995-08-04
FI953731A0 FI953731A0 (sv) 1995-08-04
FI117513B true FI117513B (sv) 2006-11-15

Family

ID=21768529

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953731A FI117513B (sv) 1993-02-08 1995-08-04 Förfarande för odling av PRRS-virus och användning därav i vacciner

Country Status (21)

Country Link
US (2) US5510258A (sv)
EP (1) EP0683816B1 (sv)
JP (1) JP3710095B2 (sv)
KR (1) KR100374295B1 (sv)
CN (1) CN1080300C (sv)
AT (1) ATE197314T1 (sv)
AU (1) AU681874B2 (sv)
BG (1) BG63170B1 (sv)
CZ (1) CZ289743B6 (sv)
DE (1) DE69426228T2 (sv)
DK (1) DK0683816T3 (sv)
ES (1) ES2152304T3 (sv)
FI (1) FI117513B (sv)
GR (1) GR3035257T3 (sv)
HU (1) HU218430B (sv)
NO (1) NO317662B1 (sv)
NZ (1) NZ261992A (sv)
PL (1) PL178609B1 (sv)
PT (1) PT683816E (sv)
SK (1) SK98695A3 (sv)
WO (1) WO1994018311A1 (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107098A2 (en) 2008-03-31 2009-10-07 Metso Power Oy A pyrolysis method in connection with a boiler and a pyrolysis apparatus

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0587780T4 (da) 1991-06-06 2008-10-13 Boehringer Ingelheim Vetmed Smitstof, som forårsager Mystery Swine Disease,vaccinepræparater og diagnostiske sæt
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US6982160B2 (en) * 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
US6042830A (en) * 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US6080570A (en) * 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
US6380376B1 (en) 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
ES2074950B1 (es) * 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
US5690940A (en) * 1995-06-21 1997-11-25 Regents Of The University Of Minnesota Low pathogencity PRRS live virus vaccines and methods of preparation thereof
ES2102971B1 (es) * 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
ZA971663B (en) * 1996-03-01 1997-08-26 Schering Corp Porcine reproductive and respiratory syndrome vaccine.
US6015663A (en) * 1996-03-01 2000-01-18 The United States Of America As Represented By The Secretary Of Agriculture Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US5976537A (en) * 1996-07-02 1999-11-02 The United States Of America As Represented By The Secretary Of Agriculture Porcine reproductive and respiratory syndrome vaccine
ATE199022T1 (de) * 1996-10-09 2001-02-15 Akzo Nobel Nv Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des sweins (prrsv)
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998035023A1 (en) * 1997-02-07 1998-08-13 Origen, Inc. Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays
JP2000512313A (ja) 1997-05-06 2000-09-19 スティヒティング ディーンスト ラントバウキュンディフ オンデルズーク ワクチンまたは診断検定用ｐｒｒｓウイルスのペプチド配列同定ｐｒｒｓｖ抗原部位
AU8393398A (en) * 1997-07-10 1999-02-08 Regents Of The University Of Minnesota Causative agent of sow abortion and mortality syndrome (sams), vaccine compositions, antibodies and method
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
CA2290220C (en) 1998-12-22 2013-11-19 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
EP1157121B1 (en) * 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replicon
AU4482200A (en) * 1999-04-22 2000-11-10 United States Department Of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
ES2300286T3 (es) * 1999-12-20 2008-06-16 Agricultural Research Council Procedimiento de inactivacion de microorganismos.
EP1255815B1 (en) * 2000-02-08 2006-07-19 Regents Of The University Of Minnesota Porcine reproductive and respiratory syndrome virus and methods of use
US6740490B2 (en) * 2001-01-29 2004-05-25 Kansas State University Research Foundation Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
TW200604526A (en) 2004-06-18 2006-02-01 Unviersity Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
PT2460817T (pt) 2004-12-30 2017-07-03 Boehringer Ingelheim Vetmedica Inc Composições imunogénicas de pcv2 e métodos de produção de tais composições
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
PT1904631E (pt) 2005-06-24 2012-07-16 Univ Minnesota Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização
HUE054868T2 (hu) 2005-12-29 2021-10-28 Boehringer Ingelheim Animal Health Usa Inc Multivalens PVC2 immunogén készítmények és eljárások ezek elõállítására
CN100523177C (zh) * 2007-01-09 2009-08-05 中国农业科学院哈尔滨兽医研究所 猪繁殖与呼吸综合症病毒弱毒疫苗株及其应用
ES2560432T3 (es) * 2007-01-12 2016-02-19 The Board Of Trustees Of The University Of Illinois Células no símicas para el desarrollo del virus del síndrome reproductivo y respiratorio porcino (PRRS)
US7666585B2 (en) * 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
CA2691755A1 (en) * 2007-06-25 2008-12-31 South Dakota State University Recombinant north american type 1 porcine reproductive and respiratory syndrome virus and methods of use
CN101363865B (zh) * 2008-05-26 2013-03-06 北京庄笛浩禾生物医学科技有限公司 一种猪蓝耳病毒胶体金检测试纸条、其制备方法及其应用
US20110117129A1 (en) * 2008-08-25 2011-05-19 Boehringer Ingelheim Vetmedica, Inc. Vaccine Against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (HP PRRS)
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
KR101746880B1 (ko) 2009-09-10 2017-06-14 메리얼 인코포레이티드 사포닌-함유 면역보강제를 포함하는 신규 백신 제형
MX346636B (es) 2011-02-17 2017-03-27 Boehringer Ingelheim Vetmedica Gmbh Procedimiento para la produccion a escala comercial de prrsv.
DK2675475T3 (en) 2011-02-17 2015-09-14 Boehringer Ingelheim Vetmed NEW EUROPEAN PRRSV TRIAL
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
CN103841963B (zh) 2011-08-12 2018-04-24 梅里亚股份有限公司 用于生物产品特别是疫苗的真空辅助保存
CA2892948C (en) 2012-12-07 2022-09-20 The Board Of Trustees Of The University Of Illinois Porcine reproductive and respiratory syndrome virus compositions and uses thereof
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
WO2015048115A1 (en) 2013-09-25 2015-04-02 Zoetis Llc Pcv2b divergent vaccine composition and methods of use
TWI745278B (zh) 2014-10-10 2021-11-11 以色列商艾畢克生物實驗有限公司 發泡性降低之疫苗組合物
CN104694485A (zh) * 2015-02-13 2015-06-10 广西壮族自治区兽医研究所 Z-ietd-fmk在提高prrsv体外培养滴度方面的应用及其方法
AU2017286727B2 (en) 2016-06-17 2024-02-08 Boehringer Ingelheim Animal Health USA Inc. Novel immunogenic formulations comprising linear or branched polyacrylic acid polymer adjuvants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213795A (en) * 1990-10-24 1993-05-25 Oxford Encephalomyocarditis virus vaccine
DK0587780T4 (da) * 1991-06-06 2008-10-13 Boehringer Ingelheim Vetmed Smitstof, som forårsager Mystery Swine Disease,vaccinepræparater og diagnostiske sæt
KR0138092B1 (ko) * 1991-08-26 1998-04-30 제임스 씨. 데세사레 미확인(Mystery) 돼지 질병 관련 바이러스제
DE601062T1 (de) * 1991-08-26 1995-05-18 James Edward Collins Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas).
WO1993006211A1 (en) * 1991-09-16 1993-04-01 Collins James E Vaccine for mystery swine disease and method for diagnosis thereof
JPH07501049A (ja) * 1991-10-14 1995-02-02 アクゾ・ノベル・エヌ・ベー ブタ生殖・呼吸系症候群ワクチン及び診断方法
FR2682966B1 (fr) * 1991-10-29 1994-12-02 Rhone Merieux Preparation d'antigenes et de vaccins du virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107098A2 (en) 2008-03-31 2009-10-07 Metso Power Oy A pyrolysis method in connection with a boiler and a pyrolysis apparatus

