DK0804417T3 - Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler - Google Patents
Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidlerInfo
- Publication number
- DK0804417T3 DK0804417T3 DK96900349T DK96900349T DK0804417T3 DK 0804417 T3 DK0804417 T3 DK 0804417T3 DK 96900349 T DK96900349 T DK 96900349T DK 96900349 T DK96900349 T DK 96900349T DK 0804417 T3 DK0804417 T3 DK 0804417T3
- Authority
- DK
- Denmark
- Prior art keywords
- levobupivacaine
- racemization
- anesthetics
- preparation
- carboxanilide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title abstract 2
- 229960004288 levobupivacaine Drugs 0.000 title abstract 2
- 229940035674 anesthetics Drugs 0.000 title 1
- 239000003193 general anesthetic agent Substances 0.000 title 1
- UICIJOHWFFTRLI-UHFFFAOYSA-N n-phenylpiperidine-1-carboxamide Chemical compound C1CCCCN1C(=O)NC1=CC=CC=C1 UICIJOHWFFTRLI-UHFFFAOYSA-N 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- -1 piperidine-2-carboxanilide compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Rolling Contact Bearings (AREA)
- Optical Head (AREA)
- Beans For Foods Or Fodder (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9501071.6A GB9501071D0 (en) | 1995-01-18 | 1995-01-18 | Racemisation |
| PCT/GB1996/000067 WO1996022281A1 (en) | 1995-01-18 | 1996-01-12 | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0804417T3 true DK0804417T3 (da) | 2003-10-06 |
Family
ID=10768271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96900349T DK0804417T3 (da) | 1995-01-18 | 1996-01-12 | Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0804417B1 (da) |
| JP (1) | JP4015696B2 (da) |
| KR (1) | KR100404390B1 (da) |
| CN (1) | CN1172912C (da) |
| AT (1) | ATE242214T1 (da) |
| AU (1) | AU701221B2 (da) |
| BR (1) | BR9606821A (da) |
| CA (1) | CA2208522C (da) |
| DE (1) | DE69628540T2 (da) |
| DK (1) | DK0804417T3 (da) |
| ES (1) | ES2201166T3 (da) |
| FI (1) | FI117437B (da) |
| GB (1) | GB9501071D0 (da) |
| HU (1) | HU227426B1 (da) |
| MX (1) | MX9705428A (da) |
| NO (1) | NO308843B1 (da) |
| PL (1) | PL184091B1 (da) |
| PT (1) | PT804417E (da) |
| WO (1) | WO1996022281A1 (da) |
| ZA (1) | ZA96403B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| SI1575569T1 (sl) | 2002-12-13 | 2010-12-31 | Durect Corp | Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale |
| EP3103477A1 (en) | 2004-09-17 | 2016-12-14 | Durect Corporation | Sustained local anesthetic composition containing saib |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| PL2117521T3 (pl) | 2006-11-03 | 2012-11-30 | Durect Corp | Transdermalne systemy dostarczania zawierające bupiwakainę |
| EP3326621A1 (en) | 2007-12-06 | 2018-05-30 | Durect Corporation | Oral pharmaceutical dosage forms |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| US9572885B2 (en) | 2013-03-15 | 2017-02-21 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| SG11201811760VA (en) | 2016-07-06 | 2019-01-30 | Durect Corp | Oral dosage form with drug composition, barrier layer and drug layer |
| CN106187864B (zh) * | 2016-07-11 | 2018-11-23 | 江苏天和制药有限公司 | 一种由盐酸布比卡因制备高纯度布比卡因碱的方法 |
| EP4090353A4 (en) | 2020-01-13 | 2023-08-09 | Durect Corporation | DELAYED-RELEASE DRUG DELIVERY SYSTEMS WITH REDUCED IMPURITIES AND RELATED PROCEDURES |
| JP2024503402A (ja) | 2021-01-12 | 2024-01-25 | デュレクト コーポレーション | 徐放性薬物送達システム及び関連の方法 |
| WO2023158722A2 (en) * | 2022-02-16 | 2023-08-24 | Teva Pharmaceuticals International Gmbh | Processes for preparation of avacopan and intermediates thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2301498A1 (fr) * | 1975-02-20 | 1976-09-17 | Maggioni & C Spa | Methode pour la racemisation d'une lysine optiquement active |
-
1995
- 1995-01-18 GB GBGB9501071.6A patent/GB9501071D0/en active Pending
-
1996
- 1996-01-12 EP EP96900349A patent/EP0804417B1/en not_active Expired - Lifetime
- 1996-01-12 AU AU43948/96A patent/AU701221B2/en not_active Expired
- 1996-01-12 DE DE69628540T patent/DE69628540T2/de not_active Expired - Lifetime
- 1996-01-12 CN CNB961915242A patent/CN1172912C/zh not_active Expired - Lifetime
- 1996-01-12 PT PT96900349T patent/PT804417E/pt unknown
- 1996-01-12 PL PL96321378A patent/PL184091B1/pl unknown
- 1996-01-12 JP JP52210296A patent/JP4015696B2/ja not_active Expired - Lifetime
- 1996-01-12 HU HU9901418A patent/HU227426B1/hu unknown
