ES2182900T3 - Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion. - Google Patents
Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion.Info
- Publication number
- ES2182900T3 ES2182900T3 ES95916523T ES95916523T ES2182900T3 ES 2182900 T3 ES2182900 T3 ES 2182900T3 ES 95916523 T ES95916523 T ES 95916523T ES 95916523 T ES95916523 T ES 95916523T ES 2182900 T3 ES2182900 T3 ES 2182900T3
- Authority
- ES
- Spain
- Prior art keywords
- supernatant
- vivo
- tumor
- extracts
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
LA PRESENTE INVENCION SE REFIERE A EXTRACTOS DE CARTILAGO DE TIBURON Y A UN METODO PARA PRODUCIRLOS, ESTOS EXTRACTOS TIENEN PROPIEDADES ANTIANGIOGENICAS (SE HA OBSERVADO IN VIVO LA REDUCCION DEL AREA DE VASOS SANGUINEOS EN TUMORES INDUCIDOS EXPERIMENTALMENTE), ACTIVIDAD REGRESIVA DEL TUMOR IN VIVO ASI COMO DEMUESTRAN UN EFECTO INHIBITORIO DIRECTO EN LAS LINEAS CELULARES DEL TUMOR. ESTE PROCESO NO NECESITA DE NINGUN PRODUCTO O SOLVENTE DESNATURALIZADOR NI EL USO DE NINGUNA ENZIMA. CONSISTE EN OBTENER UNA MEZCLA DEL CONJUNTO DEL CARTILAGO EN UNA SOLUCION ACUOSA DE PH NEUTRAL, PREFERIBLEMENTE AGUA PURA, ESTA MEZCLA ES CENTRIFUGADA GUARDANDOSE LA BOLITA Y EL SOBRENADANTE PARA UN PROCESAMIENTO POSTERIOR. LA BOLITA SE LIOFILIZA Y PRUEBA EN LAS ACTIVIDADES ANTITUMORALES Y ANTIANGIOGENICA IN VIVO E IN VITRO, CON O SIN SOBRENADANTE. EL SOBRENADANTE HA DEMOSTRADO TENER IN VIVO ACTIVIDAD ANGIOGENICA Y DE REGRESION TUMORAL. LA COMPOSICION DEL SOBRENADANTE SE HA INVESTIGADO DE DIFERENTES FORMAS. EL FRACCIONAMIENTO DE ESTE SOBRENADANTE PERMITIO LA CARACTERIZACION DE ALGUNOS DE SUS COMPONENTES ACTIVOS. LA ACTIVIDAD DIRECTA IN VIVO DE LAS FRACCIONES HA SIDO PROBADA EN LAS LINEAS CELULARES TUMORALES. ADEMAS SE ASUME QUE EL SOBRENADANTE NO FRACCIONADO TIENE LA MISMA ACTIVIDAD IN VITRO. LA LIOFILIZACION DESTRUYE SUSTANCIALMENTE LA ACTIVIDAD DE ESTAS FRACCIONES LIQUIDAS SIN QUE SE HAYA OBSERVADO ESTA DESTRUCCION EN EL EXTRACTO SOLIDO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23401994A | 1994-04-28 | 1994-04-28 | |
US08/384,555 US5618925A (en) | 1994-04-28 | 1995-02-03 | Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182900T3 true ES2182900T3 (es) | 2003-03-16 |
Family
ID=26927471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95916523T Expired - Lifetime ES2182900T3 (es) | 1994-04-28 | 1995-04-21 | Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion. |
Country Status (24)
Country | Link |
---|---|
US (2) | US5618925A (es) |
EP (1) | EP0759765B1 (es) |
JP (1) | JPH09512563A (es) |
KR (1) | KR100378787B1 (es) |
CN (2) | CN1147305C (es) |
AT (1) | ATE224198T1 (es) |
BG (1) | BG62954B1 (es) |
BR (1) | BR9507552A (es) |
CA (1) | CA2188793C (es) |
CZ (1) | CZ290520B6 (es) |
DE (1) | DE69528258T2 (es) |
DK (1) | DK0759765T3 (es) |
ES (1) | ES2182900T3 (es) |
FI (1) | FI117375B (es) |
HU (1) | HU220784B1 (es) |
IS (1) | IS1975B (es) |
NO (1) | NO317674B1 (es) |
NZ (1) | NZ284407A (es) |
PL (1) | PL181981B1 (es) |
PT (1) | PT759765E (es) |
RO (1) | RO114868B1 (es) |
RU (1) | RU2156132C2 (es) |
SI (1) | SI0759765T1 (es) |
WO (1) | WO1995032722A1 (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618925A (en) * | 1994-04-28 | 1997-04-08 | Les Laboratories Aeterna Inc. | Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof |
