ES2188672T3 - Extractos de cartilagos de tiburon, procedimiento para la obtencion y utilizaciones de los mismos. - Google Patents

Extractos de cartilagos de tiburon, procedimiento para la obtencion y utilizaciones de los mismos.

Info

Publication number
ES2188672T3
ES2188672T3 ES95935309T ES95935309T ES2188672T3 ES 2188672 T3 ES2188672 T3 ES 2188672T3 ES 95935309 T ES95935309 T ES 95935309T ES 95935309 T ES95935309 T ES 95935309T ES 2188672 T3 ES2188672 T3 ES 2188672T3
Authority
ES
Spain
Prior art keywords
procedure
cartilago
extract
extracts
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95935309T
Other languages
English (en)
Inventor
Eric Dupont
Paul Brazeau
Christina Juneau
Daniel H Maes
Kenneth Marenus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosciens Biopharma Inc
Original Assignee
Les Laboratories Aeterna Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/384,555 external-priority patent/US5618925A/en
Application filed by Les Laboratories Aeterna Inc filed Critical Les Laboratories Aeterna Inc
Application granted granted Critical
Publication of ES2188672T3 publication Critical patent/ES2188672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A EXTRACTOS DE CARTILAGO Y A UN METODO PARA PRODUCIRLOS. LOS EXTRACTOS DE CARTILAGO QUE TIENEN ACTIVIDADES ANTIANGIOGENICAS, DE PROLIFERACION DIRECTA ANTITUMORAL, ANTIINFLAMATORIA Y ANTICOLAGENOLITICA SE HAN OBTENIDO POR UN PROCEDIMIENTO MEJORADO. EL PROCEDIMIENTO INCLUYE LOS PASOS DE: OBTENER UN HOMOGENADO DE CARTILAGO EN UNA SOLUCION ACUOSA, SIENDO CENTRIFUGADO, Y ADEMAS FRACCIONADO PARA OBTENER UN EXTRACTO TOTAL QUE TIENE MOLECULAS DE UN PESO MOLECULAR COMPRENDIDO ENTRE 0 Y 500 KDA. LA COMPOSICION DEL EXTRACTO LIQUIDO SE HA INVESTIGADO POR DIFERENTES CAMINOS. EL FRACCIONAMIENTO DE ESTE EXTRACTO CONDUCE A LA CARACTERIZACION PREVIA DE ALGUNOS DE SUS COMPONENTES ACTIVOS. DEBIDO A LA MULTIPLICIDAD DE ACTIVIDADES BIOLOGICAS DEL TOTAL DE EXTRACTO LIQUIDO, SE PUEDE USAR PARA TRATAR NUMEROSAS ENFERMEDADES O CONDICIONES TALES COMO LAS QUE TIENEN COMPONENTES SELECCIONADOS EN EL GRUPO QUE CONSISTE EN LA PROLIFERACION TUMORAL, LA ANGIOGENESIS, LA INFLAMACION Y LA COLAGENOLISIS. ESTE EXTRACTO NO TIENE UN EFECTO OFENSIVO SOBRE LAS FUNCIONES NORMALES DEL CUERPO. POR LO TANTO, ESTE CARTILAGO DE TIBURON TIENE UN VALOR TERAPEUTICO MUY PROMETEDOR. EL PROCEDIMIENTO PARA LA OBTENCION DE CARTILAGO ES SENCILLO Y EFICIENTE. LOS PRODUCTOS INESPERADAMENTE VALIOSOS OBTENIDOS POR ESTE PROCEDIMIENTO SON POR LO TANTO UNA INDICACION DE UN PROCEDIMIENTO NUEVO Y NO EVIDENTE.
ES95935309T 1995-02-03 1995-10-30 Extractos de cartilagos de tiburon, procedimiento para la obtencion y utilizaciones de los mismos. Expired - Lifetime ES2188672T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/384,555 US5618925A (en) 1994-04-28 1995-02-03 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Publications (1)

Publication Number Publication Date
ES2188672T3 true ES2188672T3 (es) 2003-07-01

Family

ID=23517788

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95935309T Expired - Lifetime ES2188672T3 (es) 1995-02-03 1995-10-30 Extractos de cartilagos de tiburon, procedimiento para la obtencion y utilizaciones de los mismos.

Country Status (23)

Country Link
EP (1) EP0806960B1 (es)
JP (3) JPH11502514A (es)
KR (1) KR100347880B1 (es)
CN (1) CN1138550C (es)
AT (1) ATE230272T1 (es)
AU (1) AU717978B2 (es)
BG (1) BG63801B1 (es)
BR (1) BR9510540A (es)
CA (1) CA2212010C (es)
CZ (1) CZ292627B6 (es)
DE (1) DE69529300T2 (es)
DK (1) DK0806960T3 (es)
ES (1) ES2188672T3 (es)
FI (1) FI117376B (es)
HU (1) HU222088B1 (es)
IS (1) IS1963B (es)
MX (1) MX9705894A (es)
NO (1) NO318950B1 (es)
NZ (1) NZ294553A (es)
PL (1) PL188137B1 (es)
RO (1) RO117590B1 (es)
RU (1) RU2157695C2 (es)
WO (1) WO1996023512A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380366B1 (en) 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
US6025334A (en) * 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
AU724654B2 (en) * 1995-04-21 2000-09-28 Aeterna Zentaris Inc. Extracts of shark cartilage
US6379709B1 (en) 1997-02-20 2002-04-30 Industrial Research Limited Angiogenesis inhibitors and activators from shark cartilage
RU2195946C2 (ru) * 1997-03-11 2003-01-10 Ле Лабораториз Аетерна Инк. Противоопухолевые терапевтические средства, включающие комбинацию экстракта хряща и антинеопластического агента, обеспечивающие высокую эффективность действия при низких токсических побочных эффектах
WO1999002548A1 (en) * 1997-07-11 1999-01-21 Cv Technologies Inc. A preparation derived from shark cartilage for treatment of diseases related to excessive phf or excessive intracellular calcium
AUPO920597A0 (en) * 1997-09-16 1997-10-09 Micronized Foods Pty Ltd Pharmaceutical and/or therapeutic composition or preparation comprising shark cartilage and emu oil
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
CN1064690C (zh) * 1998-09-10 2001-04-18 中国人民解放军海军医学研究所 鲨鱼软骨血管生成抑制因子及其分离纯化方法
RU2161002C1 (ru) * 1999-07-30 2000-12-27 Государственное унитарное предприятие Тихоокеанский научно-исследовательский рыбохозяйственный центр Пищевой общеукрепляющий лечебно-профилактический продукт из хрящевой ткани акул и способ его получения
US6248341B1 (en) * 2000-01-14 2001-06-19 Color Access, Inc. Method of treating topical angiogenesis-related disorders
WO2001078674A1 (en) * 2000-04-18 2001-10-25 Ceteris Holding B.V. -Amsterdam (Olanda)- Succursale Di Lugano A composition based on natural extracts useful in the prevention and treatment of cutaneous wrinkles
AU2002216498B2 (en) * 2000-12-20 2005-10-13 Industrial Research Limited Shark meat extract
US20070010430A1 (en) * 2003-03-20 2007-01-11 Hosokawa Micron Corparation Proteoglycan isolated from cartilaginous fish and process for producing the same
ES2223291B1 (es) * 2003-08-06 2006-03-16 Bioiberica, S.A. Nuevo uso terapeutico de condroitin sulfato.
US7205006B2 (en) * 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
CN100377741C (zh) * 2004-02-23 2008-04-02 江卫世 注射用复方骨肽及其制备工艺
RU2250774C1 (ru) * 2004-04-29 2005-04-27 Научно-исследовательский институт медико-биологических проблем Владикавказского научного центра РАН и Правительства РСО-Алания (НИИ МБП ВНЦ РАН) Способ оптимизации лечения хронического простатита
US20070248930A1 (en) 2005-02-17 2007-10-25 Biolux Research Ltd. Light therapy apparatus and methods
US9242118B2 (en) 2010-12-08 2016-01-26 Biolux Research Ltd. Methods useful for remodeling maxillofacial bone using light therapy and a functional appliance
JP2015500286A (ja) * 2011-12-04 2015-01-05 リュー, デイヴィッド, エル.LIU, David, L. ナトリウムイオンおよびカルシウムイオンの医薬組成物ならびにがん、腫瘍、および非悪性腫瘍を治療する方法
RU2489906C1 (ru) * 2012-04-18 2013-08-20 Тамара Ивановна Николаева Биологически активная добавка к пище на основе денатурированного коллагена
US20130287859A1 (en) * 2012-04-26 2013-10-31 Lescarden Inc. Method for treating prupritus with cartilage extract
DE102012023927A1 (de) * 2012-12-06 2014-06-12 Heinrich Huber Heilsalbe gegen Psoriasis, auch als Wundsalbe verwendbar; 50 ml ohne Konservierung
WO2015058284A1 (en) 2013-10-22 2015-04-30 Biolux Research Ltd. Intra-oral light-therapy apparatuses and methods for their use
CN106492065A (zh) * 2016-10-20 2017-03-15 王凯茜 一种治疗风湿热的中药
KR102369902B1 (ko) * 2021-04-23 2022-03-02 이수한 전 처리된 캐비아가 함유된 철갑상어 진액 및 그 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822607A (en) * 1976-10-29 1989-04-18 Lescarden Ltd. Anti-tumor agent and method
US4473551A (en) * 1982-08-23 1984-09-25 Faxon Pharmaceuticals, Inc. Anti-inflammatory composition
US4486414A (en) * 1983-03-21 1984-12-04 Arizona Board Of Reagents Dolastatins A and B cell growth inhibitory substances
US5075112A (en) * 1990-02-12 1991-12-24 Cartilage Technologies Inc. Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage
IT1244879B (it) * 1990-12-11 1994-09-12 Alberto Bartorelli Estratti da tessuti animali, utili in terapia e in diagnostica.
RU2019180C1 (ru) * 1993-01-12 1994-09-15 Яков Давидович Безман Средство для лечения подкожной фибросаркомы и способ его получения
RU2019173C1 (ru) * 1993-01-12 1994-09-15 Яков Давидович Безман Способ лечения подкожной фибросаркомы
US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Also Published As

