MX9702210A - Procesos de racemisacion y transformacion asimetrica usados en la manufactura de levobupuvacaina y sus analogos. - Google Patents
Procesos de racemisacion y transformacion asimetrica usados en la manufactura de levobupuvacaina y sus analogos.Info
- Publication number
- MX9702210A MX9702210A MX9702210A MX9702210A MX9702210A MX 9702210 A MX9702210 A MX 9702210A MX 9702210 A MX9702210 A MX 9702210A MX 9702210 A MX9702210 A MX 9702210A MX 9702210 A MX9702210 A MX 9702210A
- Authority
- MX
- Mexico
- Prior art keywords
- racemisation
- levobupivacaine
- analogues
- manufacture
- asymmetric transformation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of Radiation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Un proceso para la racemizacion de un compuesto de piperidin-2-carboxaniladaopticamente enriquecido, que comprende calentar el compuesto en presencia de una ácido alcanoico o arilalcanoico. Un proceso para la transformacion asimétrica de un compuesto, que comprende calentar el compuesto en presencia de un ácido como definio en lo anterior, un agente de resolucion de ácido y un cosolvente inerte.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94306962 | 1994-09-23 | ||
GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
PCT/GB1995/002247 WO1996009290A1 (en) | 1994-09-23 | 1995-09-22 | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9702210A true MX9702210A (es) | 1998-05-31 |
Family
ID=26137306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9702210A MX9702210A (es) | 1994-09-23 | 1995-09-22 | Procesos de racemisacion y transformacion asimetrica usados en la manufactura de levobupuvacaina y sus analogos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5786484A (es) |
EP (1) | EP0782569B1 (es) |
JP (1) | JP3898220B2 (es) |
KR (1) | KR100393133B1 (es) |
CN (1) | CN1104416C (es) |
AT (1) | ATE214695T1 (es) |
AU (1) | AU695479B2 (es) |
CA (1) | CA2200490C (es) |
DE (1) | DE69525950T2 (es) |
DK (1) | DK0782569T3 (es) |
ES (1) | ES2173194T3 (es) |
FI (1) | FI117436B (es) |
HU (1) | HU216291B (es) |
MX (1) | MX9702210A (es) |
NO (1) | NO308074B1 (es) |
PL (1) | PL183204B1 (es) |
PT (1) | PT782569E (es) |
WO (1) | WO1996009290A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
BR0002246A (pt) * | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
WO2001096301A1 (fr) | 2000-06-14 | 2001-12-20 | Toray Industries, Inc. | Procedes de production de derive de piperidine racemique et de production de derive de piperidine a activite optique |
DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
ES2350689T3 (es) | 2002-12-13 | 2011-01-26 | Durect Corporation | Sistema de suministro de fármacos oral que comprende materiales vehículo líquidos de alta viscosidad. |
WO2006033948A2 (en) | 2004-09-17 | 2006-03-30 | Durect Corporation | Sustained local anesthetic composition containing preferably a sugar ester such as saib |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
WO2008066642A2 (en) | 2006-11-03 | 2008-06-05 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
JP2011506318A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 経口医薬製剤 |
US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
WO2014144975A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
KR20210039987A (ko) * | 2018-05-18 | 2021-04-12 | 쿠라 온콜로지, 인크. | 티피파닙의 합성 |
JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active IP Right Cessation
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 EP EP95932092A patent/EP0782569B1/en not_active Expired - Lifetime