US6028118A (en) * | 1996-08-08 | 2000-02-22 | Les Laboratoires Aeterna Inc. | Methods of using extracts of shark cartilage |
US6380366B1 (en) * | 1994-04-28 | 2002-04-30 | Les Laboratoires Aeterna Inc. | Shark cartilage extract:process of making, methods of using and compositions thereof |
US6025334A (en) * | 1994-04-28 | 2000-02-15 | Les Laboratoires Aeterna Inc. | Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof |
WO1996023512A1 (en) * | 1995-02-03 | 1996-08-08 | Les Laboratoires Aeterna Inc. | Extracts of shark cartilage, process of production and uses thereof |
US5843920A (en) * | 1996-09-16 | 1998-12-01 | Biocell Technology, Llc | Anionic saccharides for extraction of anti-angiogenic protein from cartilage |
AU6639898A (en) * | 1997-02-20 | 1998-09-09 | Industrial Research Limited | Angiogenesis inhibitors and activators from shark cartilage |
DE69815310T2 (de) | 1997-03-11 | 2004-04-22 | Les Laboratoires Aeterna Inc. | Zubereitungen zur tumorbehandlung enthaltend hai-knorpelextrakte und antineoplastische mittel |
KR100732322B1 (ko) * | 1997-07-11 | 2007-06-25 | 에프엑스 라이프 싸이언스즈 인터내셔널 게엠베하 | 피에이취에프 과다 또는 세포내 칼슘 과다와 관련한질병을 치료하기 위한 상어 연골에서 유래한 조제물 |
US5840342A (en) * | 1997-09-17 | 1998-11-24 | Raithaus; Lawrence R. | Shark liver extract for stimulating the immune system |
FR2778558B1 (fr) * | 1998-05-12 | 2001-02-16 | Oreal | Utilisation d'inhibiteur de metalloproteinases pour induire et/ou stimuler la croissance des cheveux ou des poils et/ou freiner leur chute |
CA2333147C (en) | 1998-07-13 | 2012-02-07 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US20020009501A1 (en) * | 1998-07-23 | 2002-01-24 | Eric Dupont | Preparation of cartilage extracts using organic solvents |
US6168807B1 (en) | 1998-07-23 | 2001-01-02 | Les Laboratoires Aeterna Inc. | Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof |
EP1234585A3 (en) | 1998-09-04 | 2004-01-21 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
CN1064690C (zh) * | 1998-09-10 | 2001-04-18 | 中国人民解放军海军医学研究所 | 鲨鱼软骨血管生成抑制因子及其分离纯化方法 |
US7361643B2 (en) | 2000-02-09 | 2008-04-22 | University Of Puerto Rico | Methods for inhibiting angiogenesis |
JP2004516272A (ja) * | 2000-12-20 | 2004-06-03 | インダストリアル リサーチ リミテッド | サメ肉抽出物 |
AUPR222300A0 (en) * | 2000-12-21 | 2001-01-25 | Life Therapeutics Limited | Electrophoresis device and method |
EP1401462A1 (en) * | 2001-05-30 | 2004-03-31 | Wackvom Limited | Compositions containing an active fraction isolated from ganoderma lucidum and methods of use |
US20030087830A1 (en) * | 2001-06-12 | 2003-05-08 | Eric Dupont | Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof |
US7309501B2 (en) * | 2001-06-21 | 2007-12-18 | Mote Marine Laboratory | Conditioned media to inhibit growth of tumor cells |
US6908627B2 (en) * | 2001-06-21 | 2005-06-21 | Mote Marine Laboratory | Conditioned media for inhibiting growth of tumor cells |
WO2003068249A1 (en) | 2002-02-15 | 2003-08-21 | Ocean Nutrition Canada Limited | Shark cartilage extracts and use thereof for immunomodulation |
ES2358730T3 (es) | 2002-07-15 | 2011-05-13 | Board Of Regents, The University Of Texas System | Anticuerpos seleccionados y péptidos de duramicina que se enlazan a fosfolípidos aniónicos y aminofosfolípidos y sus usos en el tratamiento de infecciones virales y del cáncer. |
