FI117375B - Hainrustouutteet, joissa on antiangiogeenistä aktiivisuutta ja vaikutusta kasvaimen takautumiseen, sekä menetelmä mainittujen uutteiden valmistamiseksi - Google Patents

Hainrustouutteet, joissa on antiangiogeenistä aktiivisuutta ja vaikutusta kasvaimen takautumiseen, sekä menetelmä mainittujen uutteiden valmistamiseksi Download PDF

Info

Publication number
FI117375B
FI117375B FI964327A FI964327A FI117375B FI 117375 B FI117375 B FI 117375B FI 964327 A FI964327 A FI 964327A FI 964327 A FI964327 A FI 964327A FI 117375 B FI117375 B FI 117375B
Authority
FI
Finland
Prior art keywords
kda
fraction
molecular weight
extract
liquid
Prior art date
Application number
FI964327A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964327A0 (fi
FI964327A (fi
Inventor
Eric Dupont
Paul Brazeau
Christina Juneau
Original Assignee
Aeterna Zentaris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Inc filed Critical Aeterna Zentaris Inc
Publication of FI964327A0 publication Critical patent/FI964327A0/fi
Publication of FI964327A publication Critical patent/FI964327A/fi
Application granted granted Critical
Publication of FI117375B publication Critical patent/FI117375B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI964327A 1994-04-28 1996-10-28 Hainrustouutteet, joissa on antiangiogeenistä aktiivisuutta ja vaikutusta kasvaimen takautumiseen, sekä menetelmä mainittujen uutteiden valmistamiseksi FI117375B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23401994A 1994-04-28 1994-04-28
US23401994 1994-04-28
US38455595 1995-02-03
US08/384,555 US5618925A (en) 1994-04-28 1995-02-03 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
PCT/CA1995/000233 WO1995032722A1 (en) 1994-04-28 1995-04-21 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
CA9500233 1995-04-21

Publications (3)

Publication Number Publication Date
FI964327A0 FI964327A0 (fi) 1996-10-28
FI964327A FI964327A (fi) 1996-12-20
FI117375B true FI117375B (fi) 2006-09-29

Family

ID=26927471

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964327A FI117375B (fi) 1994-04-28 1996-10-28 Hainrustouutteet, joissa on antiangiogeenistä aktiivisuutta ja vaikutusta kasvaimen takautumiseen, sekä menetelmä mainittujen uutteiden valmistamiseksi

Country Status (24)