- 1995-09-22 CA CA002200490A patent/CA2200490C/en not_active Expired - Lifetime
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/en active IP Right Grant
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
-
1997
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO308074B1 (no) | 2000-07-17 |
EP0782569A1 (en) | 1997-07-09 |
FI971202A (fi) | 1997-03-21 |
CA2200490A1 (en) | 1996-03-28 |
HUT77055A (hu) | 1998-03-02 |
FI971202A0 (fi) | 1997-03-21 |
PT782569E (pt) | 2002-09-30 |
HU216291B (hu) | 1999-06-28 |
CN1104416C (zh) | 2003-04-02 |
ES2173194T3 (es) | 2002-10-16 |
US5786484A (en) | 1998-07-28 |
DK0782569T3 (da) | 2002-07-22 |
AU3527995A (en) | 1996-04-09 |
CN1159184A (zh) | 1997-09-10 |
NO971358D0 (no) | 1997-03-21 |
CA2200490C (en) | 2007-01-09 |
JPH10505855A (ja) | 1998-06-09 |
DE69525950T2 (de) | 2002-09-19 |
PL319368A1 (en) | 1997-08-04 |
DE69525950D1 (de) | 2002-04-25 |
AU695479B2 (en) | 1998-08-13 |
PL183204B1 (pl) | 2002-06-28 |
ATE214695T1 (de) | 2002-04-15 |
NO971358L (no) | 1997-03-21 |
WO1996009290A1 (en) | 1996-03-28 |
FI117436B (fi) | 2006-10-13 |
JP3898220B2 (ja) | 2007-03-28 |
EP0782569B1 (en) | 2002-03-20 |
KR100393133B1 (ko) | 2003-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9702210A (es) | Procesos de racemisacion y transformacion asimetrica usados en la manufactura de levobupuvacaina y sus analogos. | |
DE69921881D1 (de) | L-Glutaminsäure-herstellendes Bakterium und Verfahren zur Herstellung von L-Glutaminsäure | |
DK0877090T3 (da) | Fremgangsmåde til produktion af L-aminosyrer | |
DE60033151D1 (de) | L-aminosäure herstellendes bakterium und verfahren zur herstellung von l-aminosäure | |
DE69941756D1 (de) | L-Glutaminsäure herstellendes Bakterium und Verfahren zur Herstellung von Glutaminsäure | |
DE69530242D1 (de) | Verfahren zur Herstellung von Glutaminsäure durch Fermentation | |
SG66356A1 (en) | Process for production of acrylic acid | |
IL140419A0 (en) | Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same | |
HUP0000728A3 (en) | Salt of naphthyridine carboxylic acid derivative, process for producing it and pharmaceutical composition containing it | |
AU5707000A (en) | Process for producing l-amino acid | |
DE69708818D1 (de) | Verfahren zur Herstellung von Salpetersäure. | |
ZA200006161B (en) | Method for production of acrylic acid and apparatus for production of acrylic acid. | |
DE69413946T2 (de) | Verfahren zur Herstellung von hochreiner 2,6-Naphthalindicarbonsäure | |
AU5571100A (en) | Process for producing l-amino acid | |
PL338215A1 (en) | Method of obtaining 3-cyano-2,4-dichlorogeno-5-fluorobenzoic acids | |
KR950700870A (ko) | 아디핀산의 제조 방법(process for preparing adipic acid) | |
DE59808082D1 (de) | Verfahren zur herstellung von langkettigen glycin-n,n-diessigsäure-derivaten | |
AU4277001A (en) | Process for producing l-amino acid via fermentation method | |
AU5707200A (en) | Process for producing l-amino acid | |
DE69503196T2 (de) | Verfahren zur Herstellung von Ranitdinbase in pharmazeutischer Reinheit | |
DE69609940T4 (de) | Verfahren zur Herstellung von Adipinsäure | |
DE69524737T2 (de) | 2-isoxazolin-derivate, verfahren zu deren herstellung sowie verfahren zur herstellung von verwandten verbindungen | |
DE69908169T2 (de) | Verfahren zum herstellen von alpha-arylalkansäuren | |
UA32939A (uk) | Сульфокамфокаїн, спосіб його виготовлення і спосіб підготовки обладнання для виготовлення сульфокамфокаїну | |
GB9607864D0 (en) | Microorganism strain, process and apparatus for the manufacture of citric acid |