FI117442B - Arakidonsyra och förfaranden för framställning av densamma och användning av densamma - Google Patents
Arakidonsyra och förfaranden för framställning av densamma och användning av densamma Download PDFInfo
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- FI117442B FI117442B FI972829A FI972829A FI117442B FI 117442 B FI117442 B FI 117442B FI 972829 A FI972829 A FI 972829A FI 972829 A FI972829 A FI 972829A FI 117442 B FI117442 B FI 117442B
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- ara
- oil
- arachidonic acid
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Claims (22)
1. Framställningsförfarande för olja, som innehaller arakidonsyra, vilken nämnd olja innehaller triglycerider, där ätminstone 25 % av fettsyragrup- 5 perna utgörs av arakidonsyra (ARA) och mängden eikosapentaensyragrupper (EPÄ) i oljan ej överskrider en femtedel av mängden arakidonsyragrupper (ARA), kännetecknat avattförfarandetomfattar (a) odling av Mortierella sp i en luftad fermentor, som innehaller ett - odlingsmedium; 10 (b) upprätthällande av pH i begynnelseskedet av odlingen inom ett .¾ omräde mellan pH-värden 5 och 6; 1 (c) upprätthällande av pH i slutet av odlingen inom ett omräde mellan pH-värden 7 och 7,5; ¥ (d) tillvaratagande av biomassan ur fermentorn och tillvaratagande 15 av nämnda arakidonsyrainnehallande olja fran nämnda biomassa.
2. Förfarande enligt patentkrav 1, kä n n e te c k n a t av att tili od- ; lingsmediet under fermenteringen sätts en kolkalla i en mängd, som motsvarar * ... över 80 g/l glukos, och en kvävekälla i en mängd, som motsvarar över 15 g/l • · *;··* jästextrakt. 20
3. Förfarande enligt patentkrav 1 eller 2, k ä n n e t e c k n a t av att 1 * · halien av löst syre i odlingsmediet är minst 35 % av luftens mättningsnivä. i
« :.*·· 4. Förfarande enligt vilket som heist av patentkraven 1 -3, kän- netecknatavatt kvävekällan delas i tva eller flera satser, som mätäs tili :T: fermentorn vid olika tider sä att minst en sats mätäs tili fermentorn vid en tid- « 25 punkt, som avvikerfrän den tidpunkt, da kolkällan sätts tili fermentorn.
? . .*. 5. Förfarande enligt vilket som heist av patentkraven 1 - 4, k a n - .·’··*. n e t e c k n a t av att Mortierella sp är Mortierella alpina. • ·
6. Förfarande enligt vilket som heist av patentkraven 1 -5, kän- : ’·· n e t e c k n a t av att det ytterligare omfattar tillvaratagande av orenad olja, • * · 30 som innehaller arakidonsyra, frän biomassan genom extrahering med ett icke- , |\ polärt lösningsmedel och klarande av den orenade oljan genom extrahering ,··*. med ett polärt organiskt lösningsmedel. • *
7. Förfarande enligt patentkrav 6, kä n n e te c k n at av att det ic- ke-polära lösningsmedlet är hexan. > 35 " 117442 36 ..,
8. Förfarande enligt patentkrav 6, kännetecknat av att den 5 polära lösningen är aceton, etanol eller isopropylalkohol.
9. Omodifierad triglyceridsvampolja, k ä n n e t e c k n a d av att över 50 % av fettsyragrupperna är arakidonsyragrupper (ARA) i en triglycerid- 5 form och att oljan omfattar eikosapentaensyra (EPÄ) i en mängd av högst en tiondedel av mängden arakidonsyra (ARA).
10. Omodifierad triglyceridsvampolja enligt patentkrav 9, kanne· tecknad av att oljans triglycerider omfattar minst 50 % arakidonsyra (ARA), men väsentligen ej alls eikosapentaensyra (EPÄ). 10
11. Förfarande för användning av en triglycerid, som innehaller ara- ; kidonsyra (ARA), i ett modersmjölksubstitut, kännetecknat av att förfa- ? randet omfattar sättning av omodifierad triglyceridsvampolja enligt patentkrav 9 4 eller 10 tili modersmjölksubstitutet i en mängd, som är tillräcklig att astadkom-ma en arakidonsyrahalt, vilken motsvarar mängden arakidonsyra i människans 15 bröstmjölk.
