DK0759765T3 - Ekstrakter af hajbrusk med anti-angiogenisk aktivitet og en effekt på tumorregression samt en proces til fremstilling af disse - Google Patents

Ekstrakter af hajbrusk med anti-angiogenisk aktivitet og en effekt på tumorregression samt en proces til fremstilling af disse

Info

Publication number
DK0759765T3
DK0759765T3 DK95916523T DK95916523T DK0759765T3 DK 0759765 T3 DK0759765 T3 DK 0759765T3 DK 95916523 T DK95916523 T DK 95916523T DK 95916523 T DK95916523 T DK 95916523T DK 0759765 T3 DK0759765 T3 DK 0759765T3
Authority
DK
Denmark
Prior art keywords
supernatant
vivo
tumor
extracts
activity
Prior art date
Application number
DK95916523T
Other languages
Danish (da)
English (en)
Inventor
Eric Dupont
Paul Brazeau
Christina Juneau
Original Assignee
Aeterna Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Lab Inc filed Critical Aeterna Lab Inc
Application granted granted Critical
Publication of DK0759765T3 publication Critical patent/DK0759765T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95916523T 1994-04-28 1995-04-21 Ekstrakter af hajbrusk med anti-angiogenisk aktivitet og en effekt på tumorregression samt en proces til fremstilling af disse DK0759765T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23401994A 1994-04-28 1994-04-28
US08/384,555 US5618925A (en) 1994-04-28 1995-02-03 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
PCT/CA1995/000233 WO1995032722A1 (en) 1994-04-28 1995-04-21 Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof

Publications (1)

Publication Number Publication Date
DK0759765T3 true DK0759765T3 (da) 2003-01-27

Family

ID=26927471

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95916523T DK0759765T3 (da) 1994-04-28 1995-04-21 Ekstrakter af hajbrusk med anti-angiogenisk aktivitet og en effekt på tumorregression samt en proces til fremstilling af disse

Country Status (24)

Country Link
US (2) US5618925A (es)
EP (1) EP0759765B1 (es)
JP (1) JPH09512563A (es)
KR (1) KR100378787B1 (es)
CN (2) CN1147305C (es)
AT (1) ATE224198T1 (es)
BG (1) BG62954B1 (es)
BR (1) BR9507552A (es)
CA (1) CA2188793C (es)
CZ (1) CZ290520B6 (es)
DE (1) DE69528258T2 (es)
DK (1) DK0759765T3 (es)
ES (1) ES2182900T3 (es)
FI (1) FI117375B (es)
HU (1) HU220784B1 (es)
IS (1) IS1975B (es)
NO (1) NO317674B1 (es)
NZ (1) NZ284407A (es)
PL (1) PL181981B1 (es)
PT (1) PT759765E (es)
RO (1) RO114868B1 (es)
RU (1) RU2156132C2 (es)
SI (1) SI0759765T1 (es)
WO (1) WO1995032722A1 (es)

