FI117437B - Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi - Google Patents

Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi Download PDF

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Publication number
FI117437B
FI117437B FI973040A FI973040A FI117437B FI 117437 B FI117437 B FI 117437B FI 973040 A FI973040 A FI 973040A FI 973040 A FI973040 A FI 973040A FI 117437 B FI117437 B FI 117437B
Authority
FI
Finland
Prior art keywords
bupivacaine
compound
preparation
levobupivacaine
optically enriched
Prior art date
Application number
FI973040A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI973040A (fi
FI973040A0 (fi
Inventor
Marianne Langston
Ulrich Conrad Dyer
Martin Woods
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of FI973040A publication Critical patent/FI973040A/fi
Publication of FI973040A0 publication Critical patent/FI973040A0/fi
Application granted granted Critical
Publication of FI117437B publication Critical patent/FI117437B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rolling Contact Bearings (AREA)
  • Optical Head (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI973040A 1995-01-18 1997-07-17 Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi FI117437B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9501071 1995-01-18
GBGB9501071.6A GB9501071D0 (en) 1995-01-18 1995-01-18 Racemisation
GB9600067 1996-01-12
PCT/GB1996/000067 WO1996022281A1 (en) 1995-01-18 1996-01-12 Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents

Publications (3)

Publication Number Publication Date
FI973040A FI973040A (fi) 1997-07-17
FI973040A0 FI973040A0 (fi) 1997-07-17
FI117437B true FI117437B (fi) 2006-10-13

Family

ID=10768271

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973040A FI117437B (fi) 1995-01-18 1997-07-17 Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi

Country Status (20)

Country Link
EP (1) EP0804417B1 (ja)
JP (1) JP4015696B2 (ja)
KR (1) KR100404390B1 (ja)
CN (1) CN1172912C (ja)
AT (1) ATE242214T1 (ja)
AU (1) AU701221B2 (ja)
BR (1) BR9606821A (ja)
CA (1) CA2208522C (ja)
DE (1) DE69628540T2 (ja)
DK (1) DK0804417T3 (ja)
ES (1) ES2201166T3 (ja)
FI (1) FI117437B (ja)
GB (1) GB9501071D0 (ja)
HU (1) HU227426B1 (ja)
MX (1) MX9705428A (ja)
NO (1) NO308843B1 (ja)
PL (1) PL184091B1 (ja)
PT (1) PT804417E (ja)
WO (1) WO1996022281A1 (ja)
ZA (1) ZA96403B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
EP2959893A1 (en) 2002-12-13 2015-12-30 DURECT Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
PL1809329T3 (pl) 2004-09-17 2012-08-31 Durect Corp Kompozycja znieczulająca zawierająca saib o przedłużonym uwalnianiu do stosowania miejscowego
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
WO2009088414A2 (en) 2007-12-06 2009-07-16 Durect Corporation Oral pharmaceutical dosage forms
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
CN106187864B (zh) * 2016-07-11 2018-11-23 江苏天和制药有限公司 一种由盐酸布比卡因制备高纯度布比卡因碱的方法
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
WO2023158722A2 (en) * 2022-02-16 2023-08-24 Teva Pharmaceuticals International Gmbh Processes for preparation of avacopan and intermediates thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2301498A1 (fr) * 1975-02-20 1976-09-17 Maggioni & C Spa Methode pour la racemisation d'une lysine optiquement active

Also Published As

Publication number Publication date
ZA96403B (en) 1997-01-20
AU701221B2 (en) 1999-01-21
ES2201166T3 (es) 2004-03-16
AU4394896A (en) 1996-08-07
JPH11501905A (ja) 1999-02-16
GB9501071D0 (en) 1995-03-08
PL184091B1 (pl) 2002-08-30
NO308843B1 (no) 2000-11-06
EP0804417A1 (en) 1997-11-05
ATE242214T1 (de) 2003-06-15
CA2208522A1 (en) 1996-07-25
FI973040A (fi) 1997-07-17
PL321378A1 (en) 1997-12-08
KR19980701432A (ko) 1998-05-15
DK0804417T3 (da) 2003-10-06
MX9705428A (es) 1997-11-29
CA2208522C (en) 2007-03-13
DE69628540D1 (de) 2003-07-10
NO973312D0 (no) 1997-07-17
KR100404390B1 (ko) 2004-01-31
PT804417E (pt) 2003-09-30
HUP9901418A3 (en) 2001-01-29
JP4015696B2 (ja) 2007-11-28
WO1996022281A1 (en) 1996-07-25
CN1168134A (zh) 1997-12-17
NO973312L (no) 1997-07-17
FI973040A0 (fi) 1997-07-17
HU227426B1 (en) 2011-05-30
BR9606821A (pt) 1997-12-23
CN1172912C (zh) 2004-10-27
EP0804417B1 (en) 2003-06-04
DE69628540T2 (de) 2004-01-08
HUP9901418A2 (hu) 1999-08-30

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