WO2004083257A1 (ja) * | 2003-03-20 | 2004-09-30 | Hosokawa Micron Corporation | 軟骨魚類から単離されたプロテオグリカンおよびその製造方法 |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
ES2223291B1 (es) * | 2003-08-06 | 2006-03-16 | Bioiberica, S.A. | Nuevo uso terapeutico de condroitin sulfato. |
EP2338442B1 (en) | 2003-12-11 | 2013-01-30 | Isto Technologies Inc. | Particulate cartilage system |
CA3031283A1 (en) | 2004-01-22 | 2005-08-04 | University Of Miami | Topical co-enzyme q10 formulations and methods of use |
CN100377741C (zh) * | 2004-02-23 | 2008-04-02 | 江卫世 | 注射用复方骨肽及其制备工艺 |
US20050288796A1 (en) * | 2004-06-23 | 2005-12-29 | Hani Awad | Native soft tissue matrix for therapeutic applications |
US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
WO2006059236A2 (en) * | 2004-11-16 | 2006-06-08 | Aeterna Zentaris Inc. | Method of using cartilage extract for increasing blood parameters |
US7815926B2 (en) * | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
JP2009508596A (ja) | 2005-09-19 | 2009-03-05 | ヒストジェニックス コーポレイション | 細胞支持基材及びその調製方法 |
DE102006060247A1 (de) * | 2006-09-15 | 2008-03-27 | Ossacur Ag | Differenzierung von Stammzellen |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
WO2008128075A1 (en) | 2007-04-12 | 2008-10-23 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
WO2009060198A1 (en) | 2007-11-09 | 2009-05-14 | Peregrine Pharmaceuticals, Inc. | Anti-vegf antibody compositions and methods |
WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
CA2749750C (en) * | 2008-04-15 | 2014-01-28 | Immanence Integrale Dermo Correction Inc. | Skin care compositions and methods of use thereof |
AU2009274512A1 (en) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of Colorado | Clip inhibitors and methods of modulating immune function |
US20100274362A1 (en) * | 2009-01-15 | 2010-10-28 | Avner Yayon | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
CN101899104B (zh) * | 2010-05-28 | 2012-04-18 | 暨南大学 | 一种鲨鱼软骨血管生成抑制因子小分子多肽及其生产纯化方法和应用 |
CN101891811B (zh) * | 2010-05-28 | 2011-11-09 | 暨南大学 | 一种鲨鱼血管生成抑制因子及其生产纯化方法和应用 |
CN103429608B (zh) * | 2011-01-19 | 2016-08-03 | 国立大学法人弘前大学 | 蛋白多糖的大量制备方法 |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
CN104894200B (zh) * | 2015-05-12 | 2020-10-30 | 浙江海洋学院 | 路氏双髻鲨软骨血管生成抑制因子的制备方法 |
KR101628982B1 (ko) | 2015-11-27 | 2016-06-09 | 김준혁 | 항종양 및 면역 증강용 건강식품 조성물 |
EP3576726A1 (en) | 2017-02-06 | 2019-12-11 | Massachusetts Institute Of Technology | Methods and products related to glutaminase inhibitors |
CN109394786A (zh) * | 2018-10-26 | 2019-03-01 | 西交利物浦大学 | 一种抗肿瘤的药物组合物 |
WO2020203812A1 (ja) * | 2019-03-29 | 2020-10-08 | 学校法人慶應義塾 | 魚介類由来成分による低酸素応答制御 |
WO2020251412A2 (ru) * | 2019-06-14 | 2020-12-17 | Общество С Ограниченной Ответственностью "Айтупайф" (Ооо "Айтулайф") | Способ получения йодированных белков с детерминированным содержанием йода |
CN112986499A (zh) * | 2021-02-26 | 2021-06-18 | 山西奥瑞生物材料有限公司 | 一种同种骨植入材料残余水量均匀度测定方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3478146A (en) * | 1965-02-26 | 1969-11-11 | Leslie L Balassa | Wound-healing cartilage powder extracting process |
US4042457A (en) * | 1975-11-10 | 1977-08-16 | Rush-Presbyterian-St. Luke's Medical Center | Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor |