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US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6025334A (en) * 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US6028118A (en) * 1996-08-08 2000-02-22 Les Laboratoires Aeterna Inc. Methods of using extracts of shark cartilage
US6380366B1 (en) * 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
CZ292627B6 (cs) * 1995-02-03 2003-11-12 Les Laboratoires Aeterna Inc. Léčivo pro léčení nemocí nebo poruch majících složku kolagenolytickou nebo zánětlivou
US5843920A (en) * 1996-09-16 1998-12-01 Biocell Technology, Llc Anionic saccharides for extraction of anti-angiogenic protein from cartilage
CA2288269A1 (en) * 1997-02-20 1998-08-27 Industrial Research Limited Angiogenesis inhibitors and activators from shark cartilage
IL131701A (en) 1997-03-11 2005-03-20 Aeterna Zentaris Inc Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
AU8379098A (en) * 1997-07-11 1999-02-08 Cv Technologies Inc. A preparation derived from shark cartilage for treatment of diseases related to excessive phf or excessive intracellular calcium
US5840342A (en) * 1997-09-17 1998-11-24 Raithaus; Lawrence R. Shark liver extract for stimulating the immune system
FR2778558B1 (fr) 1998-05-12 2001-02-16 Oreal Utilisation d'inhibiteur de metalloproteinases pour induire et/ou stimuler la croissance des cheveux ou des poils et/ou freiner leur chute
AU771224B2 (en) 1998-07-13 2004-03-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US20020009501A1 (en) * 1998-07-23 2002-01-24 Eric Dupont Preparation of cartilage extracts using organic solvents
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
EP1234585A3 (en) 1998-09-04 2004-01-21 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
CN1064690C (zh) * 1998-09-10 2001-04-18 中国人民解放军海军医学研究所 鲨鱼软骨血管生成抑制因子及其分离纯化方法
US7361643B2 (en) 2000-02-09 2008-04-22 University Of Puerto Rico Methods for inhibiting angiogenesis
BR0114470A (pt) * 2000-12-20 2004-01-13 Ind Res Ltd Extrato de carne de tubarão
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
EP1401462A1 (en) * 2001-05-30 2004-03-31 Wackvom Limited Compositions containing an active fraction isolated from ganoderma lucidum and methods of use
US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
US7309501B2 (en) * 2001-06-21 2007-12-18 Mote Marine Laboratory Conditioned media to inhibit growth of tumor cells
CA2476126A1 (en) 2002-02-15 2003-08-21 Ocean Nutrition Canada Limited Shark cartilage extracts and use thereof for immunomodulation
EP2269656B1 (en) 2002-07-15 2014-08-20 Board Of Regents, The University Of Texas Selected antibodies binding to aminophospholipids and their use in treatment, such as cancer
US20070010430A1 (en) * 2003-03-20 2007-01-11 Hosokawa Micron Corparation Proteoglycan isolated from cartilaginous fish and process for producing the same
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
ES2223291B1 (es) * 2003-08-06 2006-03-16 Bioiberica, S.A. Nuevo uso terapeutico de condroitin sulfato.
EP2335650B1 (en) 2003-12-11 2012-10-03 Isto Technologies Inc. Particulate cartilage system
KR20170102377A (ko) 2004-01-22 2017-09-08 유니버시티 오브 마이애미 국소용 코-엔자임 큐10 제형 및 그의 사용 방법
CN100377741C (zh) * 2004-02-23 2008-04-02 江卫世 注射用复方骨肽及其制备工艺
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
WO2006059236A2 (en) * 2004-11-16 2006-06-08 Aeterna Zentaris Inc. Method of using cartilage extract for increasing blood parameters
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
DE102006060247A1 (de) * 2006-09-15 2008-03-27 Ossacur Ag Differenzierung von Stammzellen
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
WO2009060198A1 (en) 2007-11-09 2009-05-14 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
EP2262469A4 (en) * 2008-04-15 2013-12-04 Immanence Integrale Dermo Correction Inc SKIN CARE COMPOSITIONS AND METHODS OF USE
EP2323679A4 (en) 2008-07-25 2012-08-22 Univ Colorado CLIP HEMMER AND METHOD FOR MODULATING THE IMMUNE FUNCTION
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
CN101899104B (zh) * 2010-05-28 2012-04-18 暨南大学 一种鲨鱼软骨血管生成抑制因子小分子多肽及其生产纯化方法和应用
CN101891811B (zh) * 2010-05-28 2011-11-09 暨南大学 一种鲨鱼血管生成抑制因子及其生产纯化方法和应用
RU2592850C2 (ru) * 2011-01-19 2016-07-27 Хиросаки Юниверсити Способ крупномасштабного получения протеогликана
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN104894200B (zh) * 2015-05-12 2020-10-30 浙江海洋学院 路氏双髻鲨软骨血管生成抑制因子的制备方法
KR101628982B1 (ko) 2015-11-27 2016-06-09 김준혁 항종양 및 면역 증강용 건강식품 조성물
US10786471B2 (en) 2017-02-06 2020-09-29 Massachusetts Institute Of Technology Methods and products related to glutaminase inhibitors
CN109394786A (zh) * 2018-10-26 2019-03-01 西交利物浦大学 一种抗肿瘤的药物组合物
JP7366377B2 (ja) * 2019-03-29 2023-10-23 慶應義塾 魚介類由来成分による低酸素応答制御
US20220241323A1 (en) * 2019-06-14 2022-08-04 "l2LIFE" LIMITED LIABILITY COMPANY("I2LIFE"LLC) Method for the production of iodinated proteins with a determinated iodine content
CN112986499A (zh) * 2021-02-26 2021-06-18 山西奥瑞生物材料有限公司 一种同种骨植入材料残余水量均匀度测定方法

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US4042457A (en) * 1975-11-10 1977-08-16 Rush-Presbyterian-St. Luke's Medical Center Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
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Also Published As

Publication number Publication date
CZ290520B6 (cs) 2002-08-14
BG62954B1 (bg) 2000-12-29
HU220784B1 (hu) 2002-05-28
DE69528258D1 (de) 2002-10-24
CA2188793C (en) 2001-01-16
PT759765E (pt) 2003-02-28
NO317674B1 (no) 2004-11-29
RU2156132C2 (ru) 2000-09-20
AU719118B2 (en) 2000-05-04
CA2188793A1 (en) 1995-12-07
WO1995032722A1 (en) 1995-12-07
PL181981B1 (en) 2001-10-31
CZ314196A3 (en) 1997-04-16
DE69528258T2 (de) 2003-04-17
IS4379A (is) 1996-10-25
EP0759765B1 (en) 2002-09-18
ATE224198T1 (de) 2002-10-15
US5618925A (en) 1997-04-08
RO114868B1 (ro) 1999-08-30
BR9507552A (pt) 1997-08-05
US5985839A (en) 1999-11-16
CN1541656A (zh) 2004-11-03
BG100941A (en) 1997-07-31
NO964547D0 (no) 1996-10-25
PL317076A1 (en) 1997-03-03
HU9602975D0 (en) 1997-01-28
KR100378787B1 (ko) 2003-06-19
SI0759765T1 (en) 2003-02-28
HUT76554A (en) 1997-09-29
IS1975B (is) 2005-01-14
EP0759765A1 (en) 1997-03-05
AU2300195A (en) 1995-12-21
KR970702729A (ko) 1997-06-10
JPH09512563A (ja) 1997-12-16
CN1153477A (zh) 1997-07-02
FI964327A0 (fi) 1996-10-28
FI117375B (fi) 2006-09-29
NO964547L (no) 1996-12-30
NZ284407A (en) 1998-04-27
ES2182900T3 (es) 2003-03-16
CN1147305C (zh) 2004-04-28
FI964327A (fi) 1996-12-20

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