- 1996-01-12 KR KR1019970704822A patent/KR100404390B1/ko not_active Expired - Lifetime
- 1996-01-12 DK DK96900349T patent/DK0804417T3/da active
- 1996-01-12 AT AT96900349T patent/ATE242214T1/de active
- 1996-01-12 WO PCT/GB1996/000067 patent/WO1996022281A1/en not_active Ceased
- 1996-01-12 BR BR9606821A patent/BR9606821A/pt unknown
- 1996-01-12 CA CA002208522A patent/CA2208522C/en not_active Expired - Lifetime
- 1996-01-12 ES ES96900349T patent/ES2201166T3/es not_active Expired - Lifetime
- 1996-01-12 MX MX9705428A patent/MX9705428A/es unknown
- 1996-01-18 ZA ZA96403A patent/ZA96403B/xx unknown
-
1997
- 1997-07-17 NO NO973312A patent/NO308843B1/no not_active IP Right Cessation
- 1997-07-17 FI FI973040A patent/FI117437B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9501071D0 (en) | 1995-03-08 |
| FI973040A0 (fi) | 1997-07-17 |
| ATE242214T1 (de) | 2003-06-15 |
| PL321378A1 (en) | 1997-12-08 |
| EP0804417B1 (en) | 2003-06-04 |
| HUP9901418A2 (hu) | 1999-08-30 |
| ES2201166T3 (es) | 2004-03-16 |
| MX9705428A (es) | 1997-11-29 |
| DE69628540T2 (de) | 2004-01-08 |
| FI117437B (fi) | 2006-10-13 |
| BR9606821A (pt) | 1997-12-23 |
| CA2208522A1 (en) | 1996-07-25 |
| NO973312L (no) | 1997-07-17 |
| EP0804417A1 (en) | 1997-11-05 |
| FI973040L (fi) | 1997-07-17 |
| CN1168134A (zh) | 1997-12-17 |
| CN1172912C (zh) | 2004-10-27 |
| PT804417E (pt) | 2003-09-30 |
| KR100404390B1 (ko) | 2004-01-31 |
| AU4394896A (en) | 1996-08-07 |
| HU227426B1 (en) | 2011-05-30 |
| ZA96403B (en) | 1997-01-20 |
| JPH11501905A (ja) | 1999-02-16 |
| DE69628540D1 (de) | 2003-07-10 |
| HUP9901418A3 (en) | 2001-01-29 |
| AU701221B2 (en) | 1999-01-21 |
| WO1996022281A1 (en) | 1996-07-25 |
| PL184091B1 (pl) | 2002-08-30 |
| JP4015696B2 (ja) | 2007-11-28 |
| CA2208522C (en) | 2007-03-13 |
| NO308843B1 (no) | 2000-11-06 |
| KR19980701432A (ko) | 1998-05-15 |
| NO973312D0 (no) | 1997-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0804417T3 (da) | Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler | |
| DE69637726D1 (de) | Gruppen zum einfangen von nukleinsäuren | |
| DE69531624D1 (de) | Verfahren zur herstellung von levobupivacaine und analoge | |
| EP0636879A3 (en) | Biosensor and method for its manufacture. | |
| DE69942068D1 (de) | Erzeugen eines nichtlinearen modells und erzeugen tzung desselben | |
| NO308074B1 (no) | FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider | |
| DK0879228T3 (da) | Fremgangsmåde til fremstilling af d-threo-(R,R)-methylphenidat og recirkulering af uønskede enantiomerer ved epimerisering | |
| HUT77631A (hu) | Eljárás a levobupivakain és származékai rezolválására | |
| ATE221533T1 (de) | Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten | |
| CY1107104T1 (el) | Διαδικασια για την παρασκευη (r)-g(a)-(2,3-διμεθοξυφαινυλο)-1-(2-(4-φθοροφαινυλο)-αιθυλο)-4- πιπεριδινομεθανολη | |
| ATE497545T1 (de) | Oligonukleotide zur detektion von salmonella | |
| DE59604829D1 (de) | Kontinuierliches Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethylpiperidin | |
| ATE194602T1 (de) | Verfahren zur herstellung von 1,4,7,10- tetraazacyclododecan und dessen derivaten | |
| DK0914605T3 (da) | Molekylemodel for VLA-4-inhibitorer | |
| ATE213782T1 (de) | Verfahren zur biotransformation von colchicinoid- verbindungen in die entsprechenden 3- glycosylderivate | |
| NO975961L (no) | Fremgangsmåte for fremstilling av 1-(3-trialkylsilylfenyl)-2,2,2-trifluorometyl-ethanonderivater | |
| ES2138734T3 (es) | Procedimiento para la preparacion de derivados de 1-(3-trialquilsililfenil)-2,2,2-trifluormetil etanona. | |
| AU7377296A (en) | Method for treating hepatitis virus infection | |
| DE60104822D1 (de) | Pseudopolymorph von (-)-cis-2-(2-chlorphenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-on hydrochlorid | |
| NO972129L (no) | Fremgangsmåte for fremstilling av 1-halo-3-trialkylsilanyl-benzenderivater | |
| ATE212969T1 (de) | Verfahren zur herstellung von 2-halogenindan-1- onen | |
| DK0819117T3 (da) | Dimethylaminbenzoat- eller -p-anisatkatalyseret fremgangsmåde til fremstilling af 4-(nitrophenyl)dihydropyridiner | |
| DE59700961D1 (de) | Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethylpiperidin (TAD) über das Zwischenprodukt 2,2,6,6-Tetramethyl-4-[(2,2,6,6-tetramethyl-4-piperidyliden)amino]-piperidin | |
| ATE421953T1 (de) | Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin |