BR9507552A - Extrato de cartilagem de tubarão tendo uma atividade angiogênica e um efeito sobre regressão de tumor e processo para a sua preparação - Google Patents

Extrato de cartilagem de tubarão tendo uma atividade angiogênica e um efeito sobre regressão de tumor e processo para a sua preparação

Info

Publication number
BR9507552A
BR9507552A BR9507552A BR9507552A BR9507552A BR 9507552 A BR9507552 A BR 9507552A BR 9507552 A BR9507552 A BR 9507552A BR 9507552 A BR9507552 A BR 9507552A BR 9507552 A BR9507552 A BR 9507552A
Authority
BR
Brazil
Prior art keywords
supernatant
vivo
tumor
activity
angiogenic
Prior art date
Application number
BR9507552A
Other languages
English (en)
Inventor
Eric Dupont
Paul Brazeau
Christian Juneau
Original Assignee
Lab Aeterna Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Aeterna Inc filed Critical Lab Aeterna Inc
Publication of BR9507552A publication Critical patent/BR9507552A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
BR9507552A 1994-04-28 1995-04-21 Extrato de cartilagem de tubarão tendo uma atividade angiogênica e um efeito sobre regressão de tumor e processo para a sua preparação BR9507552A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23401994A 1994-04-28 1994-04-28
US08/384,555 US5618925A (en) 1994-04-28 1995-02-03 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
PCT/CA1995/000233 WO1995032722A1 (en) 1994-04-28 1995-04-21 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Publications (1)

Publication Number Publication Date
BR9507552A true BR9507552A (pt) 1997-08-05

Family

ID=26927471

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507552A BR9507552A (pt) 1994-04-28 1995-04-21 Extrato de cartilagem de tubarão tendo uma atividade angiogênica e um efeito sobre regressão de tumor e processo para a sua preparação

Country Status (24)

Country Link
US (2) US5618925A (pt)
EP (1) EP0759765B1 (pt)
JP (1) JPH09512563A (pt)
KR (1) KR100378787B1 (pt)
CN (2) CN1147305C (pt)
AT (1) ATE224198T1 (pt)
BG (1) BG62954B1 (pt)
BR (1) BR9507552A (pt)
CA (1) CA2188793C (pt)
CZ (1) CZ290520B6 (pt)
DE (1) DE69528258T2 (pt)
DK (1) DK0759765T3 (pt)
ES (1) ES2182900T3 (pt)
FI (1) FI117375B (pt)
HU (1) HU220784B1 (pt)
IS (1) IS1975B (pt)
NO (1) NO317674B1 (pt)
NZ (1) NZ284407A (pt)
PL (1) PL181981B1 (pt)
PT (1) PT759765E (pt)
RO (1) RO114868B1 (pt)
RU (1) RU2156132C2 (pt)
SI (1) SI0759765T1 (pt)
WO (1) WO1995032722A1 (pt)

