ES2173194T3 - Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos. - Google Patents
Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos.Info
- Publication number
- ES2173194T3 ES2173194T3 ES95932092T ES95932092T ES2173194T3 ES 2173194 T3 ES2173194 T3 ES 2173194T3 ES 95932092 T ES95932092 T ES 95932092T ES 95932092 T ES95932092 T ES 95932092T ES 2173194 T3 ES2173194 T3 ES 2173194T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- compound
- date
- levobupivacaine
- racemization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measurement Of Radiation (AREA)
Abstract
UN PROCEDIMIENTO DE RACEMIZACION DE UN COMPUESTO DE PIPERIDINA2-CARBOXANILIDA, OPTICAMENTE ENRIQUECIDO, QUE CONSISTE EN EL CALENTAMIENTO DE DICHO COMPUESTO, EN PRESENCIA DE UN ACIDO ARILALCANOICO O ALCANOICO. UN PROCEDIMIENTO DE TRANSFORMACION ASIMETRICA DE DICHO COMPUESTO, QUE COMPRENDE EL CALENTAMIENTO DEL MISMO EN PRESENCIA DE UN ACIDO COMO EL DEFINIDO ANTERIORMENTE, UN AGENTE DE RESOLUCION DEL ACIDO QUIRAL Y UN COSOLVENTE INERTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94306962 | 1994-09-23 | ||
GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173194T3 true ES2173194T3 (es) | 2002-10-16 |
Family
ID=26137306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932092T Expired - Lifetime ES2173194T3 (es) | 1994-09-23 | 1995-09-22 | Procedimiento de racemizacion utilizado para la preparacion de levobupivacaina y sus analogos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5786484A (es) |
EP (1) | EP0782569B1 (es) |
JP (1) | JP3898220B2 (es) |
KR (1) | KR100393133B1 (es) |
CN (1) | CN1104416C (es) |
AT (1) | ATE214695T1 (es) |
AU (1) | AU695479B2 (es) |
CA (1) | CA2200490C (es) |
DE (1) | DE69525950T2 (es) |
DK (1) | DK0782569T3 (es) |
ES (1) | ES2173194T3 (es) |
FI (1) | FI117436B (es) |
HU (1) | HU216291B (es) |
MX (1) | MX9702210A (es) |
NO (1) | NO308074B1 (es) |
PL (1) | PL183204B1 (es) |
PT (1) | PT782569E (es) |
WO (1) | WO1996009290A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
BR0002246A (pt) * | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
EP1295873A4 (en) * | 2000-06-14 | 2004-05-19 | METHODS OF PRODUCING RACEMIC PIPERIDINE DERIVATIVE AND PRODUCING OPTICALLY ACTIVE PIPERIDINE DERIVATIVE | |
US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
AU2003299659A1 (en) | 2002-12-13 | 2004-07-09 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
NZ553369A (en) * | 2004-09-17 | 2010-11-26 | Durect Corp | Sustained local anesthetic composition containing preferably a sugar ester such as saib |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
PL2117521T3 (pl) | 2006-11-03 | 2012-11-30 | Durect Corp | Transdermalne systemy dostarczania zawierające bupiwakainę |
EP2219622A1 (en) | 2007-12-06 | 2010-08-25 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
US9572885B2 (en) | 2013-03-15 | 2017-02-21 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
BR112020023559A2 (pt) * | 2018-05-18 | 2021-02-09 | Kura Oncology, Inc. | método para preparar um enantiômero de tipifarnib desejado e método para transformar uma amina enantiomericamente enriquecida |
CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active IP Right Cessation
- 1995-09-22 EP EP95932092A patent/EP0782569B1/en not_active Expired - Lifetime
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/en active IP Right Grant
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 CA CA002200490A patent/CA2200490C/en not_active Expired - Lifetime
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
-
1997
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUT77055A (hu) | 1998-03-02 |
DE69525950T2 (de) | 2002-09-19 |
US5786484A (en) | 1998-07-28 |
PL319368A1 (en) | 1997-08-04 |
AU3527995A (en) | 1996-04-09 |
DK0782569T3 (da) | 2002-07-22 |
FI971202A0 (fi) | 1997-03-21 |
DE69525950D1 (de) | 2002-04-25 |
HU216291B (hu) | 1999-06-28 |
EP0782569A1 (en) | 1997-07-09 |
WO1996009290A1 (en) | 1996-03-28 |
FI971202A (fi) | 1997-03-21 |
JP3898220B2 (ja) | 2007-03-28 |
JPH10505855A (ja) | 1998-06-09 |
FI117436B (fi) | 2006-10-13 |
EP0782569B1 (en) | 2002-03-20 |
NO971358L (no) | 1997-03-21 |
PL183204B1 (pl) | 2002-06-28 |
NO971358D0 (no) | 1997-03-21 |
CA2200490C (en) | 2007-01-09 |
ATE214695T1 (de) | 2002-04-15 |
NO308074B1 (no) | 2000-07-17 |
PT782569E (pt) | 2002-09-30 |
CN1159184A (zh) | 1997-09-10 |
KR100393133B1 (ko) | 2003-11-17 |
CN1104416C (zh) | 2003-04-02 |
MX9702210A (es) | 1998-05-31 |
CA2200490A1 (en) | 1996-03-28 |
AU695479B2 (en) | 1998-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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