Country Link
US (2) US5618925A (ko)
EP (1) EP0759765B1 (ko)
JP (1) JPH09512563A (ko)
KR (1) KR100378787B1 (ko)
CN (2) CN1147305C (ko)
AT (1) ATE224198T1 (ko)
BG (1) BG62954B1 (ko)
BR (1) BR9507552A (ko)
CA (1) CA2188793C (ko)
CZ (1) CZ290520B6 (ko)
DE (1) DE69528258T2 (ko)
DK (1) DK0759765T3 (ko)
ES (1) ES2182900T3 (ko)
FI (1) FI117375B (ko)
HU (1) HU220784B1 (ko)
IS (1) IS1975B (ko)
NO (1) NO317674B1 (ko)
NZ (1) NZ284407A (ko)
PL (1) PL181981B1 (ko)
PT (1) PT759765E (ko)
RO (1) RO114868B1 (ko)
RU (1) RU2156132C2 (ko)
SI (1) SI0759765T1 (ko)
WO (1) WO1995032722A1 (ko)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028118A (en) * 1996-08-08 2000-02-22 Les Laboratoires Aeterna Inc. Methods of using extracts of shark cartilage
US6380366B1 (en) * 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6025334A (en) * 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
CZ292627B6 (cs) * 1995-02-03 2003-11-12 Les Laboratoires Aeterna Inc. Léčivo pro léčení nemocí nebo poruch majících složku kolagenolytickou nebo zánětlivou
US5843920A (en) * 1996-09-16 1998-12-01 Biocell Technology, Llc Anionic saccharides for extraction of anti-angiogenic protein from cartilage
AU6639898A (en) * 1997-02-20 1998-09-09 Industrial Research Limited Angiogenesis inhibitors and activators from shark cartilage
RU2195946C2 (ru) * 1997-03-11 2003-01-10 Ле Лабораториз Аетерна Инк. Противоопухолевые терапевтические средства, включающие комбинацию экстракта хряща и антинеопластического агента, обеспечивающие высокую эффективность действия при низких токсических побочных эффектах
AU8379098A (en) * 1997-07-11 1999-02-08 Cv Technologies Inc. A preparation derived from shark cartilage for treatment of diseases related to excessive phf or excessive intracellular calcium
US5840342A (en) * 1997-09-17 1998-11-24 Raithaus; Lawrence R. Shark liver extract for stimulating the immune system
FR2778558B1 (fr) 1998-05-12 2001-02-16 Oreal Utilisation d'inhibiteur de metalloproteinases pour induire et/ou stimuler la croissance des cheveux ou des poils et/ou freiner leur chute
PT1520588E (pt) 1998-07-13 2015-03-31 Univ Texas Usos de anticorpos para amino fosfolípidos para o tratamento do cancro
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
CN1064690C (zh) * 1998-09-10 2001-04-18 中国人民解放军海军医学研究所 鲨鱼软骨血管生成抑制因子及其分离纯化方法
US7361643B2 (en) 2000-02-09 2008-04-22 University Of Puerto Rico Methods for inhibiting angiogenesis
US20040009233A1 (en) * 2000-12-20 2004-01-15 Davis Paul Frank Shark meat extract
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
US20030095981A1 (en) * 2001-05-30 2003-05-22 Kin-Ping Wong Compositions containing an active fraction isolated from ganoderma lucidum and methods of use
US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
US7309501B2 (en) * 2001-06-21 2007-12-18 Mote Marine Laboratory Conditioned media to inhibit growth of tumor cells
US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
WO2003068249A1 (en) 2002-02-15 2003-08-21 Ocean Nutrition Canada Limited Shark cartilage extracts and use thereof for immunomodulation
NZ537690A (en) 2002-07-15 2009-07-31 Univ Texas Antibodies binding to anionic phospholipids and aminophospholipids and their use in treating viral infections
EP1614697A4 (en) * 2003-03-20 2007-10-10 Hosokawa Micron Kk FROM CORTAR FISH ISOLATED PROTEOGLYKAN AND METHOD OF MANUFACTURING THEREOF
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
ES2223291B1 (es) * 2003-08-06 2006-03-16 Bioiberica, S.A. Nuevo uso terapeutico de condroitin sulfato.
ES2403357T3 (es) 2003-12-11 2013-05-17 Isto Technologies Inc. Sistema de cartílago particulado
ME01881B (me) 2004-01-22 2014-12-20 Univ Miami Topijske formulacije koenzima q10 i postupci upotrebe
CN100377741C (zh) * 2004-02-23 2008-04-02 江卫世 注射用复方骨肽及其制备工艺
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
WO2006059236A2 (en) * 2004-11-16 2006-06-08 Aeterna Zentaris Inc. Method of using cartilage extract for increasing blood parameters
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
DE102006060247A1 (de) * 2006-09-15 2008-03-27 Ossacur Ag Differenzierung von Stammzellen
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
KR101502267B1 (ko) 2007-11-09 2015-03-18 페레그린 파마수티컬즈, 인크 항-ｖｅｇｆ 항체 조성물 및 방법
CA2749750C (en) * 2008-04-15 2014-01-28 Immanence Integrale Dermo Correction Inc. Skin care compositions and methods of use thereof
CA2737146A1 (en) 2008-07-25 2010-01-28 The Regents Of The University Of Colorado Clip inhibitors and methods of modulating immune function
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
CN101891811B (zh) * 2010-05-28 2011-11-09 暨南大学 一种鲨鱼血管生成抑制因子及其生产纯化方法和应用
CN101899104B (zh) * 2010-05-28 2012-04-18 暨南大学 一种鲨鱼软骨血管生成抑制因子小分子多肽及其生产纯化方法和应用
US9284359B2 (en) * 2011-01-19 2016-03-15 Hirosaki University Method for mass preparation of proteoglycan
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN104894200B (zh) * 2015-05-12 2020-10-30 浙江海洋学院 路氏双髻鲨软骨血管生成抑制因子的制备方法
KR101628982B1 (ko) 2015-11-27 2016-06-09 김준혁 항종양 및 면역 증강용 건강식품 조성물
US10786471B2 (en) 2017-02-06 2020-09-29 Massachusetts Institute Of Technology Methods and products related to glutaminase inhibitors
CN109394786A (zh) * 2018-10-26 2019-03-01 西交利物浦大学 一种抗肿瘤的药物组合物
WO2020203812A1 (ja) * 2019-03-29 2020-10-08 学校法人慶應義塾 魚介類由来成分による低酸素応答制御
US20220241323A1 (en) * 2019-06-14 2022-08-04 "l2LIFE" LIMITED LIABILITY COMPANY("I2LIFE"LLC) Method for the production of iodinated proteins with a determinated iodine content
CN112986499A (zh) * 2021-02-26 2021-06-18 山西奥瑞生物材料有限公司 一种同种骨植入材料残余水量均匀度测定方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3478146A (en) * 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US4042457A (en) * 1975-11-10 1977-08-16 Rush-Presbyterian-St. Luke's Medical Center Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
US4822607A (en) * 1976-10-29 1989-04-18 Lescarden Ltd. Anti-tumor agent and method
US4243582A (en) * 1979-04-26 1981-01-06 Monsanto Company Novel glycoproteins from bovine cartilage
US4350682A (en) * 1979-05-11 1982-09-21 Lescarden Ltd. Cartilage extraction processes and products
US4356261A (en) * 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
US4473551A (en) * 1982-08-23 1984-09-25 Faxon Pharmaceuticals, Inc. Anti-inflammatory composition
US4656137A (en) * 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
US4746729A (en) * 1986-07-30 1988-05-24 Kuettner Klaus E Cartilage-derived leukocyte elastase-inhibitor
US5075112A (en) * 1990-02-12 1991-12-24 Cartilage Technologies Inc. Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage
WO1994012510A1 (en) * 1992-11-30 1994-06-09 Lane I William Processing shark cartilage
DE69435342D1 (de) * 1993-07-19 2011-05-05 Angiotech Pharm Inc Anti-Angiogene Mittel und Verfahren zu deren Verwendung
US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Also Published As