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US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6025334A (en) * 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
AU717978B2 (en) * 1995-02-03 2000-04-06 Aeterna Zentaris Inc. Extracts of shark cartilage, process of production and uses thereof
US5843920A (en) * 1996-09-16 1998-12-01 Biocell Technology, Llc Anionic saccharides for extraction of anti-angiogenic protein from cartilage
AU6639898A (en) * 1997-02-20 1998-09-09 Industrial Research Limited Angiogenesis inhibitors and activators from shark cartilage
EP0967987B1 (en) * 1997-03-11 2003-06-04 Les Laboratoires Aeterna Inc. Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
CA2295519C (en) * 1997-07-11 2008-12-16 Cv Technologies Inc. A preparation derived from shark cartilage for treatment of diseases related to excessive phf or excessive intracellular calcium
US5840342A (en) * 1997-09-17 1998-11-24 Raithaus; Lawrence R. Shark liver extract for stimulating the immune system
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EP1096955B9 (en) 1998-07-13 2006-07-05 Board of Regents, The University of Texas System Uses of antibodies to aminophospholipids for cancer treatment
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
EP1234585A3 (en) 1998-09-04 2004-01-21 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
CN1064690C (zh) * 1998-09-10 2001-04-18 中国人民解放军海军医学研究所 鲨鱼软骨血管生成抑制因子及其分离纯化方法
US7361643B2 (en) 2000-02-09 2008-04-22 University Of Puerto Rico Methods for inhibiting angiogenesis
BR0114470A (pt) * 2000-12-20 2004-01-13 Ind Res Ltd Extrato de carne de tubarão
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
WO2002096450A1 (en) * 2001-05-30 2002-12-05 Wackvom Limited Compositions containing an active fraction isolated from ganoderma lucidum and methods of use
US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
US7309501B2 (en) * 2001-06-21 2007-12-18 Mote Marine Laboratory Conditioned media to inhibit growth of tumor cells
US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
CA2476126A1 (en) 2002-02-15 2003-08-21 Ocean Nutrition Canada Limited Shark cartilage extracts and use thereof for immunomodulation
BR0312692A (pt) 2002-07-15 2007-06-26 Univ Texas anticorpos selecionados e peptìdeos de duramicina que se ligam a fosfolipìdios aniÈnicos e aminofosfolipìdios e seus usos no tratamento de infecções virais e cáncer
WO2004083257A1 (ja) * 2003-03-20 2004-09-30 Hosokawa Micron Corporation 軟骨魚類から単離されたプロテオグリカンおよびその製造方法
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
ES2223291B1 (es) * 2003-08-06 2006-03-16 Bioiberica, S.A. Nuevo uso terapeutico de condroitin sulfato.
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
KR101535395B1 (ko) 2004-01-22 2015-07-08 유니버시티 오브 마이애미 국소용 코-엔자임 큐10 제형 및 그의 사용 방법
CN100377741C (zh) * 2004-02-23 2008-04-02 江卫世 注射用复方骨肽及其制备工艺
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
WO2006059236A2 (en) * 2004-11-16 2006-06-08 Aeterna Zentaris Inc. Method of using cartilage extract for increasing blood parameters
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
DE102006060247A1 (de) * 2006-09-15 2008-03-27 Ossacur Ag Differenzierung von Stammzellen
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
JP5809415B2 (ja) 2007-11-09 2015-11-10 ペレグリン ファーマシューティカルズ，インコーポレーテッド 抗ｖｅｇｆ抗体の組成物および方法
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
CA2749750C (en) * 2008-04-15 2014-01-28 Immanence Integrale Dermo Correction Inc. Skin care compositions and methods of use thereof
AU2009274512A1 (en) 2008-07-25 2010-01-28 The Regents Of The University Of Colorado Clip inhibitors and methods of modulating immune function
WO2010083051A2 (en) * 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
CN101891811B (zh) * 2010-05-28 2011-11-09 暨南大学 一种鲨鱼血管生成抑制因子及其生产纯化方法和应用
CN101899104B (zh) * 2010-05-28 2012-04-18 暨南大学 一种鲨鱼软骨血管生成抑制因子小分子多肽及其生产纯化方法和应用
WO2012099216A1 (ja) * 2011-01-19 2012-07-26 国立大学法人弘前大学 プロテオグリカンの大量調製法
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN104894200B (zh) * 2015-05-12 2020-10-30 浙江海洋学院 路氏双髻鲨软骨血管生成抑制因子的制备方法
KR101628982B1 (ko) 2015-11-27 2016-06-09 김준혁 항종양 및 면역 증강용 건강식품 조성물
US10786471B2 (en) 2017-02-06 2020-09-29 Massachusetts Institute Of Technology Methods and products related to glutaminase inhibitors
CN109394786A (zh) * 2018-10-26 2019-03-01 西交利物浦大学 一种抗肿瘤的药物组合物
WO2020203812A1 (ja) * 2019-03-29 2020-10-08 学校法人慶應義塾 魚介類由来成分による低酸素応答制御
WO2020251412A2 (ru) * 2019-06-14 2020-12-17 Общество С Ограниченной Ответственностью "Айтупайф" (Ооо "Айтулайф") Способ получения йодированных белков с детерминированным содержанием йода
CN112986499A (zh) * 2021-02-26 2021-06-18 山西奥瑞生物材料有限公司 一种同种骨植入材料残余水量均匀度测定方法

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Also Published As

Publication number Publication date
CZ290520B6 (cs) 2002-08-14
NO964547L (no) 1996-12-30
PL317076A1 (en) 1997-03-03
NZ284407A (en) 1998-04-27
PT759765E (pt) 2003-02-28
FI117375B (fi) 2006-09-29
HU9602975D0 (en) 1997-01-28
AU2300195A (en) 1995-12-21
DK0759765T3 (da) 2003-01-27
IS1975B (is) 2005-01-14
FI964327A (fi) 1996-12-20
EP0759765B1 (en) 2002-09-18
WO1995032722A1 (en) 1995-12-07
SI0759765T1 (en) 2003-02-28
ES2182900T3 (es) 2003-03-16
IS4379A (is) 1996-10-25
CN1153477A (zh) 1997-07-02
EP0759765A1 (en) 1997-03-05
KR100378787B1 (ko) 2003-06-19
CA2188793C (en) 2001-01-16
DE69528258D1 (de) 2002-10-24
PL181981B1 (en) 2001-10-31
NO964547D0 (no) 1996-10-25
BG62954B1 (bg) 2000-12-29
US5985839A (en) 1999-11-16
HUT76554A (en) 1997-09-29
ATE224198T1 (de) 2002-10-15
HU220784B1 (hu) 2002-05-28
BG100941A (en) 1997-07-31
DE69528258T2 (de) 2003-04-17
US5618925A (en) 1997-04-08
AU719118B2 (en) 2000-05-04
FI964327A0 (fi) 1996-10-28
NO317674B1 (no) 2004-11-29
RO114868B1 (ro) 1999-08-30
JPH09512563A (ja) 1997-12-16
RU2156132C2 (ru) 2000-09-20
CN1147305C (zh) 2004-04-28
CN1541656A (zh) 2004-11-03
CA2188793A1 (en) 1995-12-07
KR970702729A (ko) 1997-06-10
CZ314196A3 (en) 1997-04-16

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
TE Change of address
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: AETERNA ZENTARIS INC. (CA)

Free format text: ALTERADO DE: LES LABORATOIRES AETERNA INC.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 37, INDEFIRO O PRESENTE PEDIDO, TENDO POR BASE O ARTIGO 8O COMBINADO COM O ARTIGO 11, ARTIGO 10 INCISO IX E ARTIGO 25 DA LPI 9279 DE 14/05/96.