Publication number Publication date
MX9705894A (es) 1998-07-31
FI117376B (fi) 2006-09-29
BR9510540A (pt) 1998-06-09
CA2212010A1 (en) 1996-08-08
NO973564D0 (no) 1997-08-01
JP2003246742A (ja) 2003-09-02
HU222088B1 (hu) 2003-04-28
CN1177927A (zh) 1998-04-01
CZ245297A3 (cs) 1998-01-14
CN1138550C (zh) 2004-02-18
DK0806960T3 (da) 2003-04-22
HUT77488A (hu) 1998-05-28
BG101870A (en) 1998-04-30
NZ294553A (en) 1999-07-29
AU3738895A (en) 1996-08-21
IS1963B (is) 2004-12-15
PL188137B1 (pl) 2004-12-31
FI973195L (fi) 1997-10-01
FI973195A0 (fi) 1997-08-01
BG63801B1 (bg) 2003-01-31
JPH11502514A (ja) 1999-03-02
PL321678A1 (en) 1997-12-22
WO1996023512A1 (en) 1996-08-08
CA2212010C (en) 2004-08-17
EP0806960A1 (en) 1997-11-19
RU2157695C2 (ru) 2000-10-20
KR100347880B1 (ko) 2002-12-02
NO318950B1 (no) 2005-05-30
IS4537A (is) 1997-08-01
NO973564L (no) 1997-10-01
ATE230272T1 (de) 2003-01-15
RO117590B1 (ro) 2002-05-30
AU717978B2 (en) 2000-04-06
DE69529300D1 (de) 2003-02-06
JP2006290904A (ja) 2006-10-26
CZ292627B6 (cs) 2003-11-12
EP0806960B1 (en) 2003-01-02
DE69529300T2 (de) 2003-07-03

Similar Documents

Publication Publication Date Title
ES2188672T3 (es) Extractos de cartilagos de tiburon, procedimiento para la obtencion y utilizaciones de los mismos.
ES2190475T3 (es) Extractos de cartilago de tiburon.
ES2182900T3 (es) Extractos de cartilago de tiburon, que tienen una actividad anti-angiogenica y efecto en regresion de tumor, proceso para su produccion.
ATE412417T1 (de) Topische zusammensetzung zur behandlung von psoriasis und verwandten hautkrankheiten
ES2170274T3 (es) Metodo y preparaciones para estabilizar materiales biologicos por metodos de secado sin congelamiento.
PA8493701A1 (es) Compuestos para tratar la obesidad
DE3788231D1 (de) Kosmetisches mittel und zusammensetzung zur behandlung der haut.
ES2156107T3 (es) Un fgf-4 no glicosilado y composiciones que lo contienen.
CN107106859A (zh) 等离子体治疗感染的指甲或感染的皮肤
CN103110936A (zh) 一种促进皮肤组织快速生长修复的生物制剂
ES2111516T3 (es) Producto cosmetico con contenido de resina de ilex, procedimiento para la obtencion de resina de ilex y resina de ilex obtenida mediante dicho procedimiento.
ES2044514T3 (es) Agua de aloe, procedimiento de preparacion y composiciones que la contienen.
MX2022008203A (es) Tratamiento de trastornos cutaneos.
AR032574A1 (es) Conjugados peg de hgf-nk4
DE69734838D1 (de) Verwendung von zinksalzen der konjugierten linoleinsäuren zur behandlung von hautkrankheiten
ECSP003707A (es) Diazepanes
ES2196275T3 (es) Nuevas composiciones topicas que comprenden dosis muy bajas de melatonina o sus derivados y su utilizacion en cosmetica.
DE69629436D1 (de) Wirkungen auf der endothelauskleidung und behandlung von vasospastischen erkrankungen
CN105963162A (zh) 一种深层修复面膜及其制备方法
ES2196456T3 (es) Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen.
ES2110057T3 (es) Composicion medicinal que contiene tcf-ii.
ES2175582T3 (es) Cromanos sustituidos con sulfonamida, procedimiento para su preparacion, su utilizacion como medicamento, asi como preparados farmaceuticos que los contienen.
MXPA05012696A (es) Formulaciones de agentes antiinflamatorios no esteroides para tratar angiogenesis ocular patologica.
AR026756A1 (es) Nuevas combinaciones terapeuticas (s)-2-bencilamino-metil)-2,3,8,9-tetrahidro-7h-1,4-dioxino[2,3-e]indol-8-ona y neuroleticos para el tratamiento oprevencion de desordenes psicoticos
BE1023589A1 (nl) Verzorging van de huid