ATE214695T1 - Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen - Google Patents

Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen

Info

Publication number
ATE214695T1
ATE214695T1 AT95932092T AT95932092T ATE214695T1 AT E214695 T1 ATE214695 T1 AT E214695T1 AT 95932092 T AT95932092 T AT 95932092T AT 95932092 T AT95932092 T AT 95932092T AT E214695 T1 ATE214695 T1 AT E214695T1
Authority
AT
Austria
Prior art keywords
pct
compound
date
levobupivacaine
analogues
Prior art date
Application number
AT95932092T
Other languages
English (en)
Inventor
Ulrich Conrad Dyer
Christopher James Lock
Martin Woods
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9504927.6A external-priority patent/GB9504927D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE214695T1 publication Critical patent/ATE214695T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Measurement Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT95932092T 1994-09-23 1995-09-22 Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen ATE214695T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94306962 1994-09-23
GBGB9504927.6A GB9504927D0 (en) 1995-03-10 1995-03-10 Racemisation and asymmetric transformation
PCT/GB1995/002247 WO1996009290A1 (en) 1994-09-23 1995-09-22 Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof

Publications (1)

Publication Number Publication Date
ATE214695T1 true ATE214695T1 (de) 2002-04-15

Family

ID=26137306

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932092T ATE214695T1 (de) 1994-09-23 1995-09-22 Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen

Country Status (18)

Country Link
US (1) US5786484A (de)
EP (1) EP0782569B1 (de)
JP (1) JP3898220B2 (de)
KR (1) KR100393133B1 (de)
CN (1) CN1104416C (de)
AT (1) ATE214695T1 (de)
AU (1) AU695479B2 (de)
CA (1) CA2200490C (de)
DE (1) DE69525950T2 (de)
DK (1) DK0782569T3 (de)
ES (1) ES2173194T3 (de)
FI (1) FI117436B (de)
HU (1) HU216291B (de)
MX (1) MX9702210A (de)
NO (1) NO308074B1 (de)
PL (1) PL183204B1 (de)
PT (1) PT782569E (de)
WO (1) WO1996009290A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
EP1295873A4 (de) * 2000-06-14 2004-05-19 Verfahren zur herstellung racemischer piperidinderivate und zur herstellung optisch aktiver piperidinderivate
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
BRPI0515372B8 (pt) 2004-09-17 2021-05-25 Durect Corp composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
PL2117521T3 (pl) 2006-11-03 2012-11-30 Durect Corp Transdermalne systemy dostarczania zawierające bupiwakainę
AU2008347158B8 (en) * 2007-12-06 2013-08-22 Durect Corporation Oral pharmaceutical dosage forms
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
CN103664744B (zh) * 2013-11-30 2015-07-15 山东永泰化工有限公司 一种左布比卡因的制备方法
CA3100706A1 (en) * 2018-05-18 2019-11-21 Kura Oncology, Inc. Synthesis of tipifarnib
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
DE69525950T2 (de) 2002-09-19
CN1159184A (zh) 1997-09-10
WO1996009290A1 (en) 1996-03-28
JPH10505855A (ja) 1998-06-09
PL183204B1 (pl) 2002-06-28
CA2200490C (en) 2007-01-09
MX9702210A (es) 1998-05-31
PT782569E (pt) 2002-09-30
HUT77055A (hu) 1998-03-02
NO971358L (no) 1997-03-21
EP0782569B1 (de) 2002-03-20
FI971202A (fi) 1997-03-21
NO308074B1 (no) 2000-07-17
CN1104416C (zh) 2003-04-02
NO971358D0 (no) 1997-03-21
DK0782569T3 (da) 2002-07-22
AU3527995A (en) 1996-04-09
FI117436B (fi) 2006-10-13
JP3898220B2 (ja) 2007-03-28
ES2173194T3 (es) 2002-10-16
CA2200490A1 (en) 1996-03-28
FI971202A0 (fi) 1997-03-21
EP0782569A1 (de) 1997-07-09
HU216291B (hu) 1999-06-28
DE69525950D1 (de) 2002-04-25
US5786484A (en) 1998-07-28
PL319368A1 (en) 1997-08-04
KR100393133B1 (ko) 2003-11-17
AU695479B2 (en) 1998-08-13

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UEP Publication of translation of european patent specification