Publication number Publication date
AU719118B2 (en) 2000-05-04
FI964327A0 (fi) 1996-10-28
US5985839A (en) 1999-11-16
BG100941A (en) 1997-07-31
FI964327A (fi) 1996-12-20
WO1995032722A1 (en) 1995-12-07
NO964547D0 (no) 1996-10-25
KR100378787B1 (ko) 2003-06-19
HU9602975D0 (en) 1997-01-28
PL317076A1 (en) 1997-03-03
DK0759765T3 (da) 2003-01-27
NO317674B1 (no) 2004-11-29
IS1975B (is) 2005-01-14
CZ314196A3 (en) 1997-04-16
HU220784B1 (hu) 2002-05-28
RO114868B1 (ro) 1999-08-30
CN1541656A (zh) 2004-11-03
JPH09512563A (ja) 1997-12-16
ATE224198T1 (de) 2002-10-15
CA2188793C (en) 2001-01-16
US5618925A (en) 1997-04-08
NZ284407A (en) 1998-04-27
PL181981B1 (en) 2001-10-31
EP0759765A1 (en) 1997-03-05
RU2156132C2 (ru) 2000-09-20
BR9507552A (pt) 1997-08-05
PT759765E (pt) 2003-02-28
ES2182900T3 (es) 2003-03-16
CZ290520B6 (cs) 2002-08-14
DE69528258T2 (de) 2003-04-17
HUT76554A (en) 1997-09-29
IS4379A (is) 1996-10-25
KR970702729A (ko) 1997-06-10
BG62954B1 (bg) 2000-12-29
SI0759765T1 (en) 2003-02-28
CN1147305C (zh) 2004-04-28
DE69528258D1 (de) 2002-10-24
CN1153477A (zh) 1997-07-02
NO964547L (no) 1996-12-30
CA2188793A1 (en) 1995-12-07
AU2300195A (en) 1995-12-21
EP0759765B1 (en) 2002-09-18

Similar Documents

Publication Publication Date Title
FI117375B (fi) Hainrustouutteet, joissa on antiangiogeenistä aktiivisuutta ja vaikutusta kasvaimen takautumiseen, sekä menetelmä mainittujen uutteiden valmistamiseksi
KR100296016B1 (ko) 상어연골추출물
FI117376B (fi) Hainrustouutteiden käyttö valmistettaessa lääkettä kollagenolyysi- tai tulehdustekijän sisältävän sairauden hoitamiseksi
AU719118C (en) Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
AU724654B2 (en) Extracts of shark cartilage

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 117375

Country of ref document: FI