US4822607A (en) * | 1976-10-29 | 1989-04-18 | Lescarden Ltd. | Anti-tumor agent and method |
US4243582A (en) * | 1979-04-26 | 1981-01-06 | Monsanto Company | Novel glycoproteins from bovine cartilage |
US4350682A (en) * | 1979-05-11 | 1982-09-21 | Lescarden Ltd. | Cartilage extraction processes and products |
US4356261A (en) * | 1980-04-22 | 1982-10-26 | Rush-Presbyterian-St. Luke's Medical Center | Anti-invasion factor containing cultures |
US4473551A (en) * | 1982-08-23 | 1984-09-25 | Faxon Pharmaceuticals, Inc. | Anti-inflammatory composition |
US4656137A (en) * | 1985-09-12 | 1987-04-07 | Lescarden Inc | Method of processing animal cartilage |
US4749522A (en) * | 1985-10-31 | 1988-06-07 | Angio-Medical Corporation | Supercritical fluid extraction of animal derived materials |
US4746729A (en) * | 1986-07-30 | 1988-05-24 | Kuettner Klaus E | Cartilage-derived leukocyte elastase-inhibitor |
US5075112A (en) * | 1990-02-12 | 1991-12-24 | Cartilage Technologies Inc. | Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage |
AU5596494A (en) * | 1992-11-30 | 1994-06-22 | I. William Lane | Processing shark cartilage |
ES2290074T3 (es) * | 1993-07-19 | 2008-02-16 | Angiotech Pharmaceuticals, Inc. | Composiciones anti-angiogenicas que contienen taxol y un vehiculo no biodegradable y su uso. |
US5618925A (en) * | 1994-04-28 | 1997-04-08 | Les Laboratories Aeterna Inc. | Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof |
-
1995
- 1995-02-03 US US08/384,555 patent/US5618925A/en not_active Expired - Lifetime
- 1995-04-21 NZ NZ284407A patent/NZ284407A/en unknown
- 1995-04-21 AT AT95916523T patent/ATE224198T1/de active
- 1995-04-21 RO RO96-02058A patent/RO114868B1/ro unknown
- 1995-04-21 DE DE69528258T patent/DE69528258T2/de not_active Expired - Lifetime
- 1995-04-21 PL PL95317076A patent/PL181981B1/pl not_active IP Right Cessation
- 1995-04-21 CN CNB951934368A patent/CN1147305C/zh not_active Expired - Lifetime
- 1995-04-21 ES ES95916523T patent/ES2182900T3/es not_active Expired - Lifetime
- 1995-04-21 KR KR1019960706077A patent/KR100378787B1/ko not_active IP Right Cessation
- 1995-04-21 SI SI9530630T patent/SI0759765T1/xx unknown
- 1995-04-21 CA CA002188793A patent/CA2188793C/en not_active Expired - Lifetime
- 1995-04-21 JP JP8500104A patent/JPH09512563A/ja active Pending
- 1995-04-21 EP EP95916523A patent/EP0759765B1/en not_active Expired - Lifetime
- 1995-04-21 CZ CZ19963141A patent/CZ290520B6/cs not_active IP Right Cessation
- 1995-04-21 PT PT95916523T patent/PT759765E/pt unknown
- 1995-04-21 RU RU96123763/14A patent/RU2156132C2/ru active
- 1995-04-21 BR BR9507552A patent/BR9507552A/pt not_active Application Discontinuation
- 1995-04-21 WO PCT/CA1995/000233 patent/WO1995032722A1/en active IP Right Grant
- 1995-04-21 CN CNA2004100397718A patent/CN1541656A/zh active Pending
- 1995-04-21 HU HU9602975A patent/HU220784B1/hu not_active IP Right Cessation
- 1995-04-21 DK DK95916523T patent/DK0759765T3/da active
-
1996
- 1996-10-08 US US08/727,300 patent/US5985839A/en not_active Expired - Lifetime
- 1996-10-25 NO NO19964547A patent/NO317674B1/no unknown
- 1996-10-25 IS IS4379A patent/IS1975B/is unknown
- 1996-10-28 BG BG100941A patent/BG62954B1/bg unknown
- 1996-10-28 FI FI964327A patent/FI117375B/fi active IP Right Grant
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