Also Published As

Publication number Publication date
FI953731A (sv) 1995-08-04
WO1994018311A1 (en) 1994-08-18
PL178609B1 (pl) 2000-05-31
US5510258A (en) 1996-04-23
ATE197314T1 (de) 2000-11-15
JPH08506486A (ja) 1996-07-16
NO317662B1 (no) 2004-11-29
ES2152304T3 (es) 2001-02-01
GR3035257T3 (en) 2001-04-30
BG63170B1 (bg) 2001-05-31
CN1080300C (zh) 2002-03-06
PT683816E (pt) 2001-03-30
AU681874B2 (en) 1997-09-11
AU6128594A (en) 1994-08-29
BG99850A (bg) 1996-02-28
NO953091D0 (no) 1995-08-07
CZ203195A3 (en) 1995-12-13
DE69426228D1 (de) 2000-12-07
HU9502330D0 (en) 1996-05-28
NZ261992A (en) 1996-06-25
SK98695A3 (en) 1996-11-06
NO953091L (no) 1995-08-07
HU218430B (hu) 2000-08-28
CN1117742A (zh) 1996-02-28
CZ289743B6 (cs) 2002-03-13
EP0683816A1 (en) 1995-11-29
JP3710095B2 (ja) 2005-10-26
US5587164A (en) 1996-12-24
EP0683816B1 (en) 2000-11-02
HUT72917A (en) 1996-06-28
FI953731A0 (sv) 1995-08-04
DE69426228T2 (de) 2001-03-01
DK0683816T3 (da) 2001-01-08
PL310126A1 (en) 1995-11-27
KR100374295B1 (ko) 2003-12-24

Similar Documents

Publication Publication Date Title
FI117513B (sv) Förfarande för odling av PRRS-virus och användning därav i vacciner
JP3715675B2 (ja) ブタ生殖呼吸症候群ウイルス（ｐｒｒｓｖ）のヨーロッパワクチン株
Brooksby Portraits of viruses: foot-and-mouth disease virus
JP3473700B2 (ja) Ｓｉｒｓワクチンおよびｓｉｒｓ診断方法
US6241990B1 (en) Immunogenic composition containing inactivated swine infertility and respiratory Syndrome virus
EP0610250B1 (en) Porcine reproductive respiratory syndrome (prrs) vaccine and diagnostic
US7264804B2 (en) Kits for detecting anti-SIRS antibodies
KR20070086084A (ko) 돼지 생식기 및 호흡기 증후군 바이러스 균주 및 조성물
US8753646B2 (en) IPV-DPT vaccine
CA2224309C (en) Multivalent bovine coronavirus vaccine and method of treating bovine coronavirus infection
RU2699671C1 (ru) Вакцина для ранней защиты против ящура типа О инактивированная эмульсионная
RU2665849C1 (ru) Вакцина инактивированная эмульсионная против ящура типа О
Musser et al. Measles virus growth in canine renal cell cultures
CA2155533C (en) Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines
MXPA97007302A (en) New attenuated cepa of the virus causing the respiratory and reproductive swine syndrome (prrs), vaccines and diagnostic media obtained with the same and the procedures for your obtenc

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 117513

Country of ref document: FI