12. Modersmjölksubstitut, som innehaller en triglycerid, vilken innehaller en sadan mängd arakidonsyra som motsvarar mängden arakidonsyra, som förekommer i människans bröstmjölk, kännetecknat av att araki-... donsyran (ARA) erhallits genom tillsättande av en tillräcklig mängd av omodifi- Ψ * ' ΛΊ *;··] 20 erad svampolja enligt patentkrav 9 eller 10 tili modersmjölksubstitutet. '•'J
13. Förfarande för framställning av ett sädant farmaceutiskt prepa- :.v rat, som är avsett för administrering av arakidonsyra (ARA) för att komplettera kosten för en människa i behov att denna, kännetecknat av att förfa- • *·· randet omfattar formulering av omodifierad svampolja enligt patentkrav 9 eller f ;T: 25 10 tili en farmaceutiskt godtagbar doserform, varvid nämnda farmaceutiska preparat formulerats att ge en sadan mängd arakidonsyra (ARA), som är tili- . räcklig att ge en kostkompletterande mängd arakidonsyra (ARA) för en männi- * * * .···. ska. • · /t·'
14. Förfarande enligt patentkrav 13, kännetecknat av att : " 30 nämnda preparat formulerats att ge 0,2 - 0,8 g arakidonsyra (ARA) per dag. • · ·
15. Förfarande enligt patentkrav 13 eller 14, k ä n n e te c k n a t : av att nämnda farmaceutiska komposition är farmaceutiskt godtagbar för ente- * · · .*··. ral administrering.
16. Förfarande enligt patentkrav 13 eller 14, k ä n ne te c k n at 35 av att nämnda farmaceutiska komposition är farmaceutiskt godtagbar för parenteral administrering. 117442
17. Förfarande enligt patentkrav 13 eller 14, kännetecknat av att nämnda farmaceutiska komposition är farmaceutiskt godtagbar för lokal administrering.
18. Förfarande enligt vilket som heist av patentkraven 13-17, 5 kännetecknat av att nämnda människa är en gravid kvinna eller en ammande moder.
19. Förfarande enligt vilket som heist av patentkraven 13-17, k ä n n e t e c k n a t av att nämnda människa, som behöver komplettering av arakidonsyra (ARA), har en neurologisk sjukdom. 10
20. Förfarande enligt patentkrav 19, kännetecknat av att den Ϊ neurologiska sjukdomen är tardiv dyskinesi, schizofreni eller en peroxisomal sjukdom.
21. Förfarande enligt patentkrav 13 eller 14, k ä n n e t e c k n a t av att nämnda människa, som behöver komplettering av arakidonsyra (ARA), 15 har en sjukdom, som hänför sig tili minskning av arakidonsyrahalten i serumet.
22. Förfarande enligt patentkrav 21, k ä n n e t e c k n a t av att sjukdomen är en leversjukdom, fenylketonuri eller cystisk fibros. ··· ·1 2 3'·· • · • · · • · • · ♦ • · · • · • 1 ^ • · 1 • · ·♦:··.· * · · · 1 • · ·· i 5 • · • · · ‘1 ··· ···.- • · · .· H * · ' ' ^.Hi • · 1 . * · · ·1· * · · • · • · • · · • · • · • ·· ··· • · • · * 1 1 · · 2 • · · * 1 1 f 3 * · • · ·
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/367,881 US5658767A (en) | 1991-01-24 | 1995-01-03 | Arachidonic acid and methods for the production and use thereof |
US36788195 | 1995-01-03 | ||
PCT/US1996/000182 WO1996021037A1 (en) | 1995-01-03 | 1996-01-03 | Arachidonic acid and methods for the production and use thereof |
US9600182 | 1996-01-03 |
Publications (3)
Publication Number | Publication Date |
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FI972829A0 FI972829A0 (sv) | 1997-07-01 |
FI972829A FI972829A (sv) | 1997-09-02 |
FI117442B true FI117442B (sv) | 2006-10-13 |
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Application Number | Title | Priority Date | Filing Date |
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FI972829A FI117442B (sv) | 1995-01-03 | 1997-07-01 | Arakidonsyra och förfaranden för framställning av densamma och användning av densamma |
FI20060617A FI120648B (sv) | 1995-01-03 | 2006-06-26 | Förfarande för framställning av arakidonsyra |
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FI20060617A FI120648B (sv) | 1995-01-03 | 2006-06-26 | Förfarande för framställning av arakidonsyra |
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US (1) | US5658767A (sv) |
EP (5) | EP0800584B1 (sv) |
JP (6) | JP4014219B2 (sv) |
KR (6) | KR20080068761A (sv) |
CN (4) | CN102399831A (sv) |
AT (1) | ATE239088T1 (sv) |
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