MX9705428A - Proceso de racemizacion para utilizar en la fabricacion de levobupivacaina y agentes anestesicos de piperidincarboxanilida relacionados. - Google Patents

Proceso de racemizacion para utilizar en la fabricacion de levobupivacaina y agentes anestesicos de piperidincarboxanilida relacionados.

Info

Publication number
MX9705428A
MX9705428A MX9705428A MX9705428A MX9705428A MX 9705428 A MX9705428 A MX 9705428A MX 9705428 A MX9705428 A MX 9705428A MX 9705428 A MX9705428 A MX 9705428A MX 9705428 A MX9705428 A MX 9705428A
Authority
MX
Mexico
Prior art keywords
levobupivacaine
manufacture
piperidinecarboxanilide
anaesthetic agents
compound
Prior art date
Application number
MX9705428A
Other languages
English (en)
Inventor
Ulrich Conrad Dyer
Marianne Langston
Martin Woods
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of MX9705428A publication Critical patent/MX9705428A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Rolling Contact Bearings (AREA)
  • Optical Head (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un compuesto de piperidin-2-carboxanilida enriquecido opticamente, en donde las piperidina está N-alquilada opcionalmente se racemiza al calentar el compuesto en un medio acuoso, siempre que el medio incluye un cosolvente orgánico si el compuesto es N-alquilado. Este proceso es particularmente valioso, en conjunto con un proceso de resolucion para la fabricacion de levobupivacaina.
MX9705428A 1995-01-18 1996-01-12 Proceso de racemizacion para utilizar en la fabricacion de levobupivacaina y agentes anestesicos de piperidincarboxanilida relacionados. MX9705428A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501071.6A GB9501071D0 (en) 1995-01-18 1995-01-18 Racemisation
PCT/GB1996/000067 WO1996022281A1 (en) 1995-01-18 1996-01-12 Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents

Publications (1)

Publication Number Publication Date
MX9705428A true MX9705428A (es) 1997-11-29

Family

ID=10768271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705428A MX9705428A (es) 1995-01-18 1996-01-12 Proceso de racemizacion para utilizar en la fabricacion de levobupivacaina y agentes anestesicos de piperidincarboxanilida relacionados.

Country Status (20)

Country Link
EP (1) EP0804417B1 (es)
JP (1) JP4015696B2 (es)
KR (1) KR100404390B1 (es)
CN (1) CN1172912C (es)
AT (1) ATE242214T1 (es)
AU (1) AU701221B2 (es)
BR (1) BR9606821A (es)
CA (1) CA2208522C (es)
DE (1) DE69628540T2 (es)
DK (1) DK0804417T3 (es)
ES (1) ES2201166T3 (es)
FI (1) FI117437B (es)
GB (1) GB9501071D0 (es)
HU (1) HU227426B1 (es)
MX (1) MX9705428A (es)
NO (1) NO308843B1 (es)
PL (1) PL184091B1 (es)
PT (1) PT804417E (es)
WO (1) WO1996022281A1 (es)
ZA (1) ZA96403B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE482695T1 (de) 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
LT2767292T (lt) 2004-09-17 2016-12-12 Durect Corporation Palaikomosios vietinės anestezijos mišinys su saib
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
DK2117521T3 (da) 2006-11-03 2012-09-03 Durect Corp Transdermale indgivelsessystemer omfattende bupivacain
AU2008335809A1 (en) 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
CN106187864B (zh) * 2016-07-11 2018-11-23 江苏天和制药有限公司 一种由盐酸布比卡因制备高纯度布比卡因碱的方法
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
WO2023158722A2 (en) * 2022-02-16 2023-08-24 Teva Pharmaceuticals International Gmbh Processes for preparation of avacopan and intermediates thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2301498A1 (fr) * 1975-02-20 1976-09-17 Maggioni & C Spa Methode pour la racemisation d'une lysine optiquement active

Also Published As

Publication number Publication date
DE69628540D1 (de) 2003-07-10
JPH11501905A (ja) 1999-02-16
NO973312D0 (no) 1997-07-17
ATE242214T1 (de) 2003-06-15
KR100404390B1 (ko) 2004-01-31
NO973312L (no) 1997-07-17
HUP9901418A3 (en) 2001-01-29
AU4394896A (en) 1996-08-07
KR19980701432A (ko) 1998-05-15
NO308843B1 (no) 2000-11-06
CN1168134A (zh) 1997-12-17
PT804417E (pt) 2003-09-30
BR9606821A (pt) 1997-12-23
HUP9901418A2 (hu) 1999-08-30
EP0804417A1 (en) 1997-11-05
GB9501071D0 (en) 1995-03-08
DE69628540T2 (de) 2004-01-08
FI973040A0 (fi) 1997-07-17
EP0804417B1 (en) 2003-06-04
CN1172912C (zh) 2004-10-27
DK0804417T3 (da) 2003-10-06
CA2208522A1 (en) 1996-07-25
PL321378A1 (en) 1997-12-08
FI117437B (fi) 2006-10-13
HU227426B1 (en) 2011-05-30
WO1996022281A1 (en) 1996-07-25
ZA96403B (en) 1997-01-20
AU701221B2 (en) 1999-01-21
FI973040A (fi) 1997-07-17
CA2208522C (en) 2007-03-13
PL184091B1 (pl) 2002-08-30
JP4015696B2 (ja) 2007-11-28
ES2201166T3 (es) 2004-03-16

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