HUT77055A - A levobupivakain és analógjai előállításában alkalmazott racemizálási eljárások - Google Patents

A levobupivakain és analógjai előállításában alkalmazott racemizálási eljárások

Info

Publication number
HUT77055A
HUT77055A HU9702212A HU9702212A HUT77055A HU T77055 A HUT77055 A HU T77055A HU 9702212 A HU9702212 A HU 9702212A HU 9702212 A HU9702212 A HU 9702212A HU T77055 A HUT77055 A HU T77055A
Authority
HU
Hungary
Prior art keywords
racemisation
pct
lavobupivacaine
analogues
compound
Prior art date
Application number
HU9702212A
Other languages
English (en)
Other versions
HU216291B (hu
Inventor
Ulrich Conrad Dyer
Christopher James Lock
Martin Woods
Original Assignee
Darwin Discovery Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9504927.6A external-priority patent/GB9504927D0/en
Application filed by Darwin Discovery Limited filed Critical Darwin Discovery Limited
Publication of HUT77055A publication Critical patent/HUT77055A/hu
Publication of HU216291B publication Critical patent/HU216291B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Radiation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HU9702212A 1994-09-23 1995-09-22 A levobupivakain és analógjai előállításában alkalmazott racemizálási eljárások HU216291B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94306962 1994-09-23
GBGB9504927.6A GB9504927D0 (en) 1995-03-10 1995-03-10 Racemisation and asymmetric transformation

Publications (2)

Publication Number Publication Date
HUT77055A true HUT77055A (hu) 1998-03-02
HU216291B HU216291B (hu) 1999-06-28

Family

ID=26137306

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702212A HU216291B (hu) 1994-09-23 1995-09-22 A levobupivakain és analógjai előállításában alkalmazott racemizálási eljárások

Country Status (18)

Country Link
US (1) US5786484A (hu)
EP (1) EP0782569B1 (hu)
JP (1) JP3898220B2 (hu)
KR (1) KR100393133B1 (hu)
CN (1) CN1104416C (hu)
AT (1) ATE214695T1 (hu)
AU (1) AU695479B2 (hu)
CA (1) CA2200490C (hu)
DE (1) DE69525950T2 (hu)
DK (1) DK0782569T3 (hu)
ES (1) ES2173194T3 (hu)
FI (1) FI117436B (hu)
HU (1) HU216291B (hu)
MX (1) MX9702210A (hu)
NO (1) NO308074B1 (hu)
PL (1) PL183204B1 (hu)
PT (1) PT782569E (hu)
WO (1) WO1996009290A1 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
US6962998B2 (en) 2000-06-14 2005-11-08 Toray Industries, Inc. Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE482695T1 (de) 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
EA201001885A1 (ru) * 2004-09-17 2011-12-30 Дьюрект Корпорейшн Система контролируемой доставки
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
PT2117521E (pt) 2006-11-03 2012-09-10 Durect Corp Sistemas de administração transdérmica que compreendem bupivacaína
EP2067471B1 (en) * 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
CN103664744B (zh) * 2013-11-30 2015-07-15 山东永泰化工有限公司 一种左布比卡因的制备方法
WO2019222565A1 (en) * 2018-05-18 2019-11-21 Kura Oncology, Inc. Synthesis of tipifarnib
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
AU695479B2 (en) 1998-08-13
CN1104416C (zh) 2003-04-02
DE69525950D1 (de) 2002-04-25
ATE214695T1 (de) 2002-04-15
MX9702210A (es) 1998-05-31
PL319368A1 (en) 1997-08-04
NO308074B1 (no) 2000-07-17
AU3527995A (en) 1996-04-09
KR100393133B1 (ko) 2003-11-17
DE69525950T2 (de) 2002-09-19
JPH10505855A (ja) 1998-06-09
WO1996009290A1 (en) 1996-03-28
ES2173194T3 (es) 2002-10-16
NO971358L (no) 1997-03-21
PL183204B1 (pl) 2002-06-28
CA2200490A1 (en) 1996-03-28
FI971202A (fi) 1997-03-21
CN1159184A (zh) 1997-09-10
DK0782569T3 (da) 2002-07-22
EP0782569A1 (en) 1997-07-09
FI971202A0 (fi) 1997-03-21
NO971358D0 (no) 1997-03-21
CA2200490C (en) 2007-01-09
EP0782569B1 (en) 2002-03-20
US5786484A (en) 1998-07-28
PT782569E (pt) 2002-09-30
FI117436B (fi) 2006-10-13
HU216291B (hu) 1999-06-28
JP3898220B2 (ja) 2007-03-28

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Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: DARWIN DISCOVERY